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RETREAT MISSION STATEMENT

The Verna and Marrs McLean Department of Biochemistry and Molecular Biology

and The Department of Pharmacology and Chemical Biology

We take pride in the enormous breadth of biomedical research carried out within our two departments. This broad scope provides unique opportunities for cross-field education and intra- and inter-departmental collaboration. It is in the spirit of this cooperative venture that we hold the annual retreat, the goals of which are threefold: 1. To inform the departments as a whole about the state of research in the specific fields represented

within the departments. 2. To provide a congenial atmosphere where department members can present their research in a

manner conducive to collaboration. 3. To allow scientists at all levels the opportunity to hone their professional skills in an informal setting.

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BMB-PHARM RESEARCH CONFERENCE

OCTOBER 11 & 12, 2018

SCHEDULE OF EVENTS

Thursday, October 11th 8:00 a.m. – 8:45 a.m. Continental Breakfast Davidson South

8:00 a.m. – 8:45 a.m. Registration Davidson Annex

8:50 a.m. Opening Remarks Davidson North

9:00 a.m. – 10:00 a.m. SESSION 1 Davidson North

10:00 a.m. – 10:15 a.m. Departmental Photo Davidson Staircase

10:15 a.m. – 11:00 a.m. Poster Ranking Davidson Annex

11:00 a.m. – 12:00 p.m. SESSION 2 Davidson North

12:00 p.m. – 2:00 p.m. Lunch The Strand

2:00 p.m. – 3:00 p.m. SESSION 3 Davidson North

3:00 p.m. – 4:00 p.m. POSTER SESSION I (Odd) Davidson Annex

4:00 p.m. – 5:30 p.m. Free time

5:30 p.m. – 7:00 p.m. Cocktails & Costumes Davidson Annex

7:00 p.m. – 8:30 p.m. Dinner Davidson South

8:30 p.m. – 11:00 p.m. Dance Davidson South

Friday, October 12th

8:30 a.m. – 9:30 a.m. Breakfast Buffet Davidson South

9:30 a.m. – 10:30 a.m. SESSION 4 Davidson North

10:30 a.m. – 10:45 a.m. Break

10:45 a.m. – 11:45 a.m. POSTER SESSION II (Even) Davidson Annex

11:45 a.m. – 12:45 p.m. Lunch Davidson South

12:45 p.m. – 1:45 p.m. SESSION 5 Davidson North

1:45 p.m. – 2:00 p.m. Break

2:00 p.m. – 3:00 p.m. SESSION 6 Davidson North

3:00 p.m. – 3:30 p.m. Awards and Announcements

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1) Tacon’ Madre Food Truck (Latin American) 2100 Strand Hendley Park (no rating, 5 min walk) 2) Stranded Corner (Seafood) 2100 Strand St. (no rating, 5 min walk) 3) Old Strand Emporium (Deli) 2112 Strand St. (4.5 out of 5 stars, 4 min walk) 4) Stuttgarden Tavern (American, German) 2110 Strand St. (4 out of 5 stars, 5 min walk) 5) Starbucks (Café, American) 102 22nd St. (4.5 out of 5 stars, 4 min walk) 6) Willie G’s Seafood and Steaks (Seafood, American) 2100 Harborside Dr. (4 out of 5 stars, 7 min walk) 7) Fisherman’s Wharf (American, Seafood, Deli) 2200 Harborside Dr. (4 out of 5 stars, 5 min walk) 8) Olympia Grill at Pier 21 (American, Seafood, Mediterranean, Greek, International) 100 21st Street Harbor House Hotel (4.5 out of 5 stars, 7 min walk)

9) Hubcap Grill and Cocktail Bar (American) 2021 Strand St. (4 out of 5 stars, 5 min walk)

10) Shrimp and Stuff Downtown (American, Seafood) 2021 Strand St. (4 out of 5 stars, 5 min walk)

