r

Volume 132 Number 4 October 1985

ISSN 0003-0805

AMERICAN REVIEW OF Respiratory Disease

O F F I C I A L J O U R N A L O F T H E A M E R I C A N T H O R A C I C S O C I E T Y M E D I C A L S E C T I O N O F T H E A M E R I C A N LUNG A S S O C I A T I O N

1382 Pulmonary Morphologist — Opportuni ty for Ph.D. or M.D. for ap­pointment as Assistant or Associate Professor (research) in the In­stitute for Environmental Medicine and the Depar tment of Pathol­ogy and Laboratory Medicine at the University of Pennsylvania School of Medicine. Successful candidate will collaborate with es­tablished investigators in respiratory physiology/experimental pathology and will develop an independent research program in respiratory cell biology. Experience with electron microscopy is es­sential. Ample space, funding opportunit ies, and state-of-the-art facilities are available. Deadline for applications is December 31, 1985. Interested applicants should send C.V., statement of research interests, and names of three references to Aron B. Fisher, M.D., Director, Institute for Environmental Medicine, Chairman, Pulmo­nary Morphology Search Committee, University of Pennsylvania School of Medicine/G2, Philadelphia, PA 19104. The University of Pennsylvania is an equal opportunity/affirmative action employer.

Pulmonologist: Board certified or eligible to join expanding 2-man group in midwest city with large university. Must be proficient in all aspects of pulmonary and critical care medicine and be willing to do some internal medicine. Please reply with C.V. to Box 575.

Pulmonary physician sought to join pulmonary division of a major Canadian university hospital. Candidate must be experienced and capable of conducting independent clinical or basic research. Reply Box 583.

Pulmonologist/Internist, require BE/BC-pu lmona ry . N.Y.C. sub­urb, active ICU, office consultation, 80% pulmonary, PVT prac­

tice, teaching affiliations. Proficient all procedures. Available now or July 1986. Reply Box 582. Postdoctoral Research Fellowships in Lung Research for 1985-86 and 1986-87 available in the University of California, Davis (UCD) Interdisciplinary Pulmonary Disease Research Group. Ph.D., M.D., or DVM required. Ongoing research areas include nutritional aspects of lung disease, alveolar macrophage cytochemistry, respiratory gly­coprotein biosynthesis and metabolism, lung collagen and elastin, lung liposomes and lipoprotein metabolism, airway nerves and blood supply, relationships of xenobiotic metabolism to pulmonary cyto­toxicity, mechanism of respiratory epithelial differentiation, respira­tory tract permeability, and inhalation toxicology. Eight U C D faculty with research activities in lung disease involved in fellowship train­ing program. Send resume to: Dr. C. E. Cross, Division of Pu lmo­nary Medicine, 4301 "X" St., University of California, Davis Medi­cal Center, Sacramento, CA 95817. Equal Oppor tuni ty /Aff i rma­tive Action Institution.

Practice for sale: Pu lmonary and Internal Medicine. Active prac­tice for 11 years. Nice Chicago suburban location. Practice includes office building, fully equipped office. Will introduce. Reply to Box 584. Pulmonologist —To join 7 internists in 20-man multispeciality group. Must be able to practice excellent general internal medicine as well. City of 32,000 with 2 hospitals, serving area of 200,000. No pu lmo-nologist in area. Attractive family environment, nearby lake, con­venient to Twin Cities. Send C.V. to Administrator, Park Clinic, 890 North Eisenhower, Mason City, IA 50401.

Necrology

Warde B. Allan, M.D. Garrison, Maryland Kelly M. Berkley, M.D. Phoenix, Arizona Thomas C. Black, M.D. Temple, Texas William Brueggmann, M.D. Mainville, Ohio Kenneth G. Bulley, M.D. Fort Myers, Florida Henry A. Christian, M.D. Whiting, New Jersey E. Leslie Chusid, M.D. New York, New York Royal S. Davis, M.D. New Rochelle, New York

(April-October 1985) Joseph T. Eagan, M.D. Oneonta , New York N o r m a C. Furtos, M.D. Escondido, California Joseph C. Hart , M.D. Poughkeepsie, New York Peter P. Kozak, Jr., M.D. Santa Ana, California Wiliam H. McCain, M.D. Springfield, Illinois Walter H. Modarelli, M.D. Leonia, New Jersey Valerie J. Molzahn, M.D. Redlands, California William R. Murlin, M.D. Salem, Oregon

George C. Owen, M.D. Brookfield, Wisconsin I. Ellis Rudman, M.D. New York, New York Cecil L. Schultz, M.D. Venice, Florida Clarence Sharp, M.D. Jacksonville, Florida John Srail, M.D. Tacoma, Washington George W. Ware, M.D. Bowie, Maryland William L. Weintraub, M.D. Totowa, New Jersey

INDEX-AUTHORS

A B E L , J E F F R E Y , 1 5 9 A B E R N A T H Y , R O B E R T S . , 9 3 1 A C K E R M A N , S T E V E N J . , 9 8 1 A C O C E L L A , G I A N N I , 5 1 0 , 1 2 6 8 , 1 2 7 4 A D A M S O N , D A V I D , 9 1 6 A D K I N S O N , N . F R A N K L I N , J R . , 9 9 , 3 6 7 A G O S T I N I , C , 4 0 0 A H M E D , T A H I R , 8 3 9 A H R E N S , J O A N , 7 5 2 A L B E R T , R I C H A R D K . , 6 2 3 , 9 6 3 A L L E N . D A R R E L , 5 9 0 A L L E N . J U L I A N L . , 3 4 3 A L T O S E , M U R R A Y D . , 8 0 0 , 9 5 4 A M E N D , P H I L I P P E , 5 0 4 A N D E R S O N , R . , 1 0 4 9 A N D O , M A S A Y U K I , 2 9 9 A N D R E A D I S , N I C H O L A S , 1 3 4 4 A N G U S , G . E L S P E T H , 8 9 4 A N T H O N I S E N , N I C H O L A S R . , 8 7 1 A N T T I N E N , H E N R I K , 5 3 6 A N Z A R , U T E T . , 6 1 9 A R A K I , S H U K U R O , 2 9 9 A R B A B I A N , M A R T I N , 1 1 9 4 A R M O U R , C . L . , 3 0 A S H T O N , J U L I E T , 5 6 4 , 1 2 6 2 A S T I E R , A L A I N , 7 4 8 A T A S S I , K I N A N , 1 1 1 8 A U S T E N , F R A N K , 1 2 0 4 A V O L , E D W A R D L . , 6 1 9 B A C H M A N N , M A R L I E S , 4 7 9 B A L D W I N , S T E P H E N R . , 1 2 8 8 B A L K , R O B E R T A . , 9 2 9 B A L L A S , Z U H A I R K . , 7 7 B A N N E R , A R T H U R S . , 9 9 3 B A R N E S , P E T E R J . , 5 4 1 , 1 0 1 9 B A R O N , R O B E R T B . , 7 3 7 B A R R Y , B R E N D A E . , 5 4 8 B A R T E R , S . J . , 1 4 8 B A R T L E T T , D O N A L D , J R . , 2 1 6 , 1 2 4 2 B A S S , J O H N B . , 3 7 9 B A S S E T , F R A N C O I S E , 8 3 6 B A S S E T , G U Y , 8 8 0 B A T E S , J O S E P H H . , 3 8 6 B A T T E R , W E R N E R , 1 0 6 0 B A U G H M A N , R O B E R T P . , 3 9 0 B A U M A N N , H A N S R . , 1 0 6 0 B E A S L E Y , P A T , 9 7 6 B E A T Y , T E R R I H . , 1 1 5 B E C K E R , C A R O L I N E , 1 7 5 B E C K L A K E , M A R G A R E T R . , 1 1 2 7 B E K E R M A N , C A R L O S , 7 4 6 B E N - B A S S A T , M . , 6 0 2 B E N F I E L D , J O H N R . , 4 3 4 B E N G A L I , Z A K I R , 1 8 2 B E N O I T , G U Y , 7 4 8 B E N S O N , K I M N . , 4 7 2 B E R E N D , N O R B E R T , 5 8 2 B E R G E R , L O R E N Z C , 7 7 7 B E R G O F S K Y , E D W A R D H . , 6 3 3 B E R L I N E R , S . , 6 0 2 B E R N A U D I N , J E A N - F R A N C O I S , 7 4 8 , 1 1 1 8 B E R R Y , D A V I D D . , 5 0 0 , 1 3 1 3 B I C E , D A V I D E . , 6 4 7 , 6 6 1 B I E T H , J O S E P H G . , 5 2 4 , 8 1 8 , 9 1 3 B I G B Y , T I M O T H Y D . , 5 9 0

B I X L E R , E D W A R D O . , 9 7 2 B L E E C K E R , E U G E N E R . , 2 2 0 B O A T , T H O M A S F . , 7 7 0 B O B E Y , D A V I D G . , 4 0 9 B O N N E Y , T H O M A S B . , 1 1 7 4 B O R G E N , L O W E L L , 1 1 9 4 B O U C H E R , R I C H A R D C , 3 1 1 , 1 2 8 1 B O U D I E R , C H R I S T I A N , 9 1 3 B O U S H E Y , H . A . , 6 9 0 B O X E R , L A U R E N C E A . , 1 2 8 8 B R A D L E Y , T . D . , 2 1 1 B R A D S H E R , R O B E R T W . , J R . , 9 3 1 B R A I N , J O S E P H D . , 6 0 6 B R A U N , N O R M A M . T . , 4 2 B R E U E R , R A P H A E L , 3 6 2 , 1 1 5 5 B R I D G E S , R A Y M O N D B . , 1 1 6 2 B R O D Y , J E R O M E S . , 9 0 5 , 1 3 0 7 B R O W N , I . G . , 2 1 1 B R O W N , S T E P H E N E . , 9 6 0 B R U C E , M A R G A R E T C , 5 2 9 B R U E S K E , D E W A N E A . , 1 8 6 B U C K N E R , C . K . , 3 0 5 B U I S T , A . S O N I A , 8 2 1 , 1 1 8 6 B U R K I , N . K . , 1 2 1 0 B U R N S , S T E P H E N R . , 1 0 9 B U R R I , P E T E R H . , 7 7 7 B U R S T I N , S . , 1 3 3 B U S S E , W I L L I A M W . , 3 0 5 , 1 1 9 4 B U T K A , B R E N D A J . , 9 3 1 B U T L E R , J O H N E . , 6 2 3 , 9 6 3 , 1 0 2 7 B Y E , P E T E R T . P . , 2 3 6 C A D I E U X , R O G E R J . , 9 7 2 C A L A F I O R E , D O R O T H Y C , 2 6 1 C A L D W E L L , J A M E S , 6 2 3 , 9 6 3 C A L L E N , P E T E R W . , 1 2 5 3 C A L O R E , J . D . , 3 6 2 , 1 1 5 5 C A L V E R L E Y , P . M . A . , 8 6 C A M P B E L L , D . A . , 1 3 0 0 C A N T O R , J E R O M E O . , 6 4 0 C A R L I , G I U L I O , 8 0 6 C A R L O N E , N I C O L A A . , 1 2 6 8 , 1 2 7 4 C A R R I C O , C . J A M E S , 4 8 5 C A R S T A I R S , J . R . , 5 4 1 C A R T I E R , A N D R E , 6 4 4 , 8 4 8 C A S T A I N G , Y V E S , 3 3 2 C A S T E L L A N , R O B E R T M . , 1 1 3 9 C A T A N E S E , A N T H O N Y , 3 6 2 , 1 1 5 5 C A T T E R A L L , J . R . , 8 6 C A U T H E N , G E O R G E M . , 1 2 5 , 5 1 6 C A V A L L O , G I O R G I O , 1 2 6 8 C E D E R B A U M S , D A I N A , 5 8 2 C E R V A N T E S , P I E R R E , 7 1 2 C H A N G , H . K . , 1 0 4 , 3 5 0 C H A N - Y E U N G , M O I R A , 8 1 4 C H A P A R A S , S O T I R O S D . , 1 7 5 C H A P M A N , H A R O L D A . , J R . , 5 6 9 C H A P M A N , K . R . , 8 4 5 C H A P M A N , R O B E R T S . , 2 6 1 , 8 7 5 C H A T H A M , M A R I E D . , 3 6 C H A U S O W , A L A N , 7 4 6 C H E C K , I R E N E J . , 6 5 C H E N G , C , 3 1 1 C H E R N I A C K , N E I L S . , 1 2 1 4 C H E R N I A C K , R E U B E N M . , 5 8 2 , 5 9 0 C H E R N I C K , V I C T O R , 1 6

C H I E S U R A - C O R O N A , P . , 1 0 1 0 C H I L O S I , M . , 4 0 0 C H O L L E T - M A R T I N , S Y L V I E , 8 3 6 C H O U , J E A N , 3 8 2 C H R I S T E N S E N , L O U I S E , 4 0 9 C H R I S T E N S E N , T . G . , 3 6 2 C H R I S T I A N S D A V I D C , 1 2 0 , 1 3 7 1 C H R I S T M A N , J O H N W . , 1 5 2 , 3 9 3 C H U R C H , M A R T I N K . , 9 8 6 C H U R G , A N D R E W , 9 2 2 C I P R I A N I , A . , 4 0 0 C L A R K , J O H N C , 1 1 8 1 C L A U D E , J E A N - R O G E R , 8 1 8 C L A U S E N , J A C K L . , 6 8 5 C L A Y T O N , J A M E S , 3 2 1 C L O Z E L , J E A N - P A U L , 5 0 4 C O A L S O N , J A C Q U E L I N E J . , 3 5 8 , 1 2 6 2 C O H E N , A L L E N B . , 1 0 9 8 C O H E N , B E R N I C E H . , 1 1 5 C O L E , P H I L I P , 1 2 2 9 C O L L I E R , A L B E R T M . , 8 7 5 C O L M A N , R O B E R T W . , 1 0 9 8 C O N N A U G H T O N , J O H N J . , 2 0 6 C O N N E L L A N , S . J . , 1 4 8 C O N O L L Y , M A T T H E W E . , 1 2 C O N T I , R O B E R T , 5 1 0 C O N W A Y , W . , 5 2 0 C O O K , J A M E S L . , 1 2 4 6 C O O N E Y , T H O M A S P . , 5 9 6 C O R D O N N I E R , C A T H E R I N E , 7 4 8 , 1 1 1 8 C O R E Y , E . J . , 1 2 0 4 C O R N , C A R O L Y N J . , 1 4 3 C O R W I N , R . W I L L I A M , 5 7 6 C O S I O , M A N U E L G . , 8 9 4 , 1 3 6 6 C O T T O N , C A L V I N U . , 1 2 8 1 C O V E R , D . , 1 2 3 3 C O V E R T , D A V I D S . , 6 4 8 C R A I G , K E N N E T H C , 1 0 7 1 C R A N Z , D I A N E L . , 5 5 6 C R A P O , J A M E S D . , 5 4 8 C R A W F O R D , J A C K T . , 3 8 6 C R I T C H L E Y , J U L I A N A . J . H . , 2 0 6 C R O W L E , A . J . , 7 4 2 C R U Z , E D G A R D O , 4 8 C R Y S T A L , R O N A L D , 8 2 1 C U F F I N I , A N N A M A R I A , 1 2 6 8 , 1 2 7 4 C U L P E P P E R , J U D I T H A . , 1 0 7 5 C U L V E R , B R U C E H . , 7 8 8 C U N N I N G H A M , D . A . , 1 4 8 C U R L E Y , F R E D E R I C K J . , 1 1 3 0 C U S H L E Y , M I C H A E L J . , 1 C U S T E R , J O S E P H R . , 3 2 6 D A L V E C C H I O , L . , 1 0 1 0 D A N I E L , E . E . , 2 7 2 , 8 6 5 D A R G E N T , F R A N C O I S E , 4 7 9 D A U B E R , J A M E S H . , 1 5 2 D A U P H I N E E , B E T H , 1 2 D A V I S , G E R A L D S. , 3 9 3 D A V I S , R O B I N L . , 7 6 1 D E A L , E . C H A N D L E R , J R . , 1 2 1 4 D E A R B O R N , D O R R G . , 4 2 9 , 7 7 0 D E G R A F F , A R T H U R C , J R . , 8 5 8 D E L A C R O I X , D . L . , 8 2 9 D E L A N E Y , M O R G A N D . , 1 0 8 7 D E M A R Z O , N . , 1 0 1 0

