Reviewers, Volume 8 (1994)genesdev.cshlp.org/content/8/24/local/back-matter.pdf · Reviewers,...
Transcript of Reviewers, Volume 8 (1994)genesdev.cshlp.org/content/8/24/local/back-matter.pdf · Reviewers,...
Reviewers, Volume 8" (1994) The Editors would like to thank the Editorial Board and the following scientists who were kind enough to review papers and provide advice during 1994. Your help has been invaluable and is greatly appreciated.
*From November 16, 1993 to October 16, 1994.
Abelson, John Adams, Tom Adler, Paul Allshire, Robin Allwine, Jim /kit, Fred Altman, Sid Alwine, James Arndt, Kim Augenlicht, Leonard Avery, Leon Baker, Bruce Baker, Tania Baldwin, Albert Balmain, Alan Baltimore, David Banerjee, Utpal Barbacid, Mariano Bargmann, Cori Barlow, Denise Bass, Brenda Bate, Michael Bautch, Vicki Beach, David Beato, Miguel Beckendorf, Steve Beddington, Rosa Beggs, Jean Belasco, Joel Bell, Steve Benchimol, Sam Berk, Arnie Bernards, Rene Berns, Anton Bickmore, Wendy Bingham, Paul Bird, Adrian Bishop, J. Michael Blackburn, Elizabeth Blau, Helen Bohmann, Dirk Bolen, Joe Borst, Piet Botchan, Mike Bouck, Noel Bradley, Allan Breeden, Linda Broach, James Brow, David Brown, Pat Bryant, Peter Buckingham, Margaret
Bulido, D. Buratowski, Steve Burley, Steve Burtis, Ken Busslinger, Meinrad Butcher, Eugene Capecchi, Mario Carey, Michael Cedar, Howard Cepko, Connie Chaconas, George Chamberlin, Michael Chandler, Vicki Chater, Keith Chesebro, Bruce Clarke, Louise Clayton, David Cline, Thomas Cohen, Stanley Cole, Chuck Cooke, Howard Cooley, Lynne Corey, Suzanne Costantini, Frank Courey, A1 Crabtree, Gerald Craig, Betty Cross, Fred Cullen, Bryan Curran, Tom Darnell, Jim Davidson, Duncan Davies, Kay Davis, Ron de Lange, Titia DePamphilis, Mel Desiderio, Stephen Desplan, Claude Devreotes, Peter Dexter, T. Mike Diffley, John DiNardo, Steve Doe, Chris Donahue, Tom Draetta, Giulio Dreyfuss, Gideon Drubin, David Dubolis, Ray Dworkin, Martin Dynan, Bill Ecker, Joe Edlund, Thomas Efstratiatis, Argiris Eichele, Greg Eisenmann, Robert Elledge, Steve Ely, Bert Emerson, Beverly Emerson, Charles Engel, Doug Evan, Gerard Evans, Ron Fangman, Walt Farr, Christine
Fearon, Eric Federoff, Nina Felsenfeld, Gary Fields, Stan Finley, David Firtel, Rick Flavell, Dick Folkman, Judah Freedman, Len Friedberg, Errol Fuchs, Elaine Ganem, Don Gasser, Susan Gaynor, Richard Gill, R.E. Gilman, Mike Glass, Chris Glover, David Sober, Jim Goodfellow, Peter Goodman, Corey Gottesfeld, Joel Gottesman, Susan Gottschling, Dan Stalls, Jay Graves, Barbara Green, Michael Greenberg, Michael Greenwald, Iva Gridley, Tom Grieder, Carol Griep, Anne Griffith, Jack Grossman, Alan Grunstein, Michael Gruss, Peter Guthrie, Chris Gutmann, David Haber, Dan Haber, Jim Hafen, Ernst Hahn, Steven Hammer, Robert Hanahan, Douglas Harrison, Steve Hartwell, Leland Hawley, Scott Hearing, Patrick Heath, John Hecht, Norman Helfman, David Henikoff, Steve Hernandez, Nouria Herrick, Glenn Herskowitz, Ira Hieter, Phil Hill, Bob Hinnebusch, Allan Hochstrasse, Mark Hoeijmakers, Jan Hoffman, Michael Hogan, Brigid Hopkins, Nancy Horz, Wolfram
3080 GENES & DEVELOPMENT
Howley, Peter Hughes, David Hughes, Steve Hunter, Tony Jacks, Tyler Jackson, Ian Jackson, Richard Jackson, Steve Jacobson, Alan Jaeckle, Herbert Jaenisch, Rudi Jan, Yuh-Nung Jenkins, Nancy Johnson, Peter Johnston, Lee Jones, Katherine Joyner, Alex Kadesch, Tom Kahmann, Regine Kaiser, Chris Karin, Michael Karpen, Gary Kassavetis, George Kastan, Michael Kaufman, Paul Kay, Rob Keene, Jack Keller, Gordon Keller, Walter Keroppola, Tom Kerr, Ian Kim, Stuart Kimelman, David Kimmel, Alan Kingsley, David Kingston, Robert Kintner, Chris Kipling, David Kleckner, Nancy Klobutcher, Larry Kolodner, Richard Konarska, Maria Korsmeyer, Stanley Krainer, Adrian Krisch, Henry Krumlauf, Robb Kustu, Sydney Lambowitz, Alan Lane, David Lassar, Andrew Lehman, Ruth Lengyel, Judith Leong, Sally Levin, Dan Levin, David Levine, Arnold Lichten, Michael Lin, Jim Lis, John Little, John Lowy, Doug Luhrman, Ruth Lund, Elsebet Lundblad, Vicki Luse, Don Lustig, Art
MacDonald, Paul MacDonald, Raymond Malloy, Dan Maniatis, Tom Mann, Richard Marshall, Chris Martienssen, Rob Mattai, Ian Mayfield, Steve McCormell, Sue McKeown, Mike McMacken, Roger McStay, Brian Melchers, Fritz Meyerowitz, Elliott Mitchell, Pamela Mizuuchi, Kiyoshi Modolell, Juan Moon, Randy Moore, Claire Moran, Betty Morimoto, Rich Morin, Gregg Morris, John Mount, Steve Munger, Karl Murray, Andrew Murre, Cornelius Nasmyth, Kim Neiman, Paul Ness, Scott Nevins, Joe Newlon, Carol Nilsen, Tim Noller, Harry Nomura, Masayasu Olson, Eric Oren, Moshe Orkin, Stuart Orr-Weaver, Terry Oshima, Robert Pabo, Carl Papaioannou, Ginny Pape, Louise Paro, Renato Parslow, Tristan Pavletich, Nicolas Perlman, Phil Perlmutter, Roger Perrimon, Norbert Peterson, Craig Petes, Tom Posakony, Jim Powers, Scott Pugh, Frank Quail, Peter Radding, Charles Raft, Martin Rastan, Sohaila Reed, Steve Reeder, Ron Reinberg, Danny Rice, Andy Richter, Joel Rigby, Peter Riggs, Arthur
Rine, Jasper Rio, Don Roberts, Jeff Roberts, Jim Robertson, Liz Rochaix, Jean-David Rosbash, Michael Rosen, Craig Rosenberg, Naomi Rosenfeld, Geoff Rossant, Janet Roth, John Rothstein, Rodney Rutter, William Ruvkun, Gary Sachs, Alan Samuel, Charles Sassone-Corsi, Paolo Schaffner, Walter Scharff, Matt Schedl, Paul Schedl, Tim Schlief, Robert Schupbach, Trudi Schwarz-Sommer,
Zsuzsanna Semler, Bert Shapiro, Lucy Sharp, Phil Shekman, Randy Sherr, Charles Sherratt, David Shimkets, L. Shore, David Silver, Lee Simons, Robert Simpson, Robert Skalka, Anna Smale, Steve Smith, Jim Sollner-Webb, Barbara Sonnenberg, Nahum Sorger, Peter Spector, David Spiegelman, Bruce Spradling, Allan Sprague, George Stark, George Starlinger, Peter Stellar, Herman Stenlund, Arne Sternberg, Paul Stewart, Colin Stiles, Chuck Storb, Ursula Stragier, Patrick Strathern, Jeffrey Strickland, Sid Struhl, Gary Struhl, Kevin Stunnenberg, Henk Summers, Jesse Surani, Azim Susskind, Mimi Takeichi, Masatoshi Tegtmeyer, Peter
GENES & DEVELOPMENT 3081
Theurkauf, William Thompson, Craig Thummel, Carl Timberlake, Bill Tlsty, Thea Toda, Takashi Tomlinson, Andrew Tonks, Nick Trainor, C. Treisman, Richard Van Montagu, Marc Vermstrom, Bjorn Verma, Inder Wahl, Geoffrey Wasserman, Steve Weber, Klaus Weinberg, Robert Weintraub, Harold Wessler, Sue West, Stephen Weston, Kathleen White, Eileen Wickens, Marvin Wickner, Sue Wieschaus, Eric Wildeman, Alan Willard, Hunt Williams, Jeff Williams, Trevor Windle, Brad Winston, Fred Wise, Joanne Witte, Owen Wolffe, Alan Wormington, Michael Woychik, Rich Wright, Chris Yaffe, Michael Yamamoto, Keith Yamamoto, Masayuki Yanofsky, Charles Yanofsky, Marty Young, Rick Yudkin, Michael Zakian, Virginia Ziff, Ed
3082 GENES & DEVELOPMENT
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GENES & DEVELOPMENT 3083
Author Index, Volume 8 Abbud, R., 2302 Abovich, N., 843 Ackerman, L.D., 2123 Adams, T.H., 641 Albalat, R., 2513 Albert, D.M., 1300, 1738 Alifano, P., 3021 Allen, J.B., 2401 Allerson, C.R., 3008 Alt, F.W., 1043 Altschmied, L., 339 Aiwine, J.C., 576 Amanuma, H., 45 Andachi, Y., 1935 Andreeva, A., 2928 Andr6s, V., 245 Ansieau, S., 2781 Anton-Lamprecht, I., 2574 Aparicio, O.M., 1133 Ardman, B., 1043 Arnaud, M., 970 Arnheiter, H., 2770 Arora, K., 2588 Arraiano, C.M., 3021 Auble, D.T., 1920 Auerbach, A., 1897 Autexier, C., 563 Avigan, M., 465 Baccarini, M,, 1803 Bachhawat, A.K., 1379 Bachvarova, R.F., 2466 Badiani, P., 770 Baeza, L., 2928 Bailey, A.M., 2729 Bailly, V., 811 Baker, T.A., 2416 Baltimore, D., 783, 1030 Bang, A.G., 2058 Banuett, F., 1367 Barak, Y., 1739 Bardwell, V.J., 1664 Barettino, D., 3068 Baribault, H., 2964 Barnes, J.P., 1473 Baron, C., 376 Barone, M.V., 453 Barrett, K., 2805 Bartelmez, S., 2831 Barton, M.C., 2453 Bazar, L., 465 Beach, D., 1750 Beall, B., 234 Beijersbergen, R.L., 2680 Belair, C., 2227 Belfort, M., 1575 Bell, L.R., 2072 Benedyk, M.J., 105 Berk, A.J., 190, 995 Bernards, R., 2680 Berns, A., 757 Betsholtz, C., 1875 Bhatt, H., 2953 Bier, E., 2602 Biggin, M.D., 1678
Bilger, A., 1106 Binari, R., 300 Bindley, C., 2227 Bird, A.P., 2282 Birkenmeier, E.H., 1853 Blackburn, E.H., 84 Blackwell, T.K., 1043 Blendy, J.A., 981 B6ck, A., 376 Boeke, J.D., 2046 Bolden, A.H., 2324 Bone, J.R., 96 Bopp, D., 598 Bouvet, P., 1147 Bowler, C., 2188 Bowman, M., 720 Bradley, A., 2008 Brand, A.H., 629 Brannan, C.I., 1019, 2792 Breitman, M.L., 1897 Brewer, B.J., 554 Brill, J.A., 1759 Bronson, R.T., 277 Brophy, B., 2879 Brou, C., 2491 Brow, D.A., 221 Brown, M.S., 1910 Bruhn, L., 2691 Bruni, C.B., 3021 Buchberg, A.M., 1019, 2792 Budavari, A.I., 1224 Buettner, R., 1258 Bultman, S.J., 481, 1463 Burns, N., 1087 Biischer, D., 1803 Butler, S., 2629 Cadigan, K.M., 899 Cai, J., 2022 Campbell, A.M., 2868 Capecchi, M.R., 1949 Cardiff, R.D., 23 Carl6e, L., 2680 Carlomagno, M.S., 3021 Carrasco, C.D., 74 Caudy, M., 2743 Cech, T.R., 1198, 1984 Chait, B., 3058 Chambers, A.E., 1324 Champion-Arnaud, P., 1974 Chan, Y.-m., 2574 Chang, J.S., 598 Charlton, J., 2282 Cheatham, L.A., 1212 Chen, G.-F.T., 2641 Chen, J., 1235 Chen, J., 1356 Chen, J.-L., 2313 Chen, S., 3008 Chen, W.S., 2466 Chen, Y.-Y., 678, 688 Chen, Z., 2293 Chiao, P.J., 1258 Chiara, M.D., 245 Chien, K.R., 1007
Chittenden, T., 2665 Cho, K.R., 1174 Choi, E.-Y., 1087 Chory, J., 339 Christerson, L.B., 614 Chua, N.-H., 2188 Clark, A.M., 948 Clarkin, K., 2540 Clayton, D.E., 2617 Coetzee, T., 1575 Coffin, J.M., 1473 Collart, M.A., 525 Collins, S., 2831 Coodly, L., 2257 Cooper, C.M., 959 Cooper, J.P., 1400 Copeland, N.G., 265, 399,
1019, 1613, 2770, 2792 Corbella, P., 770 Corces, V.G., 2046 Corcoran, L.M., 1030 Cormack, B.P., 1335 Cox, L.A., 2008 Cozzarelli, N.R., 1356 Cross, F.R., 1058 Crozat, A., 453 Crozatier, M., 2718 Da Costa, M., 959 Darnell Jr., J.E., 2466 Darwiche, N., 2429 Daugherty, C., 3045 Davis, R., 2996 Davisson, M.T., 481, 1463 de la Brousse, F.C., 1853 DeCaprio, J.A., 869, 2665 Decker, C.J., 855 DeGregori, J., 265 del Amo, F.F., 707 Deng, C.-X., 3045 D6rijard, B., 2996 Deschamps, J., 757 Detwiler, L., 959 DeVeaux, L.C., 203 Dever, C.A., 1678 DeVries, S., 2227 Di Leonardo, A., 2540 Dickson, B., 428 Diederich, B., 2653 Dimitrov, S., 1147 DiNardo, S., 105 Dixit, M., 2441 Dodd, J.A., 2349 Doherty, A.S., 290 Domen, J., 757 Donovan, J.D., 1640 Donovan, J.W., 2552 Dopping-Hepenstal, P.J.C.,
2563 Downs, W.D., 1198 Doyle, S., 2162 Draetta, G.F., 1627 Driks, A., 234 Dubois, E., 796 Dumont, D.J., 1897
Duncan, G., 2805 Duncan, R., 465 Duncan, S.A., 2466 Duronio, R.J., 440 Dynes, J.L., 948 Dynlacht, B.D., 1772 Dyson, E., 1007 Eady, R.A.J., 2563 Earp, H.S., 399 Ebright, R.H., 3058 Eckner, R., 869 Ede, K., 2729 Edgar, B.A., 440 Elenbaas, B., 1235 Elion, E.A., 313 Elledge, S.J., 2401 Ellenberger, T., 970 Emanuel, P.A., 830 Emerson, B.M., 2453 Emery, J., 2602 Enslen, H., 2527 Epstein, J.A., 2022 Ernst, J.-P., 2574 Errington, J., 2653 Esnayra, J., 2729 Esposito, R.E., 796 Evans, R.M., 538, 1007 Ewen, M.E., 869 Fangman, W.L., 554 Farifias, I., 2691 Farkas, R., 1160 Farnham, P.J., 1526 Fass, D., 970 Fearon, E.R., 1174 Fearer, W.J., 2868 Feldmann, K.A., 1388 Feng, G., 2913 Fenyo, D., 3058 Finberg, K., 1087 Fink, G.R., 1759, 2974 Finney, M., 1935 Firtel, R.A., 502, 948 Fischer, W.H., 502 Fisher, D.E., 2770 Flickinger, T.W., 914 Flock, G., 538 Flores, O., 1772 Fong, G.-H., 1897 Fortner, D.M., 221 Fox, C.A., 926, 1106 Frampton, J., 33 Francois, V., 2602 Freeman, K., 2257 Freytag, S.O., 1654 Friedberg, E.C., 2401 Friedrich, G.A., 2293 Friesen, H., 2162 Fuchs, E., 2574 Fuse, N., 2270 Gardner, H.A.R., 414 Garg, P., 1270 Gasch, A., 2363 Gebre-Medhin, S., 1875 Gehring, W.J., 899
3084 GENES & DEVELOPMENT
Genetta, T., 2203 Gerasimova, T., 2046 Gerdes, M., 869 Gerety, S.J., 678 Gertsenstein, M., 1897 Gibson, T., 376 Gietz, R.D., 2035 Gigu6re, V., 538 Gilbert, J.D., 1654 Gilmour, D.S., 830 Ginsberg, D., 2665 Ginsburg, G.T., 2086 Giovane, A., 1502 Glaser, T., 2022 Glick, A.B., 2429 Glowacki, J., 277 Gober, J., 1839 Gold, L., 376 Gold, S., 2805 Golden, J.W., 74 Goldfarb, A., 3058 Goldstein, J.L., 1910 Goodrich, J.A., 515 Goto, K., 1548 Gottlieb, E., 1739 Gottschling, D.E., 1133 Gradwohl, G., 1897 Graf, T., 33 Graves, R.A., 1224 Gray, S., 1829 Greenstein, D., 1935 Greider, C.W., 563 Gridley, T., 707 Griep, A.E., 1285 Grimwade, B., 1087 Grosschedl, R., 2691 Grossniklaus, U., 899 Groudine, M., 2212 Guan, K.-L., 2939 Guarente, L., 2110 Gumeringer, C.L., 1007 Guthrie, C., 1071 Guy, C.T., 23 Hafen, E., 428 Hahn, S., 1920 Hall, P., 2151 Hallick, R.B., 1589 Han, M., 147 Harm, S.R., 2441 Hannon, G.J., 1750 Hansen, K.E., 1920 Hansen, M.J., 2770 Hardy, R.R., 1030 Harlow, E., 1772 Harpal, K., 3032 Harrington, J.J., 1344 Harrison, S.C., 970, 2504 Hartwell, L.H., 652 Hatakeyama, M., 1759 Hay, N., 2817 Hayashi, S., 2270 Heath, L.S., 2904 Hebron, C., 2913 Hedrick, L., 1174 Hemesath, T.J., 2770 Hendrick, L.L., 1984
Hengge-Aronis, R., 1600 Henkemeyer, M., 3032 Henry, N.L., 2868 Herr, W., 2756 Herrmann, B.G., 2137 Herrup, K., 2008 Herschlag, D., 1575 Herskowitz, I., 1367 Hipskind, R.A., 1803 Hird, S., 1935 Hirose, S., 2270 Hochschild, A., 1212 Hodgkinson, C.A., 2770 Holz, H., 3068 Hong, L., 1589 Horabin, I.I., 598 Horvitz, H.R., 160 Howes, K.A., 1300, 1738 Hsiao, K.-M., 1526 Hsu, J., 1270 Hsu, J.-C., 2176 Hu, E., 1224 Hu, N., 2008 Hua, X.H., 2058 Huang, M.S., 688 Huh, G.S., 1561 Hunt, T., 926 Hyer, J., 2743 Hynes, R.O., 1561 Iavarone, A., 1270 Ikeda, Y., 2302 Imai, Y., 328 Ingraham, H.A., 2302 Inostroza, J.A., 2097 Inouye, M., 2641 Iozzo, R.V., 2964 Iratni, R., 2928 Israel, A., 2491 Israel, M.A., 1270 J/ickel, A., 2574 Jackson, S.P. 2879 Jaenisch, R., 414 Jan, L.Y., 1787, 2123 Jan, Y.N., 1787, 2123 Jenkins, C.W., 2939 Jenkins, N.A., 265, 399, 1019,
1613, 2770, 2792 Jenny, A.L., 959 Jepeal, L., 2022 Jim6nez, C.G., 3068 Johnson, A.D., 2857 Johnson, A.L., 1640 Johnson, D.G., 1514 Johnson, P.F., 1131 Johnston, L.H., 1640 Jones, E.W., 1379 Jones, N., 885 Jongens, T.A., 2123 Jongeward, G.D., 60 Juven-Gershon, T., 1739 Kadesch, T., 2203 Kaiser, D., 2793 Kalderon, D., 2986 Kallunki, T., 2996 Kanaar, R., 1356, 1713 Kanllabiran, C., 2097
Kannan, P., 1258 Kapler, G.M., 84 Karaplis, A.C., 277 Karin, M., 2996 Karlsson, S., 2429 Kato, J.-y., 9 Kaufmann, J., 821 Keller, G., 1184 Kerkhoven, R.M., 2680 Keys, D.A., 2349 Khoo, B., 2879 Kim, S.K., 160 Kimmel, A.R., 2086 King, D.S., 1853 Kingsley, D., 133 Kingston, R.E., 386 Kinoshita, M., 1613 Kinzler, K.W., 1174 Kioussis, D., 770 Kirkegaard, K., 1726 Kiser, G.L., 652 Kispert, A., 2137 Kitamura, Y., 1473 Klebig, M.L., 481 Klein, W.H., 1 Klingensmith, J., 118 Klug, C.A., 678 Koff, A., 9 Kohara, Y., 1935 Kokontis, J.M., 2817 Komachi, K., 2857 Konarska, M.M., 1962 Konforti, B.B., 1962 Konrad, K.D., 1489 Komberg, R.D., 2868 Komfeld, K., 160 Kotecha, S., 1324 Kourilsky, P., 2491 Kowenz-Leutz, E., 2781 Kranz, J.E., 313 Kraut, N., 33 Kreitzer, D., 2151 Kremenstova, E., 2416 Krisak, L., 2151 Kronenberg, H,M., 277 Kronstad, J., 2805 Krug, R.M., 1817 Krutzsch, H., 465 Kuldell, N.H., 1212 Kulkarni, A.B., 2429 Kumar; S., 1613 Kurkulos, M., 2046 Kuroda, M.I., 96, 698 Kuspa, A., 948 Kuzin, B., 2478 Lackner, M.R., 160 Lala, D.S, 2302 Lamb, J., 811 Landick. R., 2913 Lane, E.B., 2563 Lane, M.E., 2986 Lane, W.S., 1920 Lange, R., 1600 Lansford, R., 1043 Lantz, V., 598 Larsson, E., 1875
Lasorella, A., 1270 Lasudry, J.G.H., 1300, 1738 Latham, K.E., 290 Lau, M.M.H., 2953 Lavendar, J., 96 Lawrence, J.B., 869 Lawrence, J.B., 2665 Lecourtois, M., 2491 Leder, P., 3045 Lee, A., 2324 Lee, B.N., 641 Lee, D.C., 399 Lee, E.Y.-H.P., 2008 Lee, J., 60 Lee, K., 1160 Lee, K.-F., 414 Lee, M.M., 2429 Lee, W.-H., 2008 Lees, I.A., 1772 Lefstin, J.A., 2842 Leigh, I.M., 2563 Leopold, P., 440 Leptin, M., 2137 Lerbs-Mache, S., 2928 Leutz, A., 2781 Lev6en, P., 1875 Levens, D., 465 Levine, A.J., 1235 Levine, M., 1247, 1829 Levine, M.S., 2588 Leviten, M.W., 2058 Li, H.-m., 339 Li, Y., 2939 Liao, X.C., 843 Liao, Y.J., 1787 Lieber, M.R., 1344 Lieberman, P.M., 995, 2324 Lin, J., 1235 Lincoln, A.J., 1131 Linders, K., 757 Lindsell, C.E., 707 Lingner, J., 1984 Linke, S.P., 2540 Liu, C., 2904 Liu, X., 190 Liu, Z., 2953 Livanos, E.M., 666 Livingston, D.M., 869, 2665 Logan, M., 1324 Logeat, F., 2491 Loomis, W.F., 948 Losick, R., 234 Louis, J.M., 2086 Lowell, C.A., 387 Lu, Y., 1817 Luehrsen, K.R., 1117 Luetteke, N.C., 399 Lunz, R., 2162 Luo, L., 1787, 2416 Luo, X., 2302 Lutz, C.S., 576 Luz, A., 277 Lygerou, Z., 1423 Ma, D., 2336 Ma, H., 745 Maas, R.L., 2022
