Role of Research in the Field of UTI -Past, Present and Future- (from my Personal History)

Role of Research in the Field of UTI-Past, Present and Future-

(from my Personal History)

Joichi Kumazawa

1: Postgraduate School (1960-1964)

2: Dept. of Urology, Kyushu University (The first term) (1964-1969)

3: Harvard Medical School (1969-1970)

4: Dept. of Urology, Kyushu University (The second term) (1970- 1979)

5: Dept. of Urology, Saga Medical College (1979-1984)

6: Dept. of Urology, Kyushu University (The third term) (1984-1998)

7: After the retirement from Kyushu University (1998-present)

My history

1: Postgraduate school (1960-1964) (Dept. of Bacteriology and Dept. of Urology)

# Chronological change of urinary isolates Method of urine collection Quantitative culture of urine: Surface spreading method Antimicrobial susceptibility test of urinary isolates

# Pathogenesis of urinary isolates: Immunological research (Serum antibody detection by hemagglutination in UTI patients)

# Annual meeting of JUA: First symposium on UTIs (Tokyo, 1962)

# UTIs in children

非特異性尿路感染症に関する研究第 1報　尿路分離菌の年次的変遷について

大学院生　熊澤淨一九州大学医学部泌尿器科教室（主任　富川梁次教授）

Studies of non-Specific Urinary Tract Infection.I. Chronological changes of Bacteria Isolated in Urinary

Tract Infection.

Zyoichi KUMAZAWA M.DDepartment of Urology (Director: Prof. Dr. R. Tomikawa), Faculty of Medicine,

Kyushu University, Fukuoka, Japan

福岡医学雑誌第 54巻第 10号（昭和 38年 11月 25日）FUKUOKA ACTA MEDICA, 54(10):1072-1083,1962

Number of bacteriain first-catch urine (VB1), mid-stream urine (VB2)

and urine by catheter-collection

Number of bacteria in urine in patients with or without UTI

1: Postgraduate school (1960-1964) Dept. of Bacteriology and Dept. of Urology



# Annual meeting of JUA: First symposium on UTIs [Tokyo, 1962]

# UTIs in children

非特異性尿路感染症に関する研究第 2報　尿路分離菌の病原性に関する免疫学的研究

大学院生　熊澤淨一九州大学医学部泌尿器科教室（主任　富川梁次教授）

Studies of non-Specific Urinary Tract Infection.I. Immunological Determination on Pathogenicity of Bacter

ia Isolated in Urinary Tract Infection.

Zyoichi KUMAZAWA M.DDepartment of Urology (Director: Prof. Dr. R. Tomikawa), Faculty of Medicine,

Kyushu University, Fukuoka, Japan

福岡医学雑誌第 54巻第 10号（昭和 38年 11月 25日）FUKUOKA ACTA MEDICA, 54(10):1084-1103,1963

Antibody titers in 22 patients with >105/ml of bacteriuria during >7 days

Bacterial species

Escherichia coliPseudomonas aeruginosaProteus sppStaphylococcus sppKlebsiella sppEnterobacter aerogenesTotal

Antibody titer>160 <160 5 1 4 2 1 1 2 2 1 317 (77.3%) 5 (22.7%)

1: Postgraduate school (1960-1964) Dept. of Bacteriology and Dept. of Urology



# Annual meeting of JUA: First symposium on UTIs [Tokyo, 1962]

# UTIs in children

小児泌尿器疾患の統計的観察S. Sakamoto, J. Kumazawa and M. Ishizu

Statistical Observation of Urogenital Diseases in Children

九州大学医学部泌尿器科教室（主任　富川梁次教授）坂本公孝熊澤淨一石津又三

皮膚と泌尿（昭和 39年 2月発行）

HIFU to HINYO 26(1):43-48,1964

UTIs in pediatric outpatients

Basic diseasesUncomplicated UTIs (Hemorrhagic cystitis)Inflammation of genital regionUrinary StoneCongenital urinary obstructionNeurogenic bladderUrinary tumorNephritis or nephrosisOthersTotal

