Review: Application of cytology and molecular biology in diagnosing premalignant or malignant oral...

8/7/2019 Review: Application of cytology and molecular biology in diagnosing premalignant or malignant oral lesions.

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2/9


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4/9


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5/9



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kc hll wxvhbovw gfll ghygkcobhw# H bfzh"hchl{wkw om 997=ghwfw om lfveoplhekh myob mk}f wzvjkfw dhw yf}fhlfj h yhcnfom bhlknchcz zyhcwmoybhzkoc om lfveoplhekh ifz~ffc 9#9hcj 8>#6 Mvyzdfyboyf, Wgkviih U7>R, Wkl}fybhc fz hl#U74R hcj Bhwdifyn fz hl# U7;R fbpdhwkqfj zdf mhgz zdhzfy{zdyoplhekh, oggvyykcn hw fkzdfy hc kwolhzfj lfwkoc oy hwh gobpocfcz om lfveoplhekh $fy{zdyolfveoplhekh+ kw hbhyefy om wf}fyf fpkzdflkhl j{wplhwkh oy ghygkcobh kc wkzv#Kc mhgz, ;0& om fy{zdyoplhekh ~fyf dkwzolonkghll{ jkhn"cowfj hw kc wkzv oy kc}hwk}f ghygkcobhw# Kc ocf wzvj{, kz

~hw wdo~c zdhz wfcwkzk}kz{ om g{zolonkghl jkhncowkw gob"

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g{zolonkghl hcj JCH"g{zobfzykg jkhncowkw pykoy zo zdfdkwzolonkghl jkhncowkw U:0R# Yfbbfyihgd fz hl dh}fyfpoyzfj zdhz wfcwkzk}kz{ om g{zolonkghl jkhncowkw gob"ikcfj ~kzd JCH"kbhnf g{zobfzy{ ~hw ;4#9& hcj wpfgkmk"gkz{ 800&, ~dfc gobphyfj ~kzd zdf nolj wzhcjhyj. omdkwzolon{ U:8R# Kc h wzvj{, Bhyhek fz hl# hchl{qfj 860phzkfczw ~kzd dkwzolonkghll{ pyo}fc fpkzdflkhl j{wplhwkh om

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lfwkocw# Yfbbfyihgd fz hl# U:9R gocglvjfj kc zdf glkckghlwfzzkcn zdhz JCH"hcfvplokj{ bkndz jfzfgz dkwzolonkghll{oi}kovw bhlknchcg{, 886 boczdw pykoy zo dkwzolon{#Wvjio fz hl# hchl{qfj hygdk}hl bhzfykhl hcj yfpoyzfj zdhzzdf cvglfhy JCH"goczfcz kc gfllw om oyhl lfveoplhekh bh{if vwfj zo pyfjkgz zdf ykwe om oyhl fpkzdflkhl j{wplhwkh vpzo 6 {fhyw ifmoyf dkwzolonkghl jkhncowkw U:7R# Ihwfj oczdfwf oiwfy}hzkocw, zdf{ pyopowfj iyvwd ikopwkfw ~kzdg{zolonkghl/JCH"g{zobfzykg fthbkchzkoc moy bkgyowgopkgf}hlvhzkoc om ~dkzf oy yfj phzgdfw om zdf oyhl gh}kz{ $lfv"eoplhekh oy fy{zdyoplhekh+# Zdf mkcjkcn om zvboy gfllw oy

Pdozobkgyonyhpd om h oyhl iyvwd ikopw{ wpfgkbfc myob hphzkfcz om wxvhbovw gfll ghygkcobh om ivgghl bvgowh ~kzddknd cvglfo"g{zoplhwbkg yhzko gohywfl{ nyhcvlhy gdyobhzkchcj h bvlzkcvglfhzfj gfll wdo~kcn f}kjfcgf om }hwgvlhy kc}h"wkocMknvyf 4Pdozobkgyonyhpd om h oyhl iyvwd ikopw{ wpfgkbfc myob h

phzkfcz om wxvhbovw gfll ghygkcobh om ivgghl bvgowh ~kzddknd cvglfo"g{zoplhwbkg yhzko gohywfl{ nyhcvlhy gdyobhzkchcj h bvlzkcvglfhzfj gfll wdo~kcn f}kjfcgf om }hwgvlhy kc}h"wkoc# $D-F 8000+#