GENES & DEVELOPMENT 3085
Mache, R., 2928 Macleod, D., 2282 MacMillan, A.M., 3008 MacMorran, W.S., 2035 Madden, S.L., 720 Madhani, H.D., 1071 Madisen, L., 2212 Magnenat, L., 2389 Magnin, T., 2653 Mahdavi, V., 245 Maira, S.-M., 1502 Malim, M.H., 1538 Mallory, M.J., 2151 Maniatis, T., 1703 Manley, J.L., 259 Manova, K., 2466 Maquat, L.E., 363 Marks, M.D., 1388 Marmorstein, R., 2504 Marsh, J.L., 1489 Marvel, J., 770 Mason, E.D., 1489 Massague, J., 9 Matera, A.G., 2939 Matsuzaki, T., 45 Matthews, K.R., 491 Matzuk, M.M., 414 Maurer, R.A., 2527 Mavilio, F., 732 Maxon, M.E., 515 Mazo, A., 2478 McGill, G., 2770 McKearin, D.M., 614 McKnight, S.L., 1853 McLean, W.H.I., 2563 McMahon, A.P., 174 McMahon, J.A., 174 McMahon, S.L., 1526 McMillan, J.R., 2563 McNagny, K.M., 33 Melchers, F., 1043 Mendelsohn, M., 1043 Mermelstein, F.H., 2097 Messenguy, F., 796 Meyer, B.E., 1538 Meyerowitz, E.M., 1548 Michaud, E.J., 481, 1463 Michelotti, G., 465 Miller, L.M., 160 Milne, G.T., 2552 Mitchell, P., 1423 Miyagawa, T., 45 Mizrokhi, L v 2478 Mlodzik, M., 2313 Mohun, T.J., 1324 Montell, C., 981 Moore, G., 2996 Moore, M.J., 587 Moore, P.A., 2324 Moran, Jr., C.P., 234 Moretti, P., 2257 Mori, I., 2389 Mueller, C.G.F., 1920 Muhlrad, D., 855 Mullen, J.R., 105 Mfiller, F., 2389
Muller, W.J., 23 Mulligan, R.C., 277 Mullins, J., 2282 Murillo, F.J., 2375 Muthuswamy, S.K., 23 Myung, P.S., 2527 Nachtigal, M.W., 2302 Najafi, S.M.A., 2653 Nasmyth, K., 885 Navsaria, H.A., 2563 Nemazee, D., 1030 Nerlov, C., 350 Nesic, D., 363 Neuhaus, G., 2188 Neuman, S., 959 Nevins, J.R., 1514 Newsome, D., 869 Newton, M.A., 2227 Nichols, M.A., 2939 Nicolas, F.J., 2375 Nilson, J.H., 2302 Noda, M., 1613 Nogi, Y., 2349 Nomura, M., 2349 Nordheim, A., 1803 Nordlund, M.L., 1019, 2792 Novak, J.E., 1726 Nusse, R., 118 Nussenzweig, M.C., 1030 O'Brien, C.A., 2891 O'Connor, M.B., 2588 O'Farrell, P.H., 440 O'Keefe, C.L., 2939 O'Neill, J.W., 2602 Oehlen, L.J.W.M., 1058 Ogura, K.-i., 2389 Ohsako, S., 2743 Ohshima, Y., 2389 Ohtani, K., 1514 Okamura, R.M., 2691 Okano, H., 981 Oki, T., 45 Oliver, I., 2743 Olson, E.N., 1 Ong, E., 538 Oren, M., 1739 Orkin, S.H., 1184 Ornitz, D.M., 3045 Otulakowski, G., 538 Ozer, J., 2324 Paetkau, D.W., 2035 Pagano, M., 1627 Paielli, D.L., 1654 Palmer, M.J., 96 Palmer, M.J., 698 Pan, H., 1285 Panganiban, G., 2743 Papermaster, D.S., 1300, 1738 Parada, L.F., 1019, 2792 Parker, K.L., 2302 Parker, R., 855 Parslow, T.G., 2691 Patel, N.H., 981 Payre, F., 2718 Peculis, B.A., 2241 Pekny, M., 1875
Penner, J., 2964 Perkins, A.S., 1019, 2792 Perrimon, N., 118, 300, 629,
2176 Petfalski, E., 1423 Pfeifer, K., 1867, 2227 Philipson, L., 453 Phillips, H.K., 399 Pintzas, A., 1502 Piscitelli, C., 3021 Pitera, R., 2563 Plasterk, R.H.A., 1935 Plump, A.S., 2466 Polyak, K., 9 Pooh, D., 2868 Posakony, J.W., 2058, 2729 Prakash, L., 811 Prakash, S., 811 Prezioso, V.R., 2466 Price, J., 1007 Priyaranian, P., 265 Proudfoot, N.J., 259 Proweller, A., 2629 Prusiner, S.B., 959 Puri, M.C., 1897 Purnell, B.A., 830 Qian, X.-Y., 1817 Qiu, T.H., 399 Query, C.C., 587, 3008 Quo, R.-G., 2691 Rabinow, L., 1160 Raghuraman, M.K., 554 Ramasubramanian, T.S., 74 Ramaswamy, K.S., 74 Ransom, N., 1300, 1738 Rao, Y., 939 Rather, N., 1019, 2792 Rauscher III, F.J., 720 Rayburn, H., 265 Redd, M.J., 2857 Reed, R., 1974 Reichman-Fried, M., 428 Reid, S.W., 1019, 2792 Reinberg, D., 2097, 2336 Ren, R., 783 Retie, W.G., 1388 Reuter, R., 2137 Reznikoff, C.A., 2227 Reznikoff, W.S., 2363 Rice, N.R., 678 Richman, R., 96, 698 Richter, L., 698 Riese, J.A., 2035 Ringquist, S., 376 Rio, D.C., 1713 Rivellini, F., 3021 Robanus-Maandag, E., 757 Roberts, J.M., 9 Roberts, R.L., 2974 Roeder, G.S., 1087 Roels, S., 234 Rolink, A., 1043 Roman, C.A.J., 1030 Ron, D., 453, 2513 Rosa, F.M., 1448 Rosbash, M., 843
Rosen, C.A., 2324 Rosenberg, N., 678, 688 Ross-Macdonald, P.B., 1087 Rossant, J., 3032 Roth, S.Y., 1400 Rotwein, P., 2953 Rowe, L.B., 1853 Rugg, E.L., 2563 Ruiz-Vfizquez, R.M., 2375 Ruley, H.E., 265 Rupp, R.A.W., 1311 Ruppert, S., 2756 Rusch, J., 1247 Russ, A., 265 Ruvkun, G., 1935 Sager, B., 2793 Salz, H.K., 914 Sarkiss, M., 1258 Sartori, D., 732 Sato, R., 1910 Satterberg, B., 313 Savelieva, E., 2227 Schedl, P., 598 Schlissel, M.S., 1030 Schmitt, M.E., 2617 Schneider, D., 376 Schnitzler, G.R., 502 Schultz, R.M., 290 Schweisguth, F., 2491 Scott, C.D., 290 Sealy, L., 2441 Sears, R.C., 2441 Sedkov, Y., 2478 Segall, J., 2162 Sekhon, G., 2227 S6raphin, B., 1423 Severinov, K., 3058 Shah, P.C., 678 Sharma, P.M., 720 Sharp, P.A., 587, 3008 Shaulsky, G., 948 Shea, M.J., 174 Sheets, M.D., 926 Sheldon, L.A., 386 Sheldon, M., 2336 Shen, M.M., 3045 Shen, W.-H., 2302 Sherr, C.J., 9 Shilo, B.-Z., 428 Shinkai, Y., 1043 Shinton, S.A., 1030 Shore, D., 2257 Siebel, C.W., 1713 Siede, W., 2401 Silver, D.P., 1030 Simpson, R.T., 1400 Singh, H., 678 Singson, A., 2058 Sitnicka, E., 2831 Sluss, H.K., 2996 Smale, S.T., 821 Smith, G.R., 203, 1693 Snider, L., 1311 Snyder, M., 1087 Sobieszczuk, P., 1502 Sofroniew, M., 757
3086 GENES & DEVELOPMENT
Solloway, M., 2602 Solomon, M.J., 9 Song, S.U., 2046 Soriano, P., 23, 387, 1888,
1999, 2293 Spanopoulou, E., 1030 Sparrow, D., 1324 Spiegelman, B.M., 1224 Sprenger, F., 440 Spyropoulos, D.D., 1949 Stargell, L.A., 1335 Stark, K.L., 174 Stavenhaven, J.B., 1411 Steber, C., 796 Steffan, J.S., 2349 Stein, P.L., 1999 Steingrimsson, E., 2770 Steitz, J.A., 2241, 2704 Sternberg, P.W., 60 Stewart, C.E.H., 2953 Stewart, C.L., 2953 Strich, R., 796, 2151 Strubin, M., 1335 StruM, K., 525, 1335 Stunnenberg, H.G., 3068 Su, B., 2996 Sucov, H.M., 1007 Suhan, J., 1379 Sukumar, S., 720 Sun, P., 2527 Sun, X., 2336 Sung, P., 811 Surosky, R.T., 796 Swedlow, J.R., 2123 Sweet, H.O., 481, 1463 Swiatek, P.J., 707 Swolin, B., 1875 Szymanski, P., 1829 Tabaee, A., 453 Tainsky, M.A., 1258 Takada, S., 174 Takeda, H., 45 Takeda, T., 885 Tam, S.W., 1627 Tang, H., 3058 Tansey, W.P., 2756 Tam, W.-Y., 2704 te Ride, H., 757 Theodoras, A.M., 1627 Thomas, J.R., 2842 Thompson, K.J., 2227 Thomer, J., 1920 Tian, M., 1703 Tilghman, S.M., 1867 Tillib, S., 2478 Tini, M., 538 Tjian, R., 515, 2313, 2756 Tlsty, T.D., 666 Tobler, H., 2389 Tollervey, D., 1423 Tomonaga, T., 465 Tontonoz, P., 1224 Towers, N., 1324 Toyn, J.H., 1640 Treisman, R., 1664 Troy, R.G., 221
Tsai, S., 2831 Tschudi, C., 491 Tsigelny, I., 2996 Tuan, R.S., 2151 Tumbough Jr., C.L., 2904 Turner, B.M., 96 Turner, D.L., 1434 Twamley, G., 2781 Tybulewicz, V.L.J., 277 Ullu, E., 491 Vairo, G., 2665 Valcfircel, R., 3068 van der Lugt, N.M.T., 757 van der Valk, M., 757 Van Doren, M., 2729 van Genderen, C., 2691 van Lohuizen, M., 757 van Roon, M., 757 van Vugt, M.J., 1463 Vande Woude, G., 926 Vandekerckhove, J., 2491 Varmus, H.E., 387 Vassalli, A., 414 Vassileva, G., 174 Vaught, J., 2770 Verdine, G.L., 3008 Verrijzer, C.P., 2313 Vilardell, J., 211 Vincent, A., 2718 Vogel, H., 1999 Vogel, K.S., 1019, 2792 Vogelstein, B., 1174 yon Melchner, H., 265 Voorhoeve, P.M., 2680 Vu, L., 2349 Wagner, A.J., 2817 Wahl, G.M., 2540 Wahle, E., 1106 Wahls, W.P., 1693 Walbot, V., 1117 Waldman, F., 2227 Walter, J., 1678 Walton, D.S., 2022 Wang, B., 1935 Wang, J., 2072 Wang, L.C., 688 Warner, J.R., 211 Wasylyk, B., 1502 Weaver, D.T., 2552 Webb, C.D., 1489 Well, P.A., 2868 Weilbaecher, R., 2913 Weinberg, R.A., 1759 Weinert, T.A., 652 Weinmaster, G., 707 Weinreich, M.D., 2363 Weinstein, D.C., 2466 Weintraub, H., 1311, 1434,
2203 Weiss, M.J., 1184 Westaway, D., 959 Weston, K., 770 Whipple, F.W., 1212 White, A.E., 666 Wickens, M., 926, 1106 Wicky, C., 2389
Widner, K.L., 2665 Wilkinson, J.F., 2653 Williams, S.C., 1131 Wilson-Heiner, M., 2964 Windle, J.J., 1300, 1738 Wingrove, J.A., 1839 Winter, E., 2151 Winters, R.S., 2151 Withers-Ward, E.S., 1473 Wittbrodt, J., 1448 Wolffe, A.P., 1147 Wolin, S.L., 2891 Woods, R.A., 2035 Woychik, R.P., 481, 1463 Wu, T.-C., 1174 Wu, X., 2939 Wu, Y., 147 Wynshaw-Boris, A., 3045 Xiao, Z.-X., 2665 Xiong, W.-C., 981 Xiong, Y., 2939 Xu, G., 2665 Yamagata, H., 2188 Yamaguchi, T.P., 3032 Yamamoto, K.R., 2842 Yamamoto, M., 328 Yamamoto, R.T., 2349 Yang, J., 1910 Ye, Z.-S., 783 Yeager, T., 2227 Yeung, K., 2336 Yeung, K.C., 2097 Yew, P.R., 190 Yim, S.O., 1258 Yokomori, K., 2313 Young, F., 1043 Yu, Q.-C., 2574 Yuan, S.-S.F., 2008 Yudkin, M.D., 2653 Yun, B., 1160 Yuspa, S.H., 2429 Zabel, B., 2574 Zakian, V.A., 1411 Zappavigna, V., 732 Zeidler, M.P., 2313 Zhai, Y., 2227 Zhang, H., 1750 Zhang, L., 2110 Zhou, Z., 2401 Zhu, L., 2680 Zhu, Y., 885 Ziff, E.B., 350 Zinszner, H., 2513 Zuliani, V., 959
GENES & DEVELOPMENT 3087
Subject Index, Volume 8 (1994)
Abelson murine leukemia, early B-cell development (Chen et al.), 688- 697
Abelson murine leukemia virus, trans- formation of B-lineage precur- sors (Klug et al.), 678-687
Abl protein-tyrosine kinase, selective binding sites for SH3 domains of Crk and Nck (Ren et al.), 784-795
Achaete-scute homolog, Xenopus, ex- pression of and effect on cell fate (Turner and Weintraub), 1434-1447
achaete transcriptional repression by hairy
(Ohsako et al.), 2743-2755 transcriptional repressor of hairy (Van
Doren et al.), 2729-2742 Activation target, of lac promoter de-
fined by mutations (Tang et al.), 3058-3067
Activin, dominant-negative variants in fish (Michaud et al.), 1463-1472
Activin/inhibin BB subunit gene, role in mouse eyelid development and female reproduction (Vassalli et al.), 414-427
Adapter molecules, Crk, Nck, and Grb2 SH3 domains (Ren et al.), 783- 795
Adenovirus 2 early 1B (Ad2 EIB), binding to amino terminus of p53 (Lin et al.), 1235-1246
Adenovirus E1A-associated proteins, p300 has transcriptional adaptor properties (Eckner et al.), 869- 884
Adenovirus E1B 55K, negative regula- tion of p53 activity (Yew et al.), 190-202
Adenylate cyclase, control of morpho- genesis in U. maydis (Gold et al.), 2805-2816
ADI (ATP-dependent inhibitor), encoded by MOT1 gene (Auble et al.), 1920-1934
Adipocyte enhancer, tissue-specific reg- ulator of, mPPARy2 (Tontonoz et al.), 1224-1234
Adipogenesis, promoted by C/EBPa (Freytag et al.), 1654-1663
Adipose tissue, G1/S growth arrest blocked by oncogene TLS- CHOP (Barone et al.), 453-464
Agouti, new dominant mutation A iapy
(Michaud et al.), 1463-1472 Agouti mice locus, reverse mutations (a
to a t and A w) (Bultman et al.), 481--490
a-factor, yeast mating pheromone (Oeh- len and Cross), 1058-1070
Alternative splicing Drosophila sex determination (Wang
and Bell), 2072-2085 of Drosophila Sxl sex determination
gene (Flickinger and Salz), 914- 925
of the Euglena gracilis ycf8 complex trinitron (Hong and Hallick), 1589-1599
factor, RNA-binding protein PSI (Sie- bel et al.), 1713-1725
of fibronectin mRNA, regulation by hexanucleotide element (Huh and Hynes), 1561-1574
mRNA, of Pax6 paired box subdomains (Epstein et al.), 2022-2134
RNA, generates distinct amino-termi- nal domains of ROR isoforms (Gigu6re et al.), 538-553
of zebrafish pou2 gene (Takada et al.), 45-59
Amino-terminal domain, p53, hydropho- bic amino acids in (Lin et al.), 1235-1246
Anabaena, xisF gene, encodes develop- mentally regulated site-specific recombinase (Carrasco et al.), 74-83
Androgenone, and genomic imprinting (Latham et al.), 290-299
Anemia, with erythroblastosis and thrombocytopenia in PDGF B-deficient mice (Lev6en et al.), 1875-1887
Aniridia human congenital eye disease, mutated PAX6 gene (Epstein et al.), 2022-2034
Anteroposterior (A/P)patterning. See also Patterning
Anteroposterior axis, of Drosophila, dis- ruption of PKA disrupts RNA localization (Lane and Kal- deron), 2986-2995
Antirepression, activity of TFIIA (Sun et al.), 2336-2348
Antirrhinum majus, flower development (Ma), 745-756 Review
aP2, adipocyte-specific gene (Tontonoz et al.), 1224-1234
AP47 mouse protein, equivalency to nematode UNC-101 protein (Lee et al.), 60-73
AP-2 transcription factor, transforma- tion by N-ras oncogene (Kannan et al.), 1258-1269
Apoptosis. See also Cell death E7 induced (Pan and Griep), 1285-
1299 induction of by mouse Nedd2 gene
(Kumar et al.}, 1613-1626 induction of requires p53 (Howes et
al.), 1300-1310 in RB mutant mice (Lee et al.), 2008-
2021
role of p53 and Myc (Wagner et al.), 2817-2830
aprt. See Phosphoribosyltransferase (Ma- cleod et al.), 2282-2292
Arabidopsis thaliana floral homeotic gene PISTILLATA (PI)
(Goto and Meyerowitz), 1548- 1560
flower development (Ma), 745-756 Re- view
phototransduction pathway (Li et al.), 339-349
role of GL2 homeo box gene in tri- chome development, role of GL2 homeo box gene (Rerie et al., 1388-1399
Arabinose, (Query et al.), 587-597 ARF6, adipocyte transcription factor
(Tontonoz et al.), 1224-1234 Arginine, rare codons regulate expression
(Chen and Inouye), 2641-2652 Asexual sporulation, Aspergillus (Lee
and Adams), 641-651 Aspergillus nidulans, fluG gene required
for production of extracellular signal (Lee and Adams), 641- 651
Asymmetric binding, by HAP1 ho- modimers (Zhang and Guar- ente), 2110-2119
aurea, phytochrome control of gene ex- pression (Bowler et al.), 2188- 2202
Autoantigen, binding to mutant 5S rRNA (O'Brien and Wolin), 2891-2903
Autoregulatory control, of E2F1 gene ex- pression during cell cycle pro- gression (Johnson et al.), 1514- 1525
Autosomal dominant disorder, neurofi- bromatosis type 1 (NF1) (Bran- nan et al.), 1019-1029
Avian leukosis virus (ALV), distribution of targets for DNA integration in vivo (Withers-Ward et al.), 1473-1487
Axial organization, development regu- lated by FGFR-1 (Deng et al.), 3045-3057
Axon elongation, role of C. elegans unc-51
(Ogura et al.), 2389-2400 guidance, role of C. elegans unc-51
(Ogura et al.), 2389-2400 outgrowth, involvement of Drosophila
Dracl (Luo et al.), 1787-1802
B
B cells development
role of retinoic acid receptors (Tsai et al.), 2831-2841
3088 GENES & DEVELOPMENT
v-abl tyrosine kinase supresses light-chain rearrangement (Chen et al.), 688-697
differentiation components of the immunoglobulin
antigen receptor, regulory role of (Spanopoulou et al.), 1030- 1042
influence of immunoglobulin ex- pression on (Young et al.), (1043-1057)
Bacillus subtilis interactions between SpoIIAA and
SpoIIAB regulate transcription- (Diederich et al.), 2653-2663
SpolVCA recombinase, similarity to Anabaena XisF protein (Car- rasco et al.), 74-83
subcellular localization in coat assem- bly (Driks et al.), 234-244
Bacteriophage T4, group I introns, self- splicing properties (Coetzee et al.), 1575-1588
Basal factors, TFIIE interactions (Maxon et al.), 515-524
Basidiomycete fungus, Ustilago maydis (Banuett and Herskowitz), 1367-1378
~-Globin, transcriptional regulation (Bar- ton and Emerson), 2453-2465
[3' subunit, of RNA polymerase, role in chain elongation (Weilbaecher et al.), 2913-2927
bHLH domain, of transcription factor E47 (E1-
lenberger et al.), 970-980 escargot, role in Drosophila develop-
ment (Fuse et al.), 2270-2281 factors, in myogenesis (Olson and
Klein), 1-8 Review mi role in DNA binding and transcrip-
tional activation (Hemesath et al.), 2770-2780
MyoD and El2 (Weintraub et al.), 2203-2211
-Zip transcription factors, role of SREBP-2 in cholesterol homeo- stasis (Yang et al.), 1910-1919
bicoid regulation by PKA in Drosophila
oocytes (Lane and Kalderon), 2986-2995
transcription controlled by serendipity (Payre et al.), 2718-2728
Binuclear duster, of PPR1 and GAL4, role in DNA binding (Marmor- stein and Harrison), 2504-2512
Blastocyte outgrowth, (Spyropoulos and Capecchi), 1949-1961
Blue light, signal pathways in M. xan- thus (Nicolas et al.), 2375-2387
bmi-1 proto-oncogene, developmental defects in bmi-1 mutants (van der Lugt et al.), 757-769
Brachyury mouse gene, Xenopus (Xbra) homolog of (Rao), 939-947
Branch nucleophile selection, bulged du- plex model (Query et al.), 587- 597
Branch site, of pre-mRNA, identification of associated proteins (Mac- Millan et al.), 3008-3020
Branchpoint sequence, U2 snRNP bind- ing (Champion-Amaud and Reed), 1974-1983
Breathless, Drosophila FGF receptor ho- molog, role in tracheal cell mi- gration (Reichman-Fried et al.), 428-439
BRF, cloning of homologs from K. lactis and C. albicans {Khoo et al.), 2879-2890
Bronze-2 (Bz2) gene, maize (Luehrsen and Walbot), 1117-1130
Budding regulation by uacl and ubcl in U.