Number143 (53)292124179

25538806

Infection67

(52)5

14139626

122

Incidence (%)46.9

(98.1)17.266.654.253.066.68.01.1

15.1


# Experimental pyelonephritis

# VUR in children

# Publish: 「尿路感染症の臨床： Clinical aspect of UTIs」 (1965)

# Chronological changes in urinary isolates

# Detection of fallen bacteria in the hospital: Pseudomonas aeruginosa

実験的腎盂腎炎に対する Enduracidinの効果Effect of Enduracidin on Experimental Pyelonephritis

S. Momose, J. Kumazawa, S. Narahashi, S. HidakaCHEMOTHERAPY 16(4):466-469,1968

百瀬俊郎熊澤淨一楢橋勝利日高正昭

九州大学医学部泌尿器科

Experimental method



# VUR in children

# 「尿路感染症の臨床： Clinical aspect of UTIs」 published (1965)

# Chronological changes in urinary isolates

# Detection of fallen bacteria in the hospital: Pseudomonas aeruginosa

いわゆる萎縮腎型腎盂腎炎に関する２，３の考察Some Aspects on So-called Atrophic Pyelonephritis

K. Sakamoto, J. Kumazawa, K. NarahashiFrom Department of Urology, Faculty of Medicine, Kyushu University (Direct

or: Prof. Dr. S. Momose)

泌尿器科紀要　第 12巻第 1号Acta Urologica Japonica 12(1):71-77,1966

VUR in patients with chronic UTIs

Generation

ChildrenAdults

Total

Number

822

30

VUR

55

10

Incidence (%)

62.522.7

33.3

Clinical aspect of UTIspublished in 1965

3: Harvard Medical School (1969-1970)


# Quantitative culture of bacteria in urine (Dip Slide Method)

基疾患を伴う実験的腎盂腎炎に対する化学療法の効果The effect of Chemotherapy for the Experimental Pyelone

phritis with Some Underlying Course

J. KumazawaDepartment of Urology(Director: Prof. S. Momose), Faculty of Medicine, Kyus

hu University, Fukuoka, JapanChanning Laboratory (Director: Prof. Edward H. Kass), Department of Medic

ine, Harvard Medical School, Boston. Mass., USA

熊澤淨一九州大学医学部泌尿器科（主任：百瀬俊郎）

西日本泌尿器科　第 33巻第 2号Nishinihon J. Urol. 33(2):183-189,1971

簡易尿中細菌定量培養法Evaluation of Simplified Quantitative Culture Methods of

Urinary Bacteria

J. Kumazawa, S. Nakamuta, H. Ito, S. HiedaDepartment of Urology(Director: Prof. S. Momose), Faculty of Medicine, Kyus

hu University, Fukuoka, Japan

熊澤淨一、中牟田誠一、伊藤秀明、稗田定九州大学医学部泌尿器科（主任：百瀬俊郎）


4: Dept. of Urology, Kyushu University (The second term) (1970

-1979)

# Anaerobic bacteria

# Clinical evaluation of drug efficacy in UTIs Kyushu University Criteria (1970) Japanese Criteria (1976) (Establishment of Japanese Research Association on UTIs)

# UTIs in children: VUR

# Nosocomial infection Pseudomonas aeruginosa Closed drainage system

# Chronological change of urinary isolates

Significance of Anaerobic Bacteria Isolated from the Urinary Tract

I. Clinical studies

J. Kumazawa, H. Kiyohara, K. Narahashi, M. Hidaka, S. MomoseFrom the Department of Urology(Director: Prof. S. Momose), Faculty of Medic

ine, Kyushu University, Fukuoka, Japan

J. Urol 112:257-260,1974

Significance of Anaerobic Bacteria Isolated from the Urinary Tract

II. Experimental studies

J. Kumazawa, H. Kiyohara, S. MomoseFrom the Department of Urology(Director: Prof. S. Momose), Faculty of Medic

ine, Kyushu University, Fukuoka, Japan

Invest. Urol. 13:309-312,1975


-1979)






Clinical Effectiveness of Piromidic Acid (PA) on Acute Nonspecific Cystitis.

