Ruth Welti Division of Biology

Kansas State University Manhattan, KS 66506

Personal information Born: October 8, 1954, Hartford, Connecticut

Office: (785) 532-6241 Email: welti@ksu.edu Web page: http://www.k-state.edu/biology/faculty_pages/welti.html

Education B.S. with Honors in Chemistry, University of Connecticut, Storrs, CT, 1976 Ph.D., Biological Chemistry, Washington University in Saint Louis, St. Louis, MO, 1982 (Advisor:

David F. Silbert) Postdoctoral Fellow, Department of Biochemistry, Kansas University Medical Center, Kansas City,

KS, 1982-1984 (Advisor: George M. Helmkamp, Jr.)

Appointments Division of Biology, Kansas State University, University Distinguished Professor, 2012- Division of Biology, Kansas State University, Professor, 2005- Director, Kansas Lipidomics Research Center, 2004-present Director, Kansas Lipidomics Research Center Analytical Laboratory, 2003-present Division of Biology, Kansas State University, Associate Professor, 1992-2005 Mass Spectrometry Laboratory, University of Kansas, Visiting Faculty, Fall 2001 Department of Biochemistry, University of Illinois at Urbana-Champaign, Visiting Faculty 1992-1993 Division of Biology, Kansas State University, Assistant Professor, 1985-1992 Department of Biochemistry, Kansas University Medical Center, Research Assistant Professor,

1984-1985; Postdoctoral Fellow, 1982-1984 Department of Biological Chemistry, Washington University School of Medicine, Research technician,

1976-1977

Honors American Heart Association, Kansas Affiliate, Inc. Postdoctoral Fellowship, 1982-1984 National Science Foundation Career Advancement Award, 1992-1993 National Science Foundation Kansas State University ADVANCE Career Advancement Award, 2004-

2005 and 2007-2008 Kansas Technology Enterprise Corporation Scholar, 2006 Sigma Xi, Kansas State University Chapter, Outstanding Senior Scientist Award, 2008 University Distinguished Professor, Kansas State University, 2012 AAAS (American Association for Advancement of Science) Fellow, Section on Biological Sciences,

2012 Pearl Award (an award for excellence in science, technology, engineering, or math), Girl Scouts of NE

Kansas and NW Missouri, 2013

Fields of research interest Lipid and membrane biochemistry Analysis of lipids by traditional and mass spectrometric methods

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Lipids in plant stress responses Lipids in metabolic signaling cascades Membership in academic societies American Society for Biochemistry and Molecular Biology American Society for Mass Spectrometry American Oil Chemists Society American Society of Plant Biologists American Society for the Advancement of Science

Editorial boards Journal of Biological Chemistry (2009-present) Frontiers in Plant Physiology (review editorial board, 2011- present) Frontiers in Technical Advances in Plant Science (review editorial board, 2011- present) Frontiers in Plant Metabolism and Chemodiversity (associate editorial board, 2011- present) Plant Metabolic Network (2011 – present)

Grant review and other granting agency panels American Heart Association, Kansas Affiliate, Inc., Peer review committee (1992-1994) American Heart Association, Kansas Affiliate, Inc., Research committee (1994-1998) American Heart Association, Kansas Affiliate, Inc., “Ad hoc committee to revise application forms”

(1996) NIH, National Institutes of Diabetes and Digestive and Kidney Diseases: Special study section on

polycystic kidney disease (1995) NIH Special Emphasis Panel: Mathematical modeling of gene expression and metabolism (2005) NIH site visit panel, Multiple Isotope Mass Spectrometry imaging facility at Brigham & Women's

Hospital, Cambridge, MA (2007) NIH Special Review Committee for Program Project Grant evaluation (2007) NIH Review panel for R13 (grants to fund conferences) proposals (real-time online meeting and

review, 2008) National Science Foundation Metabolic Biochemistry Panel, Arlington, VA (2009) NIH study section guest reviewer (phone meeting, 2010) National Science Foundation and Japan Science and Technology Agency Workshop: “Identifying

Potential Collaborative Research Opportunities in Metabolomics”, Davis, CA (2010) National Science Foundation, Molecular and Cellular Biosciences virtual full panel (2012) NIH virtual site visit panel, Multiple Isotope Mass Spectrometry imaging facility at Brigham &

Women's Hospital, Cambridge, MA (2013)

Grant proposal reviews (written) American Cancer Society Biotechnology and Biological Sciences Research Cluster (BBSRC), UK Canada Foundation for Innovation (CFI) Leaders Opportunity Fund (LOF) Cancer Research UK Programme Grant Review Council for the Earth and Life Sciences of NOW (Netherlands Organisation for Scientific Research) Kansas Agricultural Experiment Station Kentucky Science & Engineering Foundation Missouri Review Board

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NSF Netherlands Organisation for Scientific Research Research Grants Council (RGC) of Hong Kong USDA Vanderbilt Diabetes Center DRTC Pilot and Feasibility Program Wellcome Trust

External Reviewer for Promotion and/or Tenure Iowa State University Oklahoma State University St. John’s University University of California, Davis University of New Mexico University of North Texas Virginia Tech Referee for Journals (Since 1993) American Journal of Potato Research Analytical Biochemistry Analytical Chemistry Annals of Applied Biology Archives of Biochemistry Biochemistry Biochimica et Biophysica Acta Biophysical Journal Cellular and Molecular Biology Chemistry & Biology Chemistry and Physics of Lipids Current Opinion in Plant Biology Crop Science Frontiers in Plant Physiology Frontiers in Plant Science Investigative Opthamology and Visual Science Journal of the American Oil Chemists Society Journal of the American Society for Mass Spectrometry Journal of Applied Phycology Journal of Biological Chemistry Journal of Chromatography B Journal of Integrative Plant Biology Journal of Lipid Research Journal of Plant Interactions Journal of Plant Physiology Lipids Mass Spectrometry Reviews Membrane Molecular Biology Plant and Cell Physiology The Plant Journal

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Plant Methods Plant Molecular Biology Plant Physiology and Biochemistry Plants (MDPI Open Access journal) Phytochemistry Planta Plant Physiology PLoS ONE Proceedings of the National Academy of Sciences, USA Rapid Communications in Mass Spectrometry Textbook and book reviews Fitzgerald Science Press Freeman/Scientific American, Inc. John Wiley & Sons (Concept Connections) Wadsworth Chapter for a book edited by Hajime Wada and Norio Murata Invited seminars from 2002 Kansas State University, Department of Biochemistry (2002) Kansas State University, Division of Biology (2003) Kansas State University, Division of Biology (2004) Donald Danforth Plant Science Center, St. Louis, MO (2005) University of Chicago, Department of Opthlamology (2005) Johns Hopkins University Medical School, Dept. of Biochemistry (2005) University of North Texas, Dept. of Biological Sciences (2005) St. Louis University School of Medicine, Dept. of Biochemistry and Molecular Biology (2006) University of Kansas Medical Center, Dept. of Physiology (2007) Oklahoma State University, Dept. of Biochemistry (2007) Michigan State University, J. Ohlrogge and M. Pollard group, Dept. of Plant Biology (2008) Kansas State University, Sigma Xi Outstanding Senior Scientist talk (2009) Iowa State University, Bioinformatics group (2009) Texas Tech, Dept. of Chemistry and Biochemistry (2009) University of Louisville, Dept. of Chemistry (2009) Langston University, Oklahoma, Dept. of Biology (2009) Kansas State University, Dept. of Diagnostic Medicine and Pathobiology (2009) University of Nebraska, Department of Biochemistry (2010) University of Iowa, Department of Anatomy and Cell Biology (2011) University of Missouri-Columbia, Interdisciplinary Plant Biology Group (2011) Samuel Roberts Noble Foundation, Plant Biology (2012) Washington State University, Institute of Biological Chemistry (2012) Kansas State University, Department of Biochemistry (2013) Georgetown University (anticipated 2014) University of Missouri-Columbia (anticipated 2014)

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Invited oral presentations at meetings from 2001 National Plant Lipid Cooperative, South Lake Tahoe, CA (2001) American Oil Chemists Society annual meeting, Kansas City, Missouri (award for “Outstanding Paper

Presentation”) (2003) Noble Foundation Metabolomics Conference, Ardmore, Oklahoma (2003) KBRIN Student Symposium (key-note lecture), KSU Alumni Center (2004) COBRE-sponsored symposium, “What’s hot?”, University of Kansas (2004) Kansas Lipidomics Research Center workshop, KSU Alumni Center (2004) 3rd International Metabolomics conference, Iowa State University (2004) Kansas Statewide EPSCoR meeting, KSU Alumni Center (2004) International Conference on Plant-Mediated Lipid Signaling, Raleigh, NC (2005) American Oil Chemists annual meeting, St. Louis, MO (2006) 17th International Symposium on Plant Lipids, East Lansing, MI (2006) Kansas Lipidomics Research Center Annual Meeting, Kansas State University Student Union (2006) Functional Genomics Consortium Fall Workshop, Kansas State University (2007) Functional Genomics Consortium Fall Workshop, Kansas State University (2008) American Society for Mass Spectrometry Sanibel conference on Lipidomics, St. Petersburg Beach,

Florida (2009) Gordon Conference on Plant Lipids: Structure, Metabolism & Function (Discussion Leader),

Galveston, TX (2009) Metabolomics Mini-Symposium, Noble Foundation, Ardmore, OK (2009) Great Plains Plant Lipidomics Conference, Denton, TX (2010) Gordon Conference on Plant Lipids: Structure, Metabolism & Function (Discussion Leader),

Galveston, TX (2011) Functional Genomics Spring Symposium, Kansas State University (2011) American Oil Chemists annual meeting, Cincinnati, OH (2011) LIPID MAPS annual meeting, San Diego, CA (2012) Meeting Organization Co-organizer of American Oil Chemists Society “Analytical” section on Mass Spectrometry of Lipids,

Salt Lake City, UT (2005) Organizer of Kansas State University Functional Genomics Consortium Fall Workshops (2006, 2007,

2008, 2009, 2010) Organizer of Kansas State University Functional Genomics Consortium Spring Symposia (2007, 2008,

2009, 2010, 2011) Member of the committee to enhance diversity at the meeting, select speakers, and choose travel award

recipients, Gordon Conference on Plant Lipids, Galveston, TX (2009) Vice-Chair of Gordon Research Conference on Plant Lipids, Galveston, TX (2011) Chair of Gordon Research Conference on Plant Lipids, Galveston, TX (2013) Consultant Scientific consultant (unpaid) for Global Lipidomics LLC

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Contracts or other agreements for lipid analysis (by Kansas Lipidomics Research Center; Welti, Director) BASF BD Biosciences Boehringer-Ingelheim Dupont Martek Pioneer Hi-Bred International, Inc. Sime Darby Technology Centre US EPA National Resource Council of Canada Welti Lab Research Trainees

Undergraduates in Welti lab (1985-current, alphabetical) Morgan Ambruster Kristi Armstrong Brittanie Atkinson (SUROP student from Langston University) Robert Avery James Barrick Danny Bartlett Ethan Baughman Joe Bloomfield Danielle Boyer (summer student, undergraduate at Mount Union College) Cynthia Buel Chad Bulleigh Ariel Burns Christen Buseman Taran Carlisle Shad Chandler Carmen Chase Devon Claycamp Scott Coates Jamie Crane Marley Crusch Nicole Delimont Christopher Ecklund Samantha Elledge Gloria Fernandez Brigid Flynn Susan Goedecke Larson Nicole Haen Melissa Harrison Samuel Honey Ana Hooker David Hwang Levi Kinderknecht