1383

1384 AUTHOR INDEX

D E M L I N G , R O B E R T H . , 1 2 5 7 D E R K S E N , F R E D E R I K , 1 0 6 6 D E T R O Y E R , A N D R E , 5 3 , 7 9 3 D H I L L O N , D H A R A M P . , 9 2 6 D I A M O N D , L O U I S , 8 8 5 D I C K , E . C , 3 0 5 D I E R K S , S T E V E E . , 1 0 2 7 D I G I A C O M O , G . R . , 1 0 1 0 D I L L A R D , T H O M A S A . , 2 3 0 D I M A R C O , A N T H O N Y F . , 8 0 0 D I M A R C O , M A R I A N N E S . , 8 0 0 D I P E D E , F R A N C E S C O , 8 0 6 D I S E , C R A I G A . , 1 9 1 D I S T E F A N O , S A N D R A , 1 1 0 6 D O D S O N , R O N A L D F. , 1 4 3 D O H N , M I C H A E L N . , 3 9 0 D O N E V A N , R I C H A R D , 9 2 2 D O U G L A S , F R A N K L . , 9 9 3 D O U G L A S , N E I L J . , 8 6 , 2 0 6 D R A Z E N , J E F F R E Y M . , 9 5 3 , 1 2 0 4 D R E I S I N , R O B E R T B. , 1 8 6 D R E Y F U S S , D I D I E R , 8 8 0 D U A N E , G L O R I A , 1 3 1 3 D U Bois, R . M . , 1 3 0 0 D U N G W O R T H , D O N A L D L . , 5 5 6 D U N N E T T E , S A N D R A L . , 9 8 1 D U R H A M , S T E P H E N R . , 9 8 6 D U S O U I C H , P A T R I C K , 5 0 4 D U V I V I E R , C L A U D E , 7 1 2 E A S T O N , P A U L A . , 8 7 1 E G G L E S T O N , P E Y T O N A . , 9 7 6 E I S E N , E L L E N A . , 1 2 0 , 1 3 7 1 E L I A S S O N , O R N , 8 5 8 E M E R S O N , R O B E R T J . , 3 9 3 E N A R S O N , D O N A L D A . , 8 1 4 E N D E , N O R M A N , 3 8 2 E N G L A N D , S A N D R A , 7 6 6 E N T E R L I N E , P H I L I P E . , 1 1 7 4 E R D Ö S , E R V I N G . , 5 6 4 , 1 2 6 2 E S A U , S H R O N , A . , 2 3 6 E S T E N N E , M A R C , 5 3 , 7 9 3 E T C H I S O N , J A M E S R . , 5 5 6 F A B B R I , L . M . , 1 0 1 0 F A J M A N , W I L L I A M A . , 6 5 F A N T A , C H R I S T O P H E R H. , 6 6 6 , 8 5 3 F A R R O W , J O H N T . , 6 8 5 F A V A , M A R I O , 4 8 F A Z Z I , P I E R A , 8 0 6 F E I N , A L A N M . , 6 0 , 1 0 9 8 F E L D S I E N , D I A N E , 5 8 2 F E N T O N , R I C H A R D , 1 6 F E R R E T T I , R I C A R D O , 4 8 F E R R O , T H O M A S J . , 1 9 1 F E U I L H A D E D E C H A U V I N , M A R T I N E ,

7 4 8 , 1 1 8 F I E L D , K E I T H G . , 1 3 1 9 F I L L Y , R O Y A . , 1 2 5 3 F I L U K , R O B E R T B. , 8 7 1 F I S C H E R , C L A U D I A E . , 9 6 0 F I S H E R , J A M E S H. , 1 1 4 9 F I T Z G E R A L D , R . S . , 2 4 1 F L E N L E Y , D A V I D C , 8 6 , 2 0 6 F L E U R Y , J O C E L Y N E , 1 1 1 8 F O R N O - P I Z Z O G L I O , M A R T I N A , 1 2 7 4 F O S T E R , W . M I C H A E L , 6 3 3 F O W L E R , A L P H A A . , 4 7 2 , 4 9 0 Fox , R I C H A R D , 1 2 5 7 F R A N C I S , C , 8 2 9 F R A N T Z , I V A N D . , I l l , 3 4 3 F R A N Z B L A U , C , 3 6 2

F R A S E R , I A N M . , 7 6 6 F R E D B E R G , J E F F R E Y J . , 3 4 3 F R I C K , O S C A R L . , 2 9 2 F U K U D A , T A K E S H I , 9 8 1 F U L L E R , R I C H A R D K . , 7 7 0 G A G N O N , G I L L E S , 6 4 4 G A L L I N A , C L A U D I A , 7 1 2 G A M S U , G O R D O N , 1 1 2 4 , 1 2 5 3 G A N G A D H A R A M , P A T T I S A P U R . J . , 1 2 7 8 G A N T E R , B E R N A R D U S , 7 3 7 G A N Z , T . , 9 0 1 G A S P A R O T T O , G . , 4 0 0 G A I Z Y , J O H N T . , 1 2 8 1 G A U L D I E , J A C K , 8 2 G A U T H I E R , R I C H A R D , 8 4 8 G E F F R O Y , B . A . , 6 9 0 G E L B , A L A N , 2 8 3 G E L L E R T , A . R . , 8 2 4 G H E Z Z O , H E B E R T O , 8 4 8 , 8 9 4 G I B E L L I N O , F . , 1 4 8 , 7 8 4 G I L B E R T , R O B E R T , 1 9 5 G I L L E R , S . , 6 0 2 G I L M A N , M U R R A Y J . , 6 5 , 1 1 3 9 G I N , W I L L I A M , 1 1 9 9 G I O I A , F R A N K R . , 9 9 G I U N T I N I , C A R L O , 8 0 6 G L E I C H , G E R A L D J . , 9 8 1 G O D L E S K I , J O H N K . , 6 0 6 G O L D , A V R A M R . , 2 2 0 G O L D , W A R R E N M . , 2 9 2 , 1 0 1 9 G O L D B E R G , S T E V E N K . , 6 0 G O L D E N , J E F F R E Y A . , 1 1 2 4 G O L D S T E I N , N O A M , 6 0 G O M E Z , A N A M A R I A , 7 5 2 G O R D O N , J O H N B . , 9 9 G O R D O N , T E R R Y , 1 1 0 6 G O R N E Z , P A U L A , 3 5 8 G O R N Y , M I R O S L A V , 1 0 6 0 G O T T F R I E D , S T E W A R T B . , 9 5 4 G R A B A U , J O H N C , 5 1 6 G R A H A M , W I L L I A M G . B . , 3 9 3 G R A N T , M A R G A R E T M . , 1 3 0 7 G R A S S I , C A R L O , 5 1 0 G R A Y B I L L , J O H N R . , 7 5 2 G R E E N , J O S E P H , 9 9 3 G R E E N B E R G , S . D O N A L D , 1 4 3 G R E E N B E R G E R , P A U L A . , 1 8 6 G R E G O R Y , G E O R G E A . , 3 3 9 G R E G O R Y , T I M O T H Y J . , 9 9 G R Ö S C H E L , D I E T E R H . M . , 9 7 6 G R O V E , D A N I E L M . , 1 0 3 4 , 1 0 4 1 G R O V E R , R O B E R T F . , 1 1 5 2 G U D A P A T Y , S E S H A G I R I R . , 1 5 9 , 1 6 4 G U E N A R D , H E R V E , 3 3 2 G W A L T N E Y , J A C K M . , J R . , 9 7 6 H A C K E R , A L L E N D . , 3 5 4 H A C K N E Y , J A M E S D . , 6 1 9 H A I G H T , J A M E S S . J . , 1 2 2 9 H A I O U N , C O R I N E , 1 1 1 8 H A K I M , J A C Q U E S , 8 3 6 H A L E S , . C H A R L E S A . , 3 2 6 H A L P E R I N , S C O T T A . , 9 7 6 H A L W I G , H . M I C H A E L , 1 8 6 H A M M A N , R I C H A R D F . , 4 7 2 H A M M E R , S C O T T M . , 1 8 9 H A N C E , A L L A N - J O H N S O N , 8 3 6 H A N S E N , J A M E S E . , 6 1 2 H A N S E N , R U S S E L L E . , 5 1 6 H A N S E N - F L A S C H E N , J O H N H . , 1 9 1 H A R F , A L A I N , 1 0 4 , 3 5 0

H A R G R E A V E , F . E . , 2 7 2 , 8 6 5 H A R T E M A N N , D E N I S E , 5 0 4 H A R T I A L A , J A A K K O , 2 9 2 H A S S E L B L A D , V I C T O R , 2 6 1 H A Y E S , E D W A R D E . , 3 6 7 H E B E L , J . R I C H A R D , 3 6 H E C H T M A N , H E R B E R T , 1 2 5 7 H E I F E T S , L E O N I D B . , 7 1 0 , 1 2 7 8 H E I N R I C H S , W . L E R O Y , 9 1 6 H E L D T , G R E G O R Y P . , 3 3 9 H E N D L E Y , J . O W E N , 9 7 6 H E N S O N , J A N E . , 1 5 2 H E N S O N , P E T E R M . , 4 9 0 , 5 9 0 H I B B E R T , M A R I E N N E , 1 2 2 3 H I D A , W . , 2 7 8 , 6 7 1 H I G U C H I , J U N J I H. , 3 5 8 H I L L E R , F . C H A R L E S , 9 2 9 H O F F M A N , R O B E R T M . , 1 3 4 7 H O F F S T E I N , V . , 2 1 1 H O G G , J A M E S C , 7 , 3 0 , 1 2 9 4 H O I D A L , J O H N R . , 1 5 9 , 1 6 4 H O L G A T E , S T E P H E N T . , 1, 9 8 6 H O L L I N G E R , W A Y N E M . , 6 5 , 1 1 3 9 H O N D A , I Z U M I , 2 9 9 H O N D A , Y O S H I Y U K I , 1 2 1 9 H O O P , B E R N A R D , 2 4 8 H O P E W E L L , P H I L I P C , 7 3 7 H O R I K E , M A E R T H A , 6 4 8 H O R I K E , N E I L , 6 4 8 H O R I O , S U N A O , 2 9 9 H O W A R T H , P E T E R H. , 9 8 6 H O W E L L , S A N D R A , 2 4 1 H U D S O N , L E O N A R D D . , 4 8 5 , 1 0 7 1 H U E T , Y A N N , 1 1 1 8 H U G H E S , J . M . B . , 1 2 3 3 H U G H E S , J O H N D . , 9 3 Hui , K A K I T , 1 2 H U L B E R T , W . M . , 7 H U L L , S H E I L A I . , 4 0 9 H U R L O W , R O B E R T S . , 1 0 7 1 H U R S T , G E O R G E A . , 1 4 3 H U V A L , W I L L I A M , 1 2 5 7 H W A N G , C H E N - H O N G , 3 8 2 H Y D E , R I C H A R D W . , 5 1 6 H Y E R S , T H O M A S M . , 4 7 2 , 4 9 0 I C H I N O S E , M A S A K A Z U , 2 7 8 , 11 1 3 I D E L L , S T E V E N , 1 0 9 8 I K E G A M I , M A C H I K O , 5 0 0 , 1 3 1 3 I N G E N I T O , E D W A R D P . , 8 5 3 I N G R A M , R O L A N D H. , J R . , 9 5 3 I N O U E , C H I E K O , 1 1 1 3 I N O U E , H I R O S H I , 1 1 1 3 I R W I N , R I C H A R D S . , 5 7 6 , 1 1 3 0 I S A B E Y , D A N I E L , 1 0 4 I S E M A N , M I C H A E L D . , 7 1 0 , 7 3 5 , 1 2 7 8 I S H I I , M U N E H I K O , 2 7 8 , 1 1 1 3 I S R A E L , E L L I O T , 1 2 0 4 I S S A , F A I Q G . , 9 9 9 J A C O B S , H A R R I S C , 5 0 0 , 1 3 1 3 J A C Q U E S , J O H N , 1 3 6 8 J A C Q U O T , J A C K Y , 5 2 4 J A M E S , H A R O L D L . , 1 0 9 8 J A N O F F , A A R O N , 4 1 7 , 8 2 1 J A N S E N , H E N K M . , 1 6 8 J A V A H E M , S H A H R O K H , 1 0 5 5 J E N S E N , W I L L I A M A . , 1 8 9 J O B E , A L A N H. , 5 0 , 1 3 1 3 J O C H U M , M A R I A N N E , 9 1 3 J O H A N S O N , W A L D E M A R G . , J R . , 3 5 8 J O H N S O N , A L I C E R . , 5 6 4 , 1 2 6 2

