RSV:RESPIRATORY

SYNCYTIAL VIRUS

Barbara Woodall

BACKGROUND

Discovered in 1956

Childhood illnesses

Causes bronchioltitis & pneumonia

Age 2

("Respiratory syncytial virus," 2014)

BACKGROUND

Family: Paramyxovirida

Subfamily: Pneumovirinae

An enveloped RNA virus

Strains A and B

("Respiratory syncytial virus," 2014)

1

TRANSMISSION

Water droplets

Indirect contact

Spreads rapidly among children

Contagious even after 1-3 weeks

(“rsvprotection,” 2013)

PREVENTION

PREVENTION

Hand washing

Keeps hands away from face

Avoid contact with people who are sick

Cover coughs and sneezes

Clean and disinfect surfaces

Stay home when sick

("Respiratory syncytial virus," 2014)

Warm water

Soap

Remove jewelry

Wash for twenty

seconds

HAND WASHING

2

SYMPTOMS

Illness 4-6 days after exposure

Runny nose and decrease in appetite (2-8 days)

Coughing, sneezing and fever (1-3 days after)

Infants: • Irritability • Decreased activity and breathing

("Respiratory syncytial virus," 2014)

RED ALERT SIGNS

Non stop coughing or wheezing

Fast or troubled breathing

Fever > 100

Bluish color around mouth or fingernails

Spread-out nostrils and/or caved-in chest

Gasping for breath

(“rsvprotection,” 2013)

Antigen Detection Test

Suplement Antigen

Testing with cell culture

RT-PCR assay

("Respiratory syncytial

virus," 2014)

DIAGNOSING

3

TREATMENT

Recovery in 1-2 weeks

May cause Sever lung infections

Some infants may require hospitalization

("Respiratory syncytial virus," 2014)

HIGH RISK

4

HIGH RISK

Infants under 6 weeks

Born before 35 weeks

Chronic lung disease

Congenital heart disease

Weekend immune systems ( Anekwe)

(“rsvprotection,” 2013)

STATISTICS

4,500 deaths a year in the US• Infants 2-6 months

Life-threatening pneumonia• Easily diagnosed as influenza

About 1% of children will require hospitalization

Between 25-40 out of 100 young children show sings of

pneumonia or bronchiolitis ("Respiratory syncytial virus,"

2014)

(Tortora, Case & Case, 2010)

PREVALENCE

Varies by location (RSVprotection)

Time and severity vary from year to year

Usually occurs during late fall, winter and early spring

("Respiratory syncytial virus," 2014)

PREVALENCE

5

NEW DEVELOPMENTS

Immune globulin product has been approved

Protective vaccines being clinically tested

Sever symptoms helped by aerosol

Humanized monoclonal antibody

(Tortora, Case & Case, 2010)

NEW DEVELOPMENTS

Respiratory illness in older adults ("Respiratory

syncytial virus," 2014)

Palivizumab for high risk children (Anekwe, 2009)

Antivirals with anti-inflammatory therapies

("Respiratory syncytial virus," 2010)

New imaging technique to study RSV living cells

(Toon, 2013)

SUPER-RESOLUTION OPTICAL IMAGE

6

PLACES DOING RESEARCH

Arctic Investigation Program ("Respiratory syncytial virus,"

2014)• immunity

National Institute of Allergy and Infectious Diseases

("Respiratory syncytial virus," 2010)• Immunity

National Institute of General Medical Sciences (Toon, 2013)• How it enters• How it Replicates• How many genomes inserted into hosts

WORKS CITED

Anekwe, Lilian. Government considers immunizing children against RSV. (2009, January 14). Retrieved form

http://www.pulsetoday.co.uk/government-considers-immunising-children-against-rsv/10995958.article#.

UzXevNytg2w

Paving the way for respiratory syncytial virus. ( 2013, September). Retrieved form

http://www.path.org/publications/files/VAC_rsv_fs.pdf

Rsv protection. (2013). Retrieved from https://www.rsvprotection.com/index.html

Respiratory syncytial virus. (2014, April 01). Retrieved from http://www.cdc.gov/rsv/

Respiratory Syncytial Virus. (2010, March 15) Retrieved from

http://www.niaid.nih.gov/topics/rsv/research/pages/researchrole.aspx

Toon, John. (2013, December 30). Imaging Technology Could Unlock Mysteries of a Childhood Disease.

Retrieved form

http://www.news.gatech.edu/2013/12/29/imaging-technology-could-unlock-mysteries-childhood-disease

Tortora, G., Case, C., & Case, C. (2010). Microbiology: An introduction. (10th ed., p. 692). San Francisco:

Pearson Education Inc

PICTURE CITED

Respiratory syncytial virus RSV. Retrieved fromhttp

://www.bode-science-center.com/center/relevant-pathogens-from-a-z/respiratory

-syncytial-virus.html

Sucher, Peggy. Hand Washing – The #1 Deterrent to the Spread of

Contaminants. (2011, November 7) Retrieved form http

://tattooroadtrip.com/wp-content/uploads/2011/10/Handwashing-3.jpg

Respiratory Syncytial Virus. Retrieved from http

://www.corisbio.com/Products/Human-Field/RSV.php

Rsv protection. (2013). Retrieved from

https://www.rsvprotection.com/index.html

Respiratory syncytial virus. (2014, April 01). Retrieved from

http://www.cdc.gov/rsv/

Toon, John. (2013, December 30). Imaging Technology Could Unlock

Mysteries of a Childhood Disease. Retrieved formhttp

://www.news.gatech.edu/2013/12/29/imaging-technology-could-unlock-mysterie

s-childhood-disease

REVIEW QUESTIONS

1. Which state/region has the longest duration of RSV season?A. FloridaB. Region 7C. Region 3

2. By what age have most children has RSV?A. 6 monthsB. 1C. 2

3. How long are you contagious after contracting the virusA. 1-2 daysB. 1-3 weeksC. 1 month