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Jacqueline Kitchen Darren Klish Sandra Koo (high school student) Brett Kidd Bharath Krishnamoorthi (summer student from KU) Jonathan Kurche Abbey Laughlin Kaleb Lowe (summer student from Vanderbilt U.) Sara Maatta (high school student and summer student from Stanford U.) Lee Martin Tara Thacker McConkey Dedan McEllhiney Astyn Miller Elizabeth Miller Katie Mosier Elaina Murray Tamara Nun Nathan Pavlovic (summer student from Grinnell College) Neema Prakash Daniel Prohaska Gina Ragusa Anita Ranhotra Dow Richards Melanie Riley Erica Ring Gerard Ryan Mohammed Sbeih Brad Scheu Rachel Schulter Roshni Singh (high school student) Madison Sparks Michelle Thilges Travis Torres Mark Vacca Craig Whitefield David Whitmer (summer student from Fort Hays State U.) Hollie Wickham Jeremy Wiltz Kelly Zachareisen Non-degree graduate students Kathleen Clauss (visiting from Institute of Plant Biochemistry, Halle, Germany, 2009) Alfredo Cruz (visiting from Center for Research and Advanced Studies of the National Polytechnic

Institute, Irapuato, Mexico, 2005) Suha Saleh (special student)

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Ashutosh Singh (visiting from Jahwaharlal Nehru University, New Delhi, India, on an American Society of Microbiology Fellowship, 2009)

Maria Zavodszky (rotation) Masters students Amy Garner (not completed) Ana Hooker (not completed) Mark Vacca (M.S., 1998) Ph.D. students Norma Flores (Ph.D., 1998, U. Philippines; completed Ph.D. research in Welti lab under an exchange

agreement) Christopher Zien (Biology, 2000) Maoyin Li (Biochemistry, Co-major professor with Xuemin Wang, 2005) Hieu Sy “Danny” Vu (Biology, 2007-current) Postdoctoral scholars Xuesheng Xu (1992-1994) Currently: Assistant Professor, University of Colorado Health Sciences

Center Jian Zhao (Co-advised with Xuemin Wang, Biochemistry, 2002-2004); Currently: Postdoctoral fellow,

Samuel Roberts Noble Foundation Shivakumar Pattada Devaiah (Co-advised with Xuemin Wang, Biochemistry, 2002-2005), Currently:

Postdoctoral fellow: Arkansas State University Steven Wynn Esch (2006-2007); Currently: Unknown Giorgis Isaac (Mezengie) (2005-2008); Currently: Research Chemist, Waters Corporation Richard Jeannotte (2005-2011); Currently: Research Associate, University of California-Davis Sunitha Shiva (2010-current) Thilani Samarakoon (2011-2012) Visiting scientists Chien-an “Andy” Hu, University of New Mexico (2008) Walter Kpikpi, University for Development Studies, Navrongo Campus, Ghana (2008) Malathi Srinivasan, CSIR-CIMAP, India (2012) Vanina Gisela Lopez, National Laboratory (Mass Spectrometry), Buenos Aires, Argentina (2013) Mentor for junior colleagues Rachel Zufferey, Department of Biochemistry (mentor for Cancer Therapeutics NIH COBRE Award at

U. of Kansas; B. Timmermann, PI) Carolyn Ferguson, Division of Biology (Kansas State NSF ADVANCE Career Award mentor) Kathrin Schrick, Division of Biology (Division of Biology mentoring program) Timothy Durrett, Department of Biochemistry (mentor for NSF EPSCoR-funded project) Courses taught (1993 to present): Principles of Biology (BIOL 198): 1993-2000, 2002, 2004-2013 Cell Biology (BIOL 541): 1994-2004 Biomembranes (BIOL 719; formerly BIOL 697/890): 1994, 1996, 1998, 2000, 2002, 2004

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Advanced Cell Biology (BIOL 707; formerly BIOL 697/890): 2000, 2002-2006 Molecular Biology of Cellular Membranes (BIOL 855; guest lectures): 1993-2000, 2002-2006, 2010 Biochemistry 2 (BIOCH 765; guest lectures): 2005, 2010, 2011 Lipids (BIOCH 910; guest lectures): 1993, 1995, 1997, 1999, 2007 Biochemistry of Cellular Regulation (BIOCH 935; guest lecture): 2005 Advising (year: number of students in fall, number of students in spring): 1993: 7; 1994: 7, 10; 1995: 9, 13; 1996: 9, 14; 1997: 17, 19; 1998: 17, 23; 1999: 20, 31; 2000: 32, 29; 2001: 32, 30; 2002: 30, 26; 2003: 22, 21; 2004: 18, 17; 2005: 13, 13; 2006: 14, 12; 2007: 12, 11; 2008: 9, 6; 2009: 6, 6; 2010: 12, 14; 2011: 14, 15; 2012: 14, 20; 2013: 19; 20. Graduate supervisory committees (other than my own students): Ph.D. committees: Asim Abdel Mageed (Toxicology, 1993); Ralene Mitschler (Biology, 1994);

Raman Dayanidhi (Biochemistry, 1995); Rohan Thakur (Animal Science, outside chair, 1996); Craig Whiteford (Biology, 1997); Kirk Pappan (Biochemistry, 1998); Eun He Kim (Horticulture, outside chair, 1999); Li Zheng (Biochemistry, 2000); Chunbo Qin (Biochemistry, 2003); Peter Moisan (Path/Micro, not completed); Weiqi Li (Biochemistry, 2005); Micheal Barnett (Biochemistry, 2005); Venki Pegadraju (Biology, 2006); Robin Craig (Anatomy and Physiology, current); Yanli Chen (Chemistry, completed M.S., 2008); Jun Hoon Lee (Agronomy, 2008); Robin Craig (Anatomy and Physiology, 2007); Ping Ouyang (Human Nutrition, 2007); Kartikeya Krothapalli (Biology, 2008); Ke “Kurt” Zhang (Statistics, 2008); William Miller (Animal Science and Industry, outside chair, 2009); Sean Finnie (Grain Science and Industry, 2009); Akshay Moharir (Biology, not completed); Sushanth Gudlar (Biochemistry, 2012); Huaien Dai (Biochemistry, 2013); Lianqing Zheng (Statistics, 2013); Emily Archer Slone (Biology, 2013); Ashley Sheppard (Psychology, outside chair, current); Lorne Jordan (Biochemistry, current); Tam Tran Nguyen (Biochemistry, current); Sunil Bansal (Biochemistry, current); John Elson (Mechanical Engineering, outside chair, current); Patrick Ryan Gibson (Purdue University, current); Cesar Caballero (Animal Science and Industry, outside chair, current); Sruthi Narayanan (Agronomy, current).

Masters committees: Craig Whiteford (Toxicology, 1994); Heidi Hinkel (Biology, 1996); Nancy

James (Biology, 1996); Dahao Ling (Biochemistry, 2000); Weiqi Li (Biochemistry, 2002); Yueyun Hong (Biochemistry, 2005); Anisha Gupte (Biology, 2006); Jessica Morton (Biology, 2007); Lixia Fan (Statistics, 2010); Tingting Song (Statistics, 2010); Dongwon Kim (Plant Pathology, 2011); Jennifer Shelton (Biology, 2012); Daniel Stucky (Biology, 2013)

Biology committees (since 1993): Seminar: chair, 1992-1994, member, 1994-2008 Tenure and promotion, 1993-1994; 2003-2004; 2007-current Curriculum and undergraduate affairs, member, 1994-1999; chair, 1999-current, except fall 2001 Faculty search committee, chair, 2007-2008 Faculty search committee, 2009-2010 Faculty search committee for 3 positions, 2010-2011 University committees (non-Biology, since 1993): Biochemistry Graduate Group member, 1986-current

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Biochemistry Graduate Group executive committee (elected), 1993-2002 Biochemistry tenure and promotion committee consultant, 1996 Arts and Sciences pre-vet advisor, 1997-1998 Pre-health evaluation committee, 1999-2000 Search committee for Arts and Sciences associate dean, 2003-2004 Biochemistry faculty search committee, 2004 Targeted Excellence Review Panel, 2007 Biochemistry faculty search committee, 2010-2011 Ad hoc group to provide input for development of the curriculum for a Professional Masters degree in

Biotechnology, 2010 Graduate Council and Graduate Student Affairs Committee, 2011-2012 2025 College of Agriculture/Kansas State Research and Extension/Facilities and Infrastructure

committee, 2012-2013 Currently funded awards NSF MCB 0920663, Collaborative research: Metabolic profiling and functions of oxidized lipids in

plant stress responses (PI: Welti, Co-PI: Gadbury), Total award amount: $748,286, 8/1/09-7/31/14 NSF Research Opportunity Award MCB 1037957, Collaborative research: Metabolic profiling and

functions of oxidized lipids in plant stress responses (PI: Welti, Other personnel: Naidoo, Shah), Total award amount: $14,999, 8/1/09-7/31/14

NIH 1R01 A1061691 01A2, Natural antibodies and tissue injury PI: Sherry Fleming, Co-PIs: Ruth

Welti & Stephen Chapes, Total award amount: $1,424,921, 3/1/07-2/28/14 NSF (Major Research Instrumentation program) DBI 1228622, MRI: Acquisition of a high-sensitivity

triple quadrupole mass spectrometer for the Kansas Lipidomics Research Center (PI: Welti, Co-PIs: Durrett, Schrick; Senior Personnel: Shah, Wang) Total award amount: $443,484, 8/1/12-7/31/15.

USDA, 2013 Plant Lipids GRC/GRS (conference grant). (PI: Welti; Co-PI: Cahoon), Total award

amount: $ 15,000, 1/15/2013-1/14/2014. Pending proposals NSF-MCB, Collaborative Research: Lipidomic profiling, dynamics, and functions of head-group

acylation of membrane lipids in plant stress responses. (PI: Welti; Co-PIs: Gadbury, Naidoo, Nikolau, and Wurtele) Total award amount: $991,602, 8/1/2013-7/31/2017.

Department of Defense: Reperfusion injury therapeutics targeting oxidized lipids. (PI: Fleming; Co-

PI: Welti), Total award amount: $187,445, 6/1/2014-5/31/2015. Previously funded awards as PI NSF MCB 1260252, 2013 Plant Lipids GRC/GRS (conference grant). (PI: Welti; Co-PI: Cahoon),

Total award amount: $ 10,000, 11/1/2012-10/31/2013.

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NIH, 2013 Plant Lipids GRC/GRS (conference grant). (PI: Welti; Co-PI: Cahoon), Total award

amount: $ 5,000, 12/1/2012-11/30/2013. DOE, 2013 Plant Lipids GRC/GRS (conference grant). (PI: Welti; Co-PI: Cahoon), Total award

amount: $ 15,795, 12/15/20-12/14/2013. KSU Targeted Excellence program, A Functional Genomics Consortium: Building research

productivity through education, interaction, and full utilization of the Functional Genomics Laboratories at KSU (PI: Welti; Co-PIs: Kanost, Tomich, Prakash, Brown, Conrad, and Maatta) $1,998,944, 7/1/06-12/31/11

K-INBRE, Institutional Core Facility Support: Sample preparation improvements at the Kansas

Lipidomics Research Center (KLRC) (PI: Welti), Total award amount: $40,000 (direct costs), 2009-2010

NSF (Major Research Instrumentation program) Acquisition of mass spectrometers for the Kansas

State University Functional Genomics Laboratories (PI: Welti, Co-PIs: Tomich, Blecha, Kanost, Hulbert) Total award amount: $1,539,360, 9/1/05-8/31/08.

