Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.
description
Transcript of Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.
![Page 1: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/1.jpg)
Baseline Peak Reduction0
5
10
15
20
25
30
35
Perc
ent B
ody
Fat (
%)
Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.
OVEREATING STUDIES(individual subjects)
![Page 2: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/2.jpg)
Baseline Peak Reduction05
101520253035
Perc
ent B
ody
Fat
(%)
Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.
OVEREATING STUDIES(individual subjects)
Baseline Peak Reduction0
0.20.40.60.8
11.2
Glut
eal F
at C
ell S
ize
(ug
TG/c
ell)
Baseline Peak Reduction0
0.20.40.60.8
11.2
Glut
eal F
at C
ell S
ize
(ug
TG/c
ell)
Baseline Peak Reduction0
0.20.40.60.8
11.2
Abdo
min
al F
at C
ell S
ize
(ug
TG/c
ell)
![Page 3: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/3.jpg)
OVEREATING STUDIES(individual subjects)
Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.
Baseline Peak Reduction0
0.2
0.4
0.6
0.8
1
1.2Gl
utea
l Fat
Cel
l Siz
e (u
g TG
/cel
l)
![Page 4: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/4.jpg)
OVEREATING STUDIES(individual subjects)
Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.
Baseline Peak Reduction0
0.2
0.4
0.6
0.8
1
1.2Ab
dom
inal
Fat
Cel
l Siz
e (u
g TG
/cel
l)
![Page 5: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/5.jpg)
OVEREATING STUDIES(individual subjects)
Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.
Baseline Peak Reduction0
5
10
15
20
25
30
35
40
45Fa
t Cel
l Num
ber (
x109
)
![Page 6: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/6.jpg)
OVEREATING STUDIES(individual subjects)
Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.
Baseline Peak Reduction0
0.2
0.4
0.6
0.8
1
1.2Tr
icep
s Fa
t Cel
l Siz
e (u
g TG
/cel
l)
![Page 7: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/7.jpg)
TNF αIL-6
Angiotensin
Vasoconstriction
↓ NO
Adiponectin
↓ Fibrinolysis
PAI-1
Insulin Resistance
Insulin Resistance
Resistin
InflammationInsulin Resistance
Insulin Resistance
![Page 8: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/8.jpg)
![Page 9: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/9.jpg)
![Page 10: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/10.jpg)
![Page 11: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/11.jpg)
NUTRITION IN OBESITY
440
460480500520540560580600
Control Hi F & S Hi FAT Hi Sugar0
10
20
30
40
50
Control Hi F & S Hi Fat Hi Sugar
Caloric Intake Percent Fat
![Page 12: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/12.jpg)
OBESITY
Oscai et al J Lipid Research 13:588-592, 1972.
Sedentary Free Eaters
Sedentary Pair
WeightedExercise
0
10
20
30
40
50
60
Calo
ries p
er
Day
![Page 13: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/13.jpg)
OBESITY
0
5
10
15
20
25
Sed-Free Sed-Pair Exercise0
50100150200250300350400
Sed-Free Sed-Pair Exercise
Percent Fat (%)
Body Weight (g)
![Page 14: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/14.jpg)
OBESITY
Sed-Free Sed-Pair Exercise0
0.05
0.1
0.15
0.2
0.25
0.3
0.35
0.4
0.45
Sed-Free Sed-Pair Exercise0
1
2
3
4
5
6
7
Fat Cell Size Fat Cell Number
![Page 15: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/15.jpg)
Wilmore JH, Research Quarterly for Exercise and Sport 54:415-425, 1983.
Pre Post50
55
60
65
70
75
80
85
90
Fat Mass
Lean Mass
Kilo
gram
s
Changes in Lean & Fat Mass with Training - Men
![Page 16: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/16.jpg)
Wilmore JH, Research Quarterly for Exercise and Sport 54:415-425, 1983.
Pre Post30
35
40
45
50
55
60
65
70
Fat MassLean MassKi
logr
ams
Changes in Lean & Fat Mass with Training - Women
![Page 17: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/17.jpg)
Diet Exercise Diet + Exercise-12
-10
-8
-6
-4
-2
0
2
Total WtFat WtLean Wt
Kilo
gram
s
Total weight, fat mass & lean mass changes with diet and exercise
Miller, WC et al International Journal of Obesity 21:941-947, 1997
![Page 18: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/18.jpg)
Diet Exercise Diet + Ex-14-12-10-8-6-4-2024
Lean
Fat
Zuti & Golding, Physician & SportsMedicine 4:49-55, 1978
Wei
ght C
hang
e (lb
s)Lean vs. Fat Mass Loss with Diet & Exercise
![Page 19: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/19.jpg)
Normal Wt Overweight-6-5-4-3-2-1012
LeanFat
Franklin, B., et al. Research Quarterly 1976.
Wei
ght C
hang
e (lb
s)Lean vs. Fat Mass Loss In Overweight Adults
![Page 20: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/20.jpg)
Jakicic, et al. JAMA 282:1554-1560, 1999
SHORT vs. LONG BOUTS OF EXERICSE
![Page 21: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/21.jpg)
Jakicic, et al. JAMA 282:1554-1560, 1999
1-4 wks 5-8 wks 9-24 wks
7-12 Mo 13-18 Mo
0
50
100
150
200
250
ShortLongShort Eq
ADHERENCEM
inut
es p
er w
eek
![Page 22: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/22.jpg)
Jakicic, et al. JAMA 282:1554-1560, 1999
0 6 12 18
-12
-10
-8
-6
-4
-2
0
Months
Wei
ght C
hang
e (k
g)
Weight Loss
![Page 23: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/23.jpg)
Weight % Fat-3
-2.5
-2
-1.5
-1
-0.5
0
0.5
1
Exercise
Physical Activ-ity
Wei
ght (
kg)o
r Per
cent
Fat
(%)
Lifestyle Activity vs. Exercise is Weight Loss
Dunn, A.L. et al JAMA 281:327-334, 1999
![Page 24: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/24.jpg)
MORBID OBESITY
Reduce body fat in obese: Hill JO et al Physical Activity, Fitness, and Health: International Proceedings and Consensus statement, p 684-694, 1994.