maydis (Gold et al.), 2805-2816 in S. cerevisiae, involvement in mat-
ing and invasive growth (Rob- erts and Fink)i 2974-2985
Budding yeast. See Saccharomyces cere- visiae
Bulged duplex model, branch nucleo- phile selection (Query et al.), 587-597
Burkitt's lymphoma, role of IgH and c-myc genes (Madisen and Grou- dine), 2212-2226
C/EBP family,. CHOP (GAD153) (Barone et
al.), 453-464 transcriptional activation by c-myc
(Hann et al.), 2441-2452 C/EBP~, promotes adipogenesis in
mouse fibroblastic cells (Freytag et al.), 1654-1663. See also CCAAT/enhancer binding pro- tein-a
C/EBP~, phosphorylation-induced acti- vation by derepression (Ko- wenz-Leutz et al.), 2781-2791
c/ebp gene, revised sequence (Lincoln et al.), 1131-1132
c/ebp sequence. (Landschulz et al.), 786- 800 (Lincoln et al.), 1131-1132
c-Jun, cloning of JNK2 (Kallunki et al.), 2996-3007
c-myc expression stimulated by FBP (Duncan
et al.), 465-480 deregulation in plasmacytomas (Mad-
isen and Groudine), 2212-2226 c-Myc, regulation of transcription (Hann
et al.), 2441-2452 c-Src tyrosine kinase, required for mam-
mary tumorigenesis (Guy et al.), 23-32
Caenorhabditis elegans cell death gene ced-3 (Kumar et al.),
1613-1626 POU homeo box gene ceh-18, targeted
mutations in (Greenstein et al.), 1935-1948
unc-51 gene required for axonal elon- gation (Ogura et al.), 2389-2400
unc-lO1 gene encodes clathrin-associ- ated protein (Lee et al.), 60-73
vulval induction, role of MAP kinase homolog mpk-1 (Lackner et al.), 160-173
vulval signaling pathway, role of Sur-1 MAP kinase (Wu and Han), 147-159
Calcium influx, role in activation of CREB (Sun et al.), 2527-2539
Calcium-dependent, gene expression in plants (Bowler et al.), 2188- 2202
Calcium/calmodulin-dependent protein kinase, phosphorylation of CREB (Sun et al.), 2527-2539
cAMP regulation
by CREB (Sun et al.), 2527-2539 of morphogenesis in U. maydis
(Gold et al.), 2805-2816 signaling, late Dictyostelium develop-
ment, pattern formation and cell differentiation (Louis et al.), 2086-2096
Cancer, Wilms' tumor (WT) or nephro- blastoma (Sharma et al.), 720- 731
Candida albicans, cloning of BRF ho- molog (Khoo et al.), 2879-2890
CAP-dependent transcription, determi- nation of activation target for lac promoter (Tang et al.), 3058- 3067
CAR4, cAMP receptor, late Dictyostel- ium development (Louis et al.), 2086-2096
CAR80/CARGRI, identical to UME6 (Strich et al.), 796-810
Car, role in blue light response in M. xanthus (Nicolas et al.), 2375- 2387
Carcinogenesis, loss of genomic integ- rity (White et al.), 666-677
Cardiac dilation, in PDGF B-deficient mice
[Leyden et al.), 1875-1887 morphogenesis, mice, vitamin A sig-
naling pathway (Sucov et al.), 1007-1018
muscle-specific transcription, Xeno- pus embryos, regulated by SL1 protein (Chambers et al.), 1324- 1334
Cardiogenesis, role of TEF-1 in mice (Chen et al.), 2293-2301
Cardiomyopathy, from loss of Igf2r (Lau et al.), 2953-2963
GENES & DEVELOPMENT 3089
Carotenoid genes, in M. xanthus (Nico- l~is et al.), 2375-2387
Caulobacter, pole-specific repression in (Wingrove and Gober), 1839- 1852
CCAAT displacement protein, mamma- lian counterpart of Drosophila Cut homeo protein (Andr6s et al.), 245-257
CCAAT/enhancer binding protein-~ (C/ EBP% transcriptional activation of serum albumin •promoter (Nerlov and Ziff), 350-362
Cdc2 kinase, cell cycle regulator in Drosophila (Edgar et al.), 440- 452
Cdc28 kinase activity, down-regulation of in S. cerevisiae late mitosis (Donovan et al.), 1640-1653
Cdc28p protein kinase, yeast, activation of by G1 cyclins (Oehlen and Cross) (1058-1070)
CDF2, role as repressor of transcription • initiation (Iratni et al.), 2928- 2938
CDK4, identification of associated pro- teins {Guan et al.), 2939-2952
CDK6, identification of associated pro- teins (Guan et al.), 2939-2952
CDK inhibitor, P40 sDB2s, role in S. cere- visiae M/G1 transition (Dono- van et al.), 1640-1653
CED-3, gene product of C. elegans ced-3 gene, mouse Nedd2 gene en- codes protein similar to (Kumar et al.), 1613-1626
ceh-18 C. elegans gene, new member of POU homeo box genes (Green- stein et al.), 1935-1948
Cell-cell interactions, and Dictyostel- ium LagC protein (Dynes et al.), 948-958
Cell commitment, gastrula stage, ze- brafish pou2 gene (Takada et al.), 45-59
Cell cycle arrest
G1 phase, and S. pombe mating pheromone P-factor (Imai and Yamamoto), 328-338
control, mitotic checkpoint genes in budding yeast (Weinert et al.), 652-665
by inhibitor p27 Kipa (Polyak et al.), 9-22
control differential disruption of genomic
integrity in HPV-infected NHF (White et al.), 666-677
by Myc and p53 (Wagner et ai.), 2817-2830
progression, hyperphosphorylation of pRB during G 1 (Hatakeyama et al.), 1758-1771
role of p53 (Di Leonardo et al.), 2540-2551
by SAD1 (Allen et al.), 2401-2415 yeast, mechanism of position-effect
variegation (Aparicio and Gott- schling), 1133-1146
differential phosphorylation of E2F-4 (Ginsberg et al.), 2665-2679
G1/S arrest, CHOP, and TLS-CHOP (Barone et al.), 453-464
M/G1 transition in S. cerevisiae, role of P4oSDB2S (Donovan et al.), 1640-1653
multiple modes of regulation during Drosophila embryogenesis (Ed- gar et al.), 440-452
progression active cyclin kinases in quartemary
complex (Zhang et al.), 1750- 1758
G1 into S phase (Johnson et al.), 1514-1525
G1 to S phase (Hsiao et al.), 1526- 1537
role of E2F-4 (Beijersbergen et al.), 2680-2690
role of RB protein (Lee et al.), 2008- 2021
regulation of E2F transcription factor (Dyn-
lacht et al.), 1772-1786 and p21 function (Zhang et al.),
1750-1758 Cell death. See also Apoptosis
mouse Nedd2 gene product is similar to product of C. elegans ced-3 gene and mammalian IL-lf~- converting enzyme (Kumar et al.), 1613-1626
role of HNF-4 in mouse embryonic ec- toderm (Chen et al.), 2466-2477
Cell differentiation, and suppression of ld gene activity (Iavarone et al.), 1270-1284
Cell fate Drosophila
dorsoventral patterning (Mason et al.), 1489-1501
germ-cell specification (Jongens et al.), 2123-2136
and Xenopus achaete-scute homolog expression (Turner and Wein- traub), 1434-1447
Cell migration; Drosophila tracheal de- velopment, role of breathless (Reichman-Fried et al.), 428- 439
Cell movement, M. xanthus C-factor (Sager and Kaiser), 2793-2804
Cell proliferation, effect of HLH protein Id-2 on {Iavarone et al.), 1270- i284
Cerebellum, neurological abnormalities in bmi-1 mutant mice {van der Lugt et al.), 757-769
cGMP, role in chloroplast development (Bowler et al.), 2188-2202
Chain elongation, mutations in [3' sub-
unit of E. cob RNA polymerase (Weilbaecher et al.), 2913-2927
Checkpoint genes, budding yeast (Wei- nert et al.), 652-665, 948-958
Checkpoints cell cycle regulation [White et al.),
666-677 SAD1 and DNA damage (Allen et al.),
2401-2415 Chemotaxis, role of C-factor in M. xan-
thus (Sager and Kaiser), 2793- 2804
Chlorophyll a/b-binding protein, Arabi- dopsis (Li et al.), 339-349
Chloroplast, of Euglena gracilis, com- plex twintron within ycf8 gene (Hong and Hallick), 1589-1599
Chloroplasts, regulation of rDNA tran- scription (Iratni et al.), 2928-2938
CHO cells, sterol-resistant transcription in {Yang et al.), 1910-1919
Cholesterol homeostasis, and transcrip- tion factor SREBP-2 {Yang et al.), 1910-1919
Chondrocyte proliferation, role of PTHrP gene (Karaplis et al.), 277-289
Chondrodysplasia. See also Osteochon- drodysplasia
CHOP, binding to TLS and EWS, trans- formation of NIH-3T3 cells (Zinszner et al.), 2513-2526
CHOP (GADD153), growth arrest and DNA damage-inducible gene {Barone et al.), 453--464
Chromatin histone H1 incorporation and 5S
rRNA gene transcription (Bou- vet et al.), 1147-1159
repressive regions of (Cooper et al.), 1400-1410
role in transcription (Barton and Emer- son), 2453-2465
and transcriptional control in yeast (Aparicio and Gottschling), 1133-1146
Chromosome alterations induced by HPV16 E6 (Rez-
nikoff et al.), 2227-2240 breakage, Tetrahmena thermophila
rDNA minichromosome (Ka- pler and Blackburn), 84-95
binding, of Drosophila trithorax (Ku- zin et al.), 2478-2490
ends, maintenance of and telomerase (Autexier and Greider), 563-575
replication, origin activation (Ra- ghuraman et al.), 554-562
transcription of ~-globin (Barton and Emerson), 2453-2465
chs, regulation by cGMP and calcium (Bowler et al.), 2188-2202
Cipl, induction of p53 (Di Leonardo et al.), 2540-2551
Glass II genes, Drosophila, TFIID sequence
3090 GENES & DEVELOPMENT
recognition of initiator and downstream sequences (Purnell et al.), (830-842)
promoters, Drl repression of (Yeung et al.), 2097-2109
Clathrin-associated protein, encoded by C. elegans unc-lO1 (Lee et al.), 60-73
Cloning, of E2F-4 (Beijersbergen et al.), 2680-2690, (Ginsberg et al.), 2665-2679
CNS. See also Neural development Coactivator, activity of human TFIIA-~/
(Ozer et al.), 2324-2335 Coat assembly, B. subtilis, subcellular
~ !ocalization of proteins (Driks et al.), 234-244
Codon usage, in E. coli (Chen and In- ouye), 2641-2652
Coiled-coil oligomerization, in GABPI3 transcription factor (de la Brousse et al.), 1853-1865
Colorectal tumorigenesis, and human DCC gene product (Hedrick et al.), 1174-1183
Commitment complex (pre-mRNA-U1 snRNP), yeast spliceosome as- sembly (Abovich et al.), 843- 854
Complex promoter, multiple enhancers function autonomously (Gray et al.), 1829-1838
Complex twintron, within Euglena gra- cilis chloroplast ycf8 gene (Hong and Hallick), 1589-1599
Conceptus, mouse, postimplantation le- thality of (Spyropoulos and Capecchi), 1949-1961
Connective growth factor (CTGF), hu- man, weak resemblance to Drosophila protein encoded by twisted gastrulation gene (Ma- son et al.), 1489-1501
Contact inhibition, and cell cycle arrest (Polyak et al.), 9-22
Cooperative binding, to DNA (Whipple et al.), 1212-1223
Cooperative protein-protein interac- tions, cut repeat and homeo do- main of the cut homeo proteins (Andr6s et al.), 245-257
CotE B. subtilis protein, {Driks et al.), 234-244
CpG islands, methylation regulated by SP1 (Macleod et al.), 2282-2292
CPSF (polyadenylation specificity factor), and cytoplasmic polyadenyla- tion {Bilger et al.), 1106--1116
CREB phosphorylation by calcium/calmodu-
lin-dependent protein kinase (Sun et al.), 2527-2539
transcriptional activation (Sun et al.), 2527-2539
Crk adapter protein, SH3 domain binds to Abl (Ren et al.), 783-795
Cryptic splice sites, Tetrahymena group I intron (Downs and Cech), 1198-1211
Crystal structure, of PPR1-DNA com- plex (Marmorstein and Harri- son), 2504-2512
Cut homeo proteins, bipartite DNA- binding protein {Andrds et al.), 245-257
Cyanobacteria, Anabaena heterocyst differentiation (Carrasco et al.), 74-83
Cyclin 3' UTR of stimulates translation
by regulating polyadenylation (Sheets et al.), 926-938
cell cycle regulator in Drosophila (Ed- gar et al.), 440--452
Cyclin-dependent kinase inhibitor
correlation of growth suppression with pRb function (Guan et al.), 2939-2952
regulation by p53 (Wagner et al.), 2817-2830
kinases (cdks) cyclin E-Cdk2 complexes, p27 Kip1
inhibitor binds complexes and inhibits activation {Polyak et al.), 9-22
role in hyperphosphorylation of pRB (Hatakeyama et al.), 1758-1771
Cyclin D1, inhibition of DNA synthesis (Pagano et al.), 1627-1639
Cyclin kinases, p21-containing (Zhang et al.), 1750-1758
Cyclization, Tetrahymena RNA splicing (Downs and Cech), 1198-1211
D
Danforth's short tail (Sd) gene, mouse mutation (Swiatek et al.), 707- 719
Darkener of apricot {Doa) locus, Droso- phila, eye and embryonic devel- opment (Yun et al.), 1160-1173
Dbf2 protein kinase, S. cerevisiae, func- tion in late mitosis (Donovan et al.), 1640-1653
DCC human gene product, differentia- tion and tumorigenesis {He- drick et al.), 1174-1183
Dcdc42, GTPase subfamily (Luo et al.), 1787-1802
Deadenylation, triggers decay of MFA2 mRNA (Muhlrad et al.), 855- 866
Decapentaplegic {DPP) signaling mole- cule, and dorsal midline cell fate (Mason et al.), 1489-1501
Decapping, of mRNA (Muhlrad et al.), 855-866
Derepression, as a mechanism for acti- vating NF-M (Kowenz-Leutz et al.), 2781-2791
Desensitization, of cGMP and calcium signals (Bowler et al.), 2188- 2202
Development of Drosophila regulated by escargot
(Fuse et al.), 2270-2281 HNF-4 and mouse embryo {Chen et
al.), 2466-2477 role of targeted gene disruption (Chen
et al.), 2293-2301 Developmental mutant, of Dictyostel-
ium discoideum (Dynes et al.), 948-958
Developmental regulation, Wilms' tu- mor susceptibility gene (Sharma et al.), 720-731
DFGF-R1. See Breathless Dictyostelium discoideum
cAMP signaling required for pattern formation and cell differentia- tion (Louis et al.), 2086-2096
G-box binding factor (GBF) and devel- opmental switch from early to late development (Schnitzler et al.), 502-514
LagC protein functions as cell-cell sig- naling molecule (Dynes et al.), 948-958
Differential gene expression, on new dominant agouti allele {A iapy) (Michaud et al.), 1463-1472
Differentiation and human DCC gene product (He-
drick et al.), 1174-1183 -specific activation of gene expression
{Nerlov and Ziff), 350-362 Dimer-dimer interactions, specificity
determinants for (Whipple et al.), 1212-1223
Dimerization , coiled-coil dimerization between GABPI~ subunits {de la Brousse et al.), 1853-1865
Dimorphism role of MAP kinase pathway in S. cer-
evisiae (Roberts and Fink), 2974-2985
See also Fungal dimorphism Diploidy, regulation by Drosophila es-
cargot (Fuse et al.), 2270-2281 Direct repression, by adenovirus EIB
55K of p53 activity (Yew et al.), 190-202
Discard pathway, role of Ro autoantigen in 5S rRNA production (O'Brien and Wolin), 2891-2903
dishevelled {dsh) gene, Drosophila, role in Wg signaling (Klingensmith et al.), 118-130
DNA binding
activity of TFIIA (Yokomori et al.), 2313-2323
inhibited by POZ domain (Bardwell and Treisman), 1664-1677
to S. pombe MGB elements (Zhu et al.), 885-898
GENES & DEVELOPMENT 3091
binding protein, sequence-specific, single-stranded FBP activates FUSE of c-myc (Duncan et al.), 465-480
damage growth arrest and DNA damage-in-
ducible gene CHOP (Barone et al.), 453-464
induction by ~/ irradiation, role of p53 (Di Leonardo et al.), 2540- 2551
and mitotic checkpoints (Weinert et al.), 652-665
and replication origin activation (Raghuraman et al.), 554-562
role of SAD1 (Allen et al.), 2401- 2415
imprinting, and new agouti allele A iapy (Michaud et al.), 1463-1472
methylation, of CpG islands (Macleod et al.), 2282-2292
rearrangements, Anabaena heterocyst differentiation (Carrasco et al.), 74-83
recognition, by PPR1 and GAL4 (Mar- morstein and Harrison), 2504- 2512
repair branched DNA structures, impor-
tant intermediates for nucle- otide excision repair (Har- rington and Lieber), 1344-1355
role of basal factor TFIIE (Maxon et al.), 515-524
S. cerevisiae of transcriptionally silent chroma-
tin (Paetkau et al.), 2035-2045 RAD6 and RAD18 complex
(Bailly et al.), 811-820 replication
and mitotic checkpoints (Weinert et al.), 652-665
Xenopus, B-globin (Barton and Em- erson), 2453-2465
stability, in HPV16 E7-immortalized HUC cells (Reznikoff et al.), 2227-2240
synthesis, cyclin D1 inhibition of (Pa- gano et al.), 1627-1639
DNA-protein interactions, and specific- ity of HOX protein function (Zappavigna et al.), 732-744
DNA binding activity
of Drosophila hairy (Ohsako et al.), 2743-2755
inhibition of Su(H) and RBP-JK/KBF2 by H {Brou et al.), 2491-2503
of mi gene (Hemesath et al.), 2770- 2780
of S. cerevisiae RRN6 and RRN7 (Keys et al.), 2349-2362
of TBP (Tansey et al.), 2756-2769 domain
bHLH of E47 (Ellenberger et al.), 970-980
of Drosophila T gene (Kispert et al.), 2137-2150
of Ets (Kraut et al.), 33-44 of rat glucocorticoid receptor (Lefs-
tin et al.), 2842-2856 motif of TEF-1 (Chen et al.), 2293-
2301 of PAX paired domains (Epstein et al.),
2122-2134 properties
bHLH domains of transcription fac- tors (Ellenberger et al.), 970-980
of PPR1 and GAL4 (Marmorstein and Harrison), 2504-2512
protein cut repeats define novel family of bi-
partite DNA-binding proteins (Andr4s et al.), 245-257
Dictyostelium GBF transcription factor (Schnitzler et al.), 502-514
LEF-1, knockout in mice (van Gen- deren et al.), 2691-2703
RORc, isoforms (Gigu4re et al.), 538- 553
DNA-mediated allostery, Of glucocorti- coid receptor (Lefstin et al.), 2842-2856
Domain swiveling, DNA-binding do- main of HAP1 homodimer (Zhang end Guarente), 2110- 2119
Dominant interfering alleles, define role for c-Myb in T-cell develop- ment (Badiani et al.), 770-782
Dominant-negative variants, of activin in fish (Michaud et al.), 1463- 1472
Dominant-negative, allele of Rad51 (Donovan et al.), 2552-2562
Dorsal (dl) morphogen, regulation of by tor and Toll signaling pathways (Rusch and Levine), 1247-1257
Dorsal-ventral axis, ventral cells, Droso- phila sog and dpp (Francois et al.), 2602-2616
Dorsoventral (D/V) patterning. See also Patterning
Drosophila, twisted gastrulation gene (Mason et al.), 1489-1501
polarity, Drosophila oogeneis, speci- fied by Raf (Brand and Perri- mon), 629-639
DORV (double outlet right ventricle), 2792 (Corrigendum)
Dosage compensation, Drosophila male X chromosome, histone acetyla-
tion (Bone et al.), 96-104 sex specificity of (Palmer et al.), 698-
706 Double-strand break repair, role of
Rad51 and Rad52 (Donovan et al.), 2552-2562
dpp, interaction with sog (Francois et al.), 2602-2616
Dr 1 repressor of transcription, interac-
tion with TBP mediates func- tion (Yeung et al.), 2097-2109
Dracl, involved in Drosophila axonal outgrowth and myoblast fusion (Luo et al.), 1787-1802
Drosophila Cut homeo protein {Andr6s e t al.),
245-257 determination of anterior structures
by bicoid (Payre et al.), 2718- 2728
dorsal (d/) morphogen, regulation of by Toll and tot signaling pathways {Rusch and Levine), 1247-1257
dorsal midline fate requires twisted gastrudation gene (Mason et al.), 1489-1501
dosage compensation and histone acetylation (Bone et al.), 96-104
early cell cycle regulation (Edgar et al.), 440-452
embryos, short-range repression in (Gray et al.), 1829-1838
germ-cell specification, role of gcl {lon- gens et al.), 2123-2136
gypsy element has properties of insect retrovirus (Song et al.), 2046- 2057
homeo domain proteins eve and ftz, in vivo DNA binding by (Walter et al.), 1678-1692
imaginal disc, direct downstream tar- gets of proneural activators {Singson et al.), 2058-2071
neurogenesis, repo gene encodes glial- specific homeo domain protein (Xiong et al.), 981-994
oogenesis orb mutations affect polarity (Chris-
terson and McKearin), 614-628 Orb protein and RNA localization
(Lantz et al.), 598-613 pair-rule genes
odd-paired (opa) is expressed in all segments (Benedyk et al.), 105- 117
stripe-specific regulation of, by hop- scotch (Binari and Perrimon), 300-312
Raf specifies dorsoventral polarity (Brand and Perrimon), 629-639
regulation of achaete transcription by hairy {Van Doren et al.), 2729- 2742
repression of achaete by hairy (Ohsako et al.), 2743-2755
requirement of PICA for anteroposte- rior axis development (Lane and Kalderon), 2986-2995
role of sog and dpp in pattern forma- tion in dorsal region (Francois et al.), 2602-2616
role of T and Trg in hindgut specifica- tion (Kispert et al.), 2137-2150
segmentation, role of slp (Cadigan et al.), 899-913
3092 GENES & DEVELOPMENT
sex determination genes snf and Sxl (Flickinger and Salz), 914-925
sex-specific regulation of msl-1 dosage compensation gene (Palmer et al.), 698-706
signal transduction, role of dsh in Wg signaling (Klingensmith et al.), 118-130
Sxl RNA binding and splicing (Wang and Bell), 2072-2085
TFIIF binding, downstream contacts (Purnell et al.), (830-842)
tracheal development, role of breath- less (Reichman-Fried et al.), 428-439
transcriptional activation by TFIIA (Yokomori et al.), 2313-2323
trithorax, chromosomal binding (Ku- zin et al.), 2478-2490
Drosophila melanogaster, Doa locus en- codes protein kinase essential for eye and embryonic develop- ment (Yun et al.), 1160-1173
E
E1A-associated proteins, p300 transcrip- tional adaptor properties (Eck- net et al.), 869-884
E1B 55K. See also Adenovirus E1B 55K E2 box, binding by escargot protein (Fuse
et al.), 2270-2281 E2F transcription factor, regulation of
linked to cell cycle-dependent activation of kinases (Dynlacht et al.), 1772-1786
E2F-4, interaction with p107 (Ginsberg et al.), 2665-2679, (Beijersber- gen et al..), 2680-2690
E2F1 gene expression, autoregulatory control of during cell cycle pro- gression (Johnson et al.), 1514- 1525
E2F1 promoter, growth regulation of (Hsiao et al.), 1526-1537
E2F family, cloning of E2F-4 (Ginsberg et al.), 2665-2679, (Beijersbergen et al.), 2680-2690
El2, role in activation of IgH enhancer (Weintraub et al.), 2203-2211
E26 avian leukemia virus, Myb-Ets fu- sion protein (Kraut et al.), 33-44
E47 transcription factor, crystal struc- ture of (Ellenberger et al.), 970- 980
E-box binding of MyoD and El2 (Weintraub
et al.), 2203-2211 consensus sequence, DNA-binding
sites of bHLH proteins (Ellen- berger et al.), 970-980
transcriptional activation by c-myc (Harm et al.), 2441-2452
EBS, role of keratin genes (Rugg et al.), 2563-2573, (Chan et al.), 2574- 2587
EGF receptor, Drosophila (Brand and Perrimon), 629-639
EGF receptor tyrosine kinase, point mu- tation results in waved-2 phe- notype (Luetteke et al.), 399- 413
Egg chamber, Drosophila oogenesis (Lantz et al.), 598-613
EIIIB exon, of rat fibronectin (FN) gene (Huh and Hynes), 1561-1574
Elk1 activation by RAS/MAP kinase path-
ways (Hipskind et al.), 1803- 1816
ets factor, as relating to new ets mem- ber Net (Giovane et al.), 1502- 1513
Elongation factor, SELB (Ringquist et al.), 376-385
Embryogenesis zebrafish pou2, alternatively spliced
twin products of (Takada et ai.), 45-59
Drosophila, early cell cycle regula- tion (Edgar et al.), 440-452
Embryonic development
in Drosophila controlled by bicoid and serendipity (Payre et al.), 2718-2728
HNF-4 in mouse embryo (Chen et al.), 2466-2477
patterning, RNA localization (Lantz et al.), 598-613
stem (ES) cells GATA-1- and erythroid develop-
ment (Weiss et al.), 1184-1197 gene targeting generated PDGF B-re-
ceptor mutant mice (Soriano), 1888-1896
mice, targeted disruption of Nfl (Brannan et al.), 1019-1029
targeted disruption of Igf2r gene (Lau et al.}, 2953-2963
End formation, RNA 3' (Manley and Proudfoot), 259-264 Meeting Review
Endonucleases. See also Nucleases Endoribonuclease, identification of S.