K-INBRE, Comprehensive analysis of human plasma lipids as potential markers of disease (PI: Welti),

Total award amount: $35,000 (direct costs), 5/01/06-4/30/07 K-INBRE, Institutional Core Facility Support: Kansas Lipidomics Research Center Analytical

Laboratory at Kansas State University (PI: Welti), Total award amount: $35,000 (direct costs), 5/01/06-4/30/07

K-INBRE (Bioinformatics), LipidomeDB, lipidomics data mining tools, and improvements in

lipidomics data processing (Welti, L.J. Wang, Milliken, and Brown), Total award amount: $45,935 (direct costs), 5/01/06-4/30/07

Kansas NSF EPSCoR program, Acquisition of a mass spectrometer for lipidomics (PI: Welti, Co-PIs:

Schermerhorn, Shah, Valent and Wang) Total award amount: $319,999, 6/1/05-3/31/06. K-INBRE (Bioinformatics), Kansas Lipidomics Research Center Analytical Laboratory: A Database

for Lipidomics (PI: Welti; Co-PI: L.J. Wang), Total award amount: $13,195, 07/22/04-6/30/05. NSF EPSCoR/Kansas Technology Enterprise Corporation/KSU, Establishment of the Kansas

Lipidomics Research Center (PI: Welti (Original PI: Wang); Co-PIs: Shah, Rintoul, Sun, Williams, Dobrowsky, LeVine), Total award amount: $1,238,840 (for KSU, $1,002,380), 4/01/03-3/31/06

Kansas Biomedical Research Infrastructure Network (KBRIN), Core facility support for the Kansas

Lipidomics Research Center Analytical Laboratory (PI: Welti), Total award amount: $25,575, 01/1/04-6/30/04

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Philippine Department of Science and Technology, The role of epidermal growth factor receptor transmembrane domain primary signal transduction (Stipend and supply money for Norma Flores during exchange visit to Welti lab), Total award amount: $28,325, 8/1/96-1/31/98

American Cancer Society, Inc., Characterization of membrane lipid domains (PI: Welti), Total award

amount: $200,000, 7/1/91-6/30/94 American Heart Association, Kansas Affiliate, Inc., Effect of copper on synthesis, secretion, and

uptake of pulmonary surfactant by rat type II aveolar cell (PI: Welti), Total award amount: $44,000, 7/1/94-6/30/96

Fraternal Order of Eagles, Phospholipid acylation-deacylation cycles in heart mitochondria (PI: Welti),

Total Award Amount: $5,000, 10/1/93-9/30/95 American Heart Association, Kansas Affiliate, Inc., Characterization of heart mitochondrial inner

membrane lipid domains (PI: Welti), Total award amount: $44,000 (direct), 7/1/91-6/30/94 NSF (Career Advancement Award), Fluorescence microscopic visualization of lipid domains (PI:

Welti), Total award amount: $36,352 (direct), 8/1/92-7/30/94 NIH R01 GM34371, Characterization of membrane lipid domains (PI: Welti), 12/01/84-11/30/871987,

$197,134; Renewed, 12/01/87-11/30/90, amount not recorded. Previously funded awards as Co-PI NSF 2010 program MCB , Metabolomics: A functional genomics tool for deciphering functions of

Arabidopsis genes in the context of metabolic and regulatory networks (PI: Basil Nikolau, Co-PIs: Oliver Fiehn, Seung Rhee, Lloyd Sumner, and Ruth Welti) Total award amount: $244,159 (subcontract to Welti), 3/1/2009-2/28/2012.

KUMC, Analysis of estradiol (CoPIs: Welti and Jeannotte), Total award amount: $12,500, 10/1/08-

9/30-10 Cancer Therapeutics NIH COBRE Award at U. of Kansas (PI: B. Timmermann), Phosphatidylcholine

biosynthesis and anticancer agent miltefosine (PI: Zufferey, Co-PI: Welti), Total award amount (to Welti): $11,500 (direct costs), 3/1/08-2/28/09

Winn Foundation, Identification of a biomarker for masked renal failure in hyperthyroid cats (PI:

Schermerhorn, Co-PIs: Gadbury, Jeannotte, Welti), Total award amount: $15,000, 1/12009-12/31/10.

Kansas Infrastructure Network for Biomedical Research (K-INBRE), Lipidomics Bioinformatics:

Lipidome DB, Statistical applications, and data processing (Brown, Welti), Total Award Amount: $26,000, 07/1/07-4/30/08

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NSF, Role of Arabidopsis SFD1 in systemic acquired resistance (PI: Shah; Co-PI: Welti), Total Award Amount: $375,000, 9/01/06- 8/31/09

USDA-NRI, Arabidopsis-Green peach aphid interaction (PI: Shah; Co-PIs: Reese and Welti) Total

Award Amount: $378,679, 8/1/04-7/31/07 NIH, Novel proapoptotic BH3-only proteins in cancer apoptosis (PI: Hu, Co-PI: Welti) Total Award

Amount: (KSU subcontract, $72,672), 4/1/05-3/31/10 NSF 2010 Project, Metabolomics: A functional genomics tool for deciphering functions of Arabidopsis

genes in the context of metabolic and regulatory networks (PI: Nikolau, Co-PIs: Fiehn, Rhee, Sumner, and Welti), Total Award Amount: $1,000,000 (KSU award: $84,402), 9/1/05-8/31/07.

Kansas Infrastructure Network for Biomedical Research (K-INBRE), Kansas Lipidomics Research

Center Analytical Laboratory: LipidomeDB and Associated Data Mining Tools (Brown, Welti, and L.J. Wang), Total Award Amount: $22,820, 07/1/05-6/30/06

NSF, Metabolomic profiling of lipids and their compositional dynamics in plant stress response (PI:

Wang; Co-PIs: Shah, Welti and Williams) Total Award Amount: $810,976 (Welti portion, $338,013), 9/1/04-8/31/08

NSF, Metabolomic profiling of membrane lipids and their compositional dynamics in plant stress

responses (PI: Wang; Co-PIs: Shah, Welti and Williams), Total Award Amount: $488,689, 9/15/01-8/31/05

NSF (MRI program), Acquisition of five controlled environmental chambers for plant research (P.I.:

Shah; Co-P.I.s/Co-Investigators: Roe, Wang, Guikema, Reese, Muthukrishnan, Zhou and Welti), Total Award Amount: $126,419 plus KSU $54,179 (match), 8/15/00-7/31/02

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PUBLICATIONS Research Articles 1. Brenckle (Welti), Ruth, and Kornfeld, Rosalind. 1980. Structure of the oligosaccharide of mouse

immunoglobulin M secreted by the MOPC 104 E plasmacytoma. Arch. Biochem. Biophys. 201, 160-173.

2. Welti, Ruth, Rintoul, David A., Goodsaid-Zalduondo, Federico, Felder, Stephen, and Silbert, David, F. 1981. Gel phase phospholipid in the plasma membrane of sterol-depleted mouse LM cells: Analysis by fluorescence polarization and X-Ray diffraction. J. Biol. Chem. 256, 7528-7535.

3. Welti, Ruth, and Silbert, David F. 1982. Partition of parinaroyl phospholipid probes between solid and fluid phosphatidylcholine phases. Biochemistry 21, 5685-5689.

4. Welti, Ruth. 1982. Partition of parinaroyl phospholipids in mixed head group systems. Biochemistry 21, 5690-5693.

5. Welti, Ruth, and Helmkamp, George, M., Jr. 1984. Acyl chain specificity of phosphatidylcholine transfer protein from bovine liver. J. Biol. Chem. 259, 6937-6941.

6. Welti, Ruth, Mullikin, Lee, J., Yoshimura, Tetsuro, and Helmkamp, George, M., Jr. 1984. Partition of amphiphilic molecules into phospholipid vesicles and human erythrocyte ghosts: Measurements by ultraviolet difference spectroscopy. Biochemistry 23, 6086-6091.

7. Yoshimura, Tetsuro, Welti, Ruth, and Helmkamp, George M., Jr. 1988. General kinetic model for protein-mediated phospholipid transfer between membranes. Arch. Biochem. Biophys. 266, 299-312.

8. Rintoul, David A., and Welti, Ruth. 1989. Thermotropic behavior of mixtures of glycosphingolipids and phosphatidylcholine: Effect of monovalent cations on sulfatide and galactosylceramide. Biochemistry 28, 26-31.

9. Roth, Mary R., Smardo, Fred L., Jr., and Welti, Ruth. 1989. Analysis of dimeric species derived from the reaction of phosphatidylethanolamine species with dimethylsuberimidate. Chem. Phys. Lipids. 51, 39-46.

10. Roth, Mary R., Avery, Robert B., and Welti, Ruth. 1989. Cross-linking of phosphatidylethanolamine neighbors with dimethylsuberimidate is sensitive to the lipid phase. Biochim. Biophys. Acta. 986, 217-224.

11. Martin, Lee R., Avery, Robert B., and Welti, Ruth. 1990. Partition of parinaroyl phosphatidylethanolamines and parinaroyl phosphatidylglycerols in immiscible phospholipid mixtures. Biochim. Biophys. Acta. 1023, 383-388.

12. Song, Wenxia, Vacca, Mark F., Welti, Ruth, and Rintoul, David A. 1991. Effects of gangliosides GM3 and De-N-acetyl GM3 on epidermal growth factor receptor kinase activity and cell growth. J. Biol. Chem. 266, 10174-10181.

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13. Roth, Mary R. and Welti, Ruth. 1991. Lipid arrangement in fluid model membranes: analysis by cross-linking of phosphatidylethanolamines. Biochim. Biophys. Acta.1063, 2042-2046.

14. Harrison, Melissa M., Roth, Mary R., Hooker, Ana A., Rintoul, David A. and Welti, Ruth. 1993. Phase behavior and arrangement of molecular species in mixtures of a mixed chain and a symmetric phosphatidylethanolamine in the gel and fluid phases. Biochim. Biophys. Acta 1149, 292-298.

15. Song, Wenxia, Haffner-Strauss, Sabrina, Welti, Ruth, and Rintoul, David A. 1993. Synthesis and characterization of N-parinaroyl analogs of ganglioside GM3. Biochemistry 32, 8602-8607.

16. Mitschler, Ralene R., Welti, Ruth, and Upton, Steve J. 1994. A comparative study of lipid compositions of Cryptosporidium parvum (Apicomplexa) and Madin-Darby bovine kidney cells. J. Eukaryotic Microbiology 41, 8-12.

17. Roth, Mary R. and Welti, Ruth. 1994. Arrangement of phosphatidylethanolamine molecular species in Escherichia coli membranes and reconstituted lipids as determined by dimethylsuberimidate cross-linking of nearest neighbor lipids. Biochim. Biophys. Acta. 1190, 91-98.

18. Abdel-Mageed, Asim B., Welti, Ruth, Oehme, Frederick W., and Pickrell, John A. 1994. Perinatal effects of hypocuprosis on synthesis and composition of neonatal lung collagen, elastin and surfactant. Amer. J. Physiol. 267, L679-L685.

19. Bartlett, Danny, Glaser, Michael, and Welti, Ruth. 1997. Penetration depth and lipid phase preference of acyl-labeled dansyl phosphatidylcholines in phosphatidylcholine vesicles. Biochim. Biophys. Acta 1328, 48-54.

20. Wang, Cunxi, Zien, Christopher A., Afitlhile, Meshack, Welti, Ruth, Hildebrand, David F., and Wang, Xuemin. 2000. Involvement of phospholipase D in wound-induced accumulation of jasmonic acid in Arabidopsis. Plant Cell 12, 2237-2246.

21. Zien, Christopher A., Wang, Cunxi, Wang, Xuemin, and Welti, Ruth. 2001. In-vivo substrates and the contribution of the common phospholipase D, PLDα, to wound-induced metabolism of lipids in Arabidopsis. Biochim. Biophys. Acta [Molecular and Cell Biology of Lipids] 1530, 236-248.

22. Welti, Ruth, Li, Weiqi, Li, Maoyin, Sang, Yongming, Biesiada, Homigol, Zhou, Han-E, Rajashekar, C.B., Williams, Todd D., and Wang, Xuemin. 2002. Profiling membrane lipids in plant stress responses: role of phospholipase D-α in freezing-induced lipid changes in Arabidopsis. J. Biol. Chem. 277, 31994-32002.