11) Jimmy Johns (American) 102 22nd Street (4 out of 5 stars, 4 min walk) 12) Mama Teresa’s Flying Pizza (Italian) 416 21st St. (4.5 out of 5 stars, 6 min walk) 13) HuliHuli Hut (American) 312 19th St. and Mechanic (4 out of 5 stars, 9 min walk) 14) El Pinoy (Filipino, Asian) 101 21st St., Ste. 4 (3.5 out of 5 stars, 6 min walk) 15) Yaga’s Tropical Café (American) 2314 Strand St. (4 out of 5 stars, 3 min walk) 16) Trattoria La Vigna (Italian) 412 20th St. (4.5 out of 5 stars, 7 min walk) 17) The Tremont Café (American, Café) 2300 Ship Mechanic Row St. (4 out of 5 stars, 1 min walk) 18) Sky Bar Steak and Seafood (Japanese, Sushi,

American) 2105 Post Office St. (4 out of 5 stars, 7 min walk)

19) La Mixteca Mexican Restaurant (Mexican) 1818 Mechanic St. (4.5 out of 5 stars, 10 min walk) 20) Mediterranean Chef (Mediterranean, Greek, Middle Eastern) 2402 Strand St. (4 out of 5 stars, 2 min walk)

Restaurants Near the Strand

***ALL WALK TIMES LISTED ARE ONE-WAY***

Lunch on the Strand Thursday, October 11, 2018

12:00 p.m.– 2:00 p.m.

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BMB-PHARM RESEARCH CONFERENCE

OCTOBER 11 & 12, 2018

THURSDAY, OCTOBER 11 8:00 am – 8:45 am CONTINENTAL BREAKFAST Davidson South

8:00 am – 8:45 am Registration Davidson Annex

8:50 am Opening Remarks Davidson North

SESSION 1 Session Moderator: Jin Wang, Ph.D. [F] Davidson North

9:00 am – 9:20 am Ming Zhou, Ph.D. [F] Elevators in Cell Membrane: Transporters in Motion

9:20 am – 9:40 am Josephine Ferreon, Ph.D. [F] Changing Phases of Intrinsically Disor-

dered Proteins

9:40 am – 10:00 am Rui Chen, Ph.D. [F] Degeneration and Survival of Photoreceptor Cells in the

Spata7 Mutant Retina

10:00 am – 10:15 am Departmental Photo Davidson Staircase

10:15 am – 11:00 am Poster Ranking Davidson Annex

SESSION 2 Session Moderator: Diana Cox [GS] (Cooper Lab) Davidson North

11:00 am – 11:20 am Wanderson Rezende [GS] (D Young Lab) Exploring the Potential of Bi-

functional Degraders as Chemical Probes to Study the HIV Replication Cycle

11:20 am – 11:40 am Tao Wang [PD] (N Young Lab) Histone Acetylation Increases Within

Minutes after Histone Deacetylase Inhibitor Treatment

11:40 am – 12:00 pm Alex Saltzman [GS] (Malovannaya Lab) Hypothesis Generation from the

Integration of Multiproteomic Data and a posteriori Knowledge to Generate

Hypothesis from CD4+T Cell & HIV Activation

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12:00 pm – 2:00 pm Lunch The Strand

SESSION 3 Session Moderator: Thu Vu Phuc Nguyen [GS] (Golding Lab) Davidson North

2:00 pm – 2:20 pm Teng-Kuei Hsu [GS] (Lichtarge Lab) A Calculus of Mutational Landscapes

Reveals Novel Cancer Driver Genes Under Positive Selection

2:20 pm – 2:40 pm Fangrui Wu [F] (Song Lab) Synthesis, SAR and Biological Activity of Thi-

ophene-Containing Inhibitors of Histone Acetyltransferase P300/CBP

2:40 pm – 3:00 pm Ryan Haley [GS] (Z Zhou Lab) The Small GTPase RAB-35 Defines a Novel

