S 0
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Solar radiation consists of a range of wavelengths, and
has many biological effects and applications. From
solar panels to cancer treatment, from vitamin D
production to cancer induction. Our groups’ research
focuses on UVB, UVA and the visible region of solar
radiation.
Photodynamic therapy is based on
selective accumulation of protoporphyrin IX
in tumor tissue, followed by exposure to
visible light of wavelengths within the
absorption spectrum of PpIX. Upon light
activation, the PpIX molecule transfers
energy to oxygen. This leads to production of
the highly reactive product, singlet oxygen,
which can cause oxidative damage to
biomolecules and tissues close to the site of
its generation
S0
S1
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PHOTOSENSITIZER
T1
3O2
1O2
OXYGEN
Phospho-rescence
Fluores-cence
Intersystemcrossing Energy
transfer
Absorption
ENERGY
Internalconversion
Excitation Emission
Biophysics and PDT group,Department of Radiation Biology, Institute for Cancer Research,Oslo University Hospital, Radium HospitalGroup leader: Johan Moan, Prof., PhDTel:22934268 E-mail: [email protected]
Web: http://www.rr-research.no/moan
Skin pigmentation and its purposeFolate is the generic term for a family of chemically
similar compounds belonging to the vitamin B family.
Therefore, folates are vital for all living creatures.
Photodegradation of folates in humans is being
investigated and can be clinically applied as well as
shed light on the development of human skin colors.
Plasma og romfysikk, Fysisk institutt
Vitamin D synthesis
Vitamin D, known for decades for its important role for
bone health, is now being investigated as an anticancer
compound. The main source of vitamin D in humans is
exposure of skin to ultraviolet B radiation (UVB, 280-320
nm). It is believed that sun is responsible for up to 90%
of the circulating vitamin D concentrations. Therefore,
any factor that would affect the fluence of UVB at ground
level will impact greatly on the vitamin D status.
Skin cancerSkin ageningImmune supressionEye damage
Schizophrenia
Influenza
Cancer (breast, colon, prostate, lung, lymphomas, malignant melanoma)
DiabetesMetabolic syndrome
Cardio-vascular diseases
OsteomalaciaOsteoporosisRicketsFibromyalgia
Autoimmune diseases
Humans are developed in the spectrum of the sun. Skin colors are adjusted to the
fluence of solar radiation at different latitudes. Vitamin D is given to us when the sun
shines on our skin and skin cancer is generated in us if we expose ourselves too
much to the sun.
We study the diffusion of different wavelenghts of solar radiation through the
atmosphere and down into our skin. Furthermore, we investigate the health effects
of such sun exposure.