23. Welti, Ruth, Wang, Xuemin, and Williams, Todd D. 2003. Electrospray ionization tandem mass spectrometry scan modes for plant chloroplast lipids. Anal. Biochem. 314, 149-152.

24. Fauconnier, Marie-Laure, Welti, Ruth, Blée, Elisabeth, and Marlier, Michel. 2003. Lipid and oxylipin profiles during aging and sprout development in potato tubers (Solanum tuberosum L.). Biochim. Biophys. Acta 1633, 118-126.

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25. Fauconnier, Marie-Laure, Williams, Todd D, Marlier, Michel, and Welti, Ruth. 2003. Potato tuber phospholipids contain colneleic acid in the 2-position. FEBS Letters 538, 155-158.

26. Nandi, Ashis, Krothapalli, Kartik, Buseman, Christen M., Li, Maoyin, Welti, Ruth, Enyedi, Alexander, and Shah, Jyoti. 2003. The Arabidopsis thaliana sfd mutants affect plastidic lipid composition and suppress dwarfing, cell death and the enhanced disease resistance phenotypes resulting from the deficiency of a fatty acid desaturase. Plant Cell 15, 2383-2398.

27. Zhang, Wenhua, Wang, Cunxi, Qin, Chunbo, Wood, Tara, Olafsdottir, Gudrun, Welti, Ruth, and Wang, Xuemin. 2003. The oleate-stimulated phospholipase D, PLDδ, and phosphatidic acid decrease H2O2-induced cell death in Arabidopsis. Plant Cell 15, 2285-2295.

28. Nandi, Ashis, Welti, Ruth, and Shah, Jyoti. 2004. The Arabidopsis thaliana dihydroxyacetone phosphate reductase gene SUPPRESSOR OF FATTY ACID DESATURASE DEFICIENCY1 is required for glycerolipid metabolism and for the activation of systemic acquired resistance. Plant Cell 16, 465-477.

29. Li, Weiqi, Li, Maoyin, Zhang, Wenhua, Welti, Ruth, and Wang, Xuemin. 2004. The plasma membrane-bound phospholipase Dδ enhances freezing tolerance in Arabidopsis thaliana. Nature Biotech. 22, 427-433.

30. Abbadi, Amine, Domergue, Fréderic, Bauer, Jörg, Napier, Johnathan A., Welti, Ruth, Zahringer, Ulrich, Cirpus, Petra, and Heinz, Ernst. 2004. Biosynthesis of very long-chain polyunsaturated fatty acids in transgenic oilseeds: Constraints on their accumulation. Plant Cell 16, 2734-2748.

31. Sabah, Judith, McConkey, Eric, Welti, Ruth, Albin, K., and Takemoto, Larry. 2005. Role of albumin as a fatty acid carrier for biosynthesis of lens lipids. Experimental Eye Research 80, 31-36.

32. Wanjie, Sylvia W., Welti, Ruth, Moreau, Robert A., and Chapman, Kent D. 2005. Identification and quantification of glycerolipids in cotton fibers: Reconciliation with metabolic pathway predictions from DNA databases, Lipids 40, 773-785.

33. Young, Janice E., Zhao, Xin, Carey, Edward E., Welti, Ruth, Yang, Shie-Shien, and Wang, Weiqun. 2005. Phytochemical phenolics in organically-grown vegetables journal of agricultural and food chemistry. Mol. Nutr. Food Res. 49, 1136-1142.

34. Li, Maoyin, Qin, Chunbo, Welti, Ruth, and Wang, Xuemin. 2006. Double knockouts of phospholipase Dζ1 and ζ2 in Arabidopsis affect root elongation under phosphate limitation, but do not affect root hair patterning. Plant Physiol. 140, 761-770.

35. Wang, Xuemin, Devaiah, Shivakumar Pattada, Zhang, Wenhua, and Welti, Ruth. 2006. Signaling functions of phosphatidic acid. Prog. Lipid Res. 45, 250-278.

36. Devaiah, Shivakumar P., Roth, Mary R., Baughman, Ethan, Li, Maoyin, Tamura, Pamela, Jeannotte, Richard, Welti, Ruth, and Wang, Xuemin. 2006. Quantitative profiling of polar glycerolipid species and the role of phospholipase Dα1 in defining the lipid species in Arabidopsis tissues. Phytochemistry 67, 1907-1924.

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37. Buseman, Christen M., Tamura, Pamela, Sparks, Alexis A., Baughman, Ethan J., Maatta, Sara, Zhao, Jian, Roth, Mary R., Esch, Steven Wynn, Shah, Jyoti, Williams, Todd D., and Welti, Ruth 2006. Wounding stimulates the accumulation of glycerolipids containing oxophytodienoic acid and dinor-oxophytodienoic acid in Arabidopsis leaves. Plant Physiol. 142, 28-39.

38. Li, Maoyin, Welti, Ruth, and Wang, Xuemin. 2006. Quantitative profiling of Arabidopsis polar glycerolipids in response to phosphorus starvation: Roles of PLDζ1 and PLDζ2 in phosphatidylcholine hydrolysis and digalactosyldiacylglycerol accumulation in phosphorus-starved plants. Plant Physiol. 142, 750-761.

39. Esch, Steven Wynn, Tamura, Pamela, Sparks, Alexis A., Roth, Mary R., Devaiah, S. P., Heinz, Ernst, Wang, Xuemin, Williams, Todd D., and Welti, Ruth. 2007. Rapid characterization of fatty acyl composition of complex lipids by collision-induced dissociation time-of-flight mass spectrometry. J. Lipid. Res. 48, 235-241.

40. Fitzgerald, Michael L., Xavier, Ramnik, Haley, Kathleen J., Welti, Ruth, Goss, Julie L., Brown, Cari E., Zhuang, Debbie, Bell, Susan A., Lu, Naifang, Mckee, Mary, Seed, Brian, and Freeman, Mason W. 2007. ABCA3 inactivation in mice causes respiratory failure, loss of pulmonary surfactant and depletion of lung phosphatidylglycerol. J. Lipid Res. 48, 621-632.

41. Fritz, Markus, Lokstein, Heiko, Hackenberg, Dieter, Welti, Ruth, Roth, Mary, Zähringer, Ulrich, Fulda, Martin, Hellmeyer, Wiebke, Ott, Claudia, Wolter, Frank P., and Heinz, Ernst. 2007. Chanelling of eukaryotic diacylglycerol into the biosynthesis of plastidial phosphatidylglycerol. J. Biol. Chem. 282, 4613-4625.

42. Hsu, Fong-Fu, Turk, John, Williams, Todd D., and Welti, Ruth. 2007. Electrospray ionization multiple stage quadrupole ion-trap and tandem quadrupole mass spectrometric studies on phosphatidylglycerol from Arabidopsis leaves. J. Am. Soc. Mass Spec. 18, 783-790.

43. Bartz, Rene, Li, Wen-Hong, Venables, Barney, Zehmer, John, Welti, Ruth, Anderson, Richard, Liu, Ping-sheng, and Chapman, Kent D. 2007. Lipidomics reveals adiposomes store ether lipids and mediate phospholipid traffic. J. Lipid Res. 48, 837-847.

44. Yang, Wenyu, Devaiah, Shivakumar, Pan, Xiangqing, Isaac, Giorgis, Welti, Ruth, and Wang, Xuemin. 2007. AtPLAI is an LRR-containing acyl hydrolase involved in basal jasmonic acid production and Arabidopsis resistance to Botrytis cinerea. J. Biol. Chem. 282, 18116-18128.

45. Devaiah, Shivakumar P., Pan, Xiangqing, Hong, Yueyun, Roth, Mary R., Welti, Ruth, and Wang, Xuemin. 2007. Enhancing seed quality and viability by suppressing phospholipase D in Arabidopsis. Plant J. 50, 950-957.

46. Welti, Ruth, Mui, Ernie, Sparks, Alexis, Wernimont, Sarah, Isaac, Giorgis, Kirisits, Michael, Roth, Mary, Roberts, Craig W., Botté, Cyrille, Maréchal, Eric, and McLeod, Rima. 2007. Lipidomic analysis of T. gondii reveals unusual polar lipids. Biochemistry 46, 13882-13890.

47. Li, Weiqi, Wang, Ruiping, Li, Maoyin, Li, Lixia, Wang, Chuanming, Welti, Ruth, and Wang, Xuemin. 2008. Differential degradation of extraplastidic and plastidic lipids during freezing and post-freezing recovery in Arabidopsis thaliana. J. Biol. Chem. 283, 461-468.

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48. Chaturvedi, Ratnesh, Krothapalli, Kartikeya, Makandar, Ragiba, Nandi, Ashis, Sparks, Alexis, Roth, Mary, Welti, Ruth, and Shah, Jyoti. 2008. Plastid ω3-fatty acid desaturase-dependent accumulation of a systemic acquired resistance inducing activity in petiole exudates of Arabidopsis thaliana is independent of jasmonic acid. Plant J. 54, 106-117.

49. Maeda, Hiroshi, Sage, Tammy L., Isaac, Giorgis, Welti, Ruth, and DellaPenna, Dean. 2008. Tocopherols modulate extra-plastidic polyunsaturated fatty acid metabolism in Arabidopsis at low temperature. Plant Cell 20, 452-470.

50. Botté, Cyrille, Saïdani, Nadia, Mondragon, Ricardo, Mondragon, M., Isaac, Giorgis, Mui, Ernest, McLeod, Rima, Dubremetz, Jean-François, Vial, Henri, Welti, Ruth, Cesbron-Delauw, Marie-France, Mercier, Corinne, and Maréchal, Eric. 2008. Subcellular localization and dynamics of a digalactolipid-like lipid along the life cycle of the apicomplexan parasite Toxoplasma gondii. J. Lipid Res. 49, 746-762.

51. Hong, Yueyun, Pan, Xiangqing, Welti, Ruth, and Wang, Xuemin. 2008. Alterations of phospholipase Dα3 change Arabidopsis response to salinity and water deficits. Plant Cell 20, 803-816.

52. Pan, Xiangqing, Welti, Ruth, and Wang, Xuemin. 2008. Simultaneous quantification of phytohormones and related metabolites in crude plant extracts by liquid chromatography-electrospray tandem mass spectrometry. Phytochemistry 69, 1773-1781.

53. Moreau, Robert A., Doehlert, Douglas C., Welti, Ruth, Isaac, Giorgis, Roth, Mary, Tamura, Pamela, and Nuñez, Alberto. 2008. The identification of mono-, di-, tri-, and tetragalactosyl-diacylglycerols and their natural estolides in oat kernels. Lipids. 43, 533-548.

54. Hong, Yueyun, Pan, Xiangqing, Welti, Ruth, and Wang, Xuemin. 2008. The effect of phospholipase Dα3 on Arabidopsis response to hyperosmotic stress and glucose. Plant Signal Behav. 3, 1099-1100.

55. Zuo, Ying, Zhuang, Debbie Z., Han, Rong, Isaac, Giorgis, Manning, Jennifer J., McKee, Mary, Welti, Ruth, Brissette, Janice L., Fitzgerald, Michael L., and Freeman, Mason W. 2009. ABCA12 maintains the epidermal lipid permeability barrier via formation of ceramide linoleic esters J. Biol. Chem. 284, 3345–3353.

56. Hong, Yueyun, Devaiah, Shivakumar P., Bahn, SungChul, Thamasandra, Bharath N., Li, Maoyin, Welti, Ruth, and Wang, Xuemin. 2009. Phospholipase Dε and phosphatidic acid enhance Arabidopsis growth. Plant J. 58, 376-387.

