RNA transcription
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Transcript of RNA transcription
INTRODUCTIONRNA transcription is the way, a RNA strand is synthetised from a DNA strand
RNA polymerase II and III are the main enzymes in
the process
Cell aging slowed by putting brakes on noisy transciptionPerelman Medicine School at
the University of Pennsylvania(30 July 2015)
Cell aging slowed by putting brakes on noisy transciption
Chemical modification on chromatin, affects the transcription of RNA and as well, its traduction into
proteins.
Cell aging slowed by putting brakes on noisy transciption
Aging is measured by the number of times a mother cell divides to form daughters before it stops
A type of abnormal transcription dramatically
increases in aged cells
Cell aging slowed by putting brakes on noisy transciption
Reduction of this abnormal transcription can lead into the increase of lifespan about 30%
This kind of studies are incredibly important at the moment, because we can
not only increase our lifespan but also taking new steps into genetic therapy, stoping the division cicle and so,
developing new treatments for terminal diseases.
Glimmer of hope for patients with leukodystrophies
LEUKO
DYSTROPHY
DEGENERATION OF THE WHITE MATTER IN THE BRAIN.
Caused by imperfection in the growing or formation of the mielin.
Glimmer of hope for patients with leukodystrophies
POLR1C gen mutation as a new way of developing
H4 leukodystrophy.
Problem in the assembly and cellular localization of RNA
polymerase III
Glimmer of hope for patients with leukodystrophies
"The cells' lack of ability to produce RNA polymerase III compromises the genetic program controlled by this
enzyme, thereby inducing a particularly harmful effect in specialized nerve cells."
Like the autors said, this research serve as a way of knowing how is the right way to treat therapeuticaly a patient with this leukodystrophy, to make new diagnosis and as well to ‘‘light on the molecular mechanism’’ of this one.
Medical Utility
Both of the researches explain that, if an error ocurs in the RNA transcription, being from the
enzymes or the process itself
Medical Utility
Special treatment for patients with POLR1C
mutation.
Desing of new drugs and diagnosis with genes mutations
Medical Utility
Gene Therapy??
Correction of POLR1C mutation and abnormals chemical reactions
of chromatin.
Bibliography• · Perelman School of Medicine at the University of
Pennsylvania. "Cell aging slowed by putting brakes on noisy transcription." ScienceDaily, Retrieved 30 July 2015 from www.sciencedaily.com/releases/2015/07/150730172605.htm
• · McGill University Health Centre. "Glimmer of hope for patients with leukodystrophies: A new crucial gene associated with these orphan diseases discovered." ScienceDaily. Retrieved 8 July 2015 from www.sciencedaily.com/releases/2015/07/150708123321.htm
• TORO GÓMEZ, Jaime; YEPES SANZ, Manuel; PALACIOS SÁNCHEZ, Eduardo. Neurología. 2°edición. Editorial Manual moderno, 2010. 385p.