AUTHOR INDEX 1385 J O H N S O N , A R N O L D , 7 0 J O H N S O N , B R I A N F . , 1 1 3 0 J O H N S O N , L A R R Y R . , 1 1 8 6 J O N E S , P A U L K . , 7 7 0 J O N E S , S A L L Y , 1 3 1 3 J U D S O N , F . N . , 7 4 2 J U N O D , A L A I N F . , 4 7 9 K A L E S , A N T H O N Y , 9 7 2 K A P L A N , N A N C Y B . , 1 3 0 7 K A R C H M E R , A D O L F W . , 1 8 9 K A R I M A N , K H A L I L , 1 0 9 K A W A K A M I , Y O S H I K A Z U , 8 9 K A Y , A . B A R R Y , 9 8 6 , 1 1 9 9 K A Y , J . M I C H A E L , 9 2 2 K A Z E M I , H O M A Y O U N , 2 4 8 K E E F E , D O U G L A S H . , 3 4 3 K E L L E R , S T E P H E N , 6 4 0 K E L L E Y , G L O R I A D . , 1 2 5 K E L S E N , S T E V E N G . , 7 2 2 , 8 0 0 , 1 2 1 4 K E N N E D Y , S U S A N M . , 1 2 9 4 K H A N , S H A K I L , 3 8 2 K I L B U R N , J A M E S O . , 1 2 5 K I M , C H O N G S . , 1 3 7 K I M , W O N D O N G , 8 9 4 K I M M E L , D A V I D A . , 1 1 6 2 K I M M E L , E D G A R D C . , 8 8 5 K I N G , M A L C O L M , 8 9 4 K I R K P A T R I C K , M I C H A E L B . , 3 7 9 K L E I N E R M A N , J E R O M E , 1 8 2 K L I N E , L E W I S R . , 1 9 1 K L I N G E R , J E F F R E Y D . , 5 2 9 K L I N G E R , K A T H E R I N E W O O D , 1 1 4 9 K N E C H T , E D W I N A . , 1 1 8 1 K N O W L E S , M I C H A E L R . , 3 1 1 , 1 2 8 1 K N U D S O N , R O N A L D J . , 8 0 6 K N I I T H , S U S A N L . , 2 1 6 , 1 2 4 2 K O B A Y A S K I , T O S H I O , 4 9 4 K O C H , G A R Y , 1 7 5 K O I - N I G , J A N E Q . , 6 4 8 K O F P S E L L , T H O M A S , 6 2 3 K O U R O G I , H I R O T S U G U , 2 9 9 K O P P , W I L L I A M C , 1 0 2 7 K R O L , R I C H A R D C . , 2 1 6 K R Y G E R , M E I R H . , 2 2 4 Kuno, K E I S H I , 4 9 4 K u r i e n , U M B E R T O , 1 0 9 8 K U E P P E R S , F R E D R I C H , 1 0 9 8 K U L L E , T H O M A S J . , 3 6 K Ü N G , M A R K U S , 2 6 8 K U N K E L , R O B I N G . , 1 2 8 8 L A K S H M I N A R A Y A N , S . , 9 6 3 L A M P I , K A T H Y L . , 1 0 1 5 L A N G E N B A C K , E D W A R D G . , 6 3 3 L A R U M B I D E , M A R G A R E T , 1 2 6 2 L A V E N D E R , J . P . , 1 4 8 L A V I E , G . , 6 0 2 L A Z A R , J E F F R E Y D . , 9 3 L E A H Y , F E R G U S , 1 6 L E B O W I T Z , M I C H A E L D . , 8 0 6 L E D I N G H A M , J O H N , 9 2 6 L E E , E N O C H , 1 2 L E E , H Y E K Y U N G , 1 0 0 5 L E E , T A K H . , 9 8 6 , 1 2 0 4 L E E C H , J U D I T H A . , 1 1 2 7 L E H N E N , F . H . H . , 8 4 5 L E F F , A L A N R . , 9 9 3 L E H R E R , R . L , 9 0 1 L E I G H , M A R G A R E T W . , 8 7 5 L E I T E R , J A M E S C . , 2 1 6 , 1 2 4 2 L E L L O U C H , J O S E P H , 8 1 8

L E M E N , R I C H A R D J . , 3 2 1 L E M I R E , I S A B E L L E , 8 4 8 L E N N O X , A . , 6 7 9 L E O N , S H A L O M A . , 6 0 L E R T Z M A N , M O R L E Y , 2 2 4 L E S L I E , C H R I S T I N A C , 1 2 4 6 L E S O U E F , P E T E R , 1 2 2 3 L E V I S O N , H E N R Y , 7 6 6 L E V Y , J A C K , 7 6 1 L E V Y , R O B E R T D . , 2 3 6 L E W I S , R O B E R T A . , 1 2 0 4 L E W I S , T R E N T R . , 1 1 8 1 L I B E N , A R L E T T E , 1 1 2 7 L I C H T E N S T E I N , L A W R E N C E M . , 3 6 7 ,

4 0 5 , 1 0 1 5 L I E N E R , I R V I N E . , 1 5 9 , 1 6 4 L I E T C H , A . G O R D O N , 1 2 0 4 L I G H T , R I C H A R D W . , 9 6 0 L I N N , W I L L I A M S . , 6 1 9 L I P P M A N N , M I C H A E L L., 6 0 L I S B O A , C A R M E N , 4 8 Liu, Y . - N . , 2 7 8 L O K E , J A C O B , 1 9 5 L O M B A R D , R O B E R T M . , 9 7 2 L O V E , L E S L I E , 1 2 2 9 L U C A S , E D G A R A . , 9 2 9 L U C E Y , E D G A R C , 3 6 2 , 1 0 5 5 , 1 1 5 5 L U I S E T T I , M A R I O , 5 1 0 L U M , H A Z E L , 1 0 7 8 L Y N C H , D E N N I S W . , 1 1 8 1 M A C E Y , M . G . , 8 2 4 M A C G L A S H A N , D O N A L D W . , J R . , 3 6 7 ,

4 0 5 M A C K L E M , P E T E R T . , 2 3 6 M A E S T R E L L I , P . , 1 0 1 0 M A G E E , F E R G A L L , 9 2 2 M A H L E R , D O N A L D A . , 1 9 5 M A L O , J E A N - L U C , 6 4 4 , 8 4 8 M A N D L , I N E S , 6 4 0 M A N G U R A , B O N I T A T . , 3 8 2 M A N I E R , G E R A R D , 3 3 2 M A N N , J O N A T H A N S . , 1 M A P P , C H R I S T I N A , 2 9 2 , 1 0 1 0 M A R C E R , G . , 4 0 0 M A R C H A N D I S E , F . X . , 8 2 9 M A R C H E T T E , B R U C E , 8 3 9 M A R G O L I S , M I T C H E L L L., 4 3 4 M A R Q U E T T Y , C L A U D E , 8 3 6 M A R S H A L L , S U S A N G . , 6 4 8 M A R T I N , J A M E S G . , 2 3 6 , 6 7 9 M A R T I N , J E A N - P I E R R E , 8 1 8 M A R T I N , R I C H A R D R . , 6 4 4 , 8 4 8 M A R T I N , T H O M A S R . , 2 5 4 M A R W A H A , R A J K . , 1 1 3 0 M A R Z , L A U R I E , 1 1 2 7 M A S C H L E R , R E I N H A R D , 1 1 5 5 M A S O N , M A R G A R E T J . , 6 5 7 M A S O N , R O B E R T J . , 1 2 4 6 M A T S U M O T O , N O B O R U , 1 1 1 3 M A T S U O , Y O S H I Y A S U , 1 7 3 M A T T H A Y , M I C H A E L A . , 1 2 5 3 M A T T H A Y , R I C H A R D A . , 1 9 5 M A U N D E R , R I C H A R D J . , 2 5 4 M A X W E L L , D . L. , 1 2 3 3 M A Y , M A R Y H . , 7 4 2 M C C O R M I C K - S H A N N O N , K A T H L E E N ,

1 2 4 6 M C D O N A L D , D O N A L D M . , 1 1 0 6 M C D O N N E L L , W I L L I A M F . , I l l , 8 7 5 M C F A D D E N , E . R . , J R . , 8 5 3

M C H U G H , J A M E S W . , 9 6 0 M C L E A N , T . , 7 M C T I E R , R O B E R T F . , 9 6 7 M A L I K , A S R A R B . , 7 0 M E A D , J E R E , 1 2 2 3 M E L L E N S , R O B E R T B . , 6 9 4 M E L V I N , I R E N E , 1 7 5 M E N D E L M A N , P A U L M . , 7 6 1 M E N G E O T , P . M . , 6 7 9 M E N K E S , H A R O L D A . , 1 1 5 M I C H E L , R E N E P . , 1 0 8 4 M I L L E R , D O N N C , 1 0 6 6 M I L L E R , M A R T I N R . , 1 0 3 4 , 1 0 4 1 M I L L E R , Y O R K E., 1 7 8 M I L L I G A N , S H A W N A . , 1 1 2 4 M I N D O R F F , C A T H E R I N E , 7 6 6 M I N T Y , B A R B A R A D . , 1 1 7 0 M I T T M A N , C H A R L E S , 2 0 5 M I T Z N E R , W A Y N E , 1 0 7 8 M O N T G O M E R Y , A . B R U C E , 4 8 5 M O O R E , S U S A N A . , 1 5 2 M O O R M A N , W I L L I A M J . , 1 1 8 1 M O R E L , D E N I S R . , 4 7 9 M O R E L L , A N D R E A S , 1 0 6 0 M O R E N O , R O D R I G O , 4 8 M O R G A N , A N D R E W D . , 2 0 6 M O R G A N , M I C H A E L S . , 6 4 8 M O R G A N , W . K . C , 1 1 3 9 , 1371 M O R S E , D A L E L . , 5 1 6 M O R T O N , P A M E L A B . , 2 2 M Ü G G E N B U R G , B R U C E A . , 6 5 7 , 6 6 1 M U L L E N , J . B R E N D A N , 1 2 9 4 M U R A M O T O , A L L E N , 6 2 3 , 9 6 3 M U R L A S , C H R I S T O P H E R , 1 0 0 5 M U S P R A T T , S . , 1 3 3 M Y E R S , D . J . , 6 9 0 N A F F , G E O R G E B . , 7 7 0 N A G A I , A T S U S H I , 9 3 7 , 9 4 6 N A G E N D R A N , R A D H I K A C , 9 6 0 N A S H , D O N A L D R . , 1 0 9 3 N E W B A L L , H A R O L D H . , 4 0 5 N E W C O M B , R O B E R T , 1 2 N E W L A N D , A . C , 8 2 4 N E W M A N , S T E P H E N L . , 1 0 8 4 , 1 3 6 6 N I E U W E N H U I S , P A U L , 1 6 8 N L E W O E H N E R , D E N N I S E. , 1 5 9 N I M M O , A . J . , 5 4 1 N I N A N E , V I N C E N T , 7 9 3 N I S H I N O , T A K A S H I , 1 2 1 9 N O C H O M O V I T Z , M I C H A E L , 8 0 0 N O M U R A , T O S H I Y A , 1 7 3 O ' B R I E N , T H O M A S K . , 3 5 4 O ' B R O D O V I C H , H U G H M . , 6 9 4 OlKARINEN, A A R N E , 5 3 6 O L I V E N , A R I E , 1 2 1 4 O L I V E R , L . C H R I S T I N E , 1 2 0 , 1 3 7 1 O ' N E I L L , P A U L A . , 2 2 O P R Y S K , D O N N A , 1 2 2 9 O R E N , A M I , 6 1 2 O R S S A U D , G E N E V I E V E , 8 1 8 O S M A N , M O H A M E D , 6 4 0 O S M A N L I E V , D . P . , 7 8 4 Ossi, E. , 4 0 0 O ' S U L L I V A N , M I C H A E L F . , 143 PÄÄKKÖ, P A A V O , 5 3 6 P A D M A N A B H A N , R A M A V . , 1 5 9 , 1 6 4 P A O L E T T I , P A O L O , 8 0 6 P A R D Y , R I C H A R D L . , 2 3 6 P A R E , P E T E R D . , 3 0 , 1 2 9 4 P A R S O N S , P O L L Y E., 4 9 0

1386 AUTHOR INDEX

P A S Q U I E R , C A T H E R I N E , 8 3 6 P A S S E R I N I , L O U I S E , 1 3 6 6 P A S T E R K A M P , H A N S , 1 6 P A T I N O , M A R I A M E R C E D E S , 7 5 2 P A U L , J . L A W R E N C E , 9 3 7 P A U L I , G A B R I E L L E , 9 1 3 P A U L Y , N A N C Y , 2 0 6 P A Y E N , D I D I E R , 1 1 1 8 P E L H A M , F R A N K , 8 2 1 P E L L E T I E R , A N T O I N E , 9 1 3 P E P E , P A U L E . , 7 8 8 P E R E T Z , D W I G H T , 9 2 2 P E R E Z F O N T Ä N , J . J U L I O , 3 3 9 P E R E Z - P A D I L L A , R O G E L I O , 2 2 4 P E R L I N O , C A R L A . , 7 5 7 P E R U M A L , V E L U C H A M Y K . , 1 2 7 8 P E S L I N , R E N E , 7 1 2 P E T E R S , M A R G O T S . , 9 8 1 P E T E R E S , S T E P H E N P . , 3 6 7 P E T E R S E N , M A R T I N R . , 1 1 3 9 P E T T Y , T H O M A S L., 4 7 1 , 1 3 4 4 P H E L A N , P E T E R , 1 2 2 3 P H I L L I P S , M A R T I N J . , 1 0 1 9 P H I L L I I P S O N , E . A . , 2 1 1 P I A N T A D O S I , S T E V E N , 2 3 0 PlCHURKO, B O H D A N M . , 8 5 3 P I E R S O N , D A V I D J . , 1 0 7 1 P I E R S O N , W I L L I A M E . , 6 4 8 P I N C O C K , A R C H I E C , 1 0 3 4 , 1 0 4 1 P I N E , J E F F R E Y R . , 6 5 P I N E A U , L I N E , 6 4 4 P I N K H A S , J . , 6 0 2 P I Q U E T , J A C Q U E S , 1 0 4 P I S T E L L I , G I U S E P P E , 8 0 6 P I Z Z O L O , G . , 4 0 0 P L O P P E R , C H A R L E S G . , 5 5 6 P O L A T O , R A F F A E L E , 8 0 6 P O N C Z , Louis , 5 2 9 P O U L T E R , L. W . , 1 3 0 0 Pozzi , E R N E S T O , 5 1 0 P R A K A S H , U D A Y A B . S . , 7 1 5 P R A T T E R , M E L V I N R . , 1 1 3 0 P R I C E , K E N N E T H E . , 4 0 9 P R I D E , N . B . , 1 4 8 , 7 8 4 P R O P , J O C H U M , 1 6 8 P R O U D , D A V I D , 4 0 5 P U C H E L L E , E D I T H , 5 2 4 P U I S T O L A , U L L A , 5 3 6 Q U A N , S T U A R T F . , 3 2 1 R A F F I N , T H O M A S A . , 9 1 6 R A G H U , G A N E S H , 2 5 4 R A J A G O P A L , K R I S H N A N A . , 2 3 0 R A M S E Y , B O N N I E , 7 6 1 R A Y B I N , D A N I E L M . , 9 1 6 R E B U C K , A . S . , 8 4 5 R E D I N E , S U S A N , 9 5 4 R E D M O N D , S T E P H E N R . , 5 1 6 R E E D , C H A R L E S E . , 9 8 1 R E H M , S T A N L E Y R . , 1 1 6 2 R E I C H M A N , L E E B . , 3 8 2 R I C H A R D S , C A R L D . , 8 2 R I C H E R S O N , H A L B . , 1 0 2 7 R I E D E R , H A N S L., 1 3 7 1 R I E S , A N D R E W L., 6 8 5 R I M L A N D , D A V I D , 7 5 7 R I N A L D O , J E A N E . , 1 5 2 , 1 0 7 5 R I P P E Y , L A U R A L., 1 1 7 4 R O A D , J E R E M Y D . , 1 3 6 8 R O B E R T S O N , G A R Y L., 9 9 3 R O B I N S , J A M E S M . , 1 2 0 , 1 3 7 1