Evaluation with Double Blind Method

J. Kumazawa, S. Momose et alDepartment of Urology(Director: Prof. S. Momose), Faculty of Medicine, Kyus


Chemotherapy 19(5):657-664,1971

A Double Blind Controlled Study to Compare CS-1170 (Cefmetazole) and Cefazolin in the Treatment of Chronic

Complicated Urinary Tract Infections

S. Momose, J. Kumazawa, et alDepartment of Urology(Director: Prof. S. Momose), Faculty of Medicine, Kyus


Nishinihon J. Urol. 41(1):173-200,1979

UTI薬効評価基準Criteria for Evaluation of Clinical Efficacy of Antimicrobia

l Agents on Urinary Tract Infection（第 4版暫定案）

1996年 12月 5日


-1979)






小児尿路感染症 -現況と治療の問題点 -Urinary Tract Infection in Childhood

J. KumazawaDepartment of Urology(Director: Prof. S. Momose), Faculty of Medicine, Kyus


熊澤淨一九州大学医学部泌尿器科（主任：百瀬俊郎）


VUR and Pyelonephritis

J. KumazawaAssociate Professor, Department of Urology, Faculty of Medicine, Kyushu Uni

versity, Fukuoka, Japan

Proceedings of The First Asian Pacific Congress of Nephrologyp 94-97, 1979


-1979)






泌尿器科的手技と病院感染ー緑膿菌感染を中心にー

Pseudomonas aeruginosa: Hospital Infection in Urological Field

J. Kumazawa, S. Nakamuta, H. Ito, S. MomoseDepartment of Urology, Faculty of Medicine, Kyushu University, Fukuoka, Ja

pan

熊澤淨一 ,中牟田誠一、伊藤秀明、百瀬俊郎九州大学医学部泌尿器科

最新医学　第 30巻第 3号Saishin Igaku 30(3):402-407,1975

Closed drainage system（閉鎖式持続導尿装置）の使用経験

A Clinical Application of Closed Urinary Drainage System

J. Kumazawa, S Nakamuta, S. MomoseDepartment of Urology(Director: Prof. S. Momose), Faculty of Medicine, Kyus


熊澤淨一 ,中牟田誠一、百瀬俊郎九州大学医学部泌尿器科（主任：百瀬俊郎）


5: Dept. of Urology, Saga Medical College (1979-1984)

# Development of New Antimicrobial agents: A Person in Charge of Clinical trials Fluoroquinolones, Cephems, Aminoglycosides etc

# Enterococcus spp

# Establishment of STD Research Group in Fukuoka and Saga (1984)


# UTI Research Group in the Dept. of Urology, Kyushu University Leader; Dr Tetsuro Matsumoto Sub-leader; Dr Masatoshi Tanaka

Molecular biological approach in the basic and clinical research on UTIs Bacterial pili, Adherence, Superoxide, Renal scarring (VUR)

# UTIs in the elderly

# STDs

# Infection control

Increases renal scarring by bacteria with mannose-sensitive pili

T. Matsumoto, Y. Mizunoe, N. Sakamoto, M. Tanaka, J. KumazawaDepartment of Urology, Faculty of Medeicine, Kyushu University

Urol. Res. 18:299-303,1990

Role of superoxide in renal scarring following infection by mannose-sensitve piliated bacteria

T. Matsumoto, Y. Mizunoe, N. Ogata, M. Tanaka, J. KumazawaDepartment of Urology, Faculty of Medicine, Kyushu University

Urol. Res. 19:229-233,1991

分子生物学的アプローチによる尿路感染症の解析Molecular Biological Approach in the Research of UTIs

九州大学医学部泌尿器科熊澤淨一

Joichi KumazawaDepartment of Urology, Faculty of Medicine, Kyushu University

日本泌尿器科学会雑誌第 85巻第 1号Jap. J. Urol. 85(1):14-18,1994


# UTI Research Group in the Dept. of Urology, Kyushu University Leader; Tetsuro Matsumoto Sub-leader; Masatoshi Tanaka



# STDs

# Infection control

Urinary Tract Infection in Geriatric Patients

T. Matsumoto, J. KumazawaDepartment of Urology, School of Medicine, University of Occupational and Environ

mental HealthDepartment of Urology, Faculty of Medicine, Kyushu University

Int. J. Antimicrob. Agents 11:269-273,1999





# STDs

# Infection control

Emergence of In Vitro Resistance to Fluoroquinolones in Neisseria gonorrhoeae Isolated in Japan