57. Jao, Cindy Y., Roth, Mary, Welti, Ruth, and Salic, Adrian. 2009. Metabolic labeling and direct imaging of choline phospholipids in vivo. Proc Natl Acad Sci U S A. 106, 15332-15337.

58. Su, Kemin, Bremer, Dale J., Jeannotte, Richard, Welti, Ruth, and Yang, Celeste. 2009. Membrane lipid composition and heat tolerance in cool-season turfgrasses including a hybrid bluegrass. Am. Soc. Hort. Sci. 134, 511-520.

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59. Zhang, Yanyan, Zhu, Huiying, Zhang, Qun, Li, Maoyin, Yan, Min, Wang, Rong, Wang, Liling, Welti, Ruth, Zhang, Wenhua, and Wang, Xuemin. 2009. Phospholipase D 1 and phosphatidic acid regulate NADPH oxidase activity and production of reactive oxygen species in ABA-mediated stomatal closure in Arabidopsis. Plant Cell 21, 2357-2377.

60. Sparkes, Byron, Slone, Emily E, Roth, Mary, Welti, Ruth, and Fleming, Sherry D. 2010. Ischemia/reperfusion-induced intestinal lipid alterations occur prior to antibody-induced PGE2 production. Biochim. Biophys. Acta (Molecular and Cell Biology of Lipids) 1801, 517-525.

61. Bais, Preeti, Moon, Stephanie M., He, Kun, Leitao, Ricardo, Dreher, Kate, Walk, Tom, Sucaet, Yves, Barkan, Lenore, Wohlgemuth, Gert, Roth, Mary R., Wurtele, Eve S., Dixon, Philip, Fiehn, Oliver, Lange, B. Markus, Shulaev, Vladimir, Sumner, Lloyd W., Welti, Ruth, Nikolau, Basil J., Rhee, Seung Y., and Dickerson, Julie A. 2010. PlantMetabolomics.org: a web portal for plant metabolomics experiments. Plant. Physiol. 152, 1807-1816.

62. Ouyang, Ping, Jiang, Yu, Doan, Hieu M., Xie, Linglin, Vasquez, David, Welti, Ruth, Su, Xiaoyu, Lu, Nanyan, Herndon, Betty, Yang, Shie-Shien, Jeannotte, Richard, and Wang, Weiqin. 2010. Weight loss via exercise with controlled dietary intake may affect phospholipid profile for cancer prevention in murine skin tissues. Cancer Prev. Res. (Phila Pa). 3, 466-477.

63. Xiao, S., Gao, W., Chen, Q.-F., Chan, S-W., Zheng, S.-X., Ma, J., Wang, M., Welti, R., and Chye, M.-L. 2010. Overexpression of Arabidopsis acyl-CoA binding protein ACBP3 promotes starvation-induced and age-dependent leaf senescence. Plant Cell 22, 1463-1482.

64. Singh, Ashutosh, Prasad, Tulika, Kapoor, Khyati, Mandal, Ajeet, Roth, Mary, Welti, Ruth, and Prasad, Rajendra 2010. Phospholipidome of Candida: Each species of Candida has distinctive phospholipid molecular species. OMICS: A Journal of Integrative Biology 14, 665-677.

65. Doehlert, Douglas C., Moreau, Robert A., Welti, Ruth, Roth, Mary, and McMullen, Michael S. 2010. Polar lipids from oat kernels. Cereal Chemistry. 87, 467-474.

66. Pan, Xiangqing, Welti, Ruth, and Wang, Xuemin. 2010. Quantitative analysis of major plant hormones in crude plant extracts by high-performance liquid chromatography-mass spectrometry. Nat. Protoc. 5, 986-992.

67. Peters, Carlotta, Li, Maoyin, Narasimhan, R., Roth, Mary, Welti, Ruth, and Wang, Xuemin. 2010. Nonspecific phospholipase C NPC4 promotes responses to abscisic acid and tolerance to hyperosmotic stress in Arabidopsis. Plant Cell 22, 2642-2659.

68. Kilaru, Aruna, Isaac, Giorgis, Tamura, Pam, Baxter, David, Duncan, Scott R., Venables, Barney J., Welti, Ruth, Koulen, Peter, and Chapman, Kent D. 2010. Targeted lipidomics of endocannabinoid pathway metabolites in murine brain and heart. Lipids. 45, 863-875

69. Kilaru, Aruna*, Tamura, Pamela* (* = equal contribution), Puja, Garg, Isaac, Giorgis, Baxter, David, Duncan, R. Scott, Welti, Ruth, Koulen, Peter, Chapman, Kent D., and Venables, Barney J. 2010. Changes in N-acylethanolamine pathway related metabolites in a rat model of cerebral ischemia/reperfusion. J. Glycom. Lipidom. 1, 101. doi:10.4172/2153-0637.1000101

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70. Deng, Youping, Meyer, Sharon A., Guan, Xin, Escalon, Barbara Lynn, Ai, Junmei, Wilbanks, Mitchell S., Welti, Ruth, Garcia-Reyero, Natàlia, and Perkins, Edward J. 2011. Analysis of common and specific mechanisms of liver function affected by nitrotoluene compounds. PLoS ONE. 6, e14662.

71. Clauss, Kathleen, von Roepenack-Lahaye, Edda, Boettcher, Christoph, Roth, Mary R., Welti, Ruth, Erban, Alexander, Kopka, Joachim, Scheel, Dierk, Milkowski, Carsten, and Strack, Dieter. 2011. Overexpression of sinapine esterase BnSCE3 in Brassica napus seeds triggers global changes in seed metabolism. Plant Physiol. 155, 1127-1145.

72. Li, Maoyin, Bahn, Sung Chul, Guo, Liang, Musgrave, William, Berg, Howard, Welti, Ruth, and Wang, Xuemin. 2011. Patatin-related phospholipase pPLAIIIβ-induced changes in lipid metabolism alter cellulose content and cell elongation in Arabidopsis. Plant Cell. 23, 1107-1123.

73. Lee, Junghoon, Welti, Ruth, Schapaugh, William T., and Trick, Harold N. 2011. Phospholipid and triacylglycerol profiles modified by PLD suppression in soybean seed. Plant Biotechnol. J. 9, 359-372.

74. Zhou, Zhenguo, Marepally, Shantan Reddy, Nune, Daya Sagar, Pallakollu, Prashanth, Ragan, Gail, Roth, Mary R., Wang, Liangjiang, Lushington, Gerald H., Visvanathan, Mahesh, and Welti, Ruth. 2011. LipidomeDB Data Calculation Environment: Online processing of direct-infusion mass spectral data for lipid profiles. Lipids. 46, 879-884.

75. Lattif, Ali Abdul, Mukherjee, Pranab K., Chandra, Jyotsna, Roth, Mary R., Welti, Ruth, Rouabhia, Mahmoud, and Ghannoum, Mahmoud A. 2011. Lipidomics of Candida albicans biofilms reveals phase-dependent production of phospholipid molecular classes and role for lipid rafts in biofilm formation. Microbiology 157, 3232-3242. PMID: 21903752

76. Zhao, Jian, Wang, Cunxi, Welti, Ruth, Bedair, Mohamed, Sumner, Lloyd, Baxter, Ian, and Wang,

Xuemin. 2011. Suppression of phospholipase Dγs confers increased aluminum resistance in Arabidopsis thaliana. PLoS One. 6(12), e28086. doi:10.1371/journal.pone.0028086

77. Lee, Junghoon, Welti, Ruth, Roth, Mary, Schapaugh, William T., Li, Jiarui, and Trick, Harold.

2012. Enhanced seed viability and lipid compositional changes during natural aging by suppressing phospholipase Dα in soybean seed. Plant Biotechnol. J. 10, 164-173. DOI: 10.1111/j.1467-7652.2011.00650.x

78. Schrick, Kathrin, Shiva, Sunitha, Arpin, James, Delimont, Nicole, Isaac, Giorgis, Tamura, Pam, and Welti, Ruth. 2012. Steryl glucoside and acyl steryl glucoside analysis of Arabidopsis seeds by electrospray ionization tandem mass spectrometry. Lipids 47, 185-193.

79. Vu, Hieu Sy, Tamura, Pamela, Galeva, Nadezhda A., Chaturvedi, Ratnesh, Williams, Todd D., Wang, Xuemin, Shah, Jyoti, and Welti, Ruth. 2012. Direct infusion mass spectrometry of oxylipin-containing Arabidopsis thaliana membrane lipids reveals varied patterns in different stress responses. Plant Physiol. 158, 324-339.

80. Yang, Wenyu, Zheng, Yong, Bahn, SungChul, Pan, Xiangqing, Li, Maoyin, Vu, Hieu Sy, Roth,

Mary R., Scheu, Brad, Welti, Ruth, and Wang, Xuemin. 2012. Patatin-related phospholipase A

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pPLAIIα modulates oxylipin formation and water loss in Arabidopsis thaliana. Mol. Plant. 5, 452-460.

81. Quanbeck, Stephanie M., Brachova, Libuse, A., Campbell, Alexis, Guan, Xin, Perera, Ann, He,

Kun, Rhee, Seung, Bais, Preetis, Dickerson, Julie A., Dixon, Philip, Wohlgemuth, Gert, Fiehn, Oliver, Barkan, Lenore, Lange, Iris, Lange, B. Markus, Lee, Insuk, Cortes, Diego, Salazar, Caroline, Shuman, Joel, Shulaev, Vladimir, Huhman, David V., Sumner, Lloyd W., Roth, Mary R., Welti, Ruth, Ilarslan, Hilal, Wurtele, Eve S., and Nikolau, Basil J. 2012. Metabolomics as a hypothesis-generating 1 functional genomics tool for the annotation of Arabidopsis thaliana genes of “unknown function”. Front. Plant Sci. 3:15. doi: 10.3389/fpls.2012.00015

82. Guo, Liang, Mishra, Girish, Markham, Jonathan, Li, Maoyin, Tawfall, Amanda, Welti, Ruth, and Wang, Xuemin. 2012. Connections between sphingosine kinase and phospholipase D in the abscisic acid signaling in Arabidopsis. J. Biol. Chem. 287, 8286-8296.

83. Lorenc-Kukula, Katarzyna, Chaturvedi, Ratnesh, Roth, Mary, Welti, Ruth, and Shah, Jyoti. 2012. Biochemical and molecular-genetic characterization of SFD1’s involvement in lipid metabolism and defense signaling. Front. Plant Sci. 3, 26. doi: 10.3389/fpls.2012.00026

84. Zhu, Lieceng, Liu, Xuming, Wang, Haiyan, Khajuria, Chitvan, Reese, John C., Whitworth, R. Jeff,

Welti, Ruth, and Chen, Ming-Shun. Rapid mobilization of membrane lipids in wheat leaf-sheaths during incompatible interactions with Hessian fly. MPMI 25, 920-930.

85. Maatta, Sara, Scheu, Brad, Roth, Mary R., Tamura, Pamela, Li, Maoyin, Williams, Todd D.,

Wang, Xuemin, and Welti, Ruth. 2012. Levels of Arabidopsis thaliana leaf phosphatidic acids, phosphatidylserines, and most trienoate-containing polar lipid molecular species increase during the dark period of the diurnal cycle. Front. Plant Sci. 3:49. doi: 10.3389/fpls.2012.00049.

86. Kilaru, Aruna*, Tamura, Pamela* (* = equal contribution), Isaac, Giorgis, Welti, Ruth, Venables,

Barney J., and Chapman, Kent D. 2012. Lipidomic analysis of N-acylphosphatidylethanolamine molecular species in Arabidopsis suggests feedback regulation by N-acylethanolamines. Planta 236, 809-824.