R O B I N S O N , D W I G H T R., 1 2 0 4 R O B I N S O N , N . E D W A R D , 1 0 6 6 R O B I N S O N , R I C H A R D W . , 1 2 3 8 R O C H E S T E R , D U D L E Y F . , 4 2 R O D E N S T E I N , D A N I E L O . , 6 2 8 , 7 2 2 R O E H R S , T . , 5 2 0 R O F F M A N , S T E V E N , 6 4 0 R O G E R S , R O B E R T M . , 1 0 7 5 , 1 3 4 7 R O S E , R I C H A R D M . , 1 8 9 R O S E B E R R Y , H U G H , 3 2 1 R O T H , T . , 5 2 0 Roussos, C H . , 2 4 1 R O Y S T O N , D A V I D , 1 1 7 0 R U B I N , L E W I S J . , 9 3 R U D D , R. M . , 8 2 4 R U O H O , A R N O L D , 1 1 9 4 R Y H Ä N E N , L A S S D E , 5 3 6 S A C K N E R , M . A . , 1 3 7 S A E T T A , M A R I N A , 8 0 6 , 8 9 4 S T . G E O R G E , J U D I T H A . , 5 5 6 S A L O M E , C . M . , 2 5 S A N C H E Z - H E R N A N D E Z , M A U R O , 7 3 7 S A N D E R S , R O B E R T V . , 3 7 9 S A N D E R S O N , W A Y N E T . , 1 1 3 9 S A N D S , M A R K F . , 9 9 3 S A S K I , H I D E T A D A , 2 7 8 , 6 7 1 , 1 1 1 3 S A U D E R , L A R R Y R., 3 6 S A U M O N , G E O R G E S , 8 8 0 S A U N I E R , C L A U D E , 5 0 4 S B A R B A R O , J O H N A . , 1 7 7 , 7 4 2 S C H E L L E N B E R G , R. R., 3 0 S C H L E I M E R , R O B E R T P . , 3 6 7 , 1 0 1 5 S C H N E B L I , H A N S - P E T E R , 1 1 5 5 S C H R I J E N , F R A N C I N E , 5 0 4 S C H U L M A N , E D W A R D S . , 4 0 5 S C H U L Z , W E R N E R W . , 5 6 4 S C H W A R T Z , B . A . , 1 6 4 S C O G G I N , C H A R L E S H . , 9 3 5 S C O T T , G R A H A M C , 2 6 8 S C O T T , J A C Q U E L I N E S . , 1 0 6 6 S C R I M A , L A W R E N C E , 9 2 9 ScYPiNSKi , L I N D A , 1 1 0 6 S E K I Z A W A , K . , 2 7 8 , 6 7 1 S E L S T E D , M . E . , 9 0 1 S E L T Z E R , J . , 6 9 0 S E M E N Z A T O , G . , 4 0 0 S E S H A D R I , T A R A , 1 1 5 5 S H A M O O , D E B O R A H A . , 6 1 9 S H A N L E Y , J O H N D . , 7 7 S H A P I R O , B E R N A R D , 6 0 S H A P I R O , C M . , 8 6 , 2 0 6 S H A R P E , G E R A L Y N , 1 1 9 4 S H A W , R O R Y J . , 1 1 9 9 S H E P P A R D , D E A N , 2 8 3 , 6 9 0 , 1 1 0 6 S H E R M A N , M . P . , 9 0 1 S H I D A , A K I R O , 8 9 S H I E L D S , R O B E R T L . , 2 9 2 S H I H , V I V I A N E . , 2 4 8 S H I N D O H , ( C , 6 7 1 S H I N E R , R O B E R T J . , 2 3 6 S I B I L L E , Y . , 8 2 9 SlCKLESTEEL, J . , 5 2 0 S I E G E L , D A V I D , 2 8 3 S I L C O X , V E L L A A . , 1 0 9 3 S I M O N , G A R Y L . , 1 0 8 7 S I M O N , R I C H A R D H . , 1 2 8 8 S L O C O M B E , R O N A L D I . , 1 0 6 6 S L Y , P E T E R , 1 2 2 3 S M I T H , A N N , 1 1 9 4 S M I T H , A R N O L D L . , 7 6 1

S M I T H , D . L . , 8 4 5 S M I T H , P H I L I P L . , 2 2 0 S M I T H W I C K , R O N A L D W . , 1 3 7 1 S N I D E R , D I X I E E . , J R . , 1 2 5 S N I D E R , G O R D O N L . , 1 8 2 , 3 6 2 , 9 0 5 ,

1 0 5 5 , 1 1 3 9 , 1 1 5 5 S N Y D E R , P E T E R E . , 1 9 5 S O B O N Y A , R I C H A R D E . , 3 2 1 S O L E R , P A U L , 8 3 6 , 8 8 0 S O L W A Y , J U L I A N , 6 6 6 , 8 5 3 S O M M E R S , H E R B E R T M . , 1 8 6 S O N G S I R I D E J , V . , 3 0 5 S O R K N E S S , R O N A L D L . , 2 8 7 S P A R L I N G , J A M E S R . , 1 3 6 8 S P R I N G M E Y E R , S T E V E N C , 2 5 4 S T A G E R , M A R I E A . , 4 8 5 S T A N E S C U , D A N C , 6 2 8 , 7 2 2 S T A N S B U R Y , D A V I D W . , 9 6 0 S T A R K , R O N A L D D . , 2 2 S T A T O N , G E R A L D W . , J R . , 6 5 , 1 1 3 9 S T A U B , N O R M A N C , 1 2 5 3 S T E E L E , L O R R A I N E C , 4 0 9 , 1 0 9 3 S T E I N G R U B E , V I N C E N T A . , 1 0 9 3 S T E R K , P . J . , 2 7 2 , 8 6 5 S T E R N , R O B E R T C , 5 2 9 S T E V E N S O N , J A N L . , 3 2 1 S T O N E , O . L E E , 5 6 9 S T O N E , P H I L L I P J . , 3 6 2 , 1 1 5 5 S T R O P E , G E R A L D L . , 8 7 5 S T U B B I N G , D A V I D G . , 6 5 2 S T U L B A R G , M I C H A E L S . , 1 1 2 4 S U E , D A R Y L Y . , 6 1 2 S U G A R , A L A N M . , 1 3 1 9 S U G I M O T O , MlNEHARU, 2 9 9 S U L L I V A N , C O L I N E . , 9 9 9 S U R A T T , P A U L M . , 9 6 7 , 9 7 6 S U S S M A N , N A N C Y B . , 1 1 7 4 S U T E R , P E T E R M . , 4 7 9 S W E E N E Y , T H E R E S A D . , 6 0 6 S W E N S O N , J A N A M . , 4 0 9 , 1 0 9 3 S Y L V E S T E R , J . T . , 9 9 S Z E I N B E R G , A M I R , 7 6 6 S Z I D O N , P E T E R , 7 4 6 T A G E R , I . B . , 1 3 3 T A K I S H I M A , T A M O T S U , 2 7 8 , 6 7 1 , 1 1 1 3 T A L , A S H E R , 1 6 T A M , E . K . , 6 9 0 T A S A K A , H I R O M I C H I , 1 7 3 T A S H K I N , D O N A L D P . , 1 2 T A Y L O R , J O S E P H C , 2 0 5 T A Y L O R , S . M . , 3 0 T H E R O N , A . , 1 0 4 9 T H O M P S O N , N A N C Y J . , 1 2 5 T H O M P S O N , P H I L I P J . , 9 2 6 T H U R L B E C K , W I L L I A M M . , 1 8 2 , 5 9 6 ,

9 3 7 , 9 4 6 T I E R N E Y , D O N A L D F . , 3 5 4 T I L L , G E R D O . , 1 2 8 8 T O D D , E A R L W . , 7 7 0 T O M A S H E F S K I , JOSEPH F . , J R . , 5 2 9 T O U R N I E R , J E A N - M A R I E , 5 2 4 T O W N S E N D , M A R Y C , 1 1 7 4 T R E N T I N , L . , 4 0 0 T R U J I L L O , D . , 1 3 7 T R Y K A , A . F R A N C I N E , 6 0 6 T S U K A M U R A , MlCHIO, 9 1 5 T U A Z O N , C A R M E L I T A U . , 1 0 8 7 T U R I N O , G E R A R D M . , 6 4 0 , 1 3 2 4 T U R N E R - W A R W I C K , M A R G A R E T , 9 2 6 U D O U , T A K E Z O , 1 0 9 3

AUTHOR INDEX 1387 U P A D R A S H T A , B A L A S . , 1 0 2 7 U T H A Y A K U M A R , S . , 8 2 4 V A C C A R O , C H A R L E S A . , 9 0 5 V A L E N C I A , L U P E M . , 6 1 9 V A N D I V I E R E , H . M A C , 1 7 5 V A N U I T E R T , B O N N I E L . , 4 3 4 V A R M A , V I J A Y M . , 1 0 8 7 V E D A L , S V E R R E , 8 1 4 V E N E T , T H E O D O R E G . , 6 1 9 V E R N A N T , J E A N P A U L , 1 1 1 8 V I D R U K , E D W A R D H . , 2 8 7 V I E G I , G I O V A N N I , 8 0 6 V O L L M E R , W I L L I A M M . , 1 1 8 6 W A L L A C E , R I C H A R D J . J R . , 4 0 9 , 1 0 9 3 W A L S H , P E T E R N . , 1 0 9 8 W A L S H , T H O M A S J . , 7 4 6 W A N G , N A I - S A N , 8 9 4 , 1 0 8 4 W A R D , M I C H A E L E . , 6 5 2 W A S S E R M A N , K A R L M A N , 6 1 2 W A T S O N , A . , 7 8 4 W E B E R , A L L A N , 7 6 1 W E G M A N , D A V I D H . , 1 2 0 , 1 3 7 1 W E I N B A U M , G E O R G E , 1 0 9 8

W E I N B E R G , P E T E R F . , 2 8 3 W E I N B E R G E R , A . , 6 0 2 W E I N B E R G E R , M . , 6 0 2 W E I N M A N N , G A I L , 1 1 5 W E L L S , C A R O L Y N K . , 1 9 5 W E L T Y , C , 1 3 3 W E S T , P E T E R , 2 2 4 W E S T , W I L L I A M W . , 9 3 7 , 9 4 6 W E T Z E L , R A N D A L L C , 9 9 W E W E R S , M A R K , 8 2 1 W H I T E , D A V I D P . , 9 7 2 , 1 2 3 8 W I E N E R - K R O N I S H , J E A N I N E P . , 1 2 5 3 W I L D E V U U R , C H A R L E S R . H . , 1 6 8 W I L H O I T , S T E P H E N C , 9 6 7 W I L L I A M S , M A R I O N G . J R . , 1 4 3 W I L S O N , D A V I D O . , 1 3 4 7 W I L S O N , F R A N K J . , 9 2 9 W I N S E T T , D A R R E L L W . , 8 8 5 W I S N I E S K I , J E F F R E Y J . , 7 7 0 W I T O R S C H , P H I L I P , 1 0 8 7 W I T S C H I , H A N S P E T E R R . , 3 5 4 W I T T E N , M A R K L . , 3 2 1 W I T T I G , R . , 5 2 0

W O N G , C A T H E R I N E , 1 2 5 7 W O O D S , D O N A L D E . , 3 5 8 W O O L C O C K , A . J . , 2 5 W O O T E N , V I R G I L , 9 2 9 W R I G H T , J O A N N E L . , 9 2 2 , 1 2 9 4 W u , R E E N , 3 1 1 W Y A T T , R O B E R T J . , 1 1 6 2 Y A M A M O T O , H I R O S H I , 8 9 Y A N , K . , 2 5 Y A N K A S K A S , J A M E S R . , 1 2 8 1 Y E L L I N , A L O N , 4 3 4 Y O N E Z A W A , T O S H I H I D E , 1 2 1 9 Y O S H I K A W A , T A K A S H I , 8 9 Z A M B E L L O , R . , 4 0 0 Z A M B O N , R O B E R T O , 8 0 6 Z A M E L , N . , 2 1 1 , 2 7 2 , 8 6 5 Z A O U I , D R I S S , 8 1 8 Z E R B E , G A R Y O . , 4 7 2 Z I C K E R , S T E V E N C , 5 5 6 Z I D U L K A , A R N O L D , 3 5 0 Z O C C A , E . , 1 0 1 0 Z O R I C K , F . , 5 2 0 Z W I L L I C H , C L I F F O R D W. , 9 7 2 , 1 2 3 8

I N D E X - S U B J E C T S

Acquired immune deficiency syndrome, utility of gallium-67 scin­tigraphy, and bronchial washings in diagnosis and treatment of Pneumocystis carinii pneumonia in patients with, 1087

Adenosine-induced bronchoconstriction in asthma, 1 Adolescents

asthmatic , acute effect of 0.12 ppm ozone or 0.12 ppm nitrogen dioxide on pulmonary function in, 648

exercising, respiratory effects of photochemical oxidant air pol­lution in, 619

Adrenergic inhibition and parasympathetic stimulation, role of, in adenosine-induced bronchoconstriction in asthma, 1

Adult respiratory distress syndrome causes of mortality in patients with, 485 chemotact ic activity in bronchoalveolar lavage fluid from pa­

tients with, 490 indicators of risk, course, and prognosis in (editorial), 471 neutrophi l elastase-releasing factors in bronchoalveolar lavage

from patients with, 1098 neutral endopeptidase in serum samples from patients with,

compared with angiotensin-converting enzyme, 1262 problems and progress (commentary), 1344 prognosis after onset, 472 pu lmonary extraction of serotonin and propranolol in patients

with, 479 regulation of tissue oxgen extraction is disturbed in, 109

Aerosol(s) inhaled submicrometric, short-term regional clearance of, in

pu lmonary fibrosis, 606 metered-dose inhaled, size aspects of, 137

Age and body size, effect of, on reference equations for single-breath

diffusing capacity, 806 effect of, on antibody responses during lung immunization,

661 increase in tracheal size with, 784

Agonist , inhaled beta-adrenergic, aminophylline increases toxicity but not efficacy of, in treatment of acute exacerbations of as thma, 283

Air dry, effect of eucapnic hypoxia on bronchomotor tone and

response to, in asthmatic subjects, 690 -flow

limitation, chronic, ventilatory muscle function during ex­ercise in air and oxygen in patients with, 236

obstruct ion, chronic and chronic bronchitis, effects of, on lung cell populations

recovered by bronchoalveolar lavage, 254 effects of large carbohydrate load on walking performance

in, 960 prediction of ventilation at maximal exercise in, 230

hypoxic chronic, almitrine increases steady-state hypoxic ventilatory response in, 1233

and oxygen, ventilatory muscle function during exercise in, in patients with chronic air-flow limitation, 236

pollut ion, photochemical oxidant, respiratory effects of, in exercising adolescents, 619