cerevisiae SNM1 gene product as a component (Schmitt and Clayton), 2617-2628
Endothelial cell growth, mouse embryos, role of Tek RTK (Dumont et al.), 1897-1909
engrailed (en) segment polarity gene, Drosophila (Benedyk et al.), 105-117, (Cadigan et al.), 899- 913
Enhancer activity, and p300 (Eckner et al.), 869-884
Enhancers in B-globin transcription (Barton and
Emerson), 2453-2465 interaction with p300 (Eckner et al.),
869-884
and quenching in Drosophila complex promoters (Gray et al.), 1829- 1838
Epidermal differentiation, C. elegans, role of POU gene ceh-18 (Green- stein et al.), 1935-1948
Epidermolytic hyperkeratosis, role of keratin 14 (Chan et al.), 2574-- 2587
Epithelium, role of keratin 8 gene in de- velopment (Baribault et al.), 2964-2973
Epstein-Barr virus, Zta activation do- main (Lieberman and Berk), 995-1006
ERK1 human MAP kinase, and C. ele- gans MAP kinase homolog (Lackner et al.), 160--173
Erythroblastosis, in PDGF B-deficient. mice (Lev6en et al.), 1875-1887
Erythroid development, in vitro differen- tiation of GATA-1- ES cells (Weiss et al.), 1184-1197
Erythropoiesis, retinoic acid and lym- phohematopoietic progenitors (Tsai et al.), 2831-2841
ES cells. See Embryonic stem cells escargot, Drosophila, transcriptional re-
pression (Fuse et al.), 2270-2281 Escherichia coli
mutations in RNase E and RNase P and regulation of mRNA pro- cessing (Alifano et al.), 3021- 3031
proteins that stimulate group I splic- ing (Coetzee et al.), 1575-1588
role of pyrB1 operon in transcriptional initiation (Liu et al.), 2904-2912
SELB translational elongation factor, identification of binding sites and interaction with initiation com- plex (Ringquist et al.), 376-385
EsT cloning, of human TFIIA (Ozer et al.), 2324-2335
ETS-related proteins, mechanism of acti- vation (Hipskind et al.), 1803- 1816
ets gene family, new member Net en- codes transcription factor acti- vated by Ras (Giovane et al.), 1502-1513
Euglena gracilis, chloroplast ycf8 gene, complex twintron within (Hong and Hallick), 1589-1599
even-skipped (eve) gene, Drosophila homeo domain protein, in vivo DNA
binding by (Walter et al.), 1678- 1692
murine evxl homolog of (Spyropoulos and Capecchi), 1949-1961
Evolutionary conservation comparison of human and yeast
TATA-binding proteins (Cot- mack et al.), 1335-1343
cut repeats ('Andr6s et al.), 245-257 human and rat RNA editing of WT1
GENES & DEVELOPMENT 3093
transcript (Sharma et al.), 720- 731
neurofibromin (Bran_nan et al.), 1019- 1029
Notch gene (Swiatek et al.), 707-719 Ras-mediated signal-transduction path-
ways (Wu and Han), 147-159 evxl murine gene, homolog of Droso-
phila eve gene, role in initiating gastrulation (Spyropoulos and Capecchi), 1949-1961
EWS, and TLS binding to CHOP (Zin- szner et al.), 2513-2526
Expression of Drosophila trithorax and fork head
(Kuzin et al.), 2478-2490 regulation by rare arginine codons
(Chen and Inouye), 2641-2652 Extraceilular signal, produced by As-
pergillus fluG gene (Lee and Ad- ams), 641-651
Eye development human, and PAX6 mutation (Epstein
et al.), 2122-2134 Drosophila Doa locus (Yun et al.),
1160-1173 Eyelid development, mouse, and activin
B/inhibin B {Vassalli et al.), 414-427
F
FAR1 gene, S. cerevisiae, and pheromone treatment (Oehlen and Cross), (1058-1070)
FBP (FUSE-binding protein), sequence- specific, single-stranded DNA- binding protein stimulates c- myc expression (Duncan et al.), 465-480
fdxN gene, Anabaena (Carrasco et al.), 74-83
Female reproduction, mouse, and activin B/inhibin B (Vassalli et al.), 414-427
FEN-l, murine structure-specific endo- nuclease, related to S. cerevisiae RAD2 family (Harrington and Lieber), 1344-1355
Fetal growth, regulation by Igf2r (Lau et al.), 2953-2963
FGFR-1, required for postimplantation growth and axial organization (Deng et al.), 3045-3057
fgfr-1, requirement for embryonic growth during mouse gastrula- tion (Yamaguchi et al.), 3032- 3044
fgr src. See src gene family Fibroblastic cells, C/EBP~ promotes adi-
pogenesis (Freytag et al.), 1654- 1663
Fibroblast growth factor (FGF) receptor homolog, breathless, role in
Drosophila tracheal cell migra-
tion (Reichman-Fried et al.), 428--439
signaling role in axial organization (Deng et al.),
3045-3057 of fgfr-1 gene in mesoderm induc-
tion (Yamaguchi et al.), 3032- 3044
Fibroblasts human
G 1 cells, cyclin D1 function (Pagano et al.), 1627-1639,
p21-containing cyclin kinases, ac- tive and inactive states (Zhang et al.), 1750-1758
normal human diploid, p53-dependent G1 arrest (Di Leonardo et al.), 2540-2551
normal human (NHF), infected by HPV oncoproteins, differential disruption of genomic integrity (White et al.), 666-677
TGF-[M and tumor progression (Glick et al.), 2429-2440
Fibronectin mRNA, regulation of alter- native splicing by hexanucle- otide element (Huh and Hynes), 1561-1574
Filamentous fungus, Aspergillus nidu- lans (Lee and Adams), 641-651
Fission yeast. See Schizosaccharomyces pombe
5S rRNA, processing, binding to Re au- toantigen (O'Brien and Wolin), 2891-2903
Flagellar biogenesis, Caulobacter (Win- grove and Gober), 1839-1852
Flower development Arabidosis (Goto and Meyerowitz),
1548-1560 genetic and molecular analyses (Ma),
745-756 Review fluG Aspergillus gene, required for pro-
duction of extracellular devel- opmental signal (Lee and Ad- ams), 641-651
Footprinting, SP1 and CpG islands (Ma- cleod et al.), 2282-2292
fork head, regulation of expression by trithorax (Kuzin et al.), 2478- 2490
forkhead domainl of Drosophila slp pro- teins (Cadigan et al.), 899-913
fos SRE, SRF binding requires Net (Gio- vane et al.), 1502-1513
FSH[~, regulation by SF-1 (Ingraham et al.), 2302-2312
fugl gene, murine homolog of yeast RNA1 gene (DeGregori et al.), 265-276
Fungal dimorphism, Ustilago maydis (Banuett and Herskowitz), 1367-1378
Fungal life cycle, U. maydis, identifica- tion and role of Fuz7 (Banuett and Herskowitz), 1367-1378
FUS1 gene, S. cerevisiae, and pheromone treatment (Oehlen and Cross), (1058-1070)
Fus3 MAP kinase, S. cerevisiae, associ- ates with and phosphorylates Ste5 (Kranz et al.), 313-327
FUSE (far upstream element), of human c-myc proto-oncogene (Duncan et al.), 465--480
fushi tarazu (ftz), Drosophila homeo do- main protein, in vivo DNA binding of (Walter et al.), 1678- 1692
Fusion oncoproteins, Myb--Ets (Kraut et al.), 33-44
Fusion protein, S. cerevisiae (Burns et al.), 1087-1105
Fuz7, a Ustilago maydis MEK/MAPKK (Banuett and Herskowitz), 1367-1378
Fyn, tyrosine kinase Src family (Stein et al.), 1999-2007
G
G-box binding factor (GBF), Dictyostel- ium development, switch from early to late development (Schnitzler et al.), 502-514
G 1 cyclins and autoregulatory control of E2F1 ex-
pression (Johnson et al.), 1514- 1525
CLN1 and CLN2, repress mating fac- tor response pathway in yeast (Oehlen and Cross), 1058-1070
functional inactivation of retinoblas- toma protein (Hatakeyama et al.), 1758-1771
GABP~ transcription factor, molecular characterization (de la Brousse et al.), 1853-1865
GADD153 gene. See CHOP GAL4 binding sites, fusion with E1B 55K
(Yew et al.), 190-202 GAL4, DNA-binding properties in yeast
(Marmorstein and Harrison), 2504-2512
irradiation, DNA damage, effect of p53 and Cipl (Di Leonardo et al.), 2540-2551
Gastrointestinal tract, role of mk8 in de- velopment (Baribault et al.), 2964-2973
Gastrulation mice, role of evxl expression (Spyro-
poulos and Capecchi), 1949- 1961
regulation by Wnt-3a in mouse em- bryos (Takada et al.), 174-189
role of fgfr-1 gene (Yamaguchi et al.), 3032-
3044 FGFR-1 (Deng et al.), 3045-3057 HNF-4 in development (Chen et al.),
2466-2477
3094 GENES & DEVELOPMENT
Gene activation, phosphorylation of NF-M
leads to derepression (Kowenz- Leutz et al.), 2781-2791
amplification and HPV oncoproteins (White et al.),
666-677 Tetrahymena rDNA minichromo-
some, blockage by germ-line ex- cision mutation (Kapler and Blackburn), 84-95
expression, light-regulated, Arabidop- sis (Li et al.), 339-349
identification, large-scale screen de- veloped for S. cerevisiae (Burns et al.), 1087-1105
induction, and S. pombe mating pher- omone P-factor (Imai and Ya- mamoto), 328-338
knockout, of mk8 gene in mice (Bari- bault et al.), 2964-2973
regulation, mediated by RXR and RAR (Valc~ircel et al.), 3068-3079
targeting absence of fgfr-1 gene and role in
mouse gastrulation (Yamaguchi et al.), 3032-3044
deletion of FGFR- 1 and role in devel- opment {Deng et al.), 3045-3057
in ES cells, PDGF f~-receptor mutant mice (Soriano), 1888-1896
of murine PTHrP gene (Karaplis et al.), 277-289
trap identification of TEF-1 gene (Chen
et al.}, 2293-2301 mice (DeGregori et al.), 265-276 mutagenesis, characterization of
murine fugl gene (DeGregori et al.), 265-276
General recombination, S. cerevisiae Sepl protein promotes parane- mic joint (Chen et al.), 1356- 1365
Genome stability, human uroepithelial cells (HUG) (Reznikoff et al.), 2227-2240
Genomic imprinting expression of Igf2 and Igf2r in mouse
embryos (Latham et al.), 290-299
role of maternal and paternal genes in fetal growth (Lau et al.), 2953- 2963
Genomic integrity, disruption of by HPV oncoproteins (White et al.), 666-677
Germ-cell specification, Drosophila, role of gcI (Jongens et al.), 2123-2136
Germ-cell-less, Drosophila, role in germ- cell specification pathway (Jon- gens et al.), 2123-2136
Germ line development, C. elegans, role of POU
gene ceh-18 (Greenstein et al.), 1935-1948
excision mutation (rmmll/6), Tetra- hyrnena thermophila, amplifi- cation blockage (Kapler and Blackburn), 84-95
GL2. See GLABRA2 GLABRA2 (GL2) homeo box gene, role
in trichome development in Ar- abidopsis (Rerie et al.), 1388- 1399
Glial cells, Drosophila, repo gene en- codes glial-specific homeo do- main protein (Xiong et al.), 981- 994
Glomerulus development, in PDGF B-deficient mice (Lev6en et al.), 1875-1887
Glucocorticoid receptor, DNA binding, transcriptional activation (Lefs- tin et al.), 2842-2856
Gonad migration, C. elegans, role of POU gene ceh-18 (Greenstein et al.), 1935-1948
Gonadal development, regulation by SF-1 (Ingraham et al.), 2302- 2312
Gonadotrope-specific markers, regula- tion by SF-1 (Ingraham et al.), 2302-2312
Group I introns bacteriophage T4, self-splicing proper-
ties (Coetzee et al.), 1575-1588 Tetrahymena (Downs and Cech),
1198-1211 Group III intron evolution, (Hong and
Hallick), 1589-1599 Growth
inhibition, role of c-myc overexpres- sion (Harm et al.), 2441-2452
regulation, of E2F1 promoter (Hsiao et al.), 1526-1537
GTPases, distinct morphogenetic func- tion of (Luo et al.), 1787-1802
Gut, role of keratin 8 gene in develop- ment (Baribault et al.), 2964- 2973
Gynogenone, and genomic imprinting (Latham et al.), 290-299
gypsy element, Drosophila, properties of insect retrovirus (Song et al.), 2046-2057
H
H19 RNA, association with imprinting (Pfeifer and Tilghman), 1867- 1874 Commentary
H. See Hairless (Brou et al.), 2491-2503 Hf~58 mouse gene, yeast homolog of
(Bachhawat et al.), 1379-1387 Hair follicle development, mice EGFR
activity {Luetteke et al.), 399-413
Hairless, interaction with Su(H) (Brou et al.), 2491-2503
hairy, transcriptional repressor of acha- ete (Van Doren et al.), 2729-
2742, (Ohsako et al.), 2743- 2755
HAP1 transcriptional activator, yeast, DNA-binding domain (Zhang and Guarente), 2110-2119
hck src. See src gene family Helix-loop--helix proteins
Drosophila achaete (ac) and scute (sc) {Singson et al.), 2058-2071
encoded by Xenopus achaete-scute ho- mologs (Turner and Weintraub), 1434-1447
Id-2, growth enhancement and pRb binding by (Iavarone et al.), 1270-1284
Hematological disorders, in PDGF B-re- ceptor mutant mice (Soriano), 1888-1-896
Hematopoiesis in bmi-1 mutant mice (van der Lugt et
al.}, 757-769 mouse ES cells (Weiss et al.), 1184-
1197 role of retinoic acid receptors (Tsai et
al.), 2831-2841 Hematopoietic stem cells, lineage com-
mitment (Kraut et al.), 33-44 Heterocyst differentiation, Anabaena,
DNA rearrangement during (Carrasco et al.), 74-83
Heterodimer, of RXR and RAR regulates retinoid-dependent transcrip- tion (Valc~ircel et al.), 3068- 3079
Hexanucleotide element, regulation of fibronectin mRNA alternative splicing (Huh and Hynes), 1561-1574
Hindgut specification, Drosophila, role of Brachyury (T) gene (Kispert et al.), 2137-2150
his operon, role of RNase E and RNase P in mRNA processing (Alifano et al.), 3021-3031
Histone acetylation, Drosophila male X chro-
mosome, dosage compensation (Bone et al.), 96-104
H1, Xenopus, in vivo regulation of chromomosomal 5S rRNA gene transcription (Bouvet et al.), 1147-1159
HIV-1, Rev trans-activator, nuclear ex- port of (Meyer and Malim), 1538-1547
HLH, hairy a transcriptional repressor of achaete
(Ohsako et al.), 2743-2755 repressor of Drosophila achaete (Van
Doren et al.), 2729-2742 HNF, cell death in mouse embryo (Chen
et al.), 2466-2477..- hnRNP, binding to TLS and EWS (Zin-
szner et al.), 2513-2526 Homeo box gene, GLABRA2 (GL2), role
in normal trichome develop-
GENES & DEVELOPMENT 3095
ment in Arabidopsis (Rerie et al.), 1388-1399
Homeo box-containing (HOX) genes, transcription of (Zappavigna et al.), 732-744
Homeo domain of c~2 interacts with WD repeats (Ko-
machi et al.), 2857-2867 of Cut and Cut-like proteins (Andrds
et al.), 245-257 of HOX proteins (Zappavigna et al.),
732-744 proteins
Drosophila even-skipped (eve) and fushi tarazu (ftz), DNA targets of (Walter et al.), 1678-1692
Drosophila, repo gene encodes glial- specific protein (Xiong et al.), 981-994
encoded by GLABRA2 gene, role in normal trichome development in Arabidopsis (Rerie et al.), 1388-1399
Homeotic gene Arabidopsis PISTILLATA (PI) gene
(Goto and Meyerowitz), 1548- 1560
fork head, regulation of expression by trithorax (Kuzin et al.), 2478- 2490
Homodimers, HAP1, asymetric binding (Zhang end Guarente), 2110-2119
Homologous pairing, S. cerevisiae Sepl protein promotes a paranemic joint (Chen et al.), 1356-1365
Homologous recombination recombination hot spots (Wahls and
Smith), 1693-1702 and reverse mutations in mouse agouti
locus (Bultman et al.), 481-490 and S. pombe rec mutants (De Veaux
and Smith), 203-210 hopscotch (hop)gene, Drosophila, stripe-
specific regulation of pair-rule genes (Binari and Perrimon), 300-312
HOX protein function, specificity of de- pends on DNA-protein and pro- tein-protein interactions (Zap- pavigna et al.), 732-744
HPV16 E6/E7, role in senescence and ge- nome stability (Reznikoff et al.), 2227-2240
HPV oncoproteins, infection of normal human fibroblasts, differential disruption of genomic integrity (White et al.), 666-677
HPV-16 E7, expression in transgenic mice, role of p53 (Howes et al.), 1300-1310
hrp48 factor, interaction with Droso- phila PSI (Siebel et al.), 1713- 1725
hsp70 promoter, Drosophila, interaction with TFIID (Purnell et al.), (830-842)
hTAFII250 , binding to TBP (Tansey et al.), 2756-2769
HUC, human uroepithelial cells, immor- talization by HPV16 (Reznikoff et al.), 2227-2240
Hypermethylation, of U8 RNA (Peculis and Steitz), 2241-2255
Hypersensitive site, murine IgH locus, regulation by c-myc expression (Madisen and Groudine), 2212- 2226
I
Id-2 helix-loop-helix protein, growth enhancement and pRb binding by (Iavarone et al.), 1270-1284
Igf2 and Igf2r imprinted genes, inactiva- tion occurs postfertilization (Latham et al.), 290-299
IGF2, regulation of fetal growth and heart development (Lau et al.), 2953-2963
Igf2r, insulin-like growth factor II/cation- independent mannose 6-phos- phate receptor, role in fetal growth (Lau et al.), 2953-2963
IgH cis-acting negative element directed at
MyoD (Weintraub et al.), 2203- 2211
transcription, DNase I hypersensitive sites (Madisen and Groudine), 2212-2226
Imaginal disc Drosophila, direct downstream targets
of proneural activators (Singson et al.), 2058-2071
Drosophila escargot (Fuse et al.), 2270--2281
Immortalization, of lymphohematopoie- tic progenitors by retinoic acid receptors (Tsai et al.), 2831- 2841
Immune response, mice, targeted disrup- tion of src genes, hck and fgr, impairs immunity (Lowell et al.), 387-398
Immunoglobulin antigen receptor, regulatory role of
components in B-cell develop- ment (Spanopoulou et al.), 1030-1042
gene rearrangement, v-abl suppress- es light-chain rearrangement (Chen et al.), 688-697
HC and LC expression, influence on B-cell differentiation (Young et al.), (1043-1057)
transgenes, HC and LC, introduction into RAG-2-deficient mice (Young et al.), (1043-1057)
Immunoglobulin-CAM family, mem- brane-bound protein encoded by human DCC gene (Hedrick et al.), 1174-1183
Immunohistochemistry, analysis of hu- man DCC gene product (He- drick et al.), 1174-1183
Imprinting. See also Genomic imprint- ing (Binari and Perrimon), 300- 312
association with X chromosome inac- tivation (Pfeifer and Tilghman), 1867-1874 Commentary
In vitro differentiation, of GATA-1- ES cells
(Weiss et al.), 1184-1197 transcription, of E2F transcription fac-
tor (Dynlacht et al.), 1772-1786 UV cross-linking, Drosophila, mea-
sure DNA targets of homeo do- main proteins (Walter et al.), 1678-1692
Influenza virus NS1 protein, inhibition of pre-mRNA splicing (Lu et al.), 1817-1828
Inh, interaction with Tn5 (Weinreich et al.), 2363-2374
Inhibitor, p27 Kip1 cyclin-CDK inhibitor, role in cell cycle arrest (Polyak et al.), 9-22
Initiator element (Inr), core promoter element,
recognition of Inr by TFIID (Kaufmann and Smale), 821-829
within Drosophila class II gene pro- moters, TFIID sequence recog- nition of (Purnell et al.), (830- 842)
Insect retrovirus, Drosophila gypsy ele- ment (Song et al.), 2046-2057
Insertional mutagenesis, gene trap mu- tagenesis (DeGregori et al.), 265-276
Insulin-like growth factor II, required for regulating normal fetal growth (Lau et al.), 2953-2963
Integration targets, retrovirus integra- tion (Withers-Ward et al.), 1473-1487
Interleukin- 1 [~-converting enzyme, mammalian, mouse Nedd2 gene encodes protein similar to (Kumar et al.), 1613-1626
Intermediate filaments, involvement in EBS (Rugg et al.), 2563-2573, (Chan et al.), 2574-2587
Intracisternal A-particle yellow {Aiapy), dominant agouti allele (Mi- chaud et al.), 1463-1472
Introns, plants vs. yeast and animals (Luehrsen and Walbot), 1117- 1130
JNK, role in transcriptional activation of c-Jun (Kallunki et al.), 2996- 3007
JNK2, binding and phosphorylation of c- Jun (Kallunki et al.), 2996-3007
3096 GENES & DEVELOPMENT
K
K14. See Keratin (Rugg et al.), 2563- 2573, (Chan et al.), 2574-2587
K gene transcription, blocked by v-abl vi- ral transforming protein (Klug et al.), 678=687
KBF2, derived from RBP-JK gene (Brou et al.), 2491-2503
Keratin, human knockout (Rugg et al.), 2563-2573, (Chan et al.), 2574- 2587
Keratin 8, disruption causes colorectal hyperplasia (Baribault et al.), 2964-2973
Keratinocytes, TGF-f31 and tumor pro- gression (Glick et al.), 2429- 2440
Kidney development, abnormalities in PDGF ~-receptor mutant mice (Soriano), 1888-1896
Kidney malignancies, Wilms' tumor sus- ceptibility gene (WT1) (Sharma et al.), 720-731
Kinases, mice, functional overlap in the src gene family (Lowell et al.), 387-398
Kluyveromyces lactis cloning of BRF homolog (Khoo et al.),
2879-2890 RadS1 homolog (Don6van et al.),
2552-2562 Knockout, of LEF-1 in mice (van Gen-
deren et al.), 2691-2703
L
lac promoter, mutations defining activa- tion target (Tang et al.), 3058- 3067
LAMMER protein kinases, new Droso- phila protein kinase family, en- coded by Doa locus, (Yun et al.), 1160-1173
