Rigour Mortis How bad research is killing science
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mily Sena, Gillian Currie, Hanna Vesterinen, Kieren Egan, Nicki Sherratt, Cristina onseca, Zsannet Bahor, Jing Liao, Theo Hirst, Kim Wever, Hugo Pedder, Katerina yriacopoulou, Julija Baginskaite, Ye Ru, Stelios Serghiou, Aaron McLean, Catherine ick, Tracey Woodruff, Patrice Sutton, Andrew Thomson, Aparna Polturu, Sarah MaCann, illian Mead, Joanna Wardlaw, Rustam Salman, Joseph Frantzias, Robin Grant, Paul rennan, Ian Whittle, Andrew Rice, Rosie Moreland, Nathalie Percie du Sert, Paul arner, Lauralyn McIntyre, Gregers Wegener, Lindsay Thomson, David Howells, Ana ntonic, Tori O’Collins, Uli Dirnagl, H Bart van der Worp, Philip Bath, Mharie McRae, tuart Allan, Ian Marshall, Xenios Mildonis, Konstantinos Tsilidis, Orestis Panagiotou, ohn Ioannidis, Peter Batchelor, David Howells, Sanne Jansen of Lorkeers, Geoff Donnan, eter Sandercock, Emily Sena, Gillian Currie, Hanna Vesterinen, Kieren Egan, Nicki herratt, Cristina Fonseca, Zsannet Bahor, Jing Liao, Theo Hirst, Kim Wever, Hugo edder, Katerina Kyriacopoulou, Julija Baginskaite, Ye Ru, Stelios Serghiou, Aaron cLean, Catherine Dick, Tracey Woodruff, Patrice Sutton, Andrew Thomson, Aparna olturu, Sarah MaCann, Gillian Mead, Joanna Wardlaw, Rustam Salman, Joseph Frantzias, obin Grant, Paul Brennan, Ian Whittle, Andrew Rice, Rosie Moreland, Nathalie Percie du ert, Paul Garner, Lauralyn McIntyre, Gregers Wegener, Lindsay Thomson, David Howells, na Antonic, Tori O’Collins, Uli Dirnagl, H Bart van der Worp, Philip Bath, Mharie cRae, Stuart Allan, Ian Marshall, Xenios Mildonis, Konstantinos Tsilidis, Orestis anagiotou, John Ioannidis, Peter Batchelor, David Howells, Sanne Jansen of Lorkeers, eoff Donnan, Peter Sandercock, Emily Sena, Gillian Currie, Hanna Vesterinen, Kieren gan, Nicki Sherratt, Cristina Fonseca, Zsannet Bahor, Jing Liao, Theo Hirst, Kim ever, Hugo Pedder, Katerina Kyriacopoulou, Julija Baginskaite, Ye Ru, Stelios erghiou, Aaron McLean, Catherine Dick, Tracey Woodruff, Patrice Sutton, Andrew homson, Aparna Polturu, Sarah MaCann, Gillian Mead, Joanna Wardlaw, Rustam Salman, oseph Frantzias, Robin Grant, Paul Brennan, Ian Whittle, Andrew Rice, Rosie Moreland, athalie Percie du Sert, Paul Garner, Lauralyn McIntyre, Gregers Wegener, Lindsay homson, David Howells, Ana Antonic, Tori O’Collins, Uli Dirnagl, H Bart van der Worp, hilip Bath, Mharie McRae, Stuart Allan, Ian Marshall, Xenios Mildonis, Konstantinos silidis, Orestis Panagiotou, John Ioannidis, Peter Batchelor, David Howells, Sanne ansen of Lorkeers, Geoff Donnan, Peter Sandercock, Emily Sena, Gillian Currie, Hanna esterinen, Kieren Egan, Nicki Sherratt, Cristina Fonseca, Zsannet Bahor, Jing Liao, heo Hirst, Kim Wever, Hugo Pedder, Katerina Kyriacopoulou, Julija Baginskaite, Ye Ru, CAMARADES: Bringing evidence to translational medicine Rigour Mortis How bad research is killing science Malcolm Macleod Professor of Neurology and Translational Neurosciences University of Edinburgh and Honorary Consultant Neurologist, NHS Forth Valley Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies
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Rigour Mortis How bad research is killing science. Malcolm Macleod Professor of Neurology and Translational Neurosciences University of Edinburgh and Honorary Consultant Neurologist, NHS Forth Valley Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies. - PowerPoint PPT Presentation
Transcript of Rigour Mortis How bad research is killing science
