“revolutionising healthcare through continuously improving diagnostic solutions”
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Transcript of “revolutionising healthcare through continuously improving diagnostic solutions”
“revolutionising healthcare through continuously improving diagnostic solutions”
Randox Laboratories Limited
• Privately owned diagnostic and instrument company
• UK and Ireland’s largest indigenous diagnostic company
• Established in 1982
• Employs 850 people
• 200 scientists and engineers
We supply quality products to:• Hospitals, clinical laboratories and veterinary and research
laboratories
• Over 130 countries
• An estimated 60,000 clients using Randox products.
In 2009:• 4 billion diagnostic tests manufactured by Randox.
Our facilities may have been basic but we developed
excellent diagnostic
products, many of which we still
manufacture today!
Princess Royal Visit 1987
Staff Levels..
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100
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600
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NU
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82 83 84 85 86 87 88 89 90 91 92 93 94 95 96 97 98 992000200120022004200520062007200820092010
Current Product Range
• Biochip Array Technology (Including Molecular)
• Clinical Chemistry analysers and reagents
• Quality Control systems
• Life Sciences Department
• Randox Testing Services
• Randox Health Checks
We now have
60,000 customers worldwide
and have achieved significant market share
Miami-Dade CountyCalifornia, USA
“We are very happy with the huge advantages that the Evidence Investigator has brought to our death investigation abilities.”
Dr Lee Hearn
Planned Population Federation of Korea (PPFK)Seoul, South Korea
“I am very happy with the performance of the Imola as my QC results from Korea's national EQA scheme are always perfect on the RX Imola.”
Randox Offices and Distributors
Collaborations Network
Randox has an extensive network of international collaborations
~
We collaborate with 35 universities and hospitals in 7 different countries
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Including Queen’s University Belfast and the University of Ulster
20th position out of the estimated 20th position out of the estimated 1,850 diagnostic companies worldwide1,850 diagnostic companies worldwide
4th in QC serum and calibrators4th in QC serum and calibrators
Number 1 in supply to Number 1 in supply to
international EQA schemesinternational EQA schemes
Randox manufactures 8% of all clinical Randox manufactures 8% of all clinical chemistry tests in the worldchemistry tests in the world
Randox provides the reagents for 11% of Randox provides the reagents for 11% of all HDL Cholesterol tests executed all HDL Cholesterol tests executed
world wideworld wide
Last year we manufactured our Last year we manufactured our
40 billionth test40 billionth test
is a world class manufacturer !is a world class manufacturer !
Innovation
Our mission statement:
“Revolutionising healthcare through continuously improving diagnostic
solutions”
PRODUCT PORTFOLIO
Innovation
Products are designed and developed with the customer and patient in mind
~
Our rigorous design and development process ensures that all products are fit for purpose
PRODUCT PORTFOLIO
Biochip Array Technology
Primary research High throughput
Huge versatility of technology
Expanding portfolio
Complimentary clinical chemistry
Excellent QC throughout
Clinical
Randox has spent $225million
developing Biochip Array Technology
Randox Sales Conference October 2008
. . with over 400 new tests in development – more than any other company in the world
Highly innovative…
Randox in Cardiology
Randox has developed tests to
save 20% of patients lives
Cutting edge technology and novel biomarkers to
accurately diagnose patients with suspected
heart attacks
Respiratory Pathogen Biochip
Human coronavirus 229E/NL63Human coronavirus 229E/NL63
Streptococcus pneumoniaeStreptococcus pneumoniae
Haemophilus influenzaeHaemophilus influenzae
Moraxella catarrhalisMoraxella catarrhalis Influenza AInfluenza A
Influenza BInfluenza B
Chlamydophila pneumoniaeChlamydophila pneumoniae
Legionella pneumophilaLegionella pneumophila
Human bocavirus 1/2/3Human bocavirus 1/2/3
Human enterovirus A/B/CHuman enterovirus A/B/C
Human rhinovirus A/BHuman rhinovirus A/B
Human adenovirus B/C/EHuman adenovirus B/C/E
Mycoplasma penumoniaeMycoplasma penumoniae
Human parainfluenzavirus 1Human parainfluenzavirus 1
Human Respiratory Syncytial virus AHuman Respiratory Syncytial virus A
Human metapneumovirusHuman metapneumovirus
Staphylococcus aureusStaphylococcus aureus
Human Respiratory Syncytial virus BHuman Respiratory Syncytial virus B
Human parainfluenzavirus 2Human parainfluenzavirus 2
Human parainfluenzavirus 3Human parainfluenzavirus 3
Human parainfluenzavirus 4Human parainfluenzavirus 4
Human coronavirus OC43/HKU1Human coronavirus OC43/HKU1
Randox 10-plex STI Biochip
Mycoplasma genitalium (MG)Mycoplasma genitalium (MG)Neisseria gonorrhoea (NG)Neisseria gonorrhoea (NG)
Chlamydia trachomatis (CT)Chlamydia trachomatis (CT)
Trichomonas vaginalis (TV)Trichomonas vaginalis (TV)
Treponema pallidum (TP)Treponema pallidum (TP)
Herpes simplex 1 (HSV1)Herpes simplex 1 (HSV1) Herpes simplex 2 (HSV2)Herpes simplex 2 (HSV2)
Mycoplasma hominis (MH)Mycoplasma hominis (MH)
Haemophilus ducreyi (HD)Haemophilus ducreyi (HD)
Ureaplasma urealyticum (UU)Ureaplasma urealyticum (UU)
10 pathogens detected in one PCR reaction!