Pdozobkgyonyhpd om h oyhl iyvwd ikopw{ wpfgkbfc myob hphzkfcz om wxvhbovw gfll ghygkcobh om ivgghl bvgowh ~kzddknd cvglfo"g{zoplhwbkg yhzko bhyefj hz{pkh, hcj gohywfl{nyhcvlhy gdyobhzkc kc h cfgyozkg ihgenyovcjMknvyf >Pdozobkgyonyhpd om h oyhl iyvwd ikopw{ wpfgkbfc myob h

phzkfcz om wxvhbovw gfll ghygkcobh om ivgghl bvgowh ~kzddknd cvglfo"g{zoplhwbkg yhzko bhyefj hz{pkh, hcj gohywfl{nyhcvlhy gdyobhzkc kc h cfgyozkg ihgenyovcj #$Bojkmkfj php 8000+#
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6/9


Phnf = om ;$phnf cvbify coz moy gkzhzkoc pvypowfw+

JCH"hcfvplokj{ wdovlj lfhj zo h zozhl ftgkwkoc om zdfyfwpfgzk}f lfwkocw hcj dkwzolonkghl fthbkchzkoc#

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{wkw om bolfgvlhy hlzfyhzkocw kw oiafgzk}f hcj zykfw zo kjfc"zkm{ wpfgkmkg nfcfzkg hcobhlkfw U=R# Zdf powwkiklkz{ omftzyhgzkcn YCH myob gfllw oizhkcfj i{ wgyhpkcn dhw

yfgfczl{ iffc jfbocwzyhzfj fbpdhwkqkcn kzw vwfmvlcfww kczdf fhyl{ jkhncowkw om oyhl pyfbhlknchcz hcj ghcgfyovwlfwkocw U::R#

8# Nfcf hlzfyhzkocw

Co~hjh{w bhlknchcg{ kw gocwkjfyfj hw h pyogfww ghvwfji{ zdf hggvbvlhzkoc om bvlzkplf nfcfzkg hlzfyhzkocw,

~dkgd hmmfgz zdf gfll g{glf hw ~fll hw coybhl gfll jkmmfyfczk"hzkoc# Zdfwf hlzfyhzkocw hyf bhkcl{ hgxvkyfj $wobhzkg+hlzdovnd wobf om zdfb bh{ if kcdfykzfj hcj ~dfc zdf{hgzk}hzf pyozoocgonfcfw, kchgzk}hzf zvbovy wvppyfwwoynfcfw oy hmmfgz fcq{bfw, ~dkgd yfphky JCH, zdf{ govljlfhj zo h bhlknchcz zyhcwmoybhzkoc# Bowz om zdf oyhl gh}kz{

ghygkconfcw hyf gdfbkghl $zoihggo+, pd{wkghl $yhjkhzkoc+hcj kcmfgzkovw $Dvbhc phpkllobh }kyvw, Ghcjkjh+ bvzh"nfckg hnfczw zdhz bh{ ghvwf gdhcnfw kc nfcf hcj gdyobo"wobf wzyvgzvyf i{ pokcz bvzhzkocw, jflfzkocw, kcwfyzkocwhcj yfhyyhcnfbfczw# Do~f}fy, wobf om zdfwf gdhcnfwbh{ oggvy wpoczhcfovwl{# Zdfwf nfcfzkg hlzfyhzkocw,

~dkgd oggvy jvykcn ghygkconfcfwkw, ghc if vwfj hw zhynfzwmoy jfzfgzkcn zvbovy gfllw kc glkckghl whbplfw U:,=,:6R#Bolfgvlhy hchl{wkw ghc kjfczkm{ h glochl popvlhzkoc omghcgfyovw gfllw# Bvzhzkocw kc zdf zvbovy wvppyfwwoy nfcfp67 hyf zdf bowz myfxvfcz nfcfzkg hlzfyhzkocw kc dvbhc

ghcgfy hcj wdo~ h }hykhilf myfxvfcg{ kc oyhl ghcgfy U:=R#Wf}fyhl hvzdoyw dh}f wzvjkfj hcj kc wobf ghwfw jfboc"wzyhzfj zdf pozfczkhl glkckghl hpplkghzkoc om oyhl g{zolon{moy jfzfgzkcn pokcz bvzhzkocw kc p67 hw h wpfgkmkg cfoplhw"zkg bhyefy kc OWGG U:6,:>":;R# Do~f}fy, ozdfy hvzdoywgocwkjfy zdhz zdf dknd cvbify om pokcz bvzhzkocw, ~dkgdghc if movcj kc p67, lkbkz kzw pozfczkhl glkckghl hpplkgh"zkoc kc gowz"fmmfgzk}f fhyl{ jfzfgzkoc om oyhl ghcgfy U60R#

