RGD--A Repository and Cumulative Resource for Rat Strains
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RGD: A REPOSITORY AND CUMULATIVE RESOURCE FOR RAT STRAINS Rajni Nigam , Mary Shimoyama, Simon Twigger, Diane Munzenmaier, Mindy Dwinell, Howard Jacob; the RGD Team Rat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, United States of America RGD (http://rgd.mcw.edu/ ) strives to collect strain information from recent research publications, direct submissions from individual researchers, and rat providers worldwide. Users can search strains in RGD by using the keyword search or advanced strain searches. RGD houses data for more than 1600 rat strains that include different strain types as substrains, recombinant inbred strains, congenic, consomic, transgenic, and mutant strains. Strain pages have a comprehensive description of characteristics, origin, disease, phenotype and physiological information, behavior, drug reactions and reproductive notes. RGD uses controlled vocabularies like the Mammalian Phenotype Ontology (http://www.informatics.jax.org/searches/MP_form.shtml ) and Disease Ontology (http://www.nlm.nih.gov/mesh/MBrowser.html ) to annotate all strains. These annotations, in turn, allow the users to conduct effective searches for desired strain models for their studies. Links to original publications on strain report pages provide easy access to additional information. Strain data from all major phenotype and strain centers such as PGA (http://pga.mcw.edu/ ), RRRC (http://www.nrrrc.missouri.edu/ ) and NBRP (http://www.anim.med.kyoto-u.ac.jp/nbr/home.htm ) are incorporated in our website. RGD encourages researchers to submit their strain data to ensure proper nomenclature that can be used in publication of their results. In the process of registering data, RGD validates the nomenclature of the submitted strains following the nomenclature guidelines laid out by the International Committee on Standardized Genetic Nomenclature for Mouse and the Rat Genome and Nomenclature Committee. Once a correct name/symbol has been given to a strain, we ask the submitter to check the name/symbol and also request that this nomenclature be used in future publications. Direct data submission to RGD offers users an easy process to make sure that their data are available at RGD at the time their paper is published. These features continue to make RGD the premier resource for rat strain information and provide a continuous support for ongoing rat physiological, genetic and genomic research. RGD Strain Report RGD Reference Report Abstract Advantages of Registering data with RGD Strain: Consistent Nomenclature with RGNC approved guidelines Use ILAR codes to ensure proper recognition to the research groups Use ILAR codes to identify the origin and maintenance Use correct nomenclature in publications which will be the same as RGD Receive RGD_ID which can be mentioned in publications Data can be kept private until released by researchers List the source and availability Nomenclature? Help? Questions? Contact: [email protected] Additional resources Submitting Strains to RGD Some of RGD’s Strain submitting groups RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.
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Transcript of RGD--A Repository and Cumulative Resource for Rat Strains
RGD: A REPOSITORY AND CUMULATIVE RESOURCE FOR RAT STRAINS
Rajni Nigam, Mary Shimoyama, Simon Twigger, Diane Munzenmaier, Mindy Dwinell, Howard Jacob; the RGD TeamRat Genome Database, Human and Molecular Genetics Center, Medical College of Wisconsin, 8701 Watertown Plank Road, Milwaukee, WI 53226, United
States of America
RGD (http://rgd.mcw.edu/) strives to collect strain information from recentresearch publications, direct submissions from individual researchers, andrat providers worldwide. Users can search strains in RGD by using thekeyword search or advanced strain searches. RGD houses data for morethan 1600 rat strains that include different strain types as substrains,recombinant inbred strains, congenic, consomic, transgenic, and mutantstrains. Strain pages have a comprehensive description of characteristics,origin, disease, phenotype and physiological information, behavior, drugreactions and reproductive notes.RGD uses controlled vocabularies like the Mammalian Phenotype Ontology(http://www.informatics.jax.org/searches/MP_form.shtml) and DiseaseOntology (http://www.nlm.nih.gov/mesh/MBrowser.html) to annotate allstrains. These annotations, in turn, allow the users to conduct effectivesearches for desired strain models for their studies. Links to originalpublications on strain report pages provide easy access to additionalinformation. Strain data from all major phenotype and strain centers such asPGA (http://pga.mcw.edu/), RRRC (http://www.nrrrc.missouri.edu/) andNBRP (http://www.anim.med.kyoto-u.ac.jp/nbr/home.htm) are incorporated inour website.RGD encourages researchers to submit their strain data to ensure propernomenclature that can be used in publication of their results. In the processof registering data, RGD validates the nomenclature of the submitted strainsfollowing the nomenclature guidelines laid out by the InternationalCommittee on Standardized Genetic Nomenclature for Mouse and the RatGenome and Nomenclature Committee. Once a correct name/symbol hasbeen given to a strain, we ask the submitter to check the name/symbol andalso request that this nomenclature be used in future publications. Directdata submission to RGD offers users an easy process to make sure thattheir data are available at RGD at the time their paper is published. Thesefeatures continue to make RGD the premier resource for rat straininformation and provide a continuous support for ongoing rat physiological,genetic and genomic research.
RGD Strain Report
RGD Reference Report
Abstract
Advantages of Registering data with RGDStrain:Consistent Nomenclature with RGNC approved guidelinesUse ILAR codes to ensure proper recognition to the research groupsUse ILAR codes to identify the origin and maintenanceUse correct nomenclature in publications which will be the same as RGDReceive RGD_ID which can be mentioned in publicationsData can be kept private until released by researchersList the source and availability
Nomenclature?Help?Questions?Contact: [email protected]
Additional resources
Submitting Strains to RGD
Some of RGD’s Strain submitting groups
RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.