Lateral inhibitory signaling, Drosophila imaginal disc (Singson et al.), 2058-2071
LCR, role of IgH hypersensitive sites (Madisen and Groudine), 2212- 2226
LEF-1, organ development in mice (van Genderen et al.), 2691-2703
Lens development, mice, implications for tumor suppressor gene func- tion (Pan and Griep}, 1285-1299
Leucine zipper of C/EBP~, novel function of in cell-
type-specific gene expression (Nerlov and Ziff), 350-362
of CHOP, role in transformation (Zin- szner et al.), 2513-2526
proteins, C/EBPe~ promotes adipogene- sis (Freytag et al.), 1654-1663
S. cerevisiae SNM1 (Schmitt and Clay- ton), 2617-2628
Leukemogenesis, by fusion oncoproteins (Kraut et al.), 33-44
LH~, regulation by SF-1 (Ingraham et al.), 2302-2312
Light response, link with multicellular development in M. xanthus (Nicol~is et al.), 2375-2387
Lineage commitment, of hematopoietic stem cells (Kraut et al.), 33-44
LMPCR, CpG islands and methylation (Macleod et al.), 2282-2292
Locusta (Kispert et al.), 2137-2150 Lymphohematopoietic progenitors, reti-
noic acid and immortalization (Tsai et al.), 2831-2841
Lymphoid cells, Abelson routine leuke- mia virus transformation of (Chen et al.), 688-697
Lymphoid enhancer factor 1. See LEF-1 (van Genderen et al.), 2691- 2703
Lysosome, delivery of proteins to (Bach- hawat et al.), 1379-1387
M
M box, transcriptional activation by mi (Hemesath et al.), 2770-2780
M-CAT, binding factor, identity with TEF-1 (Ghen et al.), 2293-2301
Macrophages, mice, effects of hck and fgr deficiences (Lowell et al.), 387- 398
MADS box gene family, Arabidopsis PI is member of (Goto and Mey- erowitz), 1548-1560
Maize, splicing and polyadenylation, role of AU-rich motifs (Lue- hrsen and Walbot), 1117-1130
Male-specific lethal- 1 (msl-1) Drosophila gene, dosage compensation gene, sex-specific regulation of (Palmer et al.), 698-706
Mammary tumorigenesis, induced by PyV middle T antigen, c-Src re- quired for (Guy et al.), 23-32
MAP kinase cascade
in Drosophila (Hsu and Perrimon), 2176-2187
role in spore formation (Friesen et al.), 2162-2175
homolog C. elegans mpk-1, role in vulval de-
velopment (Lackner et al.), 160- 173
encoded by C. elegans sur-1 gene, role in vulval signal transduc- tion pathway (Wu and Hart), 147-159
S. cerevisiae SMK1 (Krisak et al.), 2151-2161
role ill activation of ternary complex fac-
tors (Hipskind et al.), 1803-1816
of JNK2 in phosphorylation of c-Jun (Kallunki et al.), 2996-3007
in mating and invasive growth in S. cerevisiae (Roberts and Fink}, 2974-2985
S. cerevisae Fus3, association with sig- naling component Ste5 (Kranz et al.), 313-327
Maternal mRNAs, regulation of polyade- nylation (Sheets et al.), 926-938
Maternally expressed gene, zebrafish pou2 (Takada et al.), 45-59
Mating factor response pathway, G 1 cy- clin repression of in yeast (Oehlen and Cross), 1058-1070
Mating pheromone P-factor, S. pombe (Imai and Yamamoto), 328-338
Mating type identity, yeast, role of SSN6 and TUP1 (Cooper et al.), 1400- 1410
Mating-type loci, regulation by SIR3 and RAP1 (Moretti et al.), 2257- 2269
Max, binding to c-myc (Harm et al.), 2441-2452
MCB elements, S. pombe cell division regulation (Zhu et al.), 885-898
mClox protein, mammalian counterpart of Drosophila Cut homeo pro- tein (Andrds et al.), 245-257
MCM1, yeast c, cells (Cooper et al.), 1400-1410
mdm2 proto-oncogene, regulation of ex- pression by p53 (Barak et al.), 1739-1749
mdm-2, binding to amino terminus of p53 (Linet al.), 1235-1246
Medaka fish, dominant-negative activin variants in (Michaud et al.), 1463-1472
MEF2 protein. See RSRF protein Meiosis
gene expression, transcriptional regu- lator UME6 (Strich et al.), 796- 810
S. pombe and pet1 + gene (Zhu et al.), 885-898
Meiotic recombination -deficient (rec) mutants, S. pombe (De
Veaux and Smith), 203-210 hot spot activity (Wahls and Smith),
1693-1702 region-specific activators in S. pombe
(De Veaux and Smith), 203-210 MEK, Drosophila signal transduction
(Hsu and Perrimon), 2176-2187 Melanocyte development, regulation by
mi (Hemesath et al.}, 2770-2780 Mesengial cells, absence of in PDGF
B-deficient mice (Lev4en et al.}, 1875-1887
Mesoderm formation, and Wnt signaling (Takada
et al.), 174-189 induction, role of
activin (Michaud et al:), 1463-1472
GENES & DEVELOPMENT 3097
fgfr-1 gene (Yamaguchi et al.), 3032- 3044
FGFR-1 (Deng et al.), 3045-3057 Mesodermalizing activity, of Xenopus
Brachyury gene (Xbra) (Rao), 939-947
Metastasis, mammary tumorigenesis, c-Src requirement (Guy et al.), 23-32
Metazoan splicing factor U2AF65, yeast gene MUD2 has sequence simi- larity to (Abovich et al.), 843- 854
Methylation and genomic imprinting (Latham et
al.), 290-299 role in differential expression of A i~py
mutation (Michaud et al.), 1463-1472
MFA2 mRNA, 5' --~ 3' decay (Muhrad et al.), 855-866
microphthalmia, a critical factor in me- lanocyte development (Heme- sath et al.), 2770-2780
MiT family, role in melanocyte develop- ment (Hemesath et al.), 2770- 2780
Mitosis (late), Sdb25 function leads to down-regulation of Cdc28 ki- nase activity (Donovan et al.), 1640-1653
Mitosis, early cell cycle regulation in Drosophila (Edgar et al.), 440- 452
Mitotic asynchrony, pole bud nuclei (Jongens
et al.), 2123-2136 checkpoint genes, budding yeast
(Weinert et al.), 652-665 MKS, mouse keratin 8 gene (Baribault et
al.), 2964-2973 Morphogenesis
C-factor, M. xanthus (Sager and Kai- ser), 2793-2804
cAMP and U. maydis (Gold et al.), 2805-2816
Morphogens, Drosophila dorsal (d/), reg- ulation of by tor and Toll signal- ing pathways (Rusch and Levine), 1247-1257
Motl global repressor, inhibits TBP bind- ing (Auble et al.), 1920-1934
Mouse activin B/inhibin B disruptions, eyelid
development and female repro- duction (Vassalli et al.), 414-427
agouti transcripts (Bultman et al.), 481-490
apoptosis, induction of by Nedd2 (Ku- mar et al.), 1613-1626
Brachyury gene, Xenopus homolog of (Xbra) (Rao), 939-947
development fugl gene required for postimplanta-
tion development (DeGregori et al.), 265-276
LEF-1 knockout (van Genderen et al.), 2691-2703
role of Notchl in postimplantation development (Swiatek et al.), 707-719
developmental defects in bmi-1 mu- tants (van der Lugt et al.), 757- 769
RAG-2 deficient, introduction of immunoglobulin transgenes into (Young et al.), (1043-1057)
embryonic stem (ES) cells, GATA-1- and erythroid development (Weiss et al.), 1184-1197
embryos gastrulation, regulation by Wnt-3a
(T~akada et al.), 174-189 Igf2 and Igf2r expression, genomic
imprinting and inactivation are separate processes (Latham et al.), 290-299
role of Tek RTK in vasculogenesis (Dumont et al.), 1897-1909
genes, H1358, yeast homolog of (Bach- hawat et al.),~1379-1387
HNF-4 and gastrulation (Chen et al.), 2466-2477
PDGF B mutants have renal, cardio- vascular, and hematological ab- normalities (Lev6en et al.), 1875-1887
PDGF f3-receptor mutants (Soriano), 1888-1896
Src family of tyrosine kinases (Stein et al.), 1999-2007
inactivation of src-like genes hck and fgr impairs natural immu- nity (Lowell et al.), 387-398
yeast RNA1 homolog fugl required for postimplantation development (DeGregori et al.), 265-276
mpk-1, C. elegans MAP kinase homolog, role in vulval induction (Lack- net et al.), 160-173
mPPAR~/2 (murine PPAR), adipocyte- specific transcription factor (Tontonoz et al.), 1224-1234
Murine genes, FEN-1 encodes structure-spe-
cific endonuclease (Harrington and Lieber), 1344-1355
lens morphogenesis, role of tumor sup- pressor gene products (Pan and Griep), 1285-1299
mRNA degradation, MFA2 mRNA, deadenyla-
tion followed by decapping and 5 ' ~ 3' digestion (Muhlrad et al.), 855-866
expression, XMyoD in Xenopus em- bryos (Rupp et al.), 1311-1323
localization, and Drosophila orb gene (Christerson and McKearin), 614-628
processing, role of RNase E and RNase P (Alifano et al.), 3021-3031
stability, influence of papl-1 mutants (Proweller and Butler), 2629" 2640
ms1 genes, Drosophila (Bone et al.), 96- 104
MTS2, C D K 4 - a n d CDK6-interacting protein (Guan et al.), 2939- 2952
Mu requirement for four active monomers
(Baker et al.), 2416-2428 transposase, promotion of transposi-
tion (Baker et al.), 2416-2428 MUD2 yeast protein, functional similar-
ity to metazoan splicing factor U2AF65 (Abovich et al.), 843- 854
Multicellular development, in M. xan- thus (Nicol~is et al.), 2375-2387
Multimer formation, basis for Tn5 cis preference (Weinreich et al.), 2363-2374
Multipotent progenitor cells (MEPs), transformation and prolifera- tion (Kraut et al.), 33-44
Muscle development. See also Myogenesis morphogenesis, Drosophila Dracl in-
volved in myoblast fusion (Luo et al.), 1787-1802
Myc, role of p53 in apoptosis (Wagner et al.), 2817-2830
Myelopoiesis, role of retinoic acid recep- tors (Tsai et al.), 2831-2841
Myoblast fusion, involvement of Droso- phila Dracl (Luo et al.), 1787- 1802
MyoD activation of myogenic genes (Wein-
traub et al.), 2203-2211 activity, negative regulation of (Rupp
et al.), 1311-1323 Myogenesis
bHLH factors (Olson and Klein), 1-8 Review
MyoD activity in Xenopus embryos (Rupp et al.), 1311-1323
Myogenic gene, activation by MyoD (Weintraub et al.), 2203-2211
Myosin light-chain gene, Xenopus em- bryo, regulated by SL1 protein (Chambers et al.), 1324-1334
Myxobacteria, light response and multi- cellular development (Nicol~is et al.), 2375-2387
Myxococcus xanthus role of C-factor in wave pattern (Sager
and Kaiser), 2793-2804 link between light response and mul-
ticellular development (Nicol~is et al.), 2375-2387
Myxoid liposarcoma human, presence of TLS-CHOP (Bar-
one et al.), 453-464 role of CHOP and TLS (Zinszner et
al.), 2513-2526
3098 GENES & DEVELOPMENT
N
N-ras oncogene, transformation of tran- scription factor AP-2 (Kannan et al.), 1258-1269
Natural scrapie, and Prp codon in sheep (Westaway et al.), 959-969
Negative regulation of XMyoD activity (Rupp et al.), 1311-
1323 by yeast NOT complex (Collart and
Struhl), 525-537 Negative selection, of B cells {Spanopou-
lou et al.), 1030-1042 Neural crest
LEF-1 and development (van Genderen et al.), 2691-2703
tissues derived from, 1019-1029 Neural development
mammalian, and Wnt-3a (Takada et al.), 174-189
regulation by C. elegans unc-51 (Ogura et al.), 2389-2400
Neuralizing activity, of Xenopus Brachyury mutant (Rao), 939- 947
Neurofibromatosis type 1 (NF1), targeted disruption of gene, mouse model system (Brannan et al.), 1019-1029, 2792 Corrigendum
Neurogenesis control by hairy and achaete (Van
Doren et al.), 2729-2742 Drosophila
imaginal disc (Singson et al.), 2058- 2071
repo gene encodes glial-specific ho- meo domain protein (Xiong et al.), 981-994
in Xenopus and achaete-scute ho- mologs (Turner and Weintraub), 1434-1447
Neuronal differentiation, role of RB protein (Lee
et al.), 2008-2021 morphogenesis, Drosophila Dracl in-
volved in axonal outgrowth (Luo et al.), 1787-1802
NF-KB/Rel factors, negatively regulated by v-abl tyrosine kinase (Klug et al.), 678-687
NF-M, homolog of C/EBP~ (Kowenz- Leutz et al.), 2781-2791
Nitrogen fixation, Anabaena heterocys- tous cyanobacterium (Carrasco et al.), 74-83
Nitrogen-signaling systems, and early meiotic gene expression (Strich et al.), 796-810
Non-AUG initiation, of c-myc activates transcription of C/EBP (Hann et al.), 2441-2452
NOT proteins, S. cerevisiae, inhibition of RNA polymerase II machin- ery (Collart and Struhl), 525- 537
Notochord, development and role of fgfr-1 gene (Yamaguchi et al.), 3032-3044
Nuclear export. See also Nucleocytoplasmic
transport intron evolution, (Hong and Hallick),
1589-1599 localization, of XMyoD (Rupp et al.),
1311-1323 polyadenylation factors, polyadenyla-
tion specificity factor (CPSF) and poly(A) polymerase (PAP) (Bilger et al.), 1106-1116
pores, of Drosophila pole cells (Jon- gens et al.), 2123-2136
receptor, SF-1, role in reproduction (In- graham et al.), 2302-2312
receptors (RORet family), DNA-bind- ing activity of (Gigudre et al.), 538-553
Nucleases, structure-specific endonu- cleases, murine FEN-1 related to S. cerevisiae RAD2 (Har- rington and Lieber), 1344-1355
Nucleocytoplasmic transport, HIV-1 Rev protein (Meyer and Malim), 1538-1547
Nucleolar snRNP, function in Xenopus oocytes (Peculis and Steitz), 2241-2255
Nucleophile selection, nuclear pre- mRNA splicing (Query et al.), 587-597
Nucleotide excision repair, structure- specific endonucleases FEN-1 and RAD2 are related (Har- rington and Lieber), 1344-1355
O
Oct-3 transcription factor, murine, ze- brafish pou2 related to (Takada et al.), 45-59
Oncogenes myc-mediated apoptosis (Wagner et
al.), 2817-2830 N-ras modulates transcription factor
AP-2 (Kannan et al.), 1258-1269 polyomavirus (PyV) middle T onco-
gene (Guy et al.), 23-32 ras (Giovane et al.), 1502-1513 role in derepression of NF-M (Kowenz-
Leutz et al.), 2781-2791 Oocyte
cell cycle arrest, C. elegans, role of POU gene ceh-18 (Greenstein et al.), 1935-1948
maturation, translational activation of mRNAs (Sheets et al.), 926-938
Oogenesis Drosophila, Orb protein and RNA lo-
calization (Lantz et al.), 598- 613
role of PKA in Drosophila develop-
ment (Lane and Kalderon), 2986--2995
orb gene, Drosophila oogenesis, required for A/P and D/V patterning (Christerson and McKearin), 614-628
Orb protein, and RNA localization in Drosophila oogenesis (Lantz et al.), 598-613
Organogenesis, affected by LEF-1 knock- out in mice (van Genderen et al.), 2691-2703
oskar regulation by PKA in Drosophila oocytes (Lane and Kalderon), 2986-2995
Osmotically regulated genes, Escherich- ia coli, regulation by ¢s factor (Lange and Hengge-Aronis), 1600-1612
Osteochondrodysplasias, human, poten- tial involvement of PTHrP (Ka- raplis et al.), 277-289
P
p18, CDK6-interacting protein (Guan et al.), 2939-2952
p21-containing cyclin kinases, active and inactive states of (Zhang et al.), 1750-1758
P22 repressor dimer, specificity determi- nants for dimer-dimer interac- tions (Whipple et al.), 1212- 1223
p27 Kip1 cyclin-Cdk inhibitor, role in cell cycle arrest (Polyak et al.), 9-22
P40 sDB2s, putative CDK inhibitor in- volved in S. cerevisiae M/G1 transition {Donovan et al.), 1640-1653
p53 binding to HPV16 E6 (Reznikoff et al.),
2227-2240 cell cycle arrest and induction of Cip 1
(Di Leonardo et al.), 2540-2551 gene, checkpoint function of (White et
al.), 666--677 oncoprotein expression, role in mouse
lens development (Pan and Griep}, 1285-1299
protein, mapping the amino-terminal functions (Lin et al.), 1235-1246
required for myc-mediated apoptosis (Wagner et al.), 2817-2830
transcription factor, direct repression by adenovirus E1B 55K (Yew et al.), 190-202
tumor suppressor gene, regulation of mdm2 expression (Barak et al.), 1739-1749
tumor suppressor protein regulates expression of the p21 gene
(Zhang et al.), 1750-1758 subtle role in regulation of normal
cell growth (Zhang et al.), 1750- 1758
GENES & DEVELOPMENT 3099
p107 association with E2F-4 (Beijersbergen
et al.), 2680-2690 binding to E2F-4 (Ginsberg et al.),
2665-2679 p300, 300-kD E1A-associated protein
with transcriptional adaptor properties (Eckner et al.), 869- 884
P element Drosophila, splicing of IVS3 (Siebel et
al.), 1713-1725 somatic inhibitor. See PSI
P-factor mating pheromone, S. pombe fission yeast (Imai and Ya- mamoto), 328-338
Pair-rule genes, Drosophila odd-paired (opa), expressed in all seg-
ments (Benedyk et al.), 105-117 stripe-specific regulation of by tyro-
sine kinase gene hop (Binari and Perrimon), 300-312
Paired domain, Pax (paired box) family transcription factors (Epstein et al.), 2022-2134
papl, effect on translation in S. cerevi- siae (Proweller and Butler), 2629-2640
Papillomaviral oncogenes, HPV-16 E6 and E7, inhibition of p53 and Rb (Pan and Griep), 1285-1299
Paranemic joint, and S. cerevisiae Sepl strand exchange protein {Chen et al.), 1356-1365
Parathyroid hormone-related peptide (PTHrP), role in normal skeletal development (Karaplis et al.), 277-289
Parathyroid hormone-related peptide gene, role in skeletal develop- ment (Karaplis et al.), 277-289
Particle assembly, in Xenopus oocytes (Peculis and Steitz), 2241-2255
Pattern formation. See also Pair-rule genes
Drosophila pair-rule gene expression (Binari
and Perrimon), 300-312 segment polarity genes (Cadigan et
al.), 899-913 late Dictyostelium development, reg-
ulated by cAMP receptor CAR4 (Louis et al.), 2086-2096
of primitive streak regulated by FGFR-1 {Deng et al.), 3045-3057
role of Drosophila sog and dpp (Frangois et
al.), 2602-2616 dsh in wg-mediated events (Klingen-
smith et al.), 118-130 orb gene (Christerson and McK-
earin), 614-628. Pax (paired box) transcription factors, al-
ternative binding b y subdo- mains (Epstein et al.), 2022- 2134
PCNA (proliferating cell nuclear anti- gen), and DNA repair (Pagano et al.), 1627-1639
pctl + gene, required for meiosis in S. pombe (Zhu et al.), 885-898
PDGF B. See Platelet-derived growth fac- tor B
PEP8 yeast gene, homolog of mouse H~58 gene {Bachhawat et al.), 1379-1387
Peripheral nervous system, pattern for- mation regulated by hairy and achaete (Van Doren et al.), 2729-2742
Peroxisome proliferator-activated recep- tor (PPAR), routine PPAR (mPPAR72) (Tontonoz et al.), 1224-1234
Phage k, specificity determinants for dimer-dimer interactions (Whip- ple et al.), 1212-1223
Pheromone signaling, yeast cell cycle (Oehlen and Cross), (1058-1070)
Phosphoribosyltransferase {aprt), meth- ylation of CpG islands (Macleod et al.), 2282-2292
Phosphorylation of c-Jun by JNK2 (Kallunki et al.),
2996-3007 of E2F by cyclin-kinase compexes
{Dynlacht et al.), 1772-1786 of E2F-4 during the cell cycle (Gins-
berg et al.), 2665-2679 of NF-M induces activation via dere-
pression (Kowenz-Leutz et al.), 2781-2791
of retinoblastoma protein, cyclin regu- lated (Hatakeyama et al.), 1758- 1771
of SpoIIAA by SpoIIAB (Diederich et al.), 2653-2663
Photo-cross-linking, of branch-site asso- ciated proteins (MacMillan et al.), 3008-3020
Photomorphogenesis. See also Pho- totransduction pathway
Photoreceptors, inactivation of pRB in (Howes et al.), 1300-1310
Phototransduction pathway, Arabidop- sis (Li et al.), 339-349
Phylogeny, common secondary structure of telomerase RNAs (Lingner et al.), 1984-1998
Phytochrome, signal transduction (Bowl- er et al.), 2188-2202
Pigmentation, mouse agouti locus (Bult- man et al.), 48t--490
Plant pathogen, basidiomycete fungus Ustilago maydis (Banuett and Herskowitz), 1367-1378
Plasmacytoma, murine, c-myc and IgH locus (Madisen and Groudine), 2212-2226
Plasmids, origin activity on cut and un- cut plasmids (Raghuraman et al.), 554-562
Platelet-derived growth factor (PDGF) a-receptor (Soriano), 1888-1896 l~-receptor mutant mice (Soriano),
1888-1896 B (PDGF B) defiency, mutant mice
show renal, cardiovascular and hematological abnormalities (Le- v6en et al.), 1875-1887
Polarity, Drosophila oogenesis (Brand and Perrimon), 629-639
Orb protein and RNA localization {Lantz et al.), 598-613
role of orb gene (Christerson and McKearin), 614-628
Poliovirus, RNA replication coupled to translation (Novak and Kirkeg- aard), 1726-1737
Poly(A) -deficient cells, efficient translation in
S. cerevisiae (Proweller and But- ler), 2629-2640
mRNA, inhibition of nuclear export by NS1 protein (Lu et al.), 1817- 1828
polymerase {PAP, and cytoplasmic polyadenylation (Bilger et al.), 1106-1116
Polyadenylation coupling of intron removal and 3'-end
formation (Nesic and Maquat), 363-375
CPSF and PAP recognize cytoplasmic polyadenylation elements (Bil- ger et al.), 1106-1116