87. Slone, Emily A., Pope, Michael R., Roth, Mary, Welti, Ruth, Fleming, Sherry D. 2012. TLR9 is

dispensable for intestinal ischemia/reperfusion-induced tissue damage. Am. J. Clin. Exp. Immunol. 1, 124-135.

88. Zhou, X., Mao, J., Ai, J., Deng, Y., Roth, M.R., Pound, C.R., Henegar, J., Welti, R., and Bigler,

S.A. 2012. Identification of plasma lipid biomarkers for prostate cancer by lipidomics and bioinformatics. PLoS One. 7(11):e48889. doi: 10.1371/journal.pone.0048889

89. Ju, Songwen, Mu, Jingyao, Dokland, Terje, Zhuang, Xiaoying, Wang, Qilong, Jiang, Hong, Xiang,

Xiaoyu, Deng, Zhong-Bin, Wang, Baomei, Zhang, Lifeng, Roth, Mary, Welti, Ruth, Mobley, James, Jun, Yan, Miller, Donald, and Zhang, Huang-Ge. 2013. Grape exosome-like nanoparticles induce intestinal stem cells and protect mice from DSS-induced colitis. Molecular Therapy 21, 1345-1357.

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90. Kim, Dongwon, Jeannotte, Richard, Welti, Ruth, and Bockus, William W. 2013. Lipid profiles in wheat cultivars resistant and susceptible to tan spot and the effect of disease on the profiles. Phytopathology 103, 74-80.

91. Li, Maoyin, Bahn, S.C., Fan, C., Li, J., Phan, T., Ortiz, M., Roth, Mary R., Welti, Ruth, and Wang,

Xuemin. 2013. Patatin-related phospholipase pPLAIIIδ increases seed oil content with long-chain fatty acids in Arabidopsis. Plant Physiol. 162, 39-51.

92. McHaney, Anastasia M., Welti, Ruth, Roth, Mary R., Dinnetz, Joyce M., Furney, S.R., Pendergraft, Jeffrey S., Epp, T.S., and Minton, J. Ernest. 2013. Omega-3 fatty acid supplementation affects selected phospholipids in peripheral white blood cells and in plasma of full-sized and miniature mares. J. Equine Vet. Sci. 33, 779-786.

93. Narasimhan, Rama, Wang, Geliang, Roth, Mary, Welti, Ruth, and Wang, Xuemin. 2013.

Differential changes in galactolipid and phospholipid species in soybean leaves and roots under nitrogen deficiency and after nodulation. Phytochemistry 96, 81-91.

94. Zhao, Jian, Devaiah, Shiva P., Wang, Cunxi, Li, Maoyin, Welti, Ruth, and Wang, Xuemin. 2013.

Arabidopsis phospholipase Dβ1 modulates defense responses to bacterial and fungal pathogens. New Phytol. 199, 228-240.

95. Zheng, Lianqing, Gadbury, Gary, Shah, Jyoti, and Welti, Ruth. 2013. Exploration of reactant-

product lipid pairs in mutant-wild type lipidomics experiments. The 2012 Proceedings of the Conference on Applied Statistics in Agriculture.

96. Haller, J. F., Cavallaro, P., Hernandez, N. J., Dolat, L., Soscia, S. J., Welti, R., Sun, Y., Grabowski,

G. A., Milstone, L. M., Fitzgerald, M. L., and Freeman, M. W. 2013. Endogenous β-glucocerebrosidase activity in Abca12-/-epidermis elevates ceramide levels after topical lipid application but does not restore barrier function. J. Lipid Res. In press.

97. Li, Maoyin, Baughman, Ethan, Roth, Mary R., Han, Xianlin, Welti, Ruth, and Wang, Xuemin.

2013. Quantitative profiling and pattern analysis of triacylglycerol species in Arabidopsis seeds by electrospray ionization mass spectrometry. Plant J. In press.

98. Vu, Hieu Sy, Roth, Mary R., Tamura, Pamela, Samarakoon, Thilani, Shiva, Sunitha, Honey,

Samuel, Lowe, Kaleb, Schmelz, Eric A., Williams, Todd D., and Welti, Ruth. 2013. Head-group acylation of monogalactosyldiacylglycerol is a common stress response, and the acyl-galactose acyl composition varies with the plant species and applied stress. Physiol. Plant. In press.

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Review Articles, Methods, and Book Chapters 1. Welti, Ruth and Glaser, Michael. 1994. Lipid domains in model and biological membranes.

Chem. Phys. Lipids. 73,121-137.

2. Wang, Xuemin, Wang, Cunxi, Sang, Yongming. Qin, Chunbo, and Welti, Ruth. 2002. Networking of phospholipases in plant signal transduction. Physiologica Plantarum.115, 331-335.

3. Qin, Chunbo, Li, Weiqi, Hong, Yueyun, Zhang, Wenhua, Wood, Tara, Li, Maoyin, Welti, Ruth, and Wang, Xuemin. 2003. Two novel types of Arabidopsis phospholipase D: Oleate-stimulated PLDδ and Ca2+-independent PLDς1. In “Advanced Research on Plant Lipids”, ed. Murata, N., Yamada, M., Nishida, I., Okuyama, H., Sekiya, J., and Hajime, W. Kluwer Academic Publishers, Dordrecht/Boston/London. pp. 259-262.

4. Welti, Ruth, and Wang, Xuemin. 2003. Lipidomics. Inform 14, 607-608.

5. Shah, Jyoti, Nandi, Ashis, Buseman, Christen M., Li, Maoyin, Krothapalli, Kartik, Pegadaraju, Venki, Buffington, Rachel, Morton, Jessica, Omoluabi, O., Baughman, Ethan, and Welti, Ruth. 2004. Salicylic acid signaling in plant defense: the lipid connection, In “Biology of Molecular Plant-Microbe Interaction”, B. Lugtenberg, I. Tikhonovich and N. Provorov, eds. Vol. 4. American Phytopathological Society Press.

6. Welti, Ruth, and Wang, Xuemin. 2004. Lipid species profiling: A high throughput approach to identify lipid compositional changes and determine the function of genes involved in lipid metabolism and signaling. Curr. Opin. Plant Biol. 7, 337-344.

7. Welti, Ruth, Shah, Jyoti, LeVine, Steven, Esch, S. Wynn, Williams, Todd D., and Wang, Xuemin. 2005. High throughput lipid profiling to identify and characterize genes involved in lipid metabolism, signaling, and stress response. In “Functional Lipidomics” (Chapter 14), L. Feng and G.D. Prestwich, eds. Marcel Dekker, New York, pp. 307-322.

8. Wang, Xuemin, Li, Weiqi, Li, Maoyin, and Welti, Ruth. 2006. Profiling lipid changes in plant response to low temperatures. Phys. Plantarum 126, 90-96.

9. Welti, Ruth, Isaac, Giorgis, Tamura, Pamela, Esch, Steven Wynn, Sparks, Alexis, Jeannotte, Richard, Roth, Mary, Maatta, Sara, Williams, Todd D., Shah, Jyoti, and Wang, Xuemin. 2006. Lipid profiling: Analysis of gene function and physiological responses in Arabidopsis. Proceedings of the 17th International Symposium on Plant Lipids. Eds. Benning, Christoph and Ohlrogge, John. pp. 287-291.

10. Welti, Ruth, Shah, Jyoti, Li, Weiqi, Li, Maoyin, Chen, Junping, Burke, John J., Fauconnier, Marie-Laure, Chapman, Kent, Chye, Mee-Len, and Wang, Xuemin. 2007. Plant lipidomics: Discerning biological function by profiling plant complex lipids using mass spectrometry. Frontiers in Bioscience. 12, 2494-2506

11. Welti, Ruth, Roth, Mary R., Deng, Youping, Shah, Jyoti and Wang, Xuemin. 2007. Lipidomics: ESI-MS/MS-based profiling to determine the function of genes involved in metabolism of complex lipids. In “Plant Metabolomics”, Basil Nikolau. ed. Springer, Dordrecht, The Netherlands. pp. 87-92.

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12. Isaac, Giorgis, Jeannotte, Richard, Esch, Steven Wynn, and Welti, Ruth. 2007. New mass-spectrometry-based strategies for lipids, Gen. Eng. Rev. Vol. 28. 28, 129-157.

13. Wang, Xuemin (Sam), and Welti, Ruth. Understanding plant lipids. ASBMB Today. July 2009. p. 22.

14. Li-Beisson, Y., Shorrosh, B., Beisson, F., Andersson, M., Arondel, V., Bates, P.D., Baud, S., Bird, D., DeBono, A., Durrett, T.P., Franke, R.B., Graham, I.A., Katayama, K., Kelly, A., Larson, T., Markham, J.E., Miquel, M., Molina, I., Nishida, I., Rowland, O., Samuels, L., Schmid, K.M., Wada, H., Welti, R., Xu, C., Zallot R., and Ohlrogge J. 2010. Acyl lipid metabolism. The Arabidopsis Book, 8, 1-65. http://www.bioone.org/doi/pdf/10.1043/tab.00133

15. Li-Beisson, Y., Shorrosh, B., Beisson, F., Andersson, M., Arondel, V., Bates, P.D., Baud, S., Bird, D., DeBono, A., Durrett, T.P., Franke, R.B., Graham, I.A., Katayama, K., Kelly, A., Larson, T., Markham, J.E., Miquel, M., Molina, I., Nishida, I., Rowland, O., Samuels, L., Schmid, K.M., Wada, H., Welti, R., Xu, C., Zallot R., and Ohlrogge J. 2013. Arabidopsis Book. 11:e0161. doi: 10.1199/tab.0161. Epub 2013 Jan 29.

16. Welti, Ruth. 2010. Plant lipidomics. In The AOCS Lipid Library. http://lipidlibrary.aocs.org/plantbio/plantlipidomics/index.htm

17. Samarakoon, Thilani*, Shiva, Sunitha* (* = equal contribution), Lowe, Kaleb, Tamura, Pamela, Roth, Mary R., and Welti, Ruth. 2012. Arabidopsis thaliana membrane lipid molecular species and their mass spectral analysis. In High throughput phenotyping in plants, Methods in Molecular Biology. Ed., J. Normanly. Humana Press, New York, NY. 918, 179-268.

18. Shiva, Sunitha*, Vu, Hieu Sy* (*equal contributions), Roth, Mary R., Zhou, Zhenguo, Marepally, Shantan Reddy, Nune, Daya Sagar, Lushington, Gerald H., Visvanathan, Mahesh, and Welti, Ruth. 2013. Lipidomic analysis of plant membrane lipids by direct infusion tandem mass spectrometry. In Plant Lipid Signaling Protocols, Methods in Molecular Biology. Ed. Teun Munnik and Ingo Heilmann. Humana Press, New York, NY. 1009, 79-91.

19. Vu, Hieu Sy, Shiva, Sunitha, Hall, Aaron Smalter, and Welti, Ruth. (2013). A lipidomic approach to identify cold-induced changes in Arabidopsis membrane lipid composition. In Plant Cold Acclimation, Methods in Molecular Biology. Ed., D. Hincha. Humana Press, New York, NY. In press.

Texts

1. Rintoul, David A., Welti, Ruth, Lederman, Muriel, Storrie, Brian and Van Buskirk, Robert. 1990. A Student's Companion in Molecular Cell Biology, W. H. Freeman and Company/Scientific American Books, New York.

2. Rintoul, D., Welti, R., Storrie, B., and Lederman, M. 1995. Student Companion for Molecular Biology, Third Edition. W.H. Freeman and Company/Scientific American Books, New York.

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Additional Publications* that Include Data from Lipid Analyses Performed at Kansas Lipidomics Research Center: 2006-2013. (*Welti is not an author on these publications.) 1. Cruz-Ramirez, A., Oropeza-Aburto, A., Razo-Hernandez, F., Ramirez-Chavez, E., and Herrera-Estrella, L. 2006.