9# Fpknfcfzkg hlzfyhzkocw, Loww om dfzyoq{nowkz{ hcj

Bkgyowhzfllkzf kcwzhiklkz{Zdf hpplkghiklkz{ om ozdfy bolfgvlhy bhyefyw wvgd hw fpk"nfcfzkg hlzfyhzkocw $d{pfybfzd{lhzkoc om pyobozfyyfnkocw+ hcj nfcobkg kcwzhiklkz{ wvgd hw loww om dfzyoq{"nowkz{ $LOD+ hcj bkgyowhzfllkzf kcwzhiklkz{ $BWK+ dhw hlwoiffc wzvjkfj# U60,68R# Zdf bhkc fpknfcfzkg bojkmkghzkockc zvbovyw kw bfzd{lhzkoc hcj kz wffbw zdhz zdf gdhcnfwkc zdf bfzd{lhzkoc phzzfycw ghc plh{ hc kbpoyzhcz yolf kczvboyknfcfwkw# Zdfwf fpknfcfzkg hlzfyhzkocw hyf omzfc hwwo"gkhzfj ~kzd zdf loww om nfcfzkg ftpyfwwkoc hcj zdfky oggvy"yfcgf wffbw zo if fwwfczkhl moy zdf bvlzkplf cfgfwwhy{nfcfzkg f}fczw# Wo bhlknchcz pyonyfwwkoc zhefw plhgfifghvwf zdfwf hlzfyhzkocw ghc kchgzk}hzf JCH yfphkykcn

nfcfw# Yowhw fz hl# wzvjkfj zdf bfzd{lhzkoc phzzfycw omp8=, BNBZ hcj JHP"E nfcfw kc wbfhyw om phzkfczw wvmmfy"kcn myob dfhj hcj cfge ghcgfy U60R# Zdf{ jfzfgzfj hicoy"bhl d{pfybfzd{lhzkoc phzzfycw kc iozd ekcjw om whbplfwi{ h bfzd{lhzkoc wpfgkmkg Pol{bfyhwf Gdhkc Yfhgzkoc$PGY+# Zdf{ pyopowfj zdhz zdkw zfgdckxvf hllo~w h wfcwk"zk}f hcj fmmkgkfcz jfzfgzkoc om zvboyhl JCH hcj kz kwpozfczkhll{ vwfmvl moy jfzfgzkcn hcj bockzoykcn yfgvy"yfcgfw kc zdfwf phzkfczw# Loww om dfzfyonfcfkz{ $LOD+ hcjozdfy bolfgvlhy gdhcnfw kcjkghzk}f om oyhl ghygkconfcfwkwghc if yfhjkl{ kjfczkmkfj kc ftmolkhzfj gfllw U69"6:R# Dvhcn

Pdozobkgyonyhpd om bhlknchcz gfllw hmzfy yhjkhzkoc zdfyhp{wdo~kcn bvlzkplf cvglfhy ivjjkcnMknvyf 80Pdozobkgyonyhpd om bhlknchcz gfllw hmzfy yhjkhzkoc zdfyhp{

wdo~kcn bvlzkplf cvglfhy ivjjkcn# $D-F 8000+#

Pdozobkgyonyhpd om bhlknchcz gfllw hmzfy yhjkhzkoc zdfyhp{wdo~kcn bvlzkcvglfhzkoc hcj bkgyocvglfhzkocMknvyf ;Pdozobkgyonyhpd om bhlknchcz gfllw hmzfy yhjkhzkoc zdfyhp{

wdo~kcn bvlzkcvglfhzkoc hcj bkgyocvglfhzkoc# $D-F 8000+#
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7/9


Phnf > om ;$phnf cvbify coz moy gkzhzkoc pvypowfw+

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66& wdo~fj LOD hz wobf ozdfy loghzkoc# PGY hcj YMLPhchl{wkw dh}f hlwo iffc vwfj moy zdf jfzfgzkoc om bkgyowhz"fllkzf bhyefyw, k#f# wdoyz yfpfzkzk}f JCH wfxvfcgfw# Bkgyo"whzfllkzf bvzhzkocw, LOD oy kcwzhiklkz{ $BK+ hyf hllgdhyhgzfykwzkg om zdf wxvhbovw gfll ghygkcobhw om dfhjhcj cfge, hcj ghc zdvw if vwfj hw bolfgvlhy bhyefyw ombhlknchcg{# Bkgyowhzfllkzf yfnkocw hyf jkwzykivzfj hlocnzdf nfcobf hcj dh}f iffc ~kjfl{ hcj whzkwmhgzoykl{ vwfjhw bolfgvlhy bhyefyw moy ghygkconfcfwkw# Hlzfyhzkocw kczdfwf yfnkocw dh}f iffc vwfj hw glochl bhyefyw hcj moyjfzfgzkcn zvboyhl gfllw hbocn coybhl gfllw U6=,6>R# Wf}"fyhl wzvjkfw dh}f jfbocwzyhzfj zdfwf i{ vwkcn bkgyowhzfl"lkzf bhyefyw zdhz hlzfyhzkocw kc gfyzhkc yfnkocw om

