samedicino statistikis aqtualuri sakiTxebi

marina kikviZe

Tbilisi, tfdec09.02.2010

mizani

ganvixiloT samedicino statistikis ZiriTadi meTodebi;gavecnoT kvlevis Catarebis dros daSvebul Secdomebs.

samedicino statistika

klinikuri kvlevis Sedegad miRebul klinikuri kvlevis Sedegad miRebul monacemTa damuSavbis meTodia; damuSavbis meTodia;

kvlevis saSualebaa da ara Sedegi;kvlevis saSualebaa da ara Sedegi;

klinikuri gamocdilebis gadayvana klinikuri gamocdilebis gadayvana raodenobrivi Sefasebis enaze.raodenobrivi Sefasebis enaze.

biostatistika da klinikuri praqtika

samecniero kvlevis organizaciisa da Catarebis meTodologia

samedicino literaturis swori wakiTxva

kvleva zedmiwevniT guldasmiT unda davgegmoT, xolo

Sedegebi - sworad avxsnaT

klinikur monacemTa tipebi

raodenobrivi (interval data) xarisxobrivi (nominal data) rigiTi (ordinal data)

ganawilebis tipebi

0 5 20 40 60 80 95 100 2.5 10 30 50 70 90 97.5

50

40

30

20

10

0

+/– 2 standartuli gadaxra

+/–1 standartuli gadaxra

wili populaciaSi (%)

mon

acem

is

mn

iSvn

elo

ba

normaluri ganawilebis mrudi

ganawilebis tipebi

moda : yvelaze xSiri maCvenebelimediana: wertili, romlis qvemoT da zemoT

ganlagebulia maCvenebelebis zustad naxevari, anu 50% (procentili).

saSualo: monacemTa jami dakvirvebaTa ricxvi

asimetriuli ganawilebis mrudebi

statistikuri meTodebi

monacemebis aRwera

• parametriuli (saSualo, standartuli gadaxra)

• araparametriuli (mediana, moda, procentilebi)

hipoTezis Semowmeba

nulovani hipoTezis cneba

nulovani hipoTeza (Ho) niSnavs daSvebas, rom sxvaoba or Sedarebul obieqts Soris ar aRiniSneba.

Ho miReba niSnavs, rom dadgenili sxvaoba SemTxveviTia; Ho ar miReba ki piriqiT – sxvaoba ar aris SemTxveviTi.

Ho SecdomiT uaryofis albaTobas ew. alfa-Secdoma / α-error.Ho SecdomiT miRebis albaTobas ew. beta-Secdoma / β-error.

statistikuri Secdoma

sworia

α - Secdoma

β - Secdoma

sworia

(1) sworia (2) arasworia

sinamdvileSi hipoTeza:

(1) miRebulia

(2)uaryofiliahipoTeza

statistikuri simZlavre

simZlavre = 1 - β-Secdoma rac ufro maRalia simZlavre, miT metia mkurnalobis

meTodis upiratesobis dadgenis Sansi, Tu is arsebobs. Cveulebriv sazRvraven 80% simZlavres (zogjer 90%). simZlavre matulobs sakvlevi obieqtebis raodenobis

gazrdiT.

monacemTa analizis tipiuri Secdomebi

sistematikuri SecdomaSansikolinearnobahipotezebis areva

sistematikuri Secdoma

sakvlevi masalis SerCevis dros daSvebuli Secdoma - mkvlevari araobieqtiuria jgufebSi subieqtebis

ganawilebis dros.

gazomvis dros daSvebuli Secdomebi - erT jgufSi pacientebi ukeT sazRvraven mkurnalobis

Sedegebs, vidre meoreSi.

placebos efeqti - dadebiTi efeqti, rodesac pacienti fiqrobs, rom mas

mkurnaloben

monacemTa analizis tipiuri Secdomebi

Sansi - albaToba imisa, rom Sedegi miRebul iqna SemTxveviT;

mag. р=0,05 niSnavs, rom SesaZlebelia erTi SemTxveviTi Sedegi 20-dan.

kolinearnoba - faqtori, romelic dakavSirebulia obieqtTan da ara

daavadebasTan; mag. filtvebis kiboTi daavadebulis jibeSi asanTis kolofi.

monacemTa analizis tipiuri Secdomebi

hipotezebis areva - faqtori, romlis zemoqmedeba ar iyo

gaTvaliswinebuli hipoTezis gansazRvrisas; mag. qlorvinilis zegavlena kiboTi daavadebis riskze qimiur mrewvelobaSi momuSaveTa Soris.

klinikuri kvlevebis klasifikacia

klinikuri kvlevebiklinikuri kvlevebi

observaciuliobservaciuli eqsperimentulieqsperimentuli

aRwerilobiTiaRwerilobiTi analitikurianalitikuri

•SemTxvevebis aRwera/Case reports

•SemTxvevaTa SemTxvevaTa seriebis seriebis kvleva/kvleva/Case series

•erTmomentiani erTmomentiani kvlevakvleva

•gamokiTxvebigamokiTxvebi

•klinikuri cdebi /Clinical trials

•meta-analizi/Meta-analysis

• ««SemTxvevaSemTxveva-kontroli-kontroli»» //Case-control studyCase-control study

•kohortuli /kohortuli /Cohort studyCohort study

kriteriumebikvleva

cvladiOori jgufiOori jgufi or jgufze or jgufze

metimetierTi jgufi erTi jgufi mkurnalobamkurnalobamde da mde da SemdegSemdeg

erTi jgufi erTi jgufi mkurnalobis mkurnalobis ramdenime ramdenime saxesaxe

cvladebis kavSiri

raodenobrivi (normaluri ganawileba*)

stiudentis Student(William Gosset ) kriteriumi

dispersiu;li dispersiu;li analizianalizi

stiudentis wyvili kriteriumi

ganmeorebiTi ganmeorebiTi gazomvebis gazomvebis dispersiu;li dispersiu;li analizianalizi

wrfivi wrfivi regresia, regresia, korelacia an korelacia an blend-blend-altmanis altmanis meTodimeTodi

xarisxobrivi kriteriumi x² kriteriumi x² Kmak-nimariskriteriumi

Kkokrenis kriteriumi

...koeficienti...koeficienti

rigiTi man-uitnisMann-Whitney kriteriumi

Kkruskal-uolisisKruskall-Wallis kriteriumi

uilkoksonisWilcoxon kriteriumi

Ffridmanis kriteriumi

spirmenis spirmenis rangebis rangebis korelaciis korelaciis koeficientikoeficienti

sicocxlis sicocxlis xangrZlivobaxangrZlivoba

Ggehanis kriteriumi

*Tu ganawileba asimetriulia, iyeneben analogiur araparametriul meTodebs

sarwmunoebis ori koncefcia

Sida sarwmunoebainternal validity

ganisazRvreba imiT, Tu Catarebuli kvleviT miRebuli Sedegebi Seesabameba sinamdviles , anu is axasiaTebs mxolod avadmyofTa gamokvleul jgufs.

gareTa gareTa sarwmunoeba (ganzogadoeba)

external validity or generalizability

ganisazRvreba imiT, Tu Catarebuli kvleviT miRebuli Sedegebi gamoyenebadia avadmyofTa sxva jgufze.

kompiuteruli teqnologiebi monacemTa analizisaTvis

EpiInfo

SNA - Social Network Analysis

SPSS — Statistical Package for the Social Science

Social Network Analysis (SNA)

gmadlobT yuradRebisaTvis