Phospholipase DZ2 plays an important role in extraplastidic galactolipid biosynthesis and phosphate recycling in Arabidopsis roots. Proc. Natl. Acad. Sci. USA 103, 6765-6770.

2. Chen, J., Burke, J.J., Xin, Z., Xu, C., and Velten, J. 2006. Characterization of the Arabidopsis thermosensitive mutant atts02 reveals an important role for galactolipids in thermotolerance. Plant, Cell and Environment 29, 1437-1448.

3. Kachroo, A., Shanklin, J., Whittle, E., Lapchyk, L., Hildebrand, D., and Kachroo, P. 2007. The Arabidopsis stearoyl-acyl carrier protein-desaturase family and the contribution of leaf isoforms to oleic acid synthesis. Plant Mol. Biol. 63, 257-271.

4. Im, Y.J., Perera, I.Y., Brglez, I., Davis, A.J., Stevenson-Paulik, J., Phillippy, B.Q., Johannes, E., Allen, N.S., and Boss, W.F. 2007. Increasing plasma membrane Phosphatidylinositol(4,5)Bisphosphate biosynthesis increases phosphoinositide metabolism in Nicotiana tabacum. Plant Cell 19, 1603–1616.

5. Bates, P.D., Ohlrogge, J.B., and Pollard, M. 2007. Incorporation of newly synthesized fatty acids into cytosolic glycerolipids in pea leaves occurs via acyl editing. J. Biol. Chem. 282, 31206-31216.

6. Xiao, S., Li, H.Y., Zhang, J.P., Chan, S.W., and Chye, M.L. 2008. Arabidopsis acyl-CoA-binding proteins ACBP4 and ACBP5 are subcellularly localized to the cytosol and ACBP4 depletion affects membrane lipid composition. Plant Mol. Biol. 68, 571-583.

7. Zhu, L., Liu, X., Liu, X., Jeannotte, R., Reese, J.C., Harris, M., Stuart, J.J., and Chen, M.-S. 2008. Hessian fly (Mayetiola destructor) attack causes a dramatic shift in carbon and nitrogen metabolism in wheat. Mol. Plant-Microbe Interact. 21, 70-78.

8. Regente, M., Corti Monzón, G., and de la Canal, L. 2008. Phospholipids are present in extracellular fluids of imbibing sunflower seeds and are modulated by hormonal treatments. J. Exp. Botany 59, 553-562.

9. Cunningham, T.J., Yao, L., and Lucena, A. 2008. Product inhibition of secreted phospholipase A2 may explain lysophosphatidylcholines' unexpected therapeutic properties. J. Inflamm. (Lond.). 5, 17.

10. Chen, M., Markham, J.E., Dietrich, C.R., Jaworski, J.G., and Cahoon, E.B. 2008. Sphingolipid long-chain base hydroxylation is important for growth and regulation of sphingolipid content and composition in Arabidopsis. Plant Cell 20, 1862-1878.

11. Chen, Q-F., Shi, X., and Chye, M.-L. 2008. Overexpression of the Arabidopsis 10-Kilodalton acyl-cCoenzyme A-binding protein ACBP6 enhances freezing tolerance. Plant Physiol. 148, 304–315.

12. Zhu, J., Mounzih, K., Chehab, E.F., Mitro, N., Saez, E., and Chehab, F.F. 2009. Effects of FoxO4 overexpression on cholesterol biosynthesis, triacylglycerols accumulation and glucose uptake. J. Lipid. Res. 51, 1312-1324.

13. Zufferey, R., Al-Ani, G.K., and Dunlap, K. 2009. Leishmania dihydroxyacetonephosphate acyltransferase LmDAT is important for ether lipid biosynthesis but not for the integrity of detergent resistant membranes. Mol. Biochem. Parasitol. 168, 177-185.

14. Zhang, Q., Fry, J., Rajashekar, C., Bremer, D., and Engelke, M. 2009. Membrane polar lipid changes in zoysiagrass rhizomes and their potential role in freezing tolerance. J. Am. Soc. Hort. Sci. 134, 322-328.

15. Xia, Y., Gao, Q., Yu, K., Lapchyk, L., Navarre, D., Hildebrand, D., Kachroo, A., and Kachroo, P. 2009. An intact cuticle in distal tissues is essential for the induction of systemic acquired resistance in plants. Cell Host & Microbe, 5, 151-165.

16. Regente, M., Corti-Monzón, G., Maldonado, A.M., Pinedo, M., Jorrín, J., de la Canal, L. 2009. Vesicular fractions of sunflower apoplastic fluids are associated with potential exosome marker proteins. FEBS Lett. 2583, 3363-3366.

17. Reina-Pinto, J. J., Voisin, D., Kurdyukov, S., Faust, A., Haslam, R.P., Michaelson, L.V., Efremova, N., Franke, B., Schreiber, L., Napier, J.A., and Yephremov, A. 2009. Misexpression of FATTY ACID ELONGATION1 in the Arabidopsis epidermis induces cell death and suggests a critical role for phospholipase A2 in this process. Plant Cell 21, 1252-1272.

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18. Keogh, M.R., Courtney, P.D., Kinney, A.J., and Dewey, R.E. 2009. Functional characterization of phospholipid N-methyltransferases from Arabidopsis and soybean. J. Biol. Chem. 284, 15439-15447.

19. Kirik, A., and Mudgett, M.B. 2009. SOBER1 phospholipase activity suppresses phosphatidic acid accumulation and plant immunity in response to bacterial effector AvrBsT. Proc. Natl. Acad. Sci. U S A 106, 20532-20537.

20. Hafer, A., Whittlesey, R., Brown, D.T., and Hernandez ,R. 2009. Differential incorporation of cholesterol by sindbis virus grown in mammalian or insect cells. J. Virol. 83, 9113-9121.

21. Burow, G.B., Franks, C.D., Acosta-Martinez, V., and Xin, Z. 2009. Molecular mapping and characterization of BLMC, a locus for profuse wax (bloom) and enhanced cuticular features of sorghum (Sorghum bicolor (L.) Moench.). Theor Appl Genet. 118, 423-431.

22. Cherian, G., 2009. Egg yolk conjugated linoleic acid alters phospholipid molecular species in chick tissues. European J. Lipid Sci. Tech. 111, 546-552.

23. Coronado, M., Yuan, W., Wang, D., and Dowell, F.E. 2009. Biodiesel-diesel blends using near-infrared spectroscopy. Applied Engineering in Agriculture 25, 217-221.

24. Cunningham, T.J., Yao ,L., Lucena, A., and Greenstein, J.I. 2009. Uncompetitive phospholipase A2 inhibition by CHEC sequences including oral treatment of experimental autoimmune myeloencephalitis, Open Enzyme Inhibition J. 2, 1-7.

25. Finnie, S.M., Jeannotte, R., and Faubion, J.M. 2009. Quantitative characterization of polar lipids from wheat whole-meal, flour and starch. Cereal Chem. 86, 637–645.

26. Yalcin, A., Clem, B., Makoni, S., Clem, A., Nelson, K., Thornburg, J., Siow, D., Lane, A.N., Brock, S.E., Goswami, U., Eaton, J.W., Telang, S., and Chesney, J. 2010. Selective inhibition of choline kinase simultaneously attenuates MAPK and PI3K/AKT signaling. Oncogene 29, 139–149.

27. Yergeau, E., Labour, K., Hamel, C., Vujanovic, V., Nakano-Hylander, A., Jeannotte, R., and St-Arnaud, M. 2010. Patterns of Fusarium community structure and abundance in relation to spatial, abiotic and biotic factors. FEMS Microbiol. Ecol. 71, 34-42.

28. Yu, L., Nie, J., Cao, C., Jin, Y., Yan, M., Wang, F., Liu, J., Xiao, Y., Liang, Y., and Zhang, W. 2010. Phosphatidic acid mediates salt stress response by regulation of MPK6 in Arabidopsis thaliana. New Phytol. 188, 762–773.

29. Zhu, L., Liu, X., and Chen, M.-S. 2010. Differential accumulation of phytohormones in wheat seedlings attacked by avirulent and virulent Hessian fly (Diptera: Cecidomyiidae) larvae. J. Econ. Entomol. 103, 178-185.

30. Zhu, J., Mounzih, K., Chehab, E.F., Mitro, N., Saez, E., and Chehab, F.F. 2010. Effects of FoxO4 overexpression on cholesterol biosynthesis, triacylglycerol accumulation, and glucose uptake. J. Lipid Res. 51, 1312-1324.

31. Wen, D., Androjna, C., Vasanji, A., Belovich, J., and Midura, R.J. 2010. Lipids and collagen matrix restrict the hydraulic permeability within the porous compartment of adult cortical bone. Ann. Biomed. Engin. 38, 558-569. DOI: 10.1007/s10439-009-9858-z

32. Smith, C.M., Liu, X., Wang, L.J., Liu, X., Chen, M.S., Starkey, S., and Bai, J. 2010. Aphid feeding activates expression of a transcriptome of oxylipin-based defense signals in wheat involved in resistance to herbivory. J. Chem. Ecol. 36, 260-276.

33. Shen, W., Li, J.Q., Dauk, M., Huang, Y., Periappuram, C., Wei, Y., and Zou, J. 2010. Metabolic and transcriptional responses of glycerolipid pathways to a perturbation of glycerol 3-phosphate metabolism in Arabidopsis. J. Biol. Chem. 285, 22957-22965.

34. Du, Z.Y., Xiao, S., Chen, Q.F., and Chye, M.L. 2010. Depletion of the membrane-associated acyl-coenzyme A-binding protein ACBP1 enhances the ability of cold acclimation in Arabidopsis. Plant Physiol. 152, 1585-1597.

35. Edelstein, C., Pfaffinger, D., Yang, M., Hill, J.S., and Scanu, A.M. 2010. Naturally occurring human plasminogen, like genetically related apolipoprotein(a), contains oxidized phosphatidylcholine adducts. Biochim. Biophys. Acta. 1801, 738-745.

36. Finnie, S.M., Jeannotte, R., Morris, C.F., and Faubion, J.M. 2010. Variation in polar lipid composition among near-isogenic wheat lines possessing different puroindoline haplotypes. J. Cereal Sci. 51, 66-72.

37. Finnie, S.M., Jeannotte, R., Morris, C.F., Giroux, M.J., and Faubion, J.M. 2010. Variation in polar lipids located on the surface of wheat starch. J. Cereal Sci. 51, 73-80.

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38. Gallier, S., Gragson, D., Jiménez-Flores, R., and Everett, D.W. 2010. Using confocal laser scanning microscopy to probe the milk fat globule membrane and associated proteins. J. Agric. Food Chem. 58, 4250–4257.

39. Gallier, S., Gragson, D., Cabral, C., Jiménez-Flores, R., and Everett, D.W. 2010. Composition and fatty acid distribution of bovine milk phospholipids from processed milk products. J. Agric. Food Chem. 58, 10503–10511.

40. Grim, J.M., Miles, D.R.B., and Crockett, E.L. 2010. Temperature acclimation alters oxidative capacities and composition of membrane lipids without influencing activities of enzymatic antioxidants or susceptibility to lipid peroxidation in fish muscle. J. Exp. Biol 213, 445-452.

41. Castorena, K.M., Stapleford, K.A., and Miller, D.J. 2010. Complementary transcriptomic, lipidomic, and targeted functional genetic analyses in cultured Drosophila cells highlight the role of glycerophospholipid metabolism in Flock House virus RNA replication. BMC Genomics 11, 183. doi:10.1186/1471-2164-11-183

42. Chen, H., and Xiong, L. 2010. myo-Inositol-1-phosphate synthase is required for polar auxin transport and organ development. J. Biol. Chem. 285, 24238-24247.