10 pathogens detected in one PCR reaction!
9 patient samples hybridized in one carrier
Up to 54 samples run simultaneously
9 patient samples hybridized in one carrier
Up to 54 samples run simultaneously
Bladder Cancer
Development of diagnostic
algorithm to remove the
need for cystoscopy
Breast Cancer RNA/cDNA array
Low density chip-based cDNA
arrays, using a molecular
signature panel that can
divide breast tumours into
clinically relevant sub-types
• One in nine women will be affected by breast cancer• Complex disease involving a number of sub groups • Sub-groups have treatment & prognostic significance• Current IHC methodology is not standardised• Interpretation of IHC can be problematic• IHC relies on small number of targets for diagnosis
Aim: to accurately subtype breast cancer and
predict outcome using a gene expression array
Metabolic SyndromeDefined as the Clustering of Cardiovascular Risk Factors
with 20-25% of adults affected
Metabolic Syndrome ArraysI II
Adiponectin C-Peptide
C-reactive Protein (CRP) Ferritin
Cystatin C Insulin
Interleukin-1 alpha (IL-1α)
Interleukin-6 (IL-6)
Leptin
Plasminogen Activator Inhibitor-1 (PAI-1)
Resistin
Tumour Necrosis Factor-alpha (TNFα)
Co-morbidities of Metabolic Syndrome
• Cardiomyopathy• Coronary Heart Disease• Atherogenic Dyslipidemia• Peripheral and Cerebrovascular Disease• Calcific Aortic Valvular Disease• Type 2 Diabetes• Polycystic Ovary Syndrome (PCOS)• Non-Alcoholic Fatty Liver Disease (NFALD)• Cognitive Impairment• Cancer• Chronic Kidney Disease• Mental Health Conditions
Applicability of other arrays to metabolic conditions
– Adhesion molecules array– Cardiac arrays– Cerebral arrays– Cytokine arrays– Endocrine array
Synergy with other biochip arrays available
Ovarian Cancer RNA/cDNA array
Low density chip-based
cDNA arrays, using a
molecular signature panel
that can predict responders
and non-responders to
chemotherapy (Taxol and
Platinum-based)
Ovarian Cancer RNA/cDNA array
•Low density chip-based cDNA array
• Predicts responders and non-responders to platinum and taxol
chemotherapies (using Ovarian tumours as models)
• Provides a rapid (1 day) test prior to treatment
• Ensures the patient gets the best treatment at the right time
• Standardised and easy to use protocols
Disease prediction – Cardiac disease risk• Cardiovascular disease (CVD) is a complex multifactorial and polygenic disorder
• Results from interaction between genetic makeup and environment
• Identification of SNPs in known CVD genes may therefore aid in the identification of individuals at risk
• Use with Framingham score to better gauge patient risk
• This will permit lifestyle changes or target therapy
• Includes the best 20-SNP combination for prediction of cardiac disease – derived from GWAS and meta analyses
Randox TxB Cardio® Assay
Randox Health Checks
Due to the slowness of uptake of new tests by the health service, we decided to
set up Randox Health Checks, our own clinic
Randox Health Checks
Conclusion
With the unravelling of the Human Genome Project – the potential for life changing inventions is immense
~
We, at Randox, have developed the world’s most revolutionary technology – in fact a disruptive technology in Laboratory
Medicine
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We can help improve the lives of many people in this world
Belfast is as good a place to do this as anywhere in the world
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We have a highly educated workforce open to the world
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All we need is entrepreneurial leadership to overcome hurdles and problems put in our way
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Remember that Belfast has been the source of many inventions and significant entrepreneurial endeavours
Henry George Ferguson
Ferguson designed and built a new plough which was coupled to the tractor in
three-point linkage, so that both formed a single unit. This 'Ferguson System',
building on the earlier two-point linkage patented in 1919, was patented in 1928. Together with many other inventions, it
was to revolutionise farming.
John Dunlop
Dunlop’s great invention, of the inner tube for cycle tyres, came about more or less
by chance. In 1888 his small son was prescribed cycling as cure for a heavy cold; Dunlop hit on the idea of making the boy's tricycle more comfortable by
fitting it with inflated tubes, made of canvas and bonded together with liquid rubber. He patented this idea, using the word 'pneumatic' for the first time, in the
same year.
Invention is in our genes!
Thank you for listening…
“revolutionising healthcare through continuously improving diagnostic solutions”