M. Tanaka, T. Matsumoto, I. Kobayashi, U.Uchino, J. KumazawaDepartment of Urology, Faculty of Medicine, Kyushu University

Antimicrob. Agents Chemother. 39:2367-2370,1995

Development of Fluoroquinolone Resistance and Mutations involving GyrA and ParC proteins among Neisseria gonorrhoeae

isolated in Japan

M. Tanaka, K. Takahashi, T. Saika, I. Kobayashi, T.Ueno, J. KumazawaDepartment of Urology, Faculty of Medicine, Kyushu University

J. Urol. 159:2215-2219,1998





# STDs

# Infection control

院内感染防止対策指針Guidelines for the Prevention of Nosocomial Infections

九州大学医学部附属病院院内感染予防対策委員会Infection Control Committee, Kyushu University Hospital

6: Dept. of Urology, Kyushu University (The third term)(1984-1998)

# Establish: Japanese Society for STDs (1988)

# Establish: International UTI symposium (1989)

# Establish: Japanese Research Group for UTIs (1990)

# Congress and Meeting(UTI) 1st Asian Urological Congress (1990) 7th Korea-Japan Urological Congress (1990) 7th Annual meeting of Japanese Society of Environmental Infection 5th Annual meeting of Japanese Society for STDs 82nd Annual meeting of Japanese Urological Association 42nd Annual meeting of Japanese Society of Chemotherapy

# Officer of Society; President of Japanese Society of Chemotherapy (1997-2002)

# Books (UTIs) New Urology (Nanzando) (1986) Mook Urology-Urogenital Tract Infection (Kanahara Shuppan) (1992) Urogenital Tract Infections Q & A (Iyaku Journal) (1995)

Japanese Research Association on UTIs

6: Dept. of Urology, Kyushu University (The third term)(1984-1998)

# Establish: Japanese Society for STDs (1988)

# Establish: International UTI symposium (1989)

# Establish: Japanese Research Group for UTIs (1990)

# Congress and Meeting(UTI) 1st Asian Urological Congress (1990) 7th Korea-Japan Urological Congress (1990) 7th Annual meeting of Japanese Society of Environmental Infection 5th Annual meeting of Japanese Society for STDs 82nd Annual meeting of Japanese Urological Association 42nd Annual meeting of Japanese Society of Chemotherapy

# Officer of Society; President of Japanese Society of Chemotherapy (1997-2002)

# Books (UTIs) New Urology (Nanzando) (1986) Mook Urology-Urogenital Tract Infection (Kanahara Shuppan) (1992) Urogenital Tract Infections Q & A (Iyaku Journal) (1995)

7: After the retirement from Kyushu University (1998-present)

# Congress 10th Western Pacific Congress of Chemotherapy and Infectious Diseases

(2006)

# Officers of Society President; Western Pacific Society of Chemotherapy (2000-2004) Vice President; International Society of Chemotherapy (2001-2005)

# Books (UTIs) Nosocomial and Health Care-Associated Infections in Urology (WHO) (2000) STD (Nanzando) (2004)

Future perspective and Dream

# International epidemiological research Diseases Pathogens and antimicrobial susceptibility

# International network for the prevention of infectious diseases

# Development and popularization of rapid and accurate method for the diagnosis

# Development of novel antimicrobial agents which has newer antimicrobial mechanisms

Acknowledgement

Dr Edward H. KassDr Maxwell FinlandDr Kenji Takeya

Dr Tetsuro MatsumotoDr Yong-Hyun Cho

EXTRA

# Fukuoka Medical NGO

# Fukuoka Research Group for Forensic Medicine

# Kitakyushu research group for excretion care system

Role of Research in the Field of UTI -Past, Present and Future- (from my Personal History)

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