maize, directed by AU-fich motifs (Luehr- sen and Walbot), 1117-1130
as related to trans-splicing (Matthews et al.), 491-501
role of snRNP-A protein in (Lutz and Alwine), 576-586
in S. cerevisiae (Proweller and Butler), 2629-2640
3' end formation and function {Manley and Proudfoot), 259-264 Meet- ing Review
and translation of cyclin and c-mos mRNAs (Sheets et al.), 926-938
Polycomb, interaction with trithorax (Kuzin et al.), 2478-2490
Polycomb group (Pc-G), functional con- servation of mammalian ho- molog (van der Lugt et al.), 757- 769
Polyomavirus (PyV) middle T antigen, and induction of mammary tu- morigenesis, c-Src required (Guy et al.), 23-32
POP1 gene, S. cerevisiae, encodes pro- tein component common to RNase MRP and RNase P (Lygerou et al.), 1423-1433
Position effect. See also Telomeric posi- tion effect
Position-effect variegation, yeast genes located near telomeres (Apari- cio and Gottschling), 1133-1146
3100 GENES & DEVELOPMENT
Positive regulation, of pre-mRNA splic- ing (Tian and Maniatis), 1703- 1712
Post-transcriptional regulation, of E. coli rpoS/cr S expression (Lange and Hengge-Aronis), 1600-1612
Postimplantation development, mice, role of Notchl (Swiatek et al.), 707-719
Postimplantation mouse development, fugl gene, murine homolog of yeast RNA1 gene (DeGregori et al.), 265-276
Potassium permanganate (KMNO4), modification of unpaired bases (Duncan et al.), 465-480
POU domain gene, zebrafish pou2, alterna-
q . Uvely spliced (Takada et al.), 45-59
homeo box gene, C. elegans ceh-18 gene, targeted mutation ins (Greenstein et al.), 1935-1948
POZ domain, conserved protein-protein interaction domain (Bardwell and Treisman), 1664-1677
PPR1 DNA-binding properties in yeast (Mar-
morstein and Harrison), 2504- 2512
trans-activator, yeast, overcomes telo- meric silencing in cell cycle-de- pendent manner (Aparicio and Gottschling), 1133-1146
pRb alteration by HPV16 E7 (Reznikoff et
al.), 2227-2240 requirement for growth suppression
induced by p18 or p16 (Guan et al.), 2939-2952
pre-B lymphocytes, v-abl inhibits K locus transcription (Klug et al.), 678- 687
Pre-mRNA splicing branch nucleophile selection (Query et
al.), 587-597 inhibition by influenza virus NS1 pro-
tein {Lu et al.), 1817-1828 positive regulation of (Tian and Mani-
atis), 1703-1712 regulation of requires PSI (Siebel et
al.), 1713-1725 role of SR and U1 snRNPs (Tam and
Steitz), 2704-2717 pre-mRNA, identification of associated
proteins (MacMillan et al.), 3008-3020
Prespliceosome components, SAP 49 and SAP 145 {Champion-Amaud and Reed), 1974-1983
Primitive streak role of
FGFR-1 (Deng et al.), 3045-3057 fgfr-1 in development {Yamaguchi et
al.), 3032-3044 Prion protein (Prp) gene, sheep, and sus-
ceptibility to natural scrapie (Westaway et al.), 959-969
Processing of mRNA, regulation by RNase E and RNase P (Alifano et al.), 3021-3031
Programmed cell death apoptosis, myc and p53 (Wagner et al.),
2817-2830 mouse Nedd2 is important component
of (Kumar et al.), 1613-1626 Prokaryotic glutamine synthetase I, As-
pergillus fluG gene related to (Lee and Adams), 641-651
Promoters alternative promoters (P1 and P2) of
mdm2 (Barak et al.), 1739-1749 clearance, role of basal factor TFIIE
(Maxon et al.), 515-524 DNA, activation domain enhance-
ment (Lierberman and Berk), 995-1006
Drosophila, interaction with TFIID (Purnell et al.), (830-842)
elements, transcriptional regulation by CDF2 {Iratni et al.), 2928-2938
of E2F1 (Hsiao et al.), 1526-1537 recognition of Inr elements by TFIID
(Kaufmann and Smale), 821-829 Proneural
activators, Drosophila imaginal disc, direct downstream targets of (Singson et al.), 2058-2071
genes, achaete-scute homologs in Xe- nopus embryo (Turner and Weintraub), 1434-1447
Protein kinase A (PICA), required for RNA lo-
calization along anteroposterior axis of Drosophila (Lane and Kalderon), 2986-2995
kinases activity of SAD1 (Allen et al.), 2401-
2415 Drosophila, new family--LAMMER
(Yun et al.), 1160-1173 localization, S. cerevisiae (Burns et
al.), 1087-1105 multimers, role in transposition
(Baker et al.), 2416-2428 synthesis
E. co// translational elongation fac- tor SELB and selenoprotein syn- thesis (Ringquist et al.), 376- 385
regulation by codon usage under dif- ferent growth states (Chen and Inouye), 2641-2652
in S. cerevisiae pap1-1 mutants (Proweller and Butler), 2629- 2640
Protein-DNA complexes, role in trans- position (Baker et al.), 2416- 2428
Protein-protein interactions disruption of (Whipple et al.), 1212-
1223
between H and RBP-JK/KBF2 (Brou et al.), 2491-2503
POZ domain (Bardwell and Treisman), 1664-1677
Rad51 and Rad52 (Donovan et al.), 2552-2562
between RAP1 and SIR3 (Moretti et al.), 2257-2269
SAP 49-145 prespliceosome compo- nent complex (Champion-Ar- naud and Reed), 1974-1983
and specificity of HOX protein func- tion (Zappavigna et al.), 732- 744
between TFIIA and TBP proteins (Sun et al.), 2336-2348
between Tupl and a2 (Komachi et al.), 2857-2867
Protein-tyrosine kinase, Abl SH3-bind- ing sites (Ren et al.), 783-795
Proto-oncogene bmi-1, targeted deletion in transgenic
mice (van der Lugt et al.), 757- 769
mdm2, regulation of expression by p53 (Barak et al.), 1739-1749
c-myb, role in T-cell development (Ba- diani et al.), 770-782
c-myc, FUSE-binding protein {FBP) stimulates expression (Duncan et al.), 465-480
PRP 11P, component of U2 snRNP, inter- action with MUD2P yeast pro- tein (Abovich et al.), 843-854
Pseudohyphal growth, requirement of MAP kinase pathway (Roberts and Fink), 2974-2985
PSI RNA-binding protein, alternative splicing factor required for P-el- ement pre-mRNA splicing {Sic- bel et al.), 1713-1725
PTHrP gene. See Parathyroid hormone- related peptide gene. See also Parathyroid hormone-related peptide
pyrB1 operon, regulation of expression by UTP-sensitive reiterative RNA synthesis (Liu et al.), 2904-2912
Pyrimidine gene expression, UTP-sensi- tive reiterative RNA synthesis {Liu et al.), 2904-2912
Pyrimidine-rich sequences, Trypano- soma brucei, relationship be- tween trans-splicing and polya- denylation (Matthews et al.), 491-501
Quarternary complex, cyclin, CDK, PCNA, and p21 (Zhang et al.), 1750-1758
Quenching, Drosophila sna activity (Gray et al.), 1829-1838
GENES & DEVELOPMENT 3101
RAD2, S. cerevisiae structure-specific endonuclease (Harrington and Lieber), 1344-1355
RAD6 and RAD18 proteins, S. cerevi- siae, postreplication DNA re- pair (Bailly et al.), 811-820
RAD7 DNA repair gene, interaction with SIR3 gene {Paetkau et al.), 2035-2045
Rad51, interaction with Rad52, role in DNA repair (Donovan et al.), 2552-2562
Rad52, interaction with Rad51 in S. cer- evisiae (Donovan et al.), 2552- 2562
RAD53, allelism to SAD1 (Allen et al.), 2401-2415
Raf serine/threonine kinase, specifies dorsoventral polarity in Droso- phila (Brand and Perrimon), 629-639
Raf, role of MEK in Drosophila (Hsu and Perrimon), 2176-2187
RAG gene expression, B-cell differentia- tion,~ role of v-abl in regulation of {Chen et al.), 688-697
Rag-l, role in V(D)J recombination pro- cess {Spanopoulou et al.), 1030- 1042
RAG-2-deficient mice, introduction of immunoglobulin HC and LC transgenes into (Young et al.), 1043-1057
RAP1, interaction with SIR proteins (Moretti et al.), 2257-2269
RAR-specific agonists, role in transcrip- tional activation (Valc~rcel et al.), 3068-3079
r a s
genes, C. elegans let-60 ras gene and vulval differentiation (Wu and Hart), 147-159
-mediated cell signaling, C. elegans vulval induction (Lackner et al.), 160-173
role of MEK in Drosophila (Hsu and Perrimon), 2176-2187
signal transduction, N-ras oncogene modulates transcription factor AP-2 (Kannan et al.), 1258-1269
signal transduction pathway, role of ets family members in (Giovane et al.), 1502-1513
signaling and ternary complex factors (Hipskind et al.), 1803-1816
and TGF-~I in squamous cell carci- noma (Glick et al.), 2429-2440
Rb growth suppressor protein, complexes
with E2F and inhibits transcrip- tion (Johnson et al.), 1514-1525
oncoprotein expression, role in mouse lens development {Pan and Griep), 1285-1299
RBP-JK, interaction with Drosophila hairless (Brou et al.), 2491-2503
rDNA minichromosome
excision and amplification in Tet- rahymena (Kapler and Black- bum), 84-95
Tetrahymena, excision and amplifi- cation of (Kapler and Black- bum), 84-95
transcription, role of S. cerevisiae RRN6 and RRN7 genes (Keys et al.), 2349-2362
transcriptional repression by CDF2 (Iratni et al.), 2928-2938
rec mutants, S. pombe (De Veaux and Smith), 203-210
RecA protein, E. coli single-strand trans- fer reaction, as compared to S. cerevisiae Sepl protein (Chen et al.), 1356--1365
Receptor tyrosine kinase (RTKs). See also RTK signaling pathways
Drosophila, signaling pathways (Reich- man-Fried et al.), 428-439
Drosophila Torso (Hsu and Perrimon), 2176-2187
role of Tek in mouse vasculogenesis (Dumont et al.), 1897-1909
Recombinase, site-specific developmen- tally regulated, encoded by An- abaena xisF gene (Carrasco et al.), 74-83
Recombination hot spots, correlation of heteromeric
protein binding and hot spot ac- tivity (Wahls and Smith), 1693- 1702
regulation of in S. pombe (De Veaux and Smith), 203-210
role in Mu transposase function (Baker et al.), 2416-2428
Reiterative transcription, role of pyrB1 operon (Liu et al.), 2904-2912
REMI (restriction enzyme-mediated in- tegration) mutations, in Dicty- ostelium lagC (Dynes et al.), 948-958
Replication origin, activation of near a double-stranded DNA break (Raghuraman et al.), 554-562
Repression of class II promoters by Dr t (Yeung et
al.), 2097-2109 direct repression by E1B 55K (Yew et
al.), 190-202 Drosophila embryos, short-range tran-
scriptionaI repression involves quenching {Gray et al.), 1829- 1838
pole-specific repressor in Caulobacter (Wingrove and Gober), 1839- 1852
of rDNA transcription by CDF2 (Iratni et al.), 2928-2938
Repressor, global repressor Motl inhibits
TBP binding (Auble et al.), 1920-1934
Reproduction, regulation by SF-1 (Ingra- ham et al.), 2302-2312
Retinoblastoma, mice, role of p53 (Howes et al.), 1300-1310
Retinoblastoma protein (pRb) dual roles of during development {Lee
et a1.), 2008-2021 functional inactivation by collabora-
tion of GI cyclins (Hatakeyama et al.), 1758-1771
and growth inhibition, reversed by Id-2 binding to unphosphorylated pRb (Iavarone et al.), 1270-1284
Retinoic acid receptors
role in erythroid development (Tsai et al.), 2831-2841
RORa nuclear receptors related to {Gigudre et al.), 538-553
RXRa mutant mice, cardiac defects in {Sucov et al.), 1007-1018
Retinoid X receptor (RXR) (Tontonoz et al.), 1224-1234
a, component of vitamin A signaling pathway in mice cardiac mor- phogenesis (Sucov et al.), 1007- 1018
/RAR heterodimer, regulation of reti- noid-dependent transcription (Valc~/rcel et al.), 3068-3079
Retinoids, transcriptional activation me- diated by RXR/RAR heterodi- met (Valc~ircel et al.), 3068- 3079
Retrovirus E26, Myb-Ets fusion protein of (Kraut
et al.), 33-44 integration, distribution of targets
(Withers-Ward et al.), 1473- 1487
transduction of the C/EBP~ gene (Freytag et al.), 1654--1663
Rev trans-activator of HIV-1, nuclear ex- port of (Meyer and Malim), 1538-1547
Reverse mutations, in mouse agouti lo- cus (a to a t and A w) (Bultman et al.), 481-490
Ribonucleoproteins conservation of RNA moiety of telom-
erase RNA (Lingner et al.), 1984-1998
RNase MRP and RNase P (Lygerou et al.), 1423-1433
Tetrahymena telomerase (Autexier and Greider), 563-575
Ribosomes biogenesis, in Xenopus oocytes (Pecu-
lis and Steitz), 2241-2255 E. coli selenoprotein synthesis (Ring-
quist et al.), 376--385 proteins, and bacteriophage T4 group I
splicing (Coetzee et al.I, 1575- 1588
3102 GENES & DEVELOPMENT
protein transcript RPL32, regulation of splicing by L32 protein (Vi- lardell and Warner), 211-220
RNA1 yeast gene, murine homolog of (fugl) (DeGregori et al.), 265- 276
RNA association between imprinted RNAs
and X chromosome inactivation (Pfeifer and Tilghman), 1867- 1874 Commentary
binding Drosophila, Sex-lethal amino- terminus mediates protein-pro- tein interactions (Wang and Bell), 2072-2085
chaperones, E. coli proteins that stim- ulate group I splicing (Coetzee et al.), 1575-1588
editing, of rat and human WT1 (Wilms' tumor susceptibility gene) transcripts (Sharma et al.), 720-731
localization along anteroposterior axis of Droso-
phila requires PKA-mediated signals (Lane and Kalderon), 2986-2995
Drosophila oogenesis, distribution of Orb protein (Lantz et al.), 598-613
polymerase identification of regions involved in
RNA chain elongation (Weil- baecher et al.), 2913-2927
structure and function (Tang et al.), 3058-3067
stuttering, role of UTP-sensitive RNA synthesis (Liu et al.), 2904-2912
polymerase I, requirement of S. cerevi- siae RRN6 and RRN7 (Keys et al.), 2349-2362
polymerase II cloning of yeast homolog of TFIIF
(Henry et al.), 2868-2878 cloning of yeast homologs (Khoo et
al.), 2879-2890 core promoters of, TFIID interacts
with TATA boxes and Inr ele- ments (Kaufmann and Smale), 821-829
inhibition of transcription machin- ery by yeast NOT proteins (Col- lart and Struhl), 525-537
interaction with TBP (Tansey et al.), 2756-2769
TFIIE binds selectively to unphos- phorylated form (RNA Pol IIa) (Maxon et al.), 515-524
transcription inhibited by Mot1 global repressor (Auble et al.), 1920-1934
processing coupling of
trans-splicing and polyadenyla- tion (Matthews et al.), 491-501
intron removal and 3'-end forma- tion (Nesic and Maquat), 363- 375
maize, role of AU-rich motifs (Lue- hrsen and Walbot), 1117-1130
role of RNase MRP and SNM1 (Schmitt and Clayton), 2617- 2628
yeast, POP1 gene (Lygerou et al.), 1423-1433
recognition motifs (RRMs), of U1 snRNP-A protein (Lutz and A1- wine), 576-586
replication, coupled to translation in poliovirus RNA genomes (No- yak and Kirkegaard), 1726-1737
secondary structure of telomerase (Lingner et al.), 1984-1998
splicing accuracy of Tetrahymena group I in-
tron reactions {Downs and Gech), 1198-1211
role of associated proteins {Mac- Millan et al.), 3008-3020
stability, in Xenopus oocytes (Peculis and Steitz), 2241-2255
synthesis, 3' end formation (Manley and Proudfoot), 259-264 Meet- ing Review
tertiary structure, Tetrahymena 5' splice set selection (Downs and Cech), 1198-1211
3' ends, formation and function (Man- ley and Proudfoot), 259-264 Meeting Review
virus, poliovirus, genome replication coupled to translation (Novak and Kirkegaard), 1726--1737
RNA-RNA interactions, tertiary inter- action in the spliceosome (Mad- hani and Guthrie), 1071-1086
RNA-binding proteins Orb (Lantz et al.), 598-613, (Christer-
son and McKearin), 614-628 proteins, PSI is an alternative splicing
factor (Siebel et al.), 1713-1725 ternary complex formation with TLS
and EWS (Zinszner et al.), 2513- 2526
RNase E, role in processing of polycis- tronic mRNA (Alifano et al.), 3021-3031
RNase MRP characterization of a component
{Schmitt and Clayton), 2617- 2628
ribonucleoprotein, protein component in common with RNase P (Lygerou et al.), 1423-1433
RNase P involvement in segmental stabiliza-
tion of mRNA (Alifano et al.)i 3021-3031
ribonucleoproteiI1, protein component in common with RNase MRP (Lygerou et al.), 1423-1433
RNase MRP components (Schmitt and Clayton), 2617-2628
Ro, autoantigen, binding to mutant 5S rRNA (O'Brien and Wolin), 2891-2903
RORa, novel family of orphan hormone nuclear receptors, DNA-binding activities of isoforms (Gigu6re et al.), 538-553
rpoC, f~' subunit of RNA polymerase (Weilbaecher et al.), 2913-2927
rpoS/& expression, transcriptional and post-transcriptional signals that regulate expression in E. coli (Lange and Hengge-Aronis), 1600-1612
RRN6, role in initiation of rDNA tran- scription (Keys et al.), 2349- 2362
RRN7, role in initiation of rDNA tran- scription (Keys et al.), 2349- 2362
rRNA processing, in Xenopus oocytes (Peculis and Steitz), 2241-2255
RSRF (or MEF2) proteins, SL1 regulates cardiac muscle-specific tran- scription in Xenopus (Chambers et al.), 1324-1334
RTK signaling pathways, gene expres- sion control by antirepression (Rusch and Levine}, 1247-1257
RTKs. See also Receptor tyrosine ki- nases
S
Saccharomyces cerevisiae. See also Yeast
activation of replication origin near a double-stranded DNA break (Raghuraman et al.), 554--562
Cl_3A-based silencing (Stavenhagen and Zakian), 1411-1422
conformational switch in U6 RNA (Fortner et al.), 221-233
DNA repair and chromatin structure {Paetkau et
al.), 2035-2045 complex of RAD6 and RAD18 pro-
teins (Bailly et al.), 811-820 G 1 cyclins CLN1 and CLN2 repress
mating factor response pathway {Oehlen and and Cross), 1058- 1070
large-scale screen for gene identifica- tion {Burns et al.), 1087-1105
M/G 1 transition, role of P40 sDBa5 (Donovan et al.), 1640-1653
MAP kinase Fus3 association with sig- naling component Ste5 (Kranz et al.), 313-327
mating type identity in et cells, role of SSN6 and TUP1 (Cooper et al.), 1400-1410
mimics cell cycle-dependent phospho-
GENES & DEVELOPMENT 3103
rylation of mammalian pRB (Hatakeyama et al.), 1758-1771
mitotic checkpoint genes (Weinert et al.), 652-665
MOT1 gene encodes ADI (Auble et al.), 1920-1934
NOT-mediated repression of tran- scription machinery (Collart and Struhl), 525-537
Rad51 and Rad52 proteins (Donovan et al.), 2552-2562
requirement of MAP kinase pathway in pseudohyphal growth (Rob- erts and Fink), 2974-2985
ribosomal protein L32 regulates splic- ing of RPL32 gene transcript (Vilardell and Warner), 211-220
RNA processing and RNase MRP (Schmitt and Clayton), 2617-2628
RNase MRP and RNase P ribonucle- oproteins have common protein component (Lygerou et al.), 1423-1433
role of SPS1 in spore formation (Frie- sen et al.), 2162-2175
role of RAP1 in transcriptional silenc- ing (Moretti et al.), 2257-2269
Sepl strand exchange protein pro- motes a paranemic joint (Chen et al.), 1356-1365
SMK1 a MAP kinase homolog (Krisak et al.), 2151-2161
spliceosome assembly, MUD2 protein contacts PRPII during U2 snRNP recruitment (Abovich et al.), 843-854
tertiary interaction in the spliceosome (Madhani and Guthrie), 1071- 1086
SAD1, control of multiple cell cycle checkpoints in yeast (Allen et al.), 2401-2415
SAP-l, activation by RAS/MAP kinase- independent pathways (Hip- skind et al.), 1803-1816
SAP1 ets factor, as compared to new ets member Net (Giovane et al.), 1502-1513
SAP 49-145 prespliceosome component complex, role in U2 snRNP binding (Champion-Amaud and Reed), 1974-1983
SAPKcdI,_ cloning of INK2 a human ho- molog (Kallunki et al.), 2996-3007
Schizosaccharomyces pombe mating pheromone P-factor (Imai and
Yamamoto), 328-338 meiotic recombination, region-spe-
cific activators of (De Veaux and Smith), 203-210
recombination hot spot (Wahls and Smith), 1693-1702
SDB25. See P40 sDB2s Secondary structure
of telomerase RNAs (Lingner et al.), 1984-1998
of yeast U6 RNA (Fortner et al.), 221- 233
Secreted protein precursor, sog in dorsal pattern formation in Drosophila embryo (Frangois et al.), 2602- 2616
Segment polarity genes Drosophila (Cadigan et al.), 899-913
dishevelled (dsh) gene, role in Wg signaling (Klingensmith et al.), 118-130
wingless (wg) and engrailed (en) (Benedyk et aL), 105-117
Segmentation control of pair-rule gene expression
by a tyrosine kinase (Binari and Perrimon), 300-312. See also Pair-rule gene s
Drosophila (Benedyk et al.), 105-117 SELB translational elongation factor, E.
