Revision Time

Today’s Revision Product

Collagen Bone Health

Alendronate Bone health

Aceclofenac Pain Management

Etodolac Pain Management

Febuxostat Bone health

COLLAGEN SACHET

Indication

● Promotes cartilage health

● Improves joint flexibility and mobility in joint

function

● Reduces joint pain

Help stimulate Cartilage synthesis.

COLLAGEN SACHET

Dosage: 5-10gm once daily.

Major Brand: Collaflex(Sanofi)

Any 1 Good Points: effective in stimulation of cartilage tissue.

Alendronate• Description: Prevents the loss of bone mass,

by inhibiting activity of osteoclast and prevents osteoporosis.

• Tablet : 5 mg, 10 mg, 35 mg, and 70 mg (Pure & Cure)• Dosage: Once daily 5mg/10mg and 35/70mg once weekly • Brand Leader: RESTOFOS (Sunpharma) (major brand)• Any 1 Good Point: Highly effective in Osteoporosis

Alendronate

Etodolac and Aceclofenac

Mechanism of action

Tissue Injury

Arachidonic acid

Cox-1 Cox-2

Cytoprotective prostaglandin

Provides gastric mucosa lining

Inflammatory prostaglandin

sensitize pain signals

Etodolac

AceclofenacAceclofenac

Etodolac—Long term• Osteoarthritis - To recover bones joints pain• Rehumatoid arthiritis - Generally affects on small joints i.e.

hands/Feets/finger/Toes/Hips.

Formulations • Etodolac 300/400 mg + Thiochlochioside 4/8mg • Etodolac 400+ Paracetamol 325mg

• Dosage: Twice a daily/ ER is once daily

• Major Brand: Etogesic (Zydus cadilla)

• Any 1 Good Points: Highly effective in osteoarthiritis.

Aceclofenac---Short term

• Indications: Low back pain, Traumatic pain, Dental pain, Post-operative pain, Gynecological pain, and E.N.T inflammation.

• Dosage: 100 mg once daily 200 mg SR twice daily.

• Leading Brand: Hifenac (Intas)

• Any 1 Good Points: Fewer side effects as compare to Diclofenac

Available Formulations

• Aceclofenac 100 mg tablet• Aceclofenac 200 mg SR tablet• Aceclofenac + Paracetamol• Aceclofenac + Rabeprazole• Aceclofenac + Serratiopeptidase • Aceclofenac + Paracetamol + Chlorzoxazone• Aceclofenac + Paracetamol + Rabeprazole• Aceclofenac + Paracetamol + Thiocolchicoside• Aceclofenac + Trypsin + Rutoside + Bromeleain• Aceclofenac Topical

Febuxostat How it works…..• Uric acid build up leads to inflamed joint wi• Febuxostat is a drug that inhibits Xanthine oxidase

responsible for the formation of uric acid.

Febuxostat• Indication: It is used in the treatment of chronic gout and

hyperuricemia.

• Strength: 40/80/120mg

• Dosage: Once daily

• Leading Player: • Zurig of Zydus(Major Player)• Fabulas of Intas (Major Player)

• Good Point: Highly effective & better than Allopurinol.