Airway(s) artifact, upper, in respiratory impedance measurements (Note),

712 central and peripheral, disassociation in mucociliary function

of, of asymptomatic smokers, 633 and circulating mediator responses, influence of albuterol, cromo­

lyn sodium, and ipratropium bromide on, to allergen bron­chial provocation in asthma, 986

constricted, effective sites by sympathetic beta-adrenergic and

1388

vagal nonadrenergic inhibitory stimulation in, 1113 disease

nonreversible obstructive, sustained-release theophylline re­duces dyspnea in (correspondence), 195

peripheral, pulmonary function and, in patients with mineral dust or fume exposure, 1294

hyperexcitability, slope of dose-response curve to inhaled his­tamine and methacholine and PC2 0 in subjects with symp­toms of, 644

hyperreactivity, virus-provoked, use of guinea pig as model for, 305

hyperresponsiveness and inflammation induced by toluene di-isocyanate in guinea pigs, 1106

inflammation, acute, effect of, on bronchial reactivity in guinea pigs, 7

narrowing, limited maximal, in nonasthmatic subjects, role of neural control and prostaglandin release in, 865

nasopharyngeal, collapsibility of, in obstructive sleep apnea, 967

obstruction recurrent, bronchoalveolar lavage in ponies with, 1066

reactivity in C O P D and failure of in vivo methacholine respon­siveness to correlate with cholinergic, adrenergic, or non­adrenergic responses in vitro, 30

resistance respiratory pressure sensation and its relation to changes in

breathing pattern and Pco2 during acute increase in, in COPD, 1214

upper, moderate alcohol ingestion increases, in normal sub­jects, 1238

response kinetics of recovery of, by inhaled histamine, 848 upper, during bronchoprovocation and asthma attack, 671

responsiveness induced by toluene-diisocyanate, prednisone inhibits late

asthmatic reactions and the associated increase in, 1010 to inhaled antigen, histamine, and methacholine in inbred,

ragweed-sensitized dogs, 292 reversibility after prednisolone therapy in chronic as thma is

associated with alterations in leukocyte function, 1199 wall temperature, breathing pattern affects, during cold air

hyperpnea, 853 Albumin microspheres, prevention of elastase-induced emphysema

in hamsters by intratracheal administration of synthetic elastase inhibitor bound to, 159

Albuterol, influence of, on airway and circulating mediator re­sponse to allergen bronchial provocation in as thma, 986

Alcohol ingestion, moderate, increases upper airway resistance in normal subjects, 1238

Alcoholism, leukopenia, and pneumococcal sepsis, 757 Alkalosis, respiratory

does intermittent mandatory ventilation correct, in patients re­ceiving assisted mechanical ventilation, 1071

effect of mechanical ventilator mode on tendency toward, 1075 Allergen bronchial provocation in asthma, influence of albuterol,

cromolyn sodium, and ipratropium bromide on airway and circulating mediator responses to, 986

Allograft rejection, lung, in rat, 168 Almitrine

increases steady-state hypoxic ventilatory response in hypoxic chronic air-flow obstruction, 1233

improves oxygenation when both awake and asleep in hypoxia and C 0 2 retention caused by chronic bronchitis and emphy­sema, 206

Alpha-1

SUBJECT INDEX 1389 -antitrypsin deficiency, urinary excretion of desmosine in sub­

ject with PiZZ, 821 -protease inhibitor, protective effects of ascorbate, cysteine,

and dapsone on phagocyte-mediated oxidative inactivation of, 1049

-proteinase inhibitor, serum, smoking does not reduce functional activity

of, 818 -leukocyte-elastase inhibitor complex in bronchoalveolar lavage

fluids from healthy subjects (Note), 913 Alpha-2-macroglobulin, monomeric and polymeric immunoglob­

ulin A, and immunoglobulin M in bronchoalveolar lavage, 829

Alumina-based chemical products plant, pulmonary function in relation to total dust exposure at, 1174

Alveolar macrophages. See Macrophages Alveolar

attachments, loss of, in smokers, 894 oxygen, influence of, on pulmonary vasoconstriction in newborn

lambs versus sheep, 326 permeability, acute cigarette smoke exposure increases, in rab­

bits, 321 pressure magnitude and asynchrony during high-frequency

oscillations of excised rabbit lungs, 343 septal amyloidosis, diffuse, presenting with recurrent hemoptysis

and medical dissection of pulmonary arteries (case report), 1368

type II cells, rat, macrophages stimulate DNA synthesis in, 1246 volume, effects of different derivations of, on D L C O (Note),

1127 wall basement membranes in bleomycin-induced pulmonary

fibrosis, 905 Alveolitis

endotoxin-induced neutrophil, modification by hyperoxia in vivo of, in rats, 152

high and low intensity, T-lymphocyte subsets and immunoglob­ulin concentrations in bronchoalveolar lavage of patients with, 1060

Alveolus, pulmonary, lipid interstitial cell of, age and species differences of, 1307

Amberson lecture, 1985 J. Burns, 1324 A M E R I C A N L U N G A S S O C I A T I O N

Trudeau medal for 1985, 719 Will Ross Medal for 1985, 719 Fellowship, grant announcements , 197, 435, 719, 932

A M E R I C A N T H O R A C I C S O C I E T Y Statement on cigarette smoking and health, 1133 Statement on health effects of smoking on children, 113 Statement on laboratory diagnosis of mycotic and specific fungal

infections, 1373 Amino acid metabolism and central nervous system hydrogen ion

regulation, relationship between, in hypercapnia II, 248 Aminoglycoside(s)

mutat ional resistance as mechanism of acquired drug-resistance to, in M. fortuitum and M. chelonei, 409

penetrat ion, inactivation, and efficacy in cystic fibrosis sputum, 761

Aminophyll ine comparat ive effects of, on diaphragm and cardiac contractility,

800 effect of, on hypercapnic depression of diaphragmatic contractil­

ity, 241 increases toxicity but not efficacy of inhaled beta-adrenergic

agonist in treatment of acute exacerbations of asthma, 283 Amphoter ic in B causes aggregation of neutrophils and enhances

pulmonary leukostasis, 602 Amyloidosis

diffuse alveolar septal, presenting with recurrent hemoptysis and medical dissection of pulmonary arteries (case report), 1368

pulmonary, diagnosis of, by transbronchial biopsy (case re­port), 191

Anaphylaxis, effects of fish-oil-enriched diet on pu lmonary me­chanics during, 1204

Anencephaly and hydranencephaly, lung growth and develop­ment in, 596

Anergy and boosting, assessment of, in tuberculin conversions in Indochinese refugees, 516

Anesthesia, nasal, effects of, on breathing during sleep, 972 Angiotensin-Converting enzyme

levels, serum, evaluation of, in prediction of therapeutic re­sponse in steroid-treated pulmonary sarcoidosis, 65

neutral endopeptidase in serum samples from patients with ARDS compared with, 1262

Ansamycin determination of in vitro susceptibility of mycobacteria to

(Note), 710 dynamic aspects of in vitro chemotherapeutic activity of, on

M. intracellular^ 1278 Antibody(ies)

monoclonal , immunohistochemical characterization of rhesus monkey respiratory secretions using, 556

responses after lung immunization, effect of age on, 661 Antigens

alpha, of M. avium-intracellulare, M. scrofulaceum, and re­lated species of mycobacteria, specificity and distribu­tion of, 173

histoplasmal, detection of, in mice undergoing experimental pulmonary histoplasmosis, 752

inhaled, airway responsiveness to, in inbred, ragweed-sensi­tized dogs, 292

multiple, local pulmonary immune responsiveness after ex­posure to, in cynomolgus monkey, 657

Antioxidants, protective effects of, on phagocyte-mediated oxi­dative inactivation of alpha-l-protease inhibitor, 1049

Apnea central and mixed sleep, a shift from, to obstructive sleep

apnea resulting from low-flow oxygen, 220 obstructive sleep

pharyngeal compliance in snoring subjects with and with­out, 211

and the Arnold-Chiari malformation (case report) , 929 collapsibility of nasopharyngeal airway in, 967

Arachidonic acid metabolites, pharmacologic modulat ion of re­lease of, from purified lung mast cells, 367

Arnold-Chiari malformation and sleep apnea (case report) , 929 Arteries, pulmonary, diffuse alveolar septal amyloidosis pre­

senting with recurrent hemoptysis and medical dissec­tion of (case report), 1368

Asbestos -exposed workers, lung function and exercise performance

in, smoking and nonsmoking, 612 workers

former, comparison of ferruginous body and uncoated fi­ber content of, 143

lymphocyte subpopulat ions in bronchoalveolar lavage fluid in, 824

Ascorbate, protective effects of, on phagocyte-mediated oxida­tive inactivation of alpha-l-protease inhibitor, 1049

Aspergillosis, invasive pulmonary, oxalic acid level in broncho­alveolar lavage fluid from patients with, 748

Aspiration, lipid-laden alveolar macrophages as marker of, in parenchymal lung disease, 576

Asthma adenosine-induced bronchoconstriction in, 1 adolescents with, acute effect of 0.12 ppm ozone or 0.12

ppm nitrogen dioxide on pulmonary function in, 648 aminophylline increases toxicity but not efficacy of inhaled

beta-adrenergic agonist in treatment of acute exacerba­tions, 283

1390 S U B J E C T INDEX

attack, upper airway response during, 671 bronchial, increased numbers of hypodense eosinophils in

blood of patients with, 981 chronic, airway reversibility after prenisolone therapy in, is

associated with alterations in leukocyte function, 1199 effect of

anticholinergic treatment on postexertional wheezing in, studied by phonopneumography and spirometry, 16

circadian rhythm on bronchomotor tone after deep inspira­tion in, 278

eucapnic hypoxia on bronchomotor tone and response to dry air in, 690

exacerbations of, in adults during experimental rhinovirus infec­tion, 976

homeostatic regulation of bronchomotor tone by sympathetic activation during bronchoconstriction, 993

influence of albuterol, cromolyn sodium, and ipratropium bromide on airway and circulating mediator responses to allergen bronchial provocation in, 986

late reactions in, prednisone inhibits, 1010 limited maximal airway narrowing in, role of neural control

and prostaglandin release in, 865 respiratory muscle activity and thoracoabdominal motion dur­

ing acute episodes of, during sleep, 999 workshop on investigative use of fiberoptic bronchoscopy and

bronchoalveolar lavage in (workshop summary), 180 Atelectasis, distribution of pulmonary blood flow in relation

to, in premature ventilated lambs, 500 Autoradiographic visualization of beta-adrenoceptor subtypes in

human lung, 541 Bacilli, drug-resistant and drug-susceptible, infection and dis-

sease among contacts of tuberculosis cases with, 125 Basophils from patients receiving long-term steroid therapy, in

vitro resistance to dexamethasone of, 1015 Bauxite refinery, pulmonary function in relation to total dust

exposure at, 1174 Beta

-adrenoceptor subtypes in human lung, autoradiographic visu­alization of, 541

-lactamases, isoelectric focusing of, in M. fortuitum and as­sociation of single enzyme pattern with cefoxitin resistance, 1093

Beta2-agonist, inhaled, hemodynamic effects of inhaled ipratro­pium bromide, alone and combined with, 845

Biopsy(ies) lingular lung, 1084 transbronchial

diagnosis of pulmonary amyloidosis by (case report), 191 immunocompetent cells in bronchoalveolar lavage reflect

cell populations in, in pulmonary sarcoidosis, 1300 Blastomyces dermatitidis, characteristics of pulmonary cellular

immune response to two strains of, in mouse, 1319 Blastomycosis and cutaneous t rauma (correspondence), 931 Bleomycin

-induced lung injury in rabbit, analysis and correlation of broncho­

alveolar lavage, morphometries, and fibroblast-stimulating activity in, 590

pulmonary fibrosis, alveolar wall basement membranes in, 905

in t ra t racheal^ administered, structure-function correlation of early state of lung injury induced by, in rabbit, 582

Blood flow, pulmonary, distribution of, in relation to atelectasis in

premature ventilated lambs, 500 of patients with bronchial asthma, increased numbers of hypo-

dense eosinophils in, 981 Body size and age, effect of, on reference equations for single-

breath diffusing capacity, 806 Bone marrow transplantation, allogeneic, diagnostic yield of bron­

choalveolar lavage in pneumonitis occurring after, 1118 Breathhold time, effects of different derivations of, on D L C O

(Note), 1127 Breathing

effects of nasal anesthesia on, during sleep, 972 and oxygenation during sleep are similar in normal men and

normal women, 86 pattern

affects airway wall temperature during cold air hyperpnea, 853

and Pco 2 during acute increase in airway resistance, respira­tory pressure sensation and its relation to changes in, in COPD, 1214

during sleep in patients with interstitial lung disease, 224 tidal, nitrogen washout during, with superimposed high-fre­

quency chest wall oscillation, 350 trial, National Institutes of Health positive-pressure, 937, 946

Breathlessness, do prostaglandins have a role in, 22 Bronchial

reactivity effect of acute airway inflammation on, in guinea pigs, 7 hypoxia enhances nonspecific, 839

washings, utility of, in diagnosis and treatment of Pneumo­cystis carinii pneumonia in patients with AIDS, 1087

Bronchitis, chronic almitrine improves oxygenation when both awake and asleep

in patient with hypoxia and C 0 2 retention caused by, 206 and chronic air-flow obstruction, effects of, on lung cell popu­

lations recovered by bronchoalveolar lavage, 254 Bronchoalveolar lavage

alpha-2-macroglobulin, monomeric and polymeric immuno­globulins A and B in, 829

analysis and correlation of, in bleomycin-induced lung injury in rabbit, 590

diagnostic yield of, in pneumonitis occurring after allogeneic bone marrow transplantation, 1118

effect of changing instilled volume for, in patient with interstitial lung

disease, 390 chronic bronchitis and chronic air-flow obstruction on lung

cell populations recovered by, 254 evaluation of, in prediction of therapeutic response in steroid-

treated pulmonary sarcoidosis, 65 fluid

chemotactic activity in, from patients with ARDS, 490 from healthy subjects, concentration of leukocyte elastase-

alpha-l-proteinase inhibitor complex in (Note), 913 lymphocytes subpopulat ions in, in asbestos workers, 824

from patients with invasive pulmonary aspergillosis, oxalic acid level in, 748

of healthy Vermont granite workers, mineral dust and cell re­covery from, 393

immunocompetent cells in, reflect cell populations in trans-bronchial biopsies in pulmonary sarcoidosis, 1300

and lung histology, 400 neutrophil elastase-releasing factors in, from patients with

ARDS, 1098 in ponies with recurrent airway obstruction (heaves), 1066 and serum, usefulness of tumor markers in, of patients under­

going fiberoptic bronchoscopy, 60 T-lymphocyte subsets and immunoglobulin concentrations, of

patients with sarcoidosis and high and low intensity al­veolitis, 1060

workshop on investigative use of, in asthmatics (workshop summary), 180

Bronchoconstriction acute, effects of, on respiratory activity in patients with C O P D

(correspondence), 722 adenosine-induced, in as thma, 1 differential inhibition of, by calcium channel blockers, vera-

SUBJECT INDEX 1391 pamil and nifedipine, 666

homeostatic regulation of bronchomotor tone by sympathetic activation during, in normal and asthmatic subjects, 993

limited, to methacholine using partial flow-volume curves in nonasthmatics, 272

Bronchodilation, beta-adrenergic, effect of procaterol treatment on, 1194

Bronchodilator relationship of response to, and decline in FEV, in popula­

tion studies, 1186 trials, use of criteria for reversibility and obstruction to define

patient groups for, 858 Bronchomotor tone

effect of circadian rhythm on, after deep inspiration in normal and asthmatic subjects, 278

homeostatic regulation of, by sympathetic activation during bronchoconstrict ion in normal and asthmatic subjects, 993

and response to dry air, effect of eucapnic hypoxia on, in asthmatic subjects, 690