Pathway for Apoptotic Cell Clearance in Caenorhabditis Elegans

3:00 pm – 4:00 pm POSTER SESSION 1 (Odd) Davidson Annex

4:00 pm – 5:30 pm Free time

5:30 pm – 7:00 pm Cocktails & Costumes Davidson Annex

7:00 pm – 8:30 pm Dinner Davidson South

8:30 pm – 11:00 pm Dance Davidson South

FRIDAY, OCTOBER 12

8:30 am – 9:30 am BREAKFAST BUFFET Davidson South

SESSION 4 Session Moderator: Kehan Chen [GS] (M Zhou Lab) Davidson North

9:30 am – 9:50 am Cameron Brown [GS] (Palzkill Lab) Molecular Basis for Negative Epistasis

Between Two Naturally Occurring Drug-Resistance Mutations in CTX-M-β lac-

tamases

9:50 am – 10:10 am Mahdi Moosa [PD] (A Ferreon Lab) Deciphering complexities in Sox2-DNA

Interactions Using Single-molecule Spectroscopy

10:10 am – 10:30 am Jing Zhang [GS] (Golding Lab) Measuring Transcription at a Single

Gene Copy Illuminates mRNA Dynamics and Reveals Intracellular Correlations

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10:30 am – 10:45 am Break

10:45 am – 11:45 am POSTER SESSION 2 (Even) Davidson Annex

11:45 am – 12:45 pm Lunch Davidson South

SESSION 5 Session Moderator: Vidya Sethunath [GS] (Schiff Lab) Davidson North

12:45 pm – 1:05 pm Franklin Gu [GS] (Sreekumar Lab) Kynurenine Pathway Enzyme

AADAT Promotes Breast Cancer Progression and Immunosuppression in

Triple-negative Breast Cancer

1:05 pm – 1:25 pm Renae Bertrand [GS] (R Chen Lab) Investigating the Mechanism of

Retinal Degeneration Due to Mutations in CWC27

1:25 pm – 1:45 pm Dorit Donoviel [F] (Donoviel Lab) Exciting Research & Programs at the

Translational Research Institute for Space Health

1:45 pm – 2:00 pm Break

SESSION 6 Session Moderator: Nicolas Young, Ph.D. [F] Davidson North

2:00 pm – 2:20 pm Liya Hu, Ph.D. [F] Glycan Recognition in Gastrointestinal Viral Patho-

gens

2:20 pm – 2:40 pm Koen Venken, Ph.D. [F] The Collateral Analysis of Cellular Signaling

Events Using Multiplex Luciferase Assaying

2:40 pm – 3:00 pm Charles Lin, Ph.D. [F] Targeting Transcriptional Circuitries in Disease

3:00 pm – 3:30 pm AWARDS CEREMONY: Timothy Palzkill, Ph.D. and Ted Wensel, Ph.D.

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THE JOSHI

MEMORIAL PRIZE Dr. Vadusev C. Joshi was born in Gujarat, India. He

received his B.S. degree in pharmacy from Madras

Medical College in 1959, ranking among the top 5% of

students in the state. After earning his M.S.

degree in pharmacy from Andra Pradesh University in

1961, Dr. Joshi began his Ph.D. studies in the

Department of Biochemistry at the Indian Institute of

Science in Bangalore. Under the tutelage of Dr.

T. Ramasarma, he studied ubiquinone and related

compounds, earning his doctorate in biochemistry in

1964. While a postdoctoral fellow at the Indian

Institute of Science, Dr. Joshi was awarded a Ford

Foundation Research Fellowship. In 1966, he was

awarded the prestigious Fulbright Fellowship, which

allowed him to come to the United States to further his

education at Duke University in the Departments of Pediatrics and Biochemistry. There, he

continued his studies of ubiquinone and eventually became interested in fatty acid synthesis. In

1972, Dr. Joshi accepted a position as an assistant professor in the Department of Biochemistry

at Baylor College of Medicine under the leadership of Dr. Salih J. Wakil. While at BCM, he con-

tinued his investigations of fatty acid synthesis. He was promoted to associate professor in