coli, identification of binding sites and interaction with initi- ation complex (Ringquist et al.), 376-385
Selenoprotein synthesis, E. coli, recogni- tion of mRNA selenocysteine insertion sequence by SELB (Ringquist et al.), 376-385
Self-association, of Rad51, double-strand break repair (Donovan et al.), 2552-2562
Sensory organ precursor (SOP) cells, Drosophila (Singson et al.), 2058-2071
Sepl, S. cerevisiae strand exchange pro- tein, promotes a paranemic joint (Chen et al.), 1356-1365
serendipity, regulation of bicoid tran- scription (Payre et al.), 2718- 2728
Serine/threonine kinase, activity of C. elegans unc-51 (Ogura et al.), 2389-2400
Serum albumin promoter, activation of by c/EBP~ (Nerlov and Ziff), 350-362
Sex determination Drosophila (Palmer et al.), 698-706
Sex-lethal (Sxl) gene (Wang and Bell), 2072-2085
snf gene, regulates Sxl splicing and encodes a snRNP protein (Flick- inger and Salz), 914-925
Sex-lethal (Sxl) gene, Drosophila Sex determination
system, alternative splicing of (Flickinger and Salz), 914-925
protein, Drosophila, RNA binding and splicing (Wang and Bell), 2072- 2085
Sex-specific regulation, of Drosophila msl-1 dosage compensation gene (Palmer et al.), 698-706
SF-1, nuclear receptor, role in reproduc- tion {Ingraham et al.), 2302- 2312
SH3 domains (Ren et al.), 783-795 Sheep, Prp codon 171 and natural scrapie
(Westaway et al.), 959-969 short gastrulation (sog), pattern forma-
tion in Drosophila embryos (Frangois et al.), 2602-2616
0 "54 transcriptional activator, functions as pole-specific repressor in Caulobacter (Wingrove and Go ~ ber), 1839-1852
o's factor, regulation of expression in E. coli (Lange and Hengge-Aronis), 1600-1612
Signal transduction C-factor and cell movement in M. xan-
thus (Sager and Kaiser), 2793- 2804
in Dictyostelium, GBF transcription factor activation (Schnitzler et al.), 502-514
Drosophila oogenesis, novel role for Raf (Brand
and Perrimon), 629-639 role of dsh gene in Wg signaling
(Klingensmith et al.), 118-130 interaction between cAMP and cal-
cium (Sun et al.), 2527-2539 pathways
C. elegans vulval induction role of MAP kinase (Wu and Han),
147-159 role of mpk-1 (Lackner et al.),
160-173 c-Src tyrosine kinase (Guy et al.),
23-32 mice EGFR (Luetteke et al.), 399-
413 Ras (Giovane et al.), 1502-1513
role in transcriptional activation (Hip- skind et al.), 1803-1816
in S. cerevisiae (Friesen et al.), 2162- 2175
role in mating and invasive growth (Roberts and Fink), 2974-2985
MAP kinase Fus3 associates with signaling component Ste5 (Kranz et al.), 313-327
SMK1 and spore wall assembly (Krisak et al.), 2151-2161
U. maydis life cycle (Banuett and Her- skowitz), 1367-1378
Signaling molecules Dictyostelium LagC protein (Dynes et
al.), 948-958 Drosophila receptor tyrosine kinases
(RTKs) (Reichman-Fried et al.), 428--439
Tek RTK (Dumont et al.), 1897-1909 TGF-~ superfamily (Kingsley), 133-
146 Review Toll and tor (Rusch and Levine), 1247-
1257 vitamin A signaling in mice cardiac
morphogenesis (Sucov et al.), 1007-1018
Wnt family, Wnt-3a regulates gastru-
3104 GENES & DEVELOPMENT
lation in mouse embryos (Ta- kada et al.), 174-189
Signaling protein, EGFR, mutations within have tissue specific con- sequences in mice (Luetteke et al.), 399-413
Signaling. See also cAMP signaling Silencers, CI__3A stretches of DNA in
yeast telomeres (Stavenhagen and Zakian), 1411-1422
Silencing. See also Transcriptional re- pression
SIR proteins, interaction with RAP1 proteins (Moretti et al.), 2257- 2269
SIR3 gene, S. cerevisiae silencing gene, interaction with RAD7 (Paet- kau et al.), 2035-2045
Site-specific recombinase. See also Re- combinase
Skeletal development, role of PTHrP (Karaplis et al.), 277-289
Skin disease, role of keratin 14 gene (Rugg et al.), 2563-2573, (Chan et al.), 2574-2587
SL1 protein, RSRF {or MEF2) family, regulates cardiac muscle-spe- cific transcription in Xenopus (Chambers et al.), 1324-1334
sloppy paired (slp) locus, role in Droso- phila segmentation (Cadigan et al.), 899-913
snail (sna) zinc finger repressor, short- range repression in Drosophila (Gray et al.), 1829-1838
snf gene, Drosophila sex determination gene (Flickinger and Salz), 914- 925
SNM1, a component of yeast RNase MRP (Schmitt and Clayton), 2617-2628
snRNAs, U2 and U6, tertiary interac- tions (Madhani and Guthrie), 1071-1086
snRNPs association with branch sites of pre-
mRNA (MacMillan et al.), 3008-3020
protein, encoded by Drosophila snf sex determination gene (Flickinger and Salz), 914-925
spliceosome assembly {Abovich et al.), 843-854
U2/U4/U5/U6 (Konforti and Konar- ska), 1962-1973
Somite formation, mouse embryo, regu- lation by Wnt-3a (Takada et al.), 174-189
SP1 sites, role in methylation of CpG is- lands (Macleod et al.), 2282- 2292
Splice site recognition, of Sxl, role of snf (Flick-
inger and Salz), 914-925 selection, regulation by SR proteins
(Tam and Steitz), 2704-2717
Spliceosome assembly
MUD2 protein contacts PRPII (Abo- vich et al.), 843-854
recognition of branch site (Mac- Millan et al.), 3008-3020
regulation of ribosomal protein L32 occurs at intermediate step of assembly (Vilardell and War- ner), 211-220
branch formation (Query et al.), 587-597 inhibition of pre-mRNA splicing (Lu
et al.), 1817-1828 stem/loop structure in U6 RNA de-
fines conformational switch (Fortner et al.), 221-233
tertiary interaction in (Madhani and Guthrie), 1071-1086
5'SS RNA-U4/U5/U6 snRNP com- plex (Konforti and Konarska), 1962-1973
involvement of SR proteins (Tarn and Steitz), 2704-2717
Splicing. See also Alternative splicing; specific splicing factors
coupling of intron removal and 3'-end formation (Nesic and Maquat), 363-375
enhancement, and E. coli proteins (Co- etzee et al.), 1575-1588
enhancer, dsx repeat element (dsxRE), constitutive and regulated ac- tivities of (Tian and Maniatis), 1703-1712
linked to polyadenylation process (Lutz and Alwine), 576-586
maize, intron creation and polyadeny- lation directed by AU-rich mo- tifs (Luehrsen and Walbot), 1117-1130
regulation, Drosophila Sex-lethal amino terminus is essential for {Wang and Bell), 2072-2085
ribosomal protein L32 regulates splic- ing of its own transcript (Vilardell and Warner), 211- 220
tertiary interaction in the spliceosome (Madhani and Guthrie), 1071- 1086
yeast, conformational switch in U6 RNA (Fortner et al.), 221-233
SpoIIAA, phosphorylation by SpoIIAB regulates transcription (Dieder- ich et al.), 2653-2663
SpoIIAB, regulation of transcription, phosphorylation of SpoIIAA (Diederich et al.), 2653-2663
Sporulation Aspergillus, extracellular rescue of
sporulation mutant (Lee and Adams), 641-651
B. subtilis coat assembly (Driks et al.), 234-244
regulation of transcription in B. subti- lis (Diederich et al.), 2653-2663
role of S. cerevisiae SMK1 (Krisak et al.), 2151-2161
S. cerevisiae SPS1 gene (Friesen et al.), 2162-2175
SPS1, S. cerevisiae, role in spore forma- tion (Friesen et al.), 2162-2175
Squamous cell carcinoma, involvement of TGF-~I (Glick et al.), 2429- 2440
SR protein, compensation for loss of U1 snRNP function (Tam and Steitz), 2704-2717
Src family, tyrosine kinases (Stein et al.), 1999-2007
src gene family, genetic interaction be- tween family members (hck and fgr in mice (Lowell et al.), 387- 398
SRD-1 cells, sterol-resistant cell line (Yang et al.), 1910--1919
SRE (serum response element) of fos, Net binding requires SRF {Giovane et al.), 1502-1513
SREBP-2 transcription factor, role in cholesterol homeostasis (Yang et al.), 1910--1919
SRF (serum response factor), interaction with Net ets transcription fac- tor (Giovane et al.), 1502-1513
SSN6 global transcriptional regulator, role in establishment of repres- sive chromatin structure (Coo- per et al.), 1400-1410
Ssn6, transcriptional repression (Koma- chi et al.), 2857-2867
Starvation signal, involvement in com- plex regulation of E. coli rpoS/cr s expression (Lange and Hengge- Aronis), 1600--1612
Stationary phase-induced genes, Esche- richia coli, regulation by crs fac- tor (Lange and Hengge-Aronis), 1600-1612
Ste5 signaling component, S. cerevisiae, association with MAP kinase Fus3 possibly promotes signal transduction (Kranz et al.), 313- 327
STE20, homolog, SPS1 role in spore for- mation (Friesen et al.), 2162- 2175
Sterility, caused by disruption of ink8 in mice (Baribault et al.), 2964- 2973
Steroid-hormone receptor superfamily, effect on gastrulation (Chen et al.), 2466-2477
Sterol-regulated gene transcription (Yang et al.), 1910-1919
Strand transfer, S. cerevisiae Sepl pro- tein (Chen et al.), 1356-1365
Structure of activation target of lac promoter
(Tang et al.), 3058-3067 of PPR1-DNA complex (Marmorstein
and Harrison), 2504-2512
GENES & DEVELOPMENT ,~1 O~
Su(H), interaction with H (Brou et al.), 2491-2503
Subcellular localization, in B. subtilds coat assembly (Driks et al.), 234--244
Substrate specificity, of JNKs towards c-Jun (Kallunki et al.), 2996- 3007
sur-1 gene, C. elegans MAP kinase, role in vulval signaling pathway (Wu and Han), 147-159
SV40 interaction of E1A-repressed enhanc-
ers and p300 (Eckner et al.), 869-884
upstream efficiency element (USE) of late polyadenylation signal (Lutz and Alwine), 576-586
T cells, development, role of transcrip- tion activator c-Myb (Badiani et al.), 770-782
T, in hindgut specification (Kispert et al.), 2137-2150
TAF30, indentity with TFG3 and mam- malian ANC1 (Henry et al.), 2868-2878
TAFs activity of Drosophila TFIIA (Yoko-
mori et al.), 2313-2323 identification of yeast components
(Henry et al.), 2868-2878 participation in transcriptional activa-
tion (Lieberman and Berk), 995- 1006
TBP-associated factors, and species specificity of TBP (Cormack et al.), 1335-1343
Tailbud formation, mouse embryo, regu- lation by Wnt-3a (Takada et al.), 174--189
Targeted deletion, of TGF-[~I gene in mice (Glick et al.), 2429-2440
Targeted mutagenesis, and hematopoie- sis (Weiss et al.), 1184-1197
TATA -binding
of Drosophila TFIIA (Yokomori et al.), 2313-2323
protein (TBP), yeast and human, conserved and nonconserved functions of (Cormack et al.), 1335-1343
box, recognition by TFIID (Kaufmann and Smale), 821-829
element, Drosophila (Purnell et al.), 830-842
utilization, and yeast NOT proteins (Collart and Struhl), 525-537
TBP. See also TATA-binding proteins binding to BRF (Khoo et al.), 2879-
2890 binding, inhibited by global repressor
Motl (Auble et al.), 1920-1934
interaction with Dr 1 mediates tran- scriptional repression (Yeung et al.), 2097-2109
role in transcriptional activation (Tan- sey et al.}, 2756--2769
TEF-1, role in cardiogenesis (Chen et al.), 2293-2301
Tek receptor tyrosine kinase, role in mouse vasculogenesis (Dumont et al.), 1897-1909
Telomerase common secondary structure and per-
muted template {Lingner et al.), 1984-1998
ribonucleoprotein, reconstitution of wild-type and mutant (Autexier and Greider), 563-575
Telomeres conservation of telomerase RNA sec-
ondary structure (Lingner et al.), 1984-1998
elongation, reconstitution of Tetrahy- mena telomerase (Autexier and Greider), 563-575
transcriptional silencing induced by RAP1 and SIR proteins (Moretti et al.), 2257-2269
yeast (Stavenhagen and Zakian), 1411-1422
position-effect at (Aparicio and Gottschling), 1133-1146
replication (Raghuraman et al.), 554-562
Telomeric position effect (TPE), tran- scriptional repression in yeast (Stavenhagen and Zakian), 1411-1422
Termination. See also Transcriptional termination
Ternary complex factors, role in RAS/ MAP kinase-dependent and -in- dependent signaling pathways (Hipskind et al.), 1803-1816
Tetrahymena thermophila accuracy of group I intron reactions
(Downs and Cech), 1198-1211 rDNA excision and amplification (Ka-
pier and Blackburn), 84-95 rDNA minichromosome, germ-line
mutation prevents amplification (Kapler and Blackburn), 84-95
telomerase enzyme mechanism (Au- texier and Greider), 563-575
TFIIA human, role
in transcriptional activation (Ozer et al.), 2324-2335, (Sun et al.), 2336-2348
and regulation of Xenopus chromo- somal 5S rRNA genes (Bouvet et al.), 1147-1159
transcriptional activation in Droso- phila (Yokomori et al.), 2313- 2323
TFIIB, role of BRF in transcription (Khoo et al.), 2879-2890
TFIID, binding to TBP (Tansey et al.), 2756-2769
TFIIF, cloning of yeast homolog (Henry et al.), 2868-2878
TFG1, subunit of yeast TFIIF (Henry et al.), 2868-2878
TFG2, subunit of yeast TFIIF (Henry et al.), 2868-2878
TFG3, subunit of yeast TFIIF (Henry et al.), 2868-2878
TFIID binding, Drosophila, downstream con-
tacts (Purnell et al.), 830-842 complex, recognizes promoter Inr ele-
ments and TATA boxes (Kauf- mann and Smale), 821-829
TFIID-TFIIA-promoter binding, activa- tion of (Lieberman and Berk), 995-1006
TFIIH basal factor, recruited by basal fac- tor TFIIE (Maxon et al.), 515- 524
TGF-~ superfamily (Kingsley), 133-146 Review
pattern formation in Drosophila em- bryos (Frangois et al.), 2602- 2616
TGF-~I, in squamous cell carcinoma (Glick et at.), 2429-2440
3'-Untranslated regions (3' UTRs), of c-mos and cyclin mRNAs, role in translational control (Sheets et al.), 926-938
Thrombocytopenia, in PDGF B-deficient mice (Levhen et al.), 1875-1887
Tissue culture, bHLH factors in myogen- esis (Olson and Klein), 1-8 Re- view
Tissue-specific gene expression, myo- genesis, bHLH regulatory fac- tors (Olson and Klein), 1-8 Re- view
TLS, binding to CHOP (Zinszner et al.), 2513-2526
TLS-CHOP, oncogenic variant of CHOP, blocks induction of G1/S arrest in adipose tissue (Barone et al.), 453-464
TOA2, identification of human ho- molog, TFIIA-~/ (Ozer et al.), 2324--2335
Toeprint experiments, SELB binding to mRNA in E. coli (Ringquist et al.), 376-385
Toll signaling pathway, regulation of dorsal morphogen (Rusch and Levine), 1247-1257
Tor signaling pathway, regulation of dor- sal morphogen (Rusch and Levine), 1247-1257
Torsional tension, not required for repli- cation origin activation (Ra- ghuraman et al.), 554-562
Torso, role of MEK in Drosophila (Hsu and Perrimon), 2176-2187
TPI gene, interactions of polyadenyla-
3106 GENES & DEVELOPMENT
tion and splicing (Nesic and Ma- quat), 363-375
Tracheal development, Drosophila, role of breathless (Reichman-Fried et al.), 428--439
Trans-activation domain, of C/EBP~ (Nerlov and Ziff),
350-362 of E-box element of c-myc (Hann et
al.), 2441-2452 hydrophobic amino acids in p53
amino-terminal domain (Lin et al.), 1235-1246
of RAR promoter by RXR (Valc~ircel et al.), 3068-3079
Trans-activators yeast PPR1 overcomes telomeric si-
lencing in cell-cycle-dependent way (Aparicio and Gottschling), 1133-1146
Trans-active mutant, of Tn5 (Weinreich et al.), 2363-2374
Trans-splicing, as related to polyadenyla- tion {Matthews et al.), 491-501
Transcription activation
DNA-binding domain of rat gluco- corticoid receptor (Lefstin et al.), 2842-2856
of genes at late G 1 (Zhu et al.), 885- 898
induced by human TFIIA (Ozer et al.), 2324-
2335, (Sun et al.), 2336-2348 RXR/RAR heterodimers (Valc~r-
cel et al.), 3068-3079 TFIIA in Drosophila (Yokomori et
al.), 2313-2323 of the lac promoter (Tang et al.),
3058-3067 by mi (Hemesath et al.), 2770-2780 mechanism for TAFs (Lieberman
and Berk), 995-1006 RAS/MAP kinase-dependent and
-independent signaling path- ways (Hipskind et al.), 1803- 1816
role of TBP (Tansey et al.), 2756- 2769
cr s4 functions as pole-specific repres- sor in Caulobacter (Wingrove and Gober), 1839-1852
activator DNA-binding factor c-Myb, role in
T-cell development (Badiani et al.), 770-782
HAP1, asymmetric (Zhang and Guarente), 2110-2119
adaptor protein, adenovirus E1A-asso- ciated 300-kD protein (p300) (Eckner et al.), 869-884
[~-globin (Barton and Emerson), 2453- 2465
cardiac muscle-specific in Xenopus embryos (Chambers et al.), 1324-1334
cloning of yeast TFIIF (Henry et al.), 2868-2878
complexes GABP (de la Brousse et al.), 1853-
1865 Zta-TFIID-TFIIA-promoter com-
plex (Lieberman and Berk), 995- 1006
DNA-damage induced in yeast (Allen et al.), 2401-2415
of Drosophila achaete regulated by hairy (Van
Doren et al.), 2729-2742 male X chromosome genes (Bone et
al.), 96-104, 277-289 factors,
AP-2, transformation by N-ras onco- gene (Kannan et al.), 1258-1269
bicoid controlled by serendipity (Payre et al.), 2718-2728
CCAAT/enhancer binding protein-c~ (C/EBP~, activation of serum al- bumin promoter (Nerlov and Ziff), 350-362
CHOP, interaction with TLS (Zin- szner et al.), 2513-2526
cloning of BRF homologs from K. lactis and C. albicans (Khoo et al.), 2879-2890
crystal structure of E47 (Ellenberger et al.), 970-980
Drosophila \ development (Fuse et al.), 2270-
2281 homeo domain proteins eve and
ftz, DNA targets of (Walter et al.), 1678-1692
TFIID (Purnell et al.), 830-842 E2F, regulation of linked to cell cy-
cle-dependent activation of ki- nases (Dynlacht et al.), 1772--1786
E2F-4 and transformation (Ginsberg et al.), 2665-2679, (Beijersber- gen et al.), 2680-2690
G-box binding factor, Dictyostelium development (Schnitzler et al.), 502-514
GATA-1 loss in mouse ES cells (Weiss et al.), 1184-1197
HNF-4, role in mouse development (Chen et al.), 2466-2477
IIE (TFIIE), interaction with other basal factors and RNA Pol II (Maxon et al.), 515-524
murine PPAR (mPPAR~/2), adipo- cyte-specific (Tontonoz et al.), 1224-1234
Net (new ets member) activation by Ras (Giovane et al.), 1502-1513
NF-M regulation by phosphoryla- tion (Kowenz-Leutz et al.), 2781-2791
Pax (paired box) family (Epstein et al.), 2122-2134
PPR1, crystal structure (Marmor- stein and Harrison), 2504-2512
TEF-1 in mice (Chen et al.), 2293- 2301
TFIIE recruits TFIIH (Maxon et al.), 515-524
yeast RRN6 and RRN7 genes (Keys et al.), 2349-2362
human, TFIIA-dependent (Sun et al.), 2336-2348
inhibition Rb/E2F complex (Johnson et al.),
1514-1525 by yeast NOT complex (Collart and
Struhl), 525-537 initiation
recognition of core promotor ele- ments (Kaufmann and Smale), 821-829
regulation by pyrB1 operon (Liu et al.), 2904-2912
interaction, by Drosophila H and Su(H) (Brou et al.), 2491-2503
of K gene in pre-B lymphocytes (Klug et al.), 678-687
regulation by cAMP and calcium (Sun et al.),
2527-2539 growth regulation of E2F1 promoter
(Hsiao et al.), 1526-1537 HOX protein interactions and HOX
gene promoters (Zappavigna et al.), 732-744
UME6, nitrogen repression and mei- otic development (Strich et al.), 796-810
by interactions between SpoIIAA and SpoIIAB in B. subtilis (Died- erich et al.I, 2653-2663
