Reversible cell injury

cellular swelling (Hydropic changes)

Fatty changes

Irreversible cell injury

Necrosis

Apoptosis

Cell Injury

Intracellular Accumulation and Extracellular Deposits

Fatty infiltration (steatosis)AmyloidosisHyalinosis

Gross Pathology Lesson 2

1) Normal liver 2) Fatty changes (steatosis) of the liver 3) Coagulative necrosis (renal infarction)4) Coagulative necrosis (splenic infarction)5) Myocardial infarction (recent infarction) 6) Liquifactive necrosis (brain infarction)7) Caseation necrosis8) Amyloid liver9) Anthracosis of lung

Normal liver

Section in the liver shows

enlarged and has a pale yellow, soft and greasy appearance, seen both on the capsule and cut surface.

Diagnosis :liver fatty change.

Coagulative necrosis ( renal infarction)

Section in the kidney showsa wedge-shaped pale area of coagulative necrosis (infarction) in the renal cortex

Diagnosis :

Diagnosis :Coagulative necrosis ( splenic infarction)

Section in spleen shows Two large infarctions (areas of coagulative necrosis) infarcts are often wedge-shaped with a base on the organ capsule.

Myocardial infarction

An opened heart showing Deeply hemorrhage and mural thrombus in anterior wall and apex

diagnosis : massive myocardial infarction

Section in the brain shows

an irregular depressed area with complete lost of tissue

Diagnosis :Old brain infarction

Caseation necrosis

Section in the lung shows

The hilar lymph node(2x2 ) cm, has a cheesy tan to white appearance.

Diagnosis: caseous necrosis in a hilar lymph node infected with tuberculosis

Amyloid liver

Section of the enlarged liver shows reticulated pale waxy material between liver cells

Exogenous pigment

Anthracosis of lung

Patches of blackish areas of the lung

Diagnosis : anthracosis of lung

Histopathology Slides for Lesson2

Hyalinosis of spleen

Amyloid kidney Liver steatosis (fatty liver)pulmonary thrombus true thrombus

Section in the spleen shows:Hyaline degeneration affecting the central arterioles of lymph follicles.

The wall of arterioles become structureless homogenous ,pink ,thick and narrow lumen .

Diagnosis:Hyalinosis of spleen

Hyalinosis of spleen

Section in the kidney shows:•Homogenous pink amyloid deposits in the wall of arterioles which appear thick with narrow lumen.•Amyloid deposit in the basement membrane of glomerular capillaries. •Some glomeruli are partially or completely replaced by pink amyloid deposit.•Amyloid deposit in basement membrane of the collecting tubules with albumin casts in tubular lumen.•DiagnosisAmyloid kidney

Amyloid Kidney

Section in the liver shows:Empty vacuoles in the cytoplasm of the liver cells which appear distended. These vacuoles were occupied by fat which had dissolved in xylol during preparation.The nuclei of the cells are pushed by the fat and become flattened giving the cell signet ring appearance.Diagnosis:Liver steatosis (fatty liver)