Emily Sena, Gillian Currie, Hanna Vesterinen, Kieren Egan, Nicki Sherratt, Cristina Fonseca, Zsannet Bahor, Jing Liao, Theo Hirst, Kim Wever, Hugo Pedder, Katerina Kyriacopoulou, Julija Baginskaite, Ye Ru, Stelios Serghiou, Aaron McLean, Catherine Dick, Tracey Woodruff, Patrice Sutton, Andrew Thomson, Aparna Polturu, Sarah MaCann, Gillian Mead, Joanna Wardlaw, Rustam Salman, Joseph Frantzias, Robin Grant, Paul Brennan, Ian Whittle, Andrew Rice, Rosie Moreland, Nathalie Percie du Sert, Paul Garner, Lauralyn McIntyre, Gregers Wegener, Lindsay Thomson, David Howells, Ana Antonic, Tori O’Collins, Uli Dirnagl, H Bart van der Worp, Philip Bath, Mharie McRae, Stuart Allan, Ian Marshall, Xenios Mildonis, Konstantinos Tsilidis, Orestis Panagiotou, John Ioannidis, Peter Batchelor, David Howells, Sanne Jansen of Lorkeers, Geoff Donnan, Peter Sandercock, Emily Sena, Gillian Currie, Hanna Vesterinen, Kieren Egan, Nicki Sherratt, Cristina Fonseca, Zsannet Bahor, Jing Liao, Theo Hirst, Kim Wever, Hugo Pedder, Katerina Kyriacopoulou, Julija Baginskaite, Ye Ru, Stelios Serghiou, Aaron McLean, Catherine Dick, Tracey Woodruff, Patrice Sutton, Andrew Thomson, Aparna Polturu, Sarah MaCann, Gillian Mead, Joanna Wardlaw, Rustam Salman, Joseph Frantzias, Robin Grant, Paul Brennan, Ian Whittle, Andrew Rice, Rosie Moreland, Nathalie Percie du Sert, Paul Garner, Lauralyn McIntyre, Gregers Wegener, Lindsay Thomson, David Howells, Ana Antonic, Tori O’Collins, Uli Dirnagl, H Bart van der Worp, Philip Bath, Mharie McRae, Stuart Allan, Ian Marshall, Xenios Mildonis, Konstantinos Tsilidis, Orestis Panagiotou, John Ioannidis, Peter Batchelor, David Howells, Sanne Jansen of Lorkeers, Geoff Donnan, Peter Sandercock, Emily Sena, Gillian Currie, Hanna Vesterinen, Kieren Egan, Nicki Sherratt, Cristina Fonseca, Zsannet Bahor, Jing Liao, Theo Hirst, Kim Wever, Hugo Pedder, Katerina Kyriacopoulou, Julija Baginskaite, Ye Ru, Stelios Serghiou, Aaron McLean, Catherine Dick, Tracey Woodruff, Patrice Sutton, Andrew Thomson, Aparna Polturu, Sarah MaCann, Gillian Mead, Joanna Wardlaw, Rustam Salman, Joseph Frantzias, Robin Grant, Paul Brennan, Ian Whittle, Andrew Rice, Rosie Moreland, Nathalie Percie du Sert, Paul Garner, Lauralyn McIntyre, Gregers Wegener, Lindsay Thomson, David Howells, Ana Antonic, Tori O’Collins, Uli Dirnagl, H Bart van der Worp, Philip Bath, Mharie McRae, Stuart Allan, Ian Marshall, Xenios Mildonis, Konstantinos Tsilidis, Orestis Panagiotou, John Ioannidis, Peter Batchelor, David Howells, Sanne Jansen of Lorkeers, Geoff Donnan, Peter Sandercock, Emily Sena, Gillian Currie, Hanna Vesterinen, Kieren Egan, Nicki Sherratt, Cristina Fonseca, Zsannet Bahor, Jing Liao, Theo Hirst, Kim Wever, Hugo Pedder, Katerina Kyriacopoulou, Julija Baginskaite, Ye Ru, Stelios Serghiou, Aaron McLean, Catherine Dick, Tracey Woodruff, Patrice Sutton, Andrew Thomson, Aparna Polturu, Sarah MaCann, Gillian Mead, Joanna Wardlaw, Rustam Salman, Joseph Frantzias, Robin Grant, Paul Brennan, Ian Whittle, Andrew Rice, Rosie Moreland, Nathalie Percie du Sert, Paul Garner, Lauralyn McIntyre, Gregers Wegener, Lindsay Thomson, David Howells, Ana Antonic, Tori O’Collins, Uli Dirnagl, H Bart van der Worp, Philip Bath, Mharie McRae, Stuart Allan, Ian Marshall, Xenios Mildonis, Konstantinos Tsilidis, Orestis Panagiotou, John Ioannidis, Peter Batchelor, David Howells, Sanne Jansen of Lorkeers, Geoff Donnan, Peter Sandercock, Emily Sena, Gillian Currie, Hanna Vesterinen, Kieren Egan, Nicki Sherratt, Cristina