Bronchoprovocation, upper airway response during, 671 Bronchoscope, pediatric fiberoptic, use of, in adults (case report),

715 Bronchoscopy, fiberoptic

usefulness of tumor markers in serum and bronchoalveolar lavage of patients undergoing, 60

workshop on investigative use of, in asthmatics (workshop summary) , 180

Bronchospasm, acute, contributions of rib cage and abdominal displacements to hyperinflation of, 679

Calcium channel blockers, differential inhibition of bronchocon­striction by, 666

Cancer and chromosomes, from sea urchins to (editorial), 935 lung, growth factors, and oncogenes, 178

Carbohydrate load, large, effects of, on walking performance in chronic air-flow obstruction, 960

Carbon dioxide

retention caused by chronic bronchitis and emphysema, al­mitrine improves oxygenation when both awake and asleep in patients with, 206

tension and breathing pattern during acute increase in airway

resistance, respiratory pressure sensation and its rela­tion to, in COPD, 1214

resting arterial, premorbid ventilatory response to hyper-capnia is not related to, in hamsters with elastase-induced emphysema, 1055

monoxide back pressure, effects of different derivations of, on D L C O (Note), 1127

tetrachloride injury, prevention by zinc of rat lung collagen accumulat ion in, 536

Carc inoma, bronchogenic, in the elderly (correspondence), 434 Cardiac contractility and diaphragm, comparative effects of amino­

phylline on, 800 Catalase, l iposome-encapsulated superoxide dismutase or, protec­

tion against pulmonary oxygen toxicity in rats by intra­tracheal administration of, 164

Catheps in G, neutrophil, and elastase, effect of combined, on induction of secretory cell metaplasia and emphysema in hamsters, 362

Cefoxitin resistance, association of single enzyme pattern with, 1093

Cell(s) bronchoalveolar , alteration of, during murine cytomegalovirus

interstitial pneumonit is , 77 culture, neutral metalloendopeptidase in, 564 epithelial , culture of, on collagen matrix supports, 1281 immunocompe ten t , in bronchoalveolar lavage reflect cell popu­

lations in transbronchial biopsies in pulmonary sarcoidosis, 1300

inflammatory and immunocompetent , comparative analysis of, in patients with sarcoidosis and hypersensitivity pneu­monitis, 400

lipid interstitial, of pulmonary alveolus, age and species dif­ferences of, 1307

mast, purified lung immunoglobulin E-mediated release of kininogenase from,

405 pharmacologic modulat ion of release of arachidonic acid

metabolites from, 367 and mineral dust recovery from bronchoalveolar lavage of healthy

Vermont granite workers, 393 nasal epithelial, growth and differentiation of, in serum-free,

hormone-supplemented culture medium and proteoglycan synthesis, 311

purified dog mastocytoma, characterization of, 1019 rat alveolar type II, macrophages stimulate DNA synthesis in,

1246 Cellular immune response, pulmonary, characteristics of, to two

strains of Blastomyces dermatitidis in mouse, 1319 Chemosensitivity, respiratory, age-related variation of, in mono­

zygotic twins, 89 Chemotactic activity in bronchoalveolar lavage fluid from pa­

tients with ARDS, 490 Chemotherapy

ansamycin, dynamic aspects of in vitro, on M intracellulars 1278

given intermittently in continuation phase in treatment of pulmonary tuberculosis, clinical trial of three 6-month regimens of, 374

Chest wall oscillation, superimposed high-frequency, nitrogen washout during tidal breathing with, 350

Children health effects of smoking on (ATS statement), 1137 vigorously exercising, respiratory responses of, to 0.12 ppm

ozone exposure, 875 Cholinergic, adrenergic, or nonadrenergic responses in vitro, failure

of in vivo methacholine responsiveness to correlate with, 30

Chromosomes and cancer, from sea urchins to (editorial), 935 Cigarettes. See Smoke and Smoking Circadian rhythm, effect of, on bronchomotor tone after deep

inspiration in normal and asthmatic subjects, 278 Cobra venom factor, at tenuation by 2,3-dihydroxybenzoic acid of

acute lung injury induced by, in rat, 1288 Collagen

accumulation, rat lung, prevention by zinc of, in carbon tetra­chloride injury, 536

matrix supports, culture of nasal epithelial cells on, 1281 Complement abnormalit ies and immune complexes in patients

with cystic fibrosis, 770 C O R R E S P O N D E N C E

Blastomycosis and cutaneous t rauma, 931 Bronchogenic carcinoma in the elderly, 434 Effects of acute bronchoconstriction on respiratory activity

in patients with COPD, 722 Prediction of therapeutic response in steroid-treated pulmonary

sarcoidosis, 1139 Prevalence of radiographic appearance of pneumoconiosis in

unexposed blue collar populat ion, 1138 R P M or RCF? 1371 Sustained-release theophylline reduces dyspnea in nonreversible

obstructive airway disease, 195 Cough, persistent, prevalence of, in young adults in relation to

long-term ambient sulfur oxide exposure, 261 Cromolyn sodium, influence of, on airway and circulating me­

diator responses to allergen bronchial provocation in asthma, 986

1392 S U B J E C T INDEX

Cryptococcus neoformans, serologic diagnosis of focal pneumonia caused by (case report), 189

Curvulariosis, allergic bronchopulmonary (case report), 186 Cyclooxygenase inhibitors, differential effects of, on pulmonary

transvascular fluid and protein exchange after thrombin-induced microembolism, 70

Cyclosporine immunomodulat ion in rabbit model of chronic hy­persensitivity pneumonitis, 1027

Cysteine, protective effects of, on phagocyte-mediated oxidative inactivation of alpha-l-protease inhibitor, 1049

Cystic fibrosis biochemical and pathologic evidence for proteolytic destruc­

tion of lung connective tissue in, 529 epithelia, comparison of bioelectric properties of normal and,

in culture of nasal epithelial cells on collagen matrix sup­port, 1281

gene(s) (editorial), 1149 immune complexes and complement abnormalities in patients

with, 770 maximal inspiratory and expiratory pressures are reduced in

hyperinflated, malnourished, young adult male patients with, 766

sputum aminoglycoside penetration, inactivation, and efficacy in, 761 studies with, and evidence that Pseudomonas aeruginosa

elastase does not inactivate bronchial inhibitor in presence of leukocyte elastase, 524

Cytochrome B-245 in human alveolar macrophages, 836 Cytomegalovirus interstitial pneumonitis, murine, alteration of

bronchoalveolar cells during, 77 Dapsone, protective effects of, on phagocyte-mediated oxidative

inactivation of alpha-l-protease inhibitor, 1049 Dexamethasone, in vitro resistance to, of basophils from patients

receiving long-term steroid therapy, 1015 Diaphragm and cardiac contractility, comparative effects of

aminophylline on, 800 Diaphragmatic

contractility, effects of aminophylline, isoproterenol, and neo­stigmine on hypercapnic depression of, 241

paralysis, rib cage mechanics in simulated, 793 Diazepam, effect of, on genioglossal muscle activity in normal

subjects, 216 Diffusing capacity for C 0 2 , effects of different derivation of

breathhold time and alveolar volume and of CO back pressure on (Note), 1127

Digoxin plasma kinetics, tritiated, influence of hypoxemia on, in conscious dog, 504

2,3-Dihydroxybenzoic acid, attenuation by, of acute lung injury induced by cobra venom factor in rat, 1288

DNA synthesis, macrophages stimulate, in rat alveolar type II cells, 1246

Dog conscious, influence of hypoxemia on tritiated digoxin plasma

kinetics and tissue distribution in, 504 effects of eicosanoid synthesis inhibitors on normoxic and

hypoxic pulmonary vascular tone in, 93 mastocytoma cells, purified, characterization of, 1019

Dose-response curve to inhaled histamine and methacholine, slope of, and PC2 0 in subjects with symptoms of airway hyper-excitability and in normal subjects, 644

Drug resistance, acquired, to aminoglycosides and antibacterial agents

in M. fortuiturn and M. chelonei, 409 -resistance and drug-susceptible bacilli, infection and disease

among contacts of tuberculosis cases with, 125 Dust

exposure mineral, pulmonary function and peripheral airway disease

in patients with, 1294 rapid decline in FEV, in grain handlers in relation to level

of, 814

total, pulmonary function in relation to, at bauxite refinery and alumina-based chemical products plant, 1174

mineral, and cell recovery from bronchoalveolar lavage of healthy Vermont granite workers, 393

Dysplasia, bronchopulmonary (state of art), 694 Dyspnea, sustained-release theophylline reduces, in nonreversible

obstructive airway disease (correspondence), 195 E D I T O R I A L

From sea urchins to chromosomes and cancer, 935 Indicators of risk, course, and prognosis in ARDS, 471 Tailoring a t ime-bomb: inadvertent genetic engineering, 735

Eglin-C prevents neutrophil elastase-induced emphysema and bronchial secretory cell metaplasia in hamsters, 1155

Eicosanoid synthesis inhibitors, effects of, on normoxic and hy­poxic pulmonary vascular tone in dogs, 93

Elastase -alpha-l-proteinase inhibitor complex, leukocyte, concentration

of, in bronchoalveolar lavage fluids from healthy subjects (Note), 913

and emphysema, current assessement of protease-antiprotease hy­pothesis in (state of art), 417

-induced emphysema augmentat ion of, by cigarette smoke, 885 cigarette smoke impairs elastin resynthesis in lungs of ham­

sters with, 640 neutrophil, eglin-C prevents, in hamsters, 1155 premorbid ventilatory response to hypercapnia is not related

to resting arterial C 0 2 tension in hamsters with, 1055 prevention of, in hamsters by intratracheal administration of a

synthetic elastase inhibitor bound to albumin microspheres, 159

and neutrophil cathepsin G, effect of, combined, on induction of secretory cell metaplasia and emphysema in hamsters, 362

Pseudomonas aeruginosa, evidence that, does not inactivate bronchial inhibitor in presence of leukocyte elastase, 524

-releasing factors, neutrophil, in bronchoalveolar lavage from patients with ARDS, 1098

Elastin cross-links (desmosine), urinary excretion of, in subjects with

PiZZ alpha-l-antitrypsin deficiency, 821 resynthesis, cigarette smoke impairs, in lungs of hamsters with

elastase-induced emphysema, 640 Elastolysis of combined neutrophil cathepsin G and elastase, ob­

servations on, in hamsters, 362 Electromyogram, respiratory muscle, relationship between rib

cage motion and, in tetraplegia, 53 Embolism, pulmonary determinants of hypoxemia during acute

phase of, 332 Emphysema

and chronic bronchitis, almitrine improves oxygenation when both awake and asleep in patient with hypoxia and C 0 2 retention caused by, 206

definition of: report of a NHLBI Division of Lung Diseases Workshop (workshop summary), 182

effect of combined human neutrophil cathepsin G and elastase on induction of, in hamsters, 362

elastase-induced augmentation of, by cigarette smoke, 885 cigarette smoke impairs elastin resynthesis in lungs of ham­

sters with, 640 premorbid ventilatory response to hypercapnia is not related

to resting arterial C 0 2 tension in hamsters with, 1055 prevention of, in hamsters by intratracheal administration

of synthetic elastase inhibitor bound to albumin micro­spheres, 159

and elastases, current assessment of protease-antiprotease hy­pothesis (state of art), 417

neutrophil elastase-induced, eglin-C prevents, in hamsters, 1155 pulmonary

phenotype associated with hereditary predisposition to, 821

SUBJECT INDEX 1393 aid proteolysis (editorial), 205

Endopeptidase, neutral, in serum samples from patients with ARDS compared with angiotensin-converting enzyme, 1262

Endo:oxin -incuced

lung injury, effects of OKY-046 on, in unanesthetized sheep, 494

neutrophil alveolitis, modification by hyperoxia in vivo of, in rats, 152

pulmonary hypertension, relationship of increased lung sero­tonin levels to, in sheep, 1257

induction with, and fibrinolytic inhibitor of alveolar macro­phages, 569

Endo.racheal tube, effect of gas leak around, on mean tracheal pressure during mechanical ventilation, 339

Enzyme assay, aminoglycoside-modifying, in M. fortuitum and M. che-

lonei, 409 pattern, single, association of, with cefoxitin resistance, 1093

Eosinophils, hypodense, increased numbers of, in blood of pa­tients with bronchial asthma, 981

Epidemiology of tuberculous infection in a chronic care popula­tion, 133

Epithelia, normal and cystic fibrosis, comparison of bioelectric properties of, in culture of nasal epithelial cells on col­lagen matrix supports, 1281

Ethambutol, effect of, on tubercle bacilli within cultured human macrophages, 742

Exercise accuracy of two ear oximeters at rest and during, in pulmonary

patients, 685 increases in intrathoracic pressure do not explain rise in left

ventricular end-diastolic pressure that occurs during, in patients with COPD, 623

maximal, prediction of ventilation at, in chronic air-flow obstruction, 230

nifedipine dilates pulmonary vasculature without producing symptomatic systemic hypotension during, 963

performance in smoking and nonsmoking asbestos-exposed workers, 612

respiratory effects of photochemical oxidant air pollution in adolescents

during, 619 responses of children during vigorous, to 0.12 ppm ozone

exposure, 875 ventilatory muscle function during, in air and oxygen in pa­

tients with chronic air-flow limitation, 236 Fibroblast-stimulating activity, analysis and correlation of, in

bleomycin-induced lung injury in rabbit, 590 Fibrosis

bleomycin-induced pulmonary, alveolar wall basement mem­branes in, 905

pulmonary, short-term regional clearance of inhaled submicro-metric aerosol in, 606

Fish-oil-enriched diet, effects of, on pulmonary mechanics dur­ing anaphylaxis, 1204

Flow maximal expiratory, implications for, in increase in tracheal

size with age, 784 -volume curves, partial, limited bronchoconstriction to metha-

choline using, in nonasthmatics, 272 Forced expiratory volume in one second

rapid decline in, in grain handlers, 814 relationship of response to bronchodilator and decline in, in

populat ion studies, 1186 Formalin fixation, 10%, effects of, on fixed lung volume and

lung tissue shrinkage, 1078 Fume exposure, pulmonary function and peripheral airway disease

in patients with, 1294 Gallium-67

lung scanning

evaluation of, in prediction of therapeutic response in steroid-treated pulmonary sarcoidosis, 65

in pulmonary tuberculosis, 746 scintigraphy and bronchial washings, utility of, in diagnosis

and treatment of Pneumocystis carinii pneumonia in pa­tients with AIDS, 1087

Gas(es) arterial blood, normalization of, after treatment of surfactant-

deficient lambs with Tween 20, 1313 leak around endotracheal tube, effect of, on mean tracheal

pressure during mechanical ventilation, 339 and particulate phases, comparison of, in cigarette-smoking-

induced changes in rat pulmonary clearance of " m TcDTPA, 1170

Genetic engineering, inadvertent (editorial), 735 Genioglossus, effect of

d iazepam on, in normal subjects, 216 sleep deprivation on activity of, 1242

Grain handlers, rapid decline in FEV, in, in relation to level of dust exposure, 814