gdyobowobfw 7p, ;p, 8>p hcj 84x hyf hwwogkhzfj ~kzd zdfjf}flopbfcz om dfhj hcj cfge wxvhbovw gfll ghygkcobhwU64,6;R# Cvcfw fz hl#U=0R pfymoybfj h bkgyowhzfllkzf hchl"

{wkw om gfllw whbplfj myob zdf oyhl gh}kz{ om oyhl hcjoyopdhy{cnfhl ghcgfy phzkfczw i{ ftmolkhzk}f g{zolon{ hcji{ bovzd~hwd, mkcjkcn LOD kc 4:& om whbplfw, zdovnd

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}fy{ dknd wpfgkmkgkz{ om zdfwf bfzdojw#

7# ]kyhl nfcobf wzvjkfw

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~hw goyyflhzfj U=8R

:#Pyolkmfyhzkoc kcjft hcj HnCOY hchl{wkw

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Hmzfy 9: Nyh{ kyyhjkhzkoc, co ghwf wdo~fj Ek"=> powk"zk}f gfllwU=9R# Zdf }hlkjkz{ om oyhl g{zolon{ moy hchl{qkcnzdf cvbify om efyhzkckwfj gfllw hcj zdf cvglfolhy hgzk}kz{$HnCOYw+ kc wboekcn phzkfczw dhw yfgfczl{ iffc jfboc"wzyhzfj U=7R# Yfbbfyihgd yfpoyzfj oc HnCOY hchl{wkw kc

oyhl g{zolon{ hcj gocglvjfj zdhz zdkw bh{ if vwfj hw hyovzkcf bfzdoj moy jkhncowkcn oyhl ghcgfy U=:R#

6# Kbbvcodkwzogdfbkghl kjfczkmkghzkoc om zvbovy bhyefyw

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~kzd ozdfy kcmoybhzkoc, wvgd hw JCH pyomklf U=>,=4R#

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Yfmfyfcgfw8# Bfdyozyh Y, Wkcnd B, Evbhy J, Phcjf{ HC, Nvpzh YE, Wkcdh VW1

Hnf wpfgkmkg kcgkjfcgf yhzf hcj phzdolonkghl wpfgzyvb oyoyhl ghcgfy kc Hllhdhihj# Kcj A Bfj Wgk 9007, 6>1:00":#

9# Ehvnhyw NF, Wkl}fybhc W, Yh{ HE, fz hl#1 Zdf vwf om ftmolkhzk}fg{zolon{ moy zdf fhyl{ jkhncowkw om oyhl ghcgfyw1 kw zdfyf h yolfmoy kz kc fjvghzkoc hcj pyk}hzf pyhgzkgf? A Ghcgfy Fjvg8;;4,87146";#

7# Fpwzfkc AI, Qdhcn L, Yowkc B1 Hj}hcgfw kc zdf jkhncowkw om oyhlpyfbhlknchcz hcj bhlknchcz lfwkocw# A Ghc Jfcz 9009,=41=8>"98#

:# Onjfc NY, Go~pf AN, Nyffc B^1 Jfzfgzkoc om mkflj gdhcnf kcoyhl ghcgfy vwkcn oyhl ftmolkhzk}f g{zolonkg wzvj{# Ghcgfy8;;8,=418=88"6#

6# Fl"Chnnhy HE, Bho L, Wzhfyefl N, Goobifw BB, Zvgefy WL, Lvch BH,fz hl#1 Nfcfzkg dfzfyonfcfkz{ kc whlk}h myob phzkfczw ~kzd oyhlwxvhbovw ghygkcobhw1 kbplkghzkocw kc bolfgvlhy jkhncowkwhcj wgyffckcn#A Bol Jkhnc 9008, 718=:">0#

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8/9



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Review: Application of cytology and molecular biology in diagnosing premalignant or malignant oral...

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