43. Chen, J., Xu, W., Burke, J.J., and Xin, Z. 2010. Role of phosphatidic acid in high temperature tolerance in maize. Crop Sci. 50, 2506-2515.

44. Chen, M., and Thelen, J.J. 2010. The plastid isoform of triose phosphate isomerase is required for the postgerminative transition from heterotrophic to autotrophic growth in Arabidopsis. Plant Cell 22, 77-90.

45. Chen, Q.-F., Xiao, S., Qi, W., Mishra, G., Ma, J., Wang, M., and Chye, M.-L. 2010. The Arabidopsis acbp1acbp2 double mutant lacking acyl-CoA-binding proteins ACBP1 and ACBP2 is embryo lethal. New Phytol. 186, 843–855.

46. Zhang, J., Martin, J.M., Beecher, B., Lu, C., Hannah, C., Wall, M.L., Altosaar, I., and Giroux, M.J. 2010. The ectopic expression of the wheat Puroindoline genes increase germ size and seed oil content in transgenic corn. Plant Mol. Biol. 74, 353–365

47. Kim, H.U., Vijayan, P., Carlsson, A. S., Barkan, L., Browse, J. 2010. A mutation in the LPAT1 gene suppresses the sensitivity of fab1 plants to low temperature. Plant Physiol. 153, 1135-1143.

48. Biller, S.J., Wayne, K.J., Winkler, M.E., and Burkholder, W.F. 2011. The putative hydrolase YycJ (WalJ) affects the coordination of cell division with DNA replication in Bacillus subtilis and may play a conserved role in cell wall metabolism. J. Bacteriol. 193, 896-908.

49. Hameed, S., Dhamgaye, S., Singh, A., Goswami, S.K., Prasad, R. 2011. Calcineurin signaling and membrane lipid homeostasis regulates iron mediated multidrug resistance mechanisms in Candida albicans. PLoS ONE 6(4): e18684.

50. Liegel, R., Chang, B. Dubielzig, R., and Sidjanin, D.J. 2011. Blind sterile 2 (bs2), a hypomorphic mutation in Agps, results in cataracts and male sterility in mice. Mol. Geneti. Metab. 103, 51-59.

51. Friederichs, J.M., Ghosh, S., Smoyer, C.J., McCroskey, S., Miller, B.D., Weaver, K.J., Delventahl, K.M., Unruh, J., Slaughter, B.D., and Jaspersen, S.L. 2011. The SUN protein Mps3 is required for spindle pole body insertion into the nuclear membrane and nuclear envelope homeostasis. PLoS Genet. 7(11): e1002365

52. Myers, A.M., James, M.G., Lin, Q., Yi, G., Stinard, P.S., Hennen-Bierwagen, T.A., and Becraft, P.W. 2011. Maize opaque5 encodes monogalactosyldiacylglycerol synthase and specifically affects galactolipids necessary for amyloplast and chloroplast function. Plant Cell. 23, 2311-2347.

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54. Chrisman, C.J., Albuquerque, P., Guimaraes, A.J., Nieves, E., and Casadevall, A. 2011. Phospholipids trigger Cryptococcus neoformans capsular enlargement during interactions with amoebae and macrophages. PLoS Pathog 7(5), e1002047.

55. Zhai, S.-M., Gao, Q., Xue, H.-W., Sui, Z.-H., Yue, G.-D., Yang, A.-F., and Zhang, J.R. 2011. Overexpression of the phosphatidylinositol synthase gene from Zea mays in tobacco plants alters the membrane lipids composition and improves drought stress tolerance. Planta 235, 68-84.

56. Alawode, O.E., Robinson, C., and Rayat, S. 2011. Clean photodecomposition of 1-methyl-4-phenyl-1h-tetrazole-5(4h)-thiones to carbodiimides proceeds via a biradical. J. Org. Chem., 76, 216–222.

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59. Chanda, B., Xia, Y., Mandal, M.K., Yu, K., Sekine, K.T., Gao, Q., Selote, D., Hu, Y., Stromberg, A., Navarre, D., Kachroo, A., and Kachroo, P. 2011. Glycerol-3-phosphate is a critical mobile inducer of systemic immunity in plants. Nature Genetics. 43, 421-427. doi:10.1038/ng.798

60. Clem, B.F., Clem, A.L., Yalcin, A., Goswami, U., Arumugam, S., Telang, S., Trent., J.O., and Chesney, J. 2011. A novel small molecule antagonist of choline kinase-α that simultaneously suppresses MAPK and PI3K/AKT signaling. Oncogene doi:10.1038/onc.2011.51

61. Grim, J.M., Hyndman, K.A., Kriska, T., Girotti, A.W., and Crockett, E.L. 2011. Relationship between oxidizable fatty acid content and level of antioxidant glutathione peroxidases in marine fish. J. Exp. Biol. 214, 3751-3759. doi: 10.1242/jeb.058214

62. Makandar, R., Nalam, V., Lee, H., Trick, H., Dong, Y., and Shah, J. 2012.Salicylic acid regulates basal resistance to Fusarium head blight in wheat. MPMI 25, 431-439. http://dx.doi.org/10.1094/MPMI-09-11-0232

63. McCall AS, Wang H, Desper JM, Kraft S. 2012. Bis-N-heterocyclic carbene palladium(IV) tetrachloride complexes: synthesis, reactivity, and mechanisms of direct chlorinations and oxidations of organic substrates. J. Am. Chem. Soc. 133(6):1832-48. doi: 10.1021/ja107342b.

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66. Singh, A., and Prasad, R. 2011. Comparative lipidomics of azole sensitive and resistant clinical isolates of Candida albicans reveals unexpected diversity in molecular lipid imprints. PLoS ONE 6(4): e19266. doi:10.1371/journal.pone.0019266

67. Wang, G., Sun, X. Wang, G., Wang, F., Gao, Q., Sun, X., Tang, Y., Chang, C., Lai, J., Zhu, L., Xu, Z., and Song, R. Opaque7 encodes an acyl activating enzyme-like protein that affects storage protein synthesis in maize endosperm. Genetics. 189, 1281-125. doi: 10.1534/genetics.111.133967

68. Zheng, G., Tian, B., Zhang, F., Tao, F., and Li, W. 2011. Plant adaptation to frequent alterations between high and low temperatures: remodelling of membrane lipids and maintenance of unsaturation levels. Plant Cell Environ. 34, 1431–1442.

69. Zhu, L., Chen, M.-S., and Liu, X. 2011. Changes in phytohormones and fatty acids in wheat and rice seedlings in response to Hessian fly (Diptera: Cecidomyiidae) infestation. J. Econ. Entomol. 104, 1384-1392.

70. Bais, P., Moon-Quanbeck, S.M., Nikolau, B.J., and Dickerson, J.A. 2012. Plantmetabolomics.org: mass spectrometry-based Arabidopsis metabolomics—database and tools update. Nucl. Acids Res. 40 (D1), D1216-D1220. doi: 10.1093/nar/gkr969

71. Cenzano, A.,M., Cantoro, R., Hernández-Sotomayor, S.M.T., Abdala, G.I., and Racagni, G. E. 2012. Lipid profiling by electrospray ionization tandem mass spectrometry and the identification of lipid phosphorylation by kinases in potato stolons. J. Agric. Food Chem., 60, 418–426 DOI: 10.1021/jf204269y

72. Dieck, C.B., Wood, A., Brglez, I., Rojas-Pierce, M., and Boss, W.F. 2012. Increasing phosphatidylinositol (4,5) bisphosphate biosynthesis affects plant nuclear lipids and nuclear functions. Plant Physiol. Biochem. 57, 32-44. http://dx.doi.org/10.1016/j.plaphy.2012.05.011

73. Gonorazky, G., Laxalt, A.M., Dekker, H.L., Rep, M., Munnik, T., Testerink, C., and de la Canal, L. 2012. Phosphatidylinositol 4-phosphate is associated to extracellular lipoproteic fractions and is detected in tomato apoplastic fluids. Plant Biol. 14, 41-49.

74. Jiang, Y., Ma, H., Su, X., Chen, J., Xu, J., Standard, J., Lin, D., Wang, W. 2012. IGF-1 mediates exercise-induced phospholipid alteration in the murine skin tissues. J. Nutr. Food Sci. S2-003. http://dx.doi.org/10.4172/2155-9600.S2-003

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75. Kim, K.-H., Feiz, L., Martin, J.M., and Giroux, M.J. 2012. Puroindolines are associated with decreased polar lipid breakdown during wheat seed development. J. Cereal Sci. 56, 142-146.

76. Mandal, M.K., Chandra-Shekara, A.C., Jeong, R.-D., Yu, K., Zhu, S., Chanda, B., Navarre, D., Kachroo, A., and Kachroo, P. 2012. Oleic acid–dependent modulation of NITRIC OXIDE ASSOCIATED1 protein levels regulates nitric oxide–mediated defense signaling in Arabidopsis. Plant Cell 24, 1654-1674 doi: http://dx.doi.org/10.1105/tpc.112.096768

77. Moir, R.D., Gross, D.A. Silver, D.L., and Willis, I.M. 2012, SCS3 and YFT2 link transcription of phospholipid biosynthetic genes to ER stress and the UPR. PLoS Genet 8(8): e1002890. doi:10.1371/journal.pgen.1002890

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82. Singh, A., Yadav, V., and Prasad, R. 2012. Comparative lipidomics in clinical isolates of Candida albicans reveal crosstalk between mitochondria, cell wall integrity and azole resistance. PLoS ONE 7(6): e39812. doi:10.1371/journal.pone.0039812

83. Tjellström, H., Yang, Z., Allen, D. K., and Ohlrogge, J. B. 2012. Rapid kinetic labeling of Arabidopsis cell suspension cultures: Implications for models of lipid export from plastids. Plant Physiol. 158. 601-611.

84. Zhai, S.-M., Gao, Q., Xue, H.-W., Sui, Z.-H., Yue, G.-D., Yang, A.-I., and Zhang, J.-R. 2012, Overexpression of the phosphatidylinositol synthase gene from Zea mays in tobacco plants alters the membrane lipids composition and improves drought stress tolerance. Planta 235, 69-84.

85. Zhang, P., Takeuchi, K., Csaki, L.S., and Reue, K. 2012. Lipin-1 phosphatidic acid phosphatase activity modulates phosphatidic acid levels to promote induction of peroxisome proliferator-activated receptor γ (PPARγ) gene expression during adipogenesis. J. Biol. Chem. 287, 3485-3494. 10.1074/jbc.M111.296681

86. Brewer, L.R., and Wetzel, D.L. 2012. Fourier transform infrared (FT-IR) microspectroscopic genetic expression of the waxy trait in isogenic durum and common wheat. Cereal Chemistry 89, 94-99. http://dx.doi.org/10.1094/CCHEM-11-11-0133

87. Cacho, M., Peláez, R., and Corchete, P. 2012. Lipid composition of Silybum marianum cell cultures treated with methyl jasmonate. Biologia Plantarum 56, 221-226.

88. Dwyer, J.R., Donkor, J., Zhang, P., Csaki, L.S., Vergnes, L., Lee, J.M., Dewald, J., Brindley, D.N. Atti, E., Tetradis, S., Yoshinaga, Y., DeJong, P.J., Fong, L.G., Young, S.G., and Reue, K. 2012. Mouse lipin-1 and lipin-2 cooperate to maintain glycerolipid homeostasis in liver and aging cerebellum. Proc. Natl. Acad. Sci. U.S. A. 109, E2486–E2495.

89. Wang, L., Shen, W., Kazachkov, M., Chen, G., Chen, Q., Carlsson, A.S., Stymne, S., Weselake, R.J., and Zou, J. 2012. Metabolic interactions between the Lands cycle and the Kennedy pathway of glycerolipid synthesis in Arabidopsis developing seeds. Plant Cell. 24, 4652-4669.

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