Granite workers, healthy Vermont, mineral dust and cell recovery from bronchoalveolar lavage of, 393

Guinea pigs airway hyperresponsiveness and inflammation induced by

toluene diisocyanate in, 1106 effect of acute airway inflammation on bronchial reactivity

in, 7 in vivo and in vitro studies of, as model for virus-provoked

airway hyperreactivity, 305 ozone-induced bronchial hyperreactivity in, is abolished by

BW 755C or FPL 55712 but not by indomethacin, 1005 Hamsters

dissemination of Pseudomonas aeruginosa during lung infec­tion in, 358

effect of combined neutrophil cathepsin G and induction of secretory cell metaplasia and emphysema in, 362

eglin-C prevents neutrophil elastase-induced emphysema and bronchial secretory cell metaplasia in, 1155

with elastase-induced emphysema cigarette smoke impairs elastin resynthesis in lung of, 640 premorbid ventilatory response to hypercapnia is not related

to resting arterial C 0 2 tension in, 1055 prevention of elastase-induced emphysema in, by intratracheal

administration of synthetic elastase inhibitors bound to albumin microspheres, 159

Heal th and cigarette smoking (ATS statement), 1133 effects of smoking on children (ATS statement), 1137

Hear t failure, congestive, relationship of pleural effusions to pul­monary hemodynamics in patients with, 1253

Heaves, bronchoalveolar lavage in ponies with recurrent, 1066 Hemangiomatosis , pulmonary capillary (case report), 922 Hemodynamics , pulmonary, relationship of pleural effusions to, in

patients with congestive heart failure, 1253 Hemoptysis , recurrent, diffuse alveolar septal amyloidosis pre­

senting with (case report), 1368 Hereditary predisposition to pulmonary emphysema, phenotype

associated with, 821 Herpes zoster, respiratory muscle dysfunction after (case report),

1366 His tamine

challenge, how many spirograms for a, 268 diphosphate solutions, stability of stored (Note), 1130 -induced reflex tracheal constriction is attenuated by hyperoxia

and exaggerated by hypoxia, 287 inhaled

airway responsiveness to, in inbred, ragweed-sensitized dogs, 292

kinetics of recovery of airway response caused by, 848 slope of dose-response curve to, and PC 2 0 in subjects with

symptoms of airway hyperexcitability, 644

1394 SUBJECT INDEX

release, autonomic membrane receptors and pharmacologic modulat ion of, in purified dog mastocytoma cells, 1019

Histoplasmosis, experimental pulmonary, detection of histoplas-mal antigens in mice undergoing, 752

HLA-A, -B, and -DR phenotypes and tuberculosis, 382 Hormone-supplemented, serum-free culture medium, growth and

differentiation of nasal epithelial cells in, and proteogly­can synthesis, 311

Hydranencephaly and anencephaly, lung growth and development in, 596

Hydrogen ion regulation and amino acid metabolism, relation be­tween, in hypercapnia II, 248

Hypercapnic depression of diaphragmatic contractility, effects of aminophylline, isoproterenol, and neostigmine on, 241

Hypercapnia premorbid ventilatory response to, is not related to resting

arterial C 0 2 tension in hamsters with elastase-induced emphysema, 1055

relationship between central nervous system hydrogen ion regu­lation and amino acid metabolism in II, 248

Hyperexcitability, airway, slope of dose-response curve to inhaled histamine and methacholine and PC 2 0 in subjects with symptoms of, 644

Hyperinflation of acute bronchospasm, contributions of rib cage and abdominal displacements to, 679

Hyperoxia histamine-induced reflex tracheal constriction is attenuated

by, 287 in vivo of endotoxin-induced neutrophil alveolitis in rats, 152

Hyperpnea, cold air, breathing pattern affects airway wall tem­perature during, 853

Hyperreactivity ozone-induced bronchial, in guinea pigs is abolished by BW 755C

or FPL 55712 but not by indomethacin, 1005 virus-provoked airway, use of guinea pig as model for, 305

Hyperresponsiveness airway, and inflammation induced by toluene diisocyanate in

guinea pigs, 1106 bronchial, prevalence and nature of, in COPD, 25 rebound, to muscarinic stimulation after chronic therapy with

inhaled muscarinic antagonist, 12 Hypersensitivity pneumonit is

chronic, cyclosporine immunomodula t ion in rabbit model of, 1027

comparative analysis of inflammatory and immunocompetent cells in patients with, 400

Hypertension endotoxin-induced pulmonary, relationship of increased lung

serotonin levels to, in sheep, 1257 pulmonary, secondary to COPD, nifedipine dilates pulmonary

vasculature without producing symptomatic systemic hypo­tension in upright resting and exercising patients with, 963

Hyperventilation intermittent positive-pressure, with high inflation pressures

produces pulmonary microvascular injury in rats, 880 Hypotension, symptomatic systemic, nifedipine dilates pulmonary

vasculature without, 963 Hypoxemia

determinants of, during acute phase pulmonary embolism, 332 influence of, on tritiated digoxin plasma kinetics and tissue

distribution in conscious dog, 504 Hypoxia

almitrine improves oxygenation when both awake and asleep in patient with, caused by chronic bronchitis and emphy­sema, 206

enhances nonspecific bronchial reactivity, 839 eucapnic, effect of, on bronchomotor tone and on broncho­

motor response to dry air in asthmatic subjects, 690 histamine-induced reflex tracheal constriction is exaggerated

by, 287

Immune complexes and complement abnormalities in patients with cystic

fibrosis, 770 responsiveness, local pulmonary, after multiple antigenic ex­

posures in cynomolgus monkey, 657 Immunization, lung, effect of age on antibody responses after, 661 Immunoglobulin(s)

A and M, monomeric and polymeric, in bronchoalveolar lavage, 829

A-mediated phagocytosis by mouse alveolar macrophages, 82 concentration and T-lymphocyte subsets in bronchoalveolar

lavage of patients with sarcoidosis and high and low in­tensity alveolitis, 1060

E-mediated release of kininogenase from purified lung mast cells, 405

Indochinese refugees, tuberculin conversion in, 516 Indomethacin, ozone-induced bronchial hyperreactivity in guinea

pigs is abolished by BW 755C or FPL 55712 but not by, 1005

Infection and disease among contacts of tuberculosis cases with drug-

resistant and drug-susceptible bacilli, 125 mycotic and specific fungal, laboratory diagnosis of (ATS

statement), 1373 Inflammation

and airway hyperresponsiveness induced by toluene diisocyanate in guinea pigs, 1106

acute airway, effect of, on bronchial reactivity in guinea pigs, 7 Inhalation

acute vanadium pentoxide, pulmonary effects of, in monkeys, 1181

of tobacco smoke in pipe, cigarette, and never smokers, pat­tern, 628

Ipratropium bromide hemodynamic effects of, alone and combined with inhaled

beta2-agonist, 845 influence of, on airway and circulating mediator responses to

allergen bronchial provocation in as thma, 986 Isoelectric focusing of beta-lactamases in M. fortuitum and as­

sociation of single enzyme pattern with cefoxitin resistance, 1093

Isoproterenol, effects of, on hypercapnic depression of diaphrag­matic contractility, 241

Kininogenase, immunoglobulin E-mediated release of, from puri­fied lung last cells, 405

Kyphoscoliosis, severe, inspiratory muscle function in patients with, 48

Lambs premature, ventilated, distribution of pu lmonary blood flow in

relation to atelectasis in, 500 surfactant-deficient, normalization of arterial blood gases after

treatment of, with Tween 20, 1313 Leukocyte

elastase -alpha-l-proteinase inhibitor complex, concentration of, in

bronchoalveolar lavage fluids from healthy subjects (Note), 913

evidence that Pseudomonas aeruginosa elastase does not inactivate bronchial inhibitor in presence of, 524

function, airway reversibility after prednisolone therapy in chronic as thma is associated with alterations in, 1199

Leukopenia, alcoholism, and pneumococcal sepsis, 757 Leukostasis, pulmonary, amphotericin B enhances, 602 Leukotrienes C4 and D4 , nifedipine inhibits bronchial smooth

muscle contractions induced by, 299 Lipid

-laden alveolar macrophage as marker of aspiration in parenchy­mal lung disease, 576

interstitial cell of pulmonary alveolus, age and species differ­ences of, 1307

SUBJECT INDEX 1395 Liposome-encapsulated superoxide dismutase or catalase, protec­

tion against pulmonary oxygen toxicity in rats by intra­tracheal administration of, 164

Loads added inspiratory, effect of chronic lung disease on perception

of, 652 respiratory, detection of added, in patients with restrictive

lung disease, 1210 Lung(s)

allograft rejection in rat, 168 autoradiographic visualization of beta-adrenoceptor subtypes in,

541 biopsy, lingular, 1084 cancer, growth factors, and oncogenes (commentary), 178 cell populations recovered by bronchoalveolar lavage, effects

of chronic bronchitis and chronic air-flow obstruction on, 254

collagen accumulation, rat, prevention by zinc of, in carbon tetrachloride injury, 536

disease chronic

effect of, on perception of added inspiratory loads, 652 and nutri t ion (state of art), 1347

interstitial breathing during sleep in patients with, 224 effect of changing instilled volume for bronchoalveolar

lavage in patients with, 390 parenchymal, lipid-laden alveolar macrophage as marker of

aspiration in, 576 restrictive, detection of added respiratory loads in patients

with, 1210 excised

rabbit, alveolar pressure magnitude and asynchrony during high-frequency oscillation of, 343

function and exercise performance in smoking and nonsmoking as­

bestos-exposed workers, 612 impairment, loss of alveolar at tachments in smoker as a

morphometr ic correlate of, 894 overall, abnormal ventilation scans in middle-aged smokers,

comparison with tests of, 148 growth and development in anecephaly and hydranencephaly,

596 of hamsters with elastase-induced emphysema, cigarette smoke

impairs elastin resynthesis in, 640 histology and bronchoalveolar lavage, 400 infection, dissemination of Pseudomonas aeruginosa during,

in hamsters, 358 injury

acute, induced by cobra venom factor, at tenuation by 2,3-dihydroxybenzoic acid, in rat, 1288

bleomycin-induced, in rabbit, analysis and correlation of bronchoalveolar lavage, morphometries , and fibroblast-stimulating activity in, 590

endotoxin-induced, effects of OKY-046, a selective throm­boxane synthetase inhibitor, on, in unanesthetized sheep, 494

hyperoxic, and polyamine biosynthesis, age-related differ­ences in, 354

structure-function correlation of early stage of, induced by in t ra t racheal^ administered bleomycin in rabbit, 582

unresolved neonatal acute (state of art), 694 rnast cells, purified, pharmacologic modulat ion of release of

arachidonic acid metabolites from, 367 ra t , pat terns of accumulation of platelets and neutrophils in,

during exposure to 100 and 8 5 % 0 2 , 548 regenerating rat, timing of quantitative recovery in, 777 serotonin levels, relationship of increased, to endotoxin-induced

pulmonary hypertension in sheep, 1257 shr inking , diaphragmatic dysfunction, and systemic lupus

erythematosus (case report), 926 tissue, neutral metalloendopeptidase in, 564 volume, fixed, and lung tissue shrinkage, effect of 10% formalin

fixation on, 1078 Lymphangiomyomatosis, pulmonary, successful treatment of, with

oophorectomy and progesterone (case report), 916 Lymphocyte

subpopulat ions in bronchoalveolar lavage fluid in asbestos workers, 824

subsets, T-, and immunoglobulin concentrations in broncho­alveolar lavage of patients with sarcoidosis and high and low intensity alveolitis, 1060

Macrophages alveolar

cytochrome B_245 in, 836 fibrinolytic inhibitor of, and induction with endotoxin, 569 lipid-laden, as marker of aspiration in parenchymal lung

disease, 576 production of chemotactic factors by, and ultrastructure in

modification by hyperoxia in vivo of endotoxin-induced neutrophil alveolitis, 152

cultured human, effect of ethambutol on tubercle bacilli within, 742

-ingested mycobacteria, killing of, by rifampicin, pyrazinamide, and pyrazinoic acid alone and in combinat ion, 1274

mouse alveolar, IgA-mediated phagocytosis by, 82 penetration of rifampicin, pyrazinamide, and pyrazinoic acid

into, 1268 newborn rabbit alveolar, are deficient in two microbicidal cationic

peptides, MCP-1 and MCP-2, 901 stimulate D N A synthesis in rat alveolar type II cells, 1246

Mastocytoma cells, purified dog, characterization of, 1019 Metabolism

and absorption of compounds used in initial intensive phase of short-course antituberculosis regimens, 510

amino acid, relationship between central nervous system hy­drogen ion regulation and, in hypercapnia II , 248

Metabolites, arachidonic acid, pharmacologic modulat ion of re­lease of, from purified lung mast cells, 367

Metalloendopeptidase, neutral, in lung tissue and culture cells, 564

Metaplasia bronchial secretory cell, eglin-C prevents, in hamsters, 1155 secretory cell, effect of combined neutrophil cathepsin G and

elastase on induction of, in hamsters, 362 Methacholine

inhaled airway responsiveness to, in inbred, ragweed-sensitized dogs,

292 slope of dose-response curve to, and PC 2 0 in subjects with

symptoms of airway hyperexcitability, 644 limited bronchoconstriction to, using partial flow-volume curves

in nonasthmatics, 272 responsiveness, failure in vivo of, to correlate with cholinergic,

adrenergic, or nonadrenergic responses in vitro, 30 Mice

alveolar macrophages, IgA-mediated phagocytosis by, 82 antituberculosis activity of ofloxacin (DL 8280) on experimental

tuberculosis in (Note), 915 characteristics of pulmonary cellular immune response to two

strains of Blastomyces dermatitidis in, 1319 macrophages, penetration of rifampicin, pyrazinamide, and

pyrazinoic acid into, 1268 undergoing experimental pulmonary histoplasmosis, detection

of histoplasmal antigens in, 752 Microembolism, thrombin-induced, pulmonary transvascular fluid

and protein exchange after, 70 Microvascular injury, pulmonary, intermittent positive-pressure

hyperventilation with high inflation pressures produced,

1396 SUBJECT INDEX

in rat, 880 Monkey

cynomologus, local pulmonary immune responsiveness after multiple antigenic exposure in, 657

pu lmonary effects of acute vanadium pentoxide inhalation in, 1181

rhesus, respiratory secretions, immunohistochemical character­ization of, using monoclonal antibodies, 556

Morphometr ies , analysis and correlation of, in bleomycin-induced lung injury in rabbit, 590

Mucocil iary function of central and peripheral airways, dis-association in, of asymptomatic smokers, 633

Muscarinic antagonist , inhaled, rebound hyperresponsiveness to muscarinic stimulation after chronic therapy with, 12