Fonseca, Zsannet Bahor, Jing Liao, Theo Hirst, Kim Wever, Hugo Pedder, Katerina Kyriacopoulou, Julija Baginskaite, Ye Ru, Stelios Serghiou, Aaron McLean, Catherine Dick, Tracey Woodruff, Patrice Sutton, Andrew Thomson, Aparna Polturu, Sarah MaCann, Gillian Mead, Joanna Wardlaw, Rustam Salman, Joseph Frantzias, Robin Grant, Paul Brennan, Ian Whittle, Andrew Rice, Rosie Moreland, Nathalie Percie du Sert, Paul Garner, Lauralyn McIntyre, Gregers Wegener, Lindsay Thomson, David Howells, Ana Antonic, Tori O’Collins, Uli Dirnagl, H Bart van der Worp, Philip Bath, Mharie McRae, Stuart Allan, Ian Marshall, Xenios Mildonis, Konstantinos Tsilidis, Orestis Panagiotou, John Ioannidis, Peter Batchelor, David Howells, Sanne Jansen of Lorkeers, Geoff Donnan, Peter Sandercock,
CAMARADES: Bringing evidence to translational medicine
Rigour MortisHow bad research is killing science
Malcolm MacleodProfessor of Neurology and Translational Neurosciences
University of Edinburghand
Honorary Consultant Neurologist, NHS Forth Valley
Collaborative Approach to Meta-Analysis and Review of Animal Data from Experimental Studies
CAMARADES: Bringing evidence to translational medicine
Purposes of an inaugural lecture
• To try to explain to family and friends what it is that you actually do
• To try to convince colleagues that what you do is actually useful
• To try to encourage the next generation of researchers and teachers to improve on what you do
CAMARADES: Bringing evidence to translational medicine
I am not in the office at the
moment. Send any work to be translated.
What is translational neuroscience?
My Definition: using information from one research domain to guide research in a different research domain
CAMARADES: Bringing evidence to translational medicine
Winner of the 2012 Ignoble Prize for Neuroscience
CAMARADES: Bringing evidence to translational medicine
What is a stroke?
• Interruption of the blood supply to part of the brain• Stops that bit of the brain from working• The consequences depend on which part of the brain is
affected• In a warning stroke the blockage is temporary• If the blockage is permanent that part of the brain dies• When this happens, other bits of brain can sometimes
learn to take over some of the functions which have been lost
CAMARADES: Bringing evidence to translational medicine
A couple of important things about the brain …
CAMARADES: Bringing evidence to translational medicine
CAMARADES: Bringing evidence to translational medicine
The burden of stroke
• 5.5m people die worldwide each year – one every 6 seconds
• ~150,000 per year in the UK
• 40% of patients die
• 30% become disabled as a result of their stroke
CAMARADES: Bringing evidence to translational medicine
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Developing treatments for stroke
Developed in in vitro and in vivo experimentsO’Collins et al, 2006
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Tested in focal ischaemiaO’Collins et al, 2006
Developing treatments for stroke
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Effective in focal ischaemiaO’Collins et al, 2006
Developing treatments for stroke
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Tested in clinical trialO’Collins et al, 2006
Developing treatments for stroke
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Effective in clinical trialO’Collins et al, 2006
Developing treatments for stroke
CAMARADES: Bringing evidence to translational medicine
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