No Wt Loss
Trend
Wt Loss
![Page 25: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/25.jpg)
Body Weight Fat Mass Waist Circumference-3
-2
-1
0
1
2
3
Control
Walk 1
Walk 2Chan
ge (k
g or
cm)
Fogelholm, et al. Arch Int Medicine 160:2177-2184, 2000
PHYSICAL ACTIVITY & WEIGHT MAINTENANCE
![Page 26: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/26.jpg)
Wal
den
et a
l, Am
J Cl
in N
utr 4
7:22
9-23
4,
1988
.
N= 20 upperN= 20 lower
LOWER:• Lost Abd & Glut
UPPER:• Lost more on WHR• Lost only from Abd• Lost more weight
![Page 27: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/27.jpg)
Baseline Peak Reduction05
101520253035
Perc
ent B
ody
Fat
(%)
Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.
OVEREATING STUDIES(individual subjects)
Baseline Peak Reduction0
0.20.40.60.8
11.2
Glut
eal F
at C
ell S
ize
(ug
TG/c
ell)
Baseline Peak Reduction0
0.20.40.60.8
11.2
Abdo
min
al F
at C
ell S
ize
(ug
TG/c
ell)
Baseline Peak Reduction0
1020304050
Fat C
ell N
umbe
r (x1
09)
![Page 28: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/28.jpg)
0102030405060708090
% Fat Fat Cell Size
Ex ObeseEliteSed Control
Tremblay, A., Int J Obesity 8:641-648, 1984.
EXERCISE & THE FAT CELL
![Page 29: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/29.jpg)
Lean Normal Obese0
0.5
1
1.5
2
2.5
UnfitFitRe
lativ
e Ri
sk
Lee, C.D., et al. American Journal of Clinical Nutrition 69:373-380, 1999
Fitness & Fatness
![Page 30: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/30.jpg)
EXERCISE & NUTRITION
05
10152025303540
Sed-Low Sed-High Ex-High
Perc
ent B
o dy
Fat (
%)
Pitts, et al Am J Physiol 246:R495, 1984
![Page 31: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/31.jpg)
EXERCISE & METABOLIC RATE
0102030405060708090
0.8 0.9 1 1.1 1.2
RMR/kg hr
VO2
max
(ml/m
in k
g)
Poehlman, E.T., Med Sci Sports Exerc 21:515-525, 1989
![Page 32: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/32.jpg)
EXERCISE & FOOD INTAKE
Neiman, D.C., J A, Dietetic Assoc 90: 1557-1562, 1990
1400
1600
1800
2000
2200
0 3 5 9 12 15
Kca
l int
ake
ControlExercise
![Page 33: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/33.jpg)
0 1 2 3 4 5 60
0.5
1
1.5
2
2.5
3
Control
Time (hrs)
Trig
lyce
rides
(mM
ol/L
Postprandial Lipemia and Exercise
Aldred, H.E, et al Metabolism 43:836-841, 1994
![Page 34: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/34.jpg)
Control Diet Exercise Diet & Exercise
808284868890929496
Body
Wei
ght (
kg)
Control Diet Exercise Diet & Exercise
20
21
22
23
24
25
26
Perc
ent F
at (%
)
Baseline
1 year
Control Diet Exercise Diet & Exercise
0
2
4
6
8
10
12
Lepti
n (n
g/m
L)
Control Diet Exercise Diet & Exercise
02468
10121416
Adip
onec
tin (u
g/m
L)
* ** *
**
*
![Page 35: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/35.jpg)
Control Diet Exercise Diet & Exercise
808284868890929496
Body
Wei
ght (
kg)
Control Diet Exercise Diet & Exercise
20
21
22
23
24
25
26
Perc
ent F
at (%
)
Baseline
1 year
Control Diet Exercise Diet & Ex0
0.51
1.52
2.53
3.54
IL-6
(pg/
mL)
Control Diet Exercise Diet & Exercise
0
1
2
3
4
5
6
TNF-
α (p
g/m
L)
*interaction
![Page 36: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/36.jpg)
Control Diet Exercise Diet & Exercise
0123456789
Resi
stin
(ng/
mL)
Control Diet Exercise Diet & Exercise
0
5
10
15
20
25
30
PAI-1
(U/m
L)
Control Diet Exercise Diet & Exercise
808284868890929496
Body
Wei
ght (
kg)
Control Diet Exercise Diet & Exercise
20
21
22
23
24
25
26
Perc
ent F
at (%
)
Baseline
1 year
![Page 37: Salans, L.B., et al. Journal of Clinical Investigation 50:1005-1011, 1971.](https://reader036.fdocuments.net/reader036/viewer/2022062813/56816546550346895dd7bd9f/html5/thumbnails/37.jpg)
Control Diet Exercise Diet & Ex0
0.51
1.52
2.53
3.54
IL-6
(pg/
mL)
Control Diet Exercise Diet & Exercise
0
2
4
6
8
10
12Le
ptin
(ng/
mL)
Control Diet Exercise Diet & Exercise
02468
10121416
Adip
onec
tin (u
g/m
L)
Control Diet Exercise Diet & Exercise
0
1
2
3
4
5
6
TNF-
α (p
g/m
L)