Richard P. Hugtenburg - NPLresource.npl.co.uk/docs/science_technology/ionising... · Fathy Saeedi,...
Transcript of Richard P. Hugtenburg - NPLresource.npl.co.uk/docs/science_technology/ionising... · Fathy Saeedi,...
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Dose and microdosimetry in sub-cellular volumes associated with the uptake of
high-Z materials
Richard P. Hugtenburg1,2
1. School of Physics and Astronomy, University of Birmingham, U.K2. Queen Elizabeth Medical Centre, University Hospital Birmingham, U.K.
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Synchrotron binary therapy at ESRF with cisplatin (Pt) better than BNCT for F98 Glioma cells in Fischer rats
Biston et al., 2004, Cancer Research 64 2317–2323
Cisplatin + radiotherapy
Controls
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Biston et al., 2004, show that irradiation with monoenergetic synchrotron X-rays less than 500 eV above and below K-edge
of Pt are indistinguishable
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Dosimeter intercomparisons on Station 16.5 – SRS
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Measurement of variation of dose-rate on Wiggler 16 at the SRS (Daresbury, UK)
2.0E-05
2.2E-05
2.4E-05
2.6E-05
2.8E-05
3.0E-05
24.0 24.5 25.0 25.5 26.0 26.5 27.0
Energy (keV)
Res
pons
eG
y/m
A/S
ec0.0E+00
5.0E-05
1.0E-04
1.5E-04
2.0E-04
2.5E-04
3.0E-04
5 10 15 20 25Energy (keV)
Rela
tive
Resp
onse
Gy/
mA
/Sec
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Models of the response agree with expt to within 5% over a wide range of energies (5 keV – 5 MeV)
0.0
0.2
0.4
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0.8
1.0
0 5 10 15 20 25Energy (keV)
Rat
io o
f Dos
e D
iam
ond:
Ion
cham
ber
0.0
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0.6
0.8
1.0
5 55 105 155 205
Enrgy (kev )
Rat
io o
f Dos
e di
amon
d/ch
ambe
r
ratio C/Wratio diam/WExp. ratioYin No. !7
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Experimental set-up and Monte Carlo models
DETECTOR(DIAMOND)
PHANTOM(rw-1)
2 cmPOLYTHENE
0.03 cmDIAMOND
0.15 cmPOLYTHENE
DIAMONDDETECTOR
DETECTOR(WATER)
PHANTOM(WATER)
IONISATIONCHAMBER
1×10 mm
Synchrotron beam
Parallel Plate Chamber
1×10 mm
Synchrotron beam
Diamond Detector Impeded in RW-1
1×10 mm
Synchrotron beam
Diamond Detector Impeded in RW-1
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Silver FLUORESCENT
0
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-400 -200 0 200 400 600 800 1000
Gold FLUORESCENT
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More detailed Monte Carlo models incorporating data obtained from µXRF
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EGS4/LSCAT v. absorption models for Ag
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Hainfeld et al., 2004Au nanoparticles for enhanced 250 kVp RT,PMB, 49: N309, 2004
Adam et al, 2003, Synchrotron RT of I and Gd loaded glioma, IntJ RadiatOncBiolPhys 57: 1413
Dose enhancement through high-Z targeted RT
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Maximum enhancement occurs beyond K-edge
Energy used by Adam et al.
Biston et al., 2004, Irradiation above or below K-edge radiobiologically indistinguishable, Cancer Res., 64: 2317
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EGS4/LSCAT versus absorption models for Pt
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Dose enhancement for localised 10 mg/ml concentrations of Pt relative to that of a water-filled volume
Region size @ 10 mg/ml 78.0 keV 78.8 keV 90 keV
0.2 micron 1.02 1.20 1.16
2 micron 1.10 1.33 1.38
20 micron 1.26 1.53 1.51
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Determination of energy deposition within small volumes – Going beyond dose and LET
• Tissue equivalent proportional counter (TEPC)• Lineal energy calculations via PENELOPE
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Schematic and photograph of a single wire TEPC microdosimeter
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0.00
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Lineal energy (keV/µm)
y.d(y
) (a
rb.u
nits)
Photons
ProtonsHeavy ions
f
Microdosimetry measurements of mixed photon neutron field using TEPC
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Variation in mean lineal energy with photons energy
f
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Photon energy (keV)
Mea
n lin
eal e
nerg
y
y_D 1000nmy_T 1000nmy_D 200nmy_T 200 nm
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Transformation rate of CGL-1 for a 29 kVp Mo X-ray mammography set relative to Sr-90 beta electrons and A-bomb like linear accelerator irradiations
Heyes and Mill, 2004, Radiat. Res. 162: 120-7
29 kVp Mo X-rays
Sr 90
A-bomb
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Lineal energy spectra for 29 kVp Mo X-rays relative to Sr-90 beta-electrons
-0.10
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0.01 0.1 1 10 100
y, lineal energy (keV / µm)
y. d
(y),
dose
wie
ghte
d fr
eq.
29 kVp Mo X-raysSr-90 beta-rays
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Lineal energy spectra for 15 keV photons in a 2 micron site
f
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0.1 1.0 10.0 100.0y, lineal energy (keV / µm)
y. d
(y),
dose
wie
ghte
d fr
eq.
15 keV, water15 keV, TEP15 keV TEPC meas.
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Lineal energy spectra for 33 keV for a 2 micron cell
f
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0.1 1.0 10.0 100.0y, lineal energy (keV / µm)
y. d
(y),
dose
wie
ghte
d fr
eq.
33 keV, water33 keV, plastic33 keV TEPC meas.
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Lineal energy in water and aq. Gd inside a 1 micron cell
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Lineal energy spectra from Gd particle outside a 1 micron site
f
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f
Lineal energy spectra for Pt enhanced medical radiation (1 micron site)
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y, lineal energy (keV / µm)
y. d
(y),
dose
wie
ghte
d fr
eq.
78.0 keV in aq Pt78.8 keV in aq. Pt78.8 keV in water90 keV in aq. Pt
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Lineal energy spectra from U particle enhancing natural background radiation (1 micron site)
f
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y. d
(y),
dose
wie
ghte
d fr
eq.
NBG in H2ONBG near U
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Acknowledgements and Participants:
University of Birmingham:Fathy Saeedi, Adam Baker, Mohammed Ariff
Queen Elizabeth Medical Centre:Stuart Green, Alun Beddoe, Bleddyn Jones
University of South Australia:John Pattison
University of Setif, Algeria:Zine-El-Abidine Chaoui