1977 and was honored with a prestigious Research Career Development Award from the Na-

tional Institutes of Health the same year. During his tenure at BCM, Dr. Joshi published numer-

ous papers and was an active member of the Admissions Committee. In 1980, Dr. Joshi spent

a year in the laboratory of Dr. Hargovind Khorana in the Department of Chemistry at the Massa-

chusetts Institute of Technology. After returning to BCM in late 1981, he continued his research

in fatty acid synthesis and gene regulation until his untimely death in 1982. Dr. Joshi not only

was a committed and hardworking scientist; he was an active member of the Indian community

and a strong patron of the arts. Most importantly, Dr. Joshi was a devoted husband to his wife

Yogini and a doting father to his three daughters, Harshini, Yamini, and Meena.

As a tribute to Dr. Joshi for his dedication to excellence in education and research, his family,

friends, and colleagues established a memorial fund in his honor in 1986. The Joshi

Memorial Prize is granted to students and postdoctoral trainees within the Department of

Biochemistry in recognition of their outstanding oral and poster presentations at the annual re-

search conference.

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JUDGING CRITERIA Oral Presentations

I PRESENTATION (30%)

Organization of talk, clarity of presentation

Quality of slides, legibility & clarity of labeling, color & contrast

Engaging, entertaining, style

Time management

II RESEARCH (40%)

Significance for biomedical or basic science

Quality of data, difficulty of experiments

Interpretations justified, conclusions sound

Innovative approach or techniques

Clear acknowledgment of work by others

III INTERACTION (30%)

Did the talk stimulate questions

Ability to respond to questions

Display knowledge outside prepared presentation

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JUDGING CRITERIA Poster Presentations

I POSTER (30%)

Organization of poster, clear flow, aesthetics

Abstract, hypothesis or question, conclusions, acknowledgments

Legible figures, clearly & concisely labeled

II RESEARCH (40%)

Significance for biomedical or basic science

Quality of data, difficulty of experiments

Interpretations justified, conclusions sound

Innovate approach or techniques

How much work is done by the presenter

III INTERACTION (30%)

Was the poster presented clearly

Ability to respond to questions

Knowledge outside prepared presentation

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POSTER RANKING CRITERIA

I POSTER (40%)

Organization of poster, clear flow, aesthetics

Abstract, hypothesis or questions, conclusions, acknowledgments

Legible figures, clearly & concisely labeled

II RESEARCH (60%)

Significance for biomedical or basic science

Quality of data, difficulty of experiments

Interpretations justified, conclusions sound

Innovative approach or techniques

How much work is done by the presenter

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POSTER RANKING SHEETS THURSDAY, 10:15 A.M. - 11:00 A.M.

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POSTER FEEDBACK SHEET THURSDAY, 3:00 P.M. - 4:00 P.M.

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POSTER FEEDBACK SHEETS FRIDAY, 10:45 A.M. - 11:45 A.M.

SPECIAL THANKS

Biochemistry and Molecular Biology Chair:

Ted Wensel, Ph.D.

Pharmacology and Chemical Biology Chair:

Tim Palzkill, Ph.D.

Retreat Organizing Committee:

B.V.V. Prasad, Ph.D.

Akhila Balasubramanian

Renae Bertrand

Imani Bijou

David Boragine

Elizabeth Bowling

Shelton Boyd

Shawn Briley

Christy Charles

Kehan Chen

Diana Cox

Adam Fluty

Secondra Holmes

Heyuan Li

Andrew McCullough

Quynh Nguyen

Thu Vu Phuc Nguyen

Omar Peña Ramos

Ruth Reeves

Liying Qin

Alexander Saltzman

Victoria Soeung

Vidyalakshmi Sethunath

Doris Taylor

Kim Tran

Lie Wang

Photography:

Omar Peña Ramos

Andrew McCullough

Registration:

Ruth Reeves

1st-year graduate students

Retreat Website:

Steve Ludtke

Adam Fluty

Alex Saltzman

Poster Judging Committee

Oral Presentation Judging Committee