repression direct repression by E1B 55K of
p53 activity (Yew et al.), 190- 202
induced by Tupl and Ssn6 (Komachi et al.), 2857-2867
of rDNA by CDF2 (Iratni et al.), 2928-2938
selectively masked by a receptor ty- rosine kinase (Rusch and Levine), 1247-1257
telomeric position effect (TPE) in yeast (Stavenhagen and Zakian), 1411-1422
yeast, repression of a cell-specific expression in c, cells (Cooper et al.), 1400-1410
repression of class II genes by Dr 1 (Yeung et al.),
2097-2109 Drosophila achaete by hairy
(Ohsako et al.}, 2743-2755 MyoD by IgH enhancer (Weintraub
et al.), 2203-2211 repressors. See also Repression self-interference, resulting from high-
level expression of transcription factor AP-2 (Kannan et al.), 1258-1269
GENES & DEVELOPMENT 3107
silencing. See also Transcriptional re- pression
induced by RAP1 mutants (Moretti et al.), 2257-2269
yeast SIR3 gene (Paetkau et al.), 2035-2045
termination as related to initiation, elongation
and polyadenylation (Manley and Proudfoot), 259-264 Meet- ing Review
role of RNA polymerase (Weft- baecher et al.}, 2913-2927
RNA polymerase II, Motl global re- pressor of (Auble et al.), 1920- 1934
Xenopus chromosomal 5S rRNA, in vivo regulation by histone H1 (Bouvet et al.), 1147-1159
yeast and human TATA-binding pro- teins (Cormack et al.), 1335- 1343
Transesterification reactions, splicing (Query et al.), 587-597
Transformation induced by E2F-4 (Beijersbergen et al.),
2680-2690, (Ginsberg et al.), 2665-2679
N-ras induced, role of transcription factor AP-2 (Kannan et al.), 1258-1269
Transformer (Tra) and Transformer2 (Tra2) proteins, Drosophila, and dsxRE activity (Tian and Maniatis), 1703-1712
Transforming growth factor-f~. See also TGF-~
and cell cycle arrest (Polyak et al.), 9- 22
superfamily, activins and inhibins (Vassalli et al.), 414-427
Transgenic mice apoptosis or retinoblastoma (Howes et
al.), 1300-1310 c-Src required for induction of mam-
mary turmorigenesis (Guy et al.), 23-32
HPV-16 E6 or E7 (Pan and Griep), 1285-1299
Translation codon usage, regulation during differ-
ent growth stages (Chen and In- ouye), 2641-2652
coupled to RNA replication in poliovi- rus (Novak and Kirkegaard), 1726-1737
effect on initiation in S. cerevisiae papl-1 mutants (Proweller and Butler), 2629-2640
elongation factor SELB, identification of binding sites and interaction with initiation complex in E. coli (Ringquist et al.), 376-385
and polyadenylation (Manley and Proudfoot), 259-264 Meeting Review
role of RNase E and RNase P (Alifano et al.), 3021-3031
Translational control alternative mdm2 promoters produce
transcripts with different trans- lation potentials (Barak et al.), 1739-1749
poly(A) addition to mRNAs during early development (Bilger et al.), 1106-1116
via 3' UTR regulation of cytoplasmic polyadenylation (Sheets et al.), 926-938
Transposable element, Drosophila gypsy element-retrotransposon or ret- rovirus (Song et al.), 2046-2057
Transposase, activity of bacterial Trip (Weinreich et al.), 2363-2374
Transposition, promotion by tetramer of Mu (Baker et al.), 2416-2428
Transposon Tel, tagging to C. elegans unc-51
(Ogura et al.), 2389-2400 Tn5, nonproductive multimerization
(Weinreich et al.), 2363-2374 Trg, in hindgut specification (Kispert et
al.), 2137-2150 Tribolium (Kispert et al.), 2137-2150 Trichome development, Arabidopsis,
role of GL2 homeo box gene (Rerie et al.), 1388-1399
trithorax, regulation of expression in Drosophila (Kuzin et al.), 2478- 2490
tRNA, least abundant form regulates ex- pression (Chen and Inouye), 2641-2652
Trypanosoma brucei, coupling of trans- splicing and polyadenylation re- quires pyrimidine-rich motif (Matthews et al.), 491-501
Tumor cell, proliferation, role of TGF-~I
(Glick et al.), 2429-2440 suppressor, p53, role in Myc-mediated
apoptosis (Wagner et al.), 2817- 2830
suppressor gene human DCC (Hedrick et al.), 1174--
1183 Nfl (Brannan et al.), 1019-1029 p53, regulation of mdm2 expression
(Barak et al.), 1739-1749 products p53 and Rb, role in routine
lens morphogenesis (Pan and Griep), 1285-1299
RB (Howes et al.), 1300-1310 Tumorigenesis. See also Colorectal tum-
origenesis TUP1 global transcriptional regulator,
role in establishment of repres- sive chromatin structure (Coo- per et al.), 1400-1410
Tup 1, interaction with homeo domain of c~2 (Komachi et al.), 2857-2867
Twisted gastrulation gene, Drosophila,
encodes protein related to hu- man connective tissue growth factor (Mason et al.), 1489-1501
Two-hybrid interaction between Rad51 and Rad52
(Donovan et al.), 2552-2562 screen for
CDK6-interacting proteins (Guan et al.), 2939-2952
RAPl-interacting factors (Moretti et al.), 2257-2269
system S. cerevisiae, interaction of RAD7
and SIR3 gene products (Paet- kau et al.), 2035-2045
yeast, Drl-TBP interaction (Yeung et al.), 2097-2109
Tyrosine kinase receptor, epidermal growth factor receptor (EGFR) (Luetteke et al.), 399-413
Tyrosine kinases. See also c-Src combined deficiencies of Src, Fyn, and
Yes in mutant mice (Stein et al.), 1999-2007
encoded by Drosophila hop gene, stripe-specific regulation of pair-rule genes (Binari and Per- rimon), 300-312
v-abl negatively regulates NF-KB/Rel
function (Klug et al.), 678-687 suppresses light-chain rearrange-
ment (Chen et al.), 688-697
U
U1 snRNP-A protein, direct interaction with USE of SV40 (Lutz and A1- wine), 576-586
U1 snRNPs, functional replacement by SR proteins (Tam and Steitz), 2704--2717
U2 snRNP binding, SAP 49-145 com- plex implicated in (Champion- Arnaud and Reed), 1974--1983
U4/U5/U6 snRNP, recognition of 5' splice site (Konforti and Konar- ska), 1962-1973
U6 RNA, S. cerevisiae, stem/loop struc- ture defines conformational switch required for pre-mRNA splicing (Fortner et al.), 221-233
U6 snRNA, association of pre-mRNA splicing {Lu et al.), 1817-1828
uacl, induction of filamentous growth in U. maydis (Gold et al.), 2805-2816
ubcl, regulation of morphogenesis in U. maydis (Gold et al.), 2805-2816
Ubiquitin-conjugating enzyme, S. cere- visiae postreplication DNA re- pair (Bailly et al.), 811-820
UME6 transcriptional regulator identical to CAR80/CARGRI (Strich
et al.), 796-810
3108 GENES & DEVELOPMENT
of nitrogen repression and meiotic de- velopment (Strich et al.), 796- 810
unc-51, C. elegans, role in axonal elon- gation (Ogura et al.), 2389-2400
Upstream efficiency element (USE), of SV40 late polyadenylation signal, interaction with U1 snRNPA protein (Lutz and A1- wine), 576-586
Ustilago maydis Fuz7 identification, a MEK/MAPKK
homolog (Banuett and Her- skowitz), 1367-1378
role of cAMP in morphogenesis (Gold et al.), 2805-2816
UV cross-linking, SAP 49 to pre-mRNA in prespliceosome complex (Champion-Arnaud and Reed), 1974-1983
UV-damaged DNA, postreplication re- pair in S. cerevisiae (Bailly et al.), 811-820
V
V(D)J recombination B- and T-cell development (Young et
al.), 1043-1057 role of Rag-1 (Spanopoulou et al.),
1030-1042 v-abl
tyrosine kinase, block light-chain rear- rangement (Chen et al.), 688- 697
viral transforming protein (tyrosine ki- nase), blocks K gene transcrip- tion in pre-B lymphocytes (Klug et al.), 678-687
Vacuole, delivery of proteins to (Bachha- wat et al.), 379-1387
Vision, Drosophila, role of repo gene (Xiong et al.), 981-994
Vitamin A, signaling pathway in mice cardiac morphogenesis (Sucov et al.), 1007-1018
VL30 insertion elements, in mouse agouti- locus (Bultman et al.), 481-490
Vulval development, C. elegans, role of MAP
kinase homolog mpk-1 (Lackner et al.), 160-173
differentiation, C. elegans, negative regulation of and unc-lO1 gene (Lee et al.), 60-73
W
wa-2 mouse defect, naturally occurring EGFR mutation (Luetteke et al.), 399--413
Wave propagation, C-factor, M. xanthus (Sager and Kaiser), 2793-2804
WD repeats, of Tupl interact with e~2 (Komachi et al.), 2857-2867
Wilms' tumor (WT) susceptibility gene
(WT1), RNA editing in (Sharma et al.), 720-731
wingless (wg) segment polarity gene, Drosophila (Benedyk et al.), 105- 117, (Cadigan et al.), 899-913
Wingless (Wg) signaling, Drosophila, and role of dsh (Klingensmith et al.), 118-130
Wnt signaling molecules, Wnt-3a regu- lates gastrulation in mouse em- bryos (Takada et al.), 174-189
WT1. See Wilms' tumor susceptibility gene.
X
X chromosome inactivation, association with imprinting (Pfeifer and Til- ghman), 1867-1874 Commen- tary
Xenopus laevis embryos, SL1 protein regulates cardiac
muscle-specific transcription (Chambers et al.), 1324-1334
5S rRNA processing (O'Brien and Wo- lin), 2891-2903
oocyte, 5S rRNA genes, histone HI- regulated transcription in vivo (Bouvet et al.), 1147-1159
polyadenylation and translation of ma- ternal mRNAs (Sheets et al.), 926-938
proneural function of achaete-scute homologs ASH3a and ASH3b (Turner and Weintraub), 1434- 1447
snRNP function (Peculis and Steitz), 2241-2255
transcription of f~-globin (Barton and Emerson), 2453-2465
Xbra gene (homolog of mouse gene Brachyury), neuralizing activity of mutant (Rao), 939-947
XMyoD regulation (Rupp et al.), 1311- 1323
xisF gene, Anabaena, encodes develop- mentally regulated site-specific recombinase (Carrasco et al.), 74--83
Xist RNA, and X chromosome inactiva- tion (Pfeifer and Tilghman), 1867-1874 Commentary
XKL51 O, S. cerevisiae structure-specific endonuclease (Harrington and Lieber), 1344-1355
Yeast. See also Saccharomyces cere- visiae; Schizosaccharomyces pombe
growth inhibition by mutant glucocor- ticoid receptors (Lefstin et al.), 2842-2856
homolog, of mouse H~58 gene (Bach- hawat et al.), 1379-1387
MAP kinase cascade (Krisak et al.), 2151-2161
position-effect at telomeres (Aparicio and Gottschling), 1133-1146
RNA1 gene fugl is murine homolog of (DeGre-
gori et al.), 265-276 routine homolog of (fugl) (DeGre-
gori et al.), 265-276 similarity between S. pombe P-factor
and S. cerevisiae e~-factor (Imai and Yamamoto), 328-338
TATA-binding protein {TBP) as com- pared to human TBP (Cormack et al.), 1335-1343
transcriptional activator HAP1, DNA- binding domain (Zhang end Guarente), 2110-2119
UME6 and CAR80/CARGRI are iden- tical (Strich et al.), 796-810
Yes, tyrosine kinase Src family (Stein et al.), 1999-2007
Z
Zebra fish dominant-negative acivin variants in
(Michaud et al.), 1463-1472 embryo, POU domain gene pou2, al-
ternately spliced products of (Takada et al.), 45-59
ZID (zinc finger protein with interaction domain), contains POZ pro- tein-protein interaction do- main {Bardwell and Treisman), 1664--1677
Zinc cluster, S. cerevisiae SNM1 (Schmitt and Clayton), 2617-2628
Zinc finger protein
Drosophila, encoded by pair-rule gene odd-paired (opa) (Benedyk et al.), 105-117
serendipity and regulation of bicoid transcription (Payre et al.), 2718-2728
ZID (zinc finger protein with inter- action domain) contains POZ domain (Bardwell and Treis- man), 1664--1677
repressor, Drosophila snail (sna} func- tions through short-range re- pression (Gray et al.), 1829-1838
role in DNA binding (Marmorstein and Harrison), 2504--2512
Zn2Cys6, binuclear cluster of PPR1 and GAL4, role in DNA recognition (Marmorstein and Harrison), 2504--2512
Zta activation domain, of Epstein-Barr vi o
rus, interaction with TFIID- TFIIA-promoter complex (Lie- berman and Berk), 995-1006
binding to TFIIA (Ozer et al.), 2324- 2335
GENES & DEVELOPMENT 3109
INFORMATION FOR CONTRIBUTORS (1994)
Aims and Scope
Genes & Development welcomes high-quality research papers of general interest and biological significance in molecular bi- ology, molecular genetics, and related areas. Publication time from acceptance of manuscript is between two and three months. For papers accepted subject to revision, only one re- vised version will be considered; it must be submitted within 2 months of the provisional acceptance.
Submission of Papers The journal accepts papers which present original research that has not previously been published. Submission to the Journal implies that a paper is not currently being considered for an- other journal or book. Closely related papers that are in press elsewhere or that have been submitted elsewhere should be included with the submitted manuscript. It is also understood that researchers who submit papers to this journal are prepared to make available to qualified academic researchers materials needed to duplicate their research results (DNA, cell lines, an- tibodies, microbial strains, and the like). Authors should submit nucleic acid and protein sequences to the appropriate data bank.
Contributors from North and South America, Asia, and Aus- tralia should submit their papers to the Cold Spring Harbor Laboratory office. Contributors from Europe and Africa should submit their papers to the Edinburgh office. Questions regard- ing papers should be directed to Judy Cuddihy, Managing Editor, at Cold Spring Harbor Laboratory (516-367-8492).
Manuscript Preparation 1. General. Papers should be concise and conform to the fol-
lowing length requirements. Papers accepted by the journal will occupy 5 up to a maximum of 10-12 journal pages. Authors of short papers (5-8 pages) are encouraged to submit their manu- scripts to the journal. A manuscript of 28-32 typed, double- spaced pages total (including methods, references, tables, and figure legends), with 27 lines of text per page (a manuscript length of 63,000 eharaeters), and with six single-column figures and one single-column table will translate to 10-12 pages in the journal. The entire paper (including tables, figure legends, ref- erences, footnotes) should be typed double-spaced on standard- sized European or American bond paper with at least 1-in (2.5 cm) margins on all four sides. Computer printouts should be of letter quality, and should use a computer typeface of at least 11 point size. Each page should be labeled with the first author's name and a page number. Five copies should be submitted; at least four of these copies should have original art. A cover letter should include: (a) name, address, telephone number, and FAX number of author responsible for correspondence regarding the manuscript; (b) statement that the manuscript has been seen and approved by all listed authors; (c) any specific requirements for reproduction of art; and (d) status of any permissions needed.
2. Submitting Papers on Computer Discs. Publication can be speeded up if accepted papers are supplied on 31/2 - or 51/4-inch floppy discs. We can accept IBM PC, Macintosh, or compatible, formats. Please supply the manuscript on the disc as a "text" or ASCII file, if possible. Indicate on the disc: computer brand
name, whether the disc contains a text or word-processing file (name of software), and the disc format. Five hardcopy versions should also be submitted for use by referees and editors.
3. Form. The following order should be followed: Title page, Abstract, Introduction, Results, Discussion, Methods, Ac- knowledgments, References, Tables, Figure legends. The Title page should include: (a) title; (b) all authors' full names; (c) all affiliations clearly indicated; (d) a shortened version of the title for use as a running head (maximum 45 characters); and (e) key words (up to 6) for use in indexing. The Abstract should be about 200 words long and should summarize the aim of the report, the methodological approach, and the significance of the results. Methods will appear at the end of the paper and should be de- tailed enough to allow any qualified researcher to duplicate the results.
4. Figures and Legends. Five sets of figures should be sup- plied as high-quality glossy prints. Half-tones should be high- contrast, particularly in the case of gels, for the best reproduc- tion. Line drawings, graphs, charts, and chemical formulae should be professionally prepared and labeled. Multiple-part fig- ures should be submitted as mounted, camera-ready compos- ites. Authors submitting color figures as essential data for re- view with manuscripts undertake to pay the publication costs of four-color artwork. Price estimates are supplied upon accep- tance of the paper.
The back of each figure should be labeled with the first au- thor's name, figure number, and an indication of "top." The figures should be numbered consecutively in the order to which they are referred in the text. The size of the figures will be ad- justed to fit the Journal format, therefore please try to keep labels, symbols, and other call-out devices in proportion to the figure size and detail.
Figure legends should be brief and should not contain methods. Symbols indicated in the figure should be identified in the legend text. If figures are reprinted from another source, permission to reprint is required.
5. Tables. Tabular data should be presented concisely and logically. Tables should be numbered consecutively according to the order cited in the text and each should have a title. Use only horizontal rules and make sure column headings are un- ambiguous in indicating columns to which they refer. Table legends and footnotes should be included where needed. If tables are reprinted from another source or if data included are from another source, permission to reprint is required.
6. References. References are name/date citations in text; please do not cite by number. Undated citations (unpublished, in preparation, personal communication) should include first initials and last names of authors. Bibliographic information should be supplied in the following order. For Journal articles: Author{s), year, article title, journal title, volume, inclusive page numbers. For books: Author(s), year, chapter title, book title, editors' names, volume, inclusive page numbers, pub- lisher, city of publication.
7. Proofs. Proofs are considered the final form of the paper and correction can be made only in the case of factual errors. If additional information must be added at this stage, it should be in the form of "Note added in proof," subject to the approval of the editors.
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To help defray the cost of publication, a charge of $25 per page will be made for publication in Genes & Development. Authors unable to meet these charges should include a letter of explanation upon acceptance for publication; inability to meet these charges will have no effect on acceptance and publication of submitted papers.
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