Muscle activity, respiratory, and thoracoabdominal motion during acute

episodes of as thma during sleep, 999 contract ions, bronchial smooth, induced by leukotrienes C4

and D 4 , prostaglandin F 2 a , and potassium, nifedipine inhibits, 299

dysfunction, respiratory, after Herpes zoster (case report), 1366 electromyogram, respiratory, relationship between rib cage mo­

tion and, in tetraplegia, 53 function

inspiratory, in patients with severe kyphoscoliosis, 48 ventilatory, during exercise in air and oxygen in patients with

chronic air-flow limitation, 236 genioglossal, effect of diazepam on, in normal subjects, 216

Muta t iona l resistance as mechanism of acquired drug-resistance to aminoglycosides and antibacterial agents in M fortui-tum and M. chelonei, 409

Mycobacter ia determinat ion of in vitro susceptibility of, to ansamycin (Note),

710 macrophage-ingested, killing of, by rifampicin, pyrazinamide, and

pyrazinoic acid alone and in combination, 1274 Mycobacterium

avium-in tracellulare-scrofulaceum complex, phage typing of, 386 and related species of mycobacteria, specificity and distribu­

tion of alpha antigens of, 173 fortuitum and M. chelonei, mutational resistance as mechanism

of acquired drug-resistance to aminoglycosides and anti­bacterial agents in, 409

intracellular, dynamic aspects of in vitro chemotherapeutic activity of ansamycin on, 1278

Nasal epithelial cells, growth and differentiation of, in serum-free,

hormone-supplemented medium and proteoglycan synthesis, 311

resistance, dynamic components of, 1229 Nat ional Institutes of Health intermittent positive-pressure breath­

ing trial, 937, 946 Neonata l acute lung injury, unresolved (state of art), 694 Neostigmine, effects of, on hypercapnic depression of diaphrag­

matic contractility, 241 Neutrophil(s)

amphoter ic in B causes aggregation of, 602 cathepsin G and elastase, effect of combined, on induction

of secretory cell metaplasia and emphysema in hamsters, 362

-elastase -induced emphysema, eglin-C prevents, in hamsters, 1155 -releasing factors in bronchoalveolar lavage for patients with

A R D S , 1098 pat terns of accumulation of, in rat lungs during exposure to

100 and 8 5 % 0 2 , 548 differential inhibition of bronchoconstriction by, 666 dilates pu lmonary vasculature without producing symptomatic

systemic hypotension in upright and exercising patients

with pulmonary hypertension secondary to COPD, 963 inhibits human bronchial smooth muscle contractions induced

by leukotrienes C4 and D4 , prostaglandin F 2 a , and potas­sium, 299

Nitrogen dioxide, acute effects of 0.12 ppm of, and 0.12 ppm ozone on

pulmonary function in healthy and asthmatic adolescents, 644

washout and mortality, 115 during tidal breathing with superimposed high-frequency

chest wall oscillation, 350 Normocapnia , stable, during high-frequency body surface oscilla­

tion in rabbits, 104 Nutrition and chronic lung disease (state of art), 1347 Ofloxacin (DL 8280), antituberculosis activity of, on experimen­

tal tuberculosis in mice (Note), 915 OKY-046, effects of, on endotoxin-induced lung injury in un-

anesthetized sheep, 494 Oncogenes, growth factors, and lung cancer (commentary), 178 Oophorectomy and progesterone, successful treatment of pul­

monary lymphangiomyomatosis with (case report), 916 Oscillation

high-frequency alveolar pressure magnitude and asynchrony during, of ex­

cised rabbit lungs, 343 body surface, stable normocapnia during, in rabbits, 104

superimposed high-frequency chest wall, nitrogen washout dur­ing tidal breathing with, 350

Oxalic acid level in bronchoalveolar lavage fluid from patients with invasive pulmonary aspergillosis, 748

Oximeters, ear, accuracy of 2, at rest and during exercise in pul­monary patients, 685

Oxygen and air, ventilatory muscle function during exercise in, in pa­

tients with chronic air-flow limitation, 236 alveolar, influence of, on pulmonary vasoconstriction in new­

born lambs versus sheep, 326 consumption, independently measured, during reduction of

oxygen delivery by positive end-expiratory pressure, 788 extraction, tissue, regulation of, is disturbed in ARDS, 109 -induced lung injury, role of, in dissemination of Pseudomonas

aeruginosa during lung infection in hamsters, 358 low-flow, shift from central and mixed sleep apnea to obstruc­

tive sleep apnea resulting from, 220 100 and 8 5 % , patterns of accumulation of platelets and neu­

trophils in rat lungs during exposure to, 548 toxicity, pulmonary, protection against, in rats by intratracheal

administration of liposome-encapsulated superoxide dis-mutase or catalase, 164

Oxygenation almitrine improves, when both awake and asleep in patients

with hypoxia and C 0 2 retention caused by chronic bron­chitis and emphysema, 206

and breathing during sleep are similar in normal men and normal women, 86

Ozone acute effect of 0.12 ppm, or 0.12 ppm nitrogen dioxide on pul­

monary function in healthy and asthmatic adolescents, 648 exposure, 0.12 ppm, respiratory responses to vigorously exer­

cising children to, 875 -induced bronchial hyperreactivity in guinea pigs is abolished by

BW 755C or FPL 55712, but not by indomethacin, 10-05 response relationship in healthy nonsmokers, 36

Parenchyma, lung, a dynamic matrix (Amberson lecture), 1324 PC2 0 , slope of dose-response curve to inhaled histamine a n d

methacholine and, in subjects with symptoms of airway hyperexcitability, 644

Pectus excavatum, rib cage mobility in, 1223 Peptides, two microbicidal cationic (MCP-1 and MCP-2), newborn

SUBJECT INDEX

rabbit alveolar macrophages are deficient in, 901 Peru, results of 8- and 12-month antituberculosis regimens in, 737 Phage typing of M. avium-intracellulare-scrofulaceum complex,

386 Phagocyte-mediated oxidative inactivation of alpha-l-protease

inhibitor, protective effects of ascorbate, cysteine, and dap-sone on, 1049

Phagocytosis, IgA-mediated, by mouse alveolar macrophages, 82 Phenotype(s)

associated with hereditary predisposition to pulmonary emphy­sema, 821

HLA-A, -B, and -DR, and tuberculosis, 382 Phlegm, persistent, prevalence of, in young adults in relation to

long-term ambient sulfur oxide exposure, 261 Phonopneumography, effect of anticholinergic treatment on post-

exertional wheezing in asthma studied by, 16 Plasma kinetics, tritiated digoxin, influence of hypoxemia on, in

conscious dog, 504 Plasmid analysis, mutational frequencies, and aminoglycoside-

modifying enzyme assays, 409 Platelets, patterns of accumulation of, in rat lungs during ex­

posure to 100 and 8 5 % 0 2 , 548 Pleural effusions, relationship of, to pulmonary hemodynamics in

patients with congestive heart failure, 1253 Pneumoconiosis, prevalence of radiographic appearance of, in

unexposed blue collar populat ion (correspondence), 1139 Pneumocystis carinii

radiographically simulating tuberculosis, 1124 utility of gallium-67 scintigraphy and bronchial washings in

diagnosis and treatment of, in patients with AIDS, 1087 Pneumonia

focal, serologic diagnosis of, caused by Cryptococcus neofor­mans (case report), 189

Pneumocystis carinii radiographically simulating tuberculosis, 1124 utility of gallium-67 scintigraphy and bronchial washings

in diagnosis and treatment of, in patients with AIDS, 1087 Pneumonit is

chronic hypersensitivity, cyclosporine immunomodula t ion in rabbit model of, 1027

diagnostic yield of bronchoalveolar lavage in, occurring after allogenic bone marrow transplantation, 1118

hypersensitivity, comparative analysis of inflammatory and immunocompetent cells in patients with, 400

murine cytomegalovirus interstitial alteration of bronchoalveo­lar cells during, 77

Polyamine biosynthesis and hyperoxic lung injury, age-related differences in, 354

Polymorphonuclear leukocyte responsiveness, effect of procaterol treatment on, 1194

Ponies with recurrent airway obstruction (heaves), bronchoalveolar lavage in, 1066

Positive end-expiratory pressure, independently measured oxygen consumption during reduction of oxygen delivery by, 788

Potassium, nifedipine inhibits bronchial smooth muscle contractions induced by, 299

Prednisone inhibits late asthmatic reactions and associated increase in air­

way responsiveness induced by toluene-diisocyanate in sensi­tized subjects, 1010

therapy, airway reversibility after, in chronic asthma is as­sociated with alterations in leukocyte function, 1199

Procaterol treatment, effect of, on beta-adrenergic bronchodilation and polymorphonuclear leukocyte responsiveness, 1194

Progesterone and oophorectomy, successful treatment of pulmonary lymphangiomyomatosis with (case report), 916

Propranolol , pulmonary extraction of, in patients with ARDS, 479

Prostacyclin, role of, in high-frequency ventilation attenuation of hypoxic pulmonary vasoconstriction, 99

1397 Prostaglandin(s)

do they have a role in breathlessness? 22 release and neural control, role of, in limited maximal airway

narrowing in nonasthmatic subjects, 865 F 2 a , nifedipine inhibits bronchial smooth muscle contract ions

induced by, 299 Protease-antiprotease hypothesis, current assessment of, in elas-

tases and emphysema (state of art), 417 Protein

exchange and pulmonary transvascular fluid after th rombin-induced microembolism, 70

pure, studies with, and evidence that Pseudomonas aeruginosa elastase does not inactivate bronchial inhibitor in presence of leukocyte elastase, 524

Proteoglycan synthesis, growth and differentiation of nasal epi­thelial cells in serum-free, hormone-supplemented medium and, 311

Proteolysis and pulmonary emphysema (editorial), 205 Proteolytic destruction of lung connective tissue, biochemical

and pathologic evidence for, in cystic fibrosis, 529 Pseudomonas aeruginosa

dissemination of, during lung infection in hamsters, 358 elastase does not inactivate bronchial inhibitor in presence

leukocyte elastase, 524 Pulmonary

circulation, politics (editorial), 1152 disease, chronic obstructive

airway reactivity in, 30 determinants of maximal inspiratory pressure in, 42 effects of acute bronchoconstriction on respiratory activity

in patients with, 722 increases in intrathoracic pressure do not explain rise in left

ventricular end-diastolic pressure that occurs during exer­cise in patients with, 623

nifedipine dilates pulmonary vasculature without producing symptomatic systemic hypotension in upright resting and exercising patients with pulmonary hypertension secondary to, 963

prevalence and nature of bronchial hyperresponsiveness in, 25 respiratory

pressure sensation and its relation to changes in breathing pattern and Pco2 during acute increase in airway resistance in patients with, 1214

sensation in, 954 responses to large doses of salbutamol and theophylline in

patients with, 871 function

acute effects of 0.12 ppm ozone or 0.12 ppm nitrogen dioxide on, in healthy and asthmatic adolescents, 648

and peripheral airway disease in patients with mineral dust or fume exposure, 1294

in relation to total dust exposure at Bauxite refinery and alumina-based chemical products plant, 1174

mechanics, effects of fish-oil-enriched diet on, during ana­phylaxis, 1204

transvascular fluid and protein exchange after thrombin-induced microembolism, 70

vascular tone, effects of eicosanoid synthesis inhibitors on, in dogs, 93

Pyrazinamide killing of macrophage-ingested mycobacteria by, 1274 penetration of, into mouse macrophages, 1268

Pyrazinoic acid killing of macrophage-ingested mycobacteria by, 1274 penetration of, into mouse macrophages, 1268

Rabbit(s) acute cigarette smoke exposure increases alveolar permeabili ty

in, 321 alveolar macrophages, newborn, are deficient in two micro­

bicidal cationic peptides, MCP-1 and MCP-2, 901

1398 S U B J E C T INDEX

bleomycin-induced lung injury in, analysis and correlation of bronchoalveolar lavage, morphometr ies , and fibroblast-st imulating activity, 590

lungs, excised, alveolar pressure magni tude and asynchrony during high-frequency oscillations of, 343

model of chronic hypersensitivity pneumoni t is , cyclosporine immunomodula t ion in, 1027

stable normocapn ia during high-frequency body surface oscil­lation in, 104

structure-function correlation of early stages of lung injury induced by in t r a t r achea l^ administered bleomycin in, 582

Ragweed-sensitized dogs, inbred, airway responsiveness to inhaled antigen, histamine, and methachol ine in, 292

Rat(s) alveolar type II cells, macrophages st imulate D N A synthesis in,

1246 a t tenuat ion by 2,3-dihydroxybenzoic acid of acute lung injury

induced by cobra venom factor in, 1288 intermittent positive-pressure hyperventilation with high infla­

tion pressures produces pu lmonary microvascular injury in, 880

lung collagen accumulation, prevention by zinc of, in carbon tetra­

chloride injury, 536 pat terns of accumulat ion of platelets and neutrophils in,

dur ing exposure to 100 and 8 5 % 0 2 , 548 regenerating, t iming of quanti tat ive recovery in, 777 modification by hyperoxia in vivo of endotoxin-induced neu­

trophil alveolitis in, 152 protection against pulmonary oxygen toxicity in, by intratracheal

administrat ion of l iposome-encapsulated superoxide dis-mutase or catalase, 164

pu lmonary clearance of " m T c D T P A , cigarette-smoke-induced changes in, 1170

Respiration, cont inuous, effects of swallowing pattern of, in adults , 1219

Respiratory activity, effects of acute bronchoconstr ict ion on, in patients with

C O P D (correspondence), 722 disturbances, sleep-related, sleep-wake complaints in patients

with, 520 effects of photochemical oxidant air pollution in exercising

adolescents, 619 impedance measurements, upper airway artifact in (Note), 712 pressure sensation and its relation to changes in breathing pat­

tern and Pco 2 during acute increase in airway resistance in C O P D , 1214

responses of vigorously exercising children to 0.12 ppm ozone exposure, 875

secretions, rhesus monkey, immunohis tochemical characteriza­tion of, using monoclonal ant ibodies, 556

sensation in C O P D , 954 Rhinovirus infection, experimental , exacerbations of asthma in

adults during, 976 Rib cage

and abdominal displacements, contr ibut ions of, to hyperinfla­tion of acute bronchospasm, 679

mechanics in simulated d iaphragmat ic paralysis, 793 mobility in pectus excavatum, 1223 motion, relationship between respiratory muscle electromyogram

and, in tetraplegia, 53 Rifabutine, dynamic aspects of in vitro chemotherapeut ic activity

of, on M. intracellular, 1278 Rifampicin

killing of macrophage-ingested mycobacteria by, 1274 penetrat ion of, into mouse macrophages , 1268

R P M or RCF? (correspondence), 1371 Salbutamol, responses to large doses of, in patients with COPD, 871 Sarcoidosis

comparative analysis of inf lammatory and immunocompetent cells in patients with, 400

pulmonary immunocompetent cells in bronchoalveolar lavage reflect cell

populations in transbronchial biopsies in, 1300 prediction of therapeutic response in steroid-treated, 65

steroid-treated pulmonary, prediction of therapeutic response in (correspondence), 1139

T-lymphocyte subsets and immunoglobul in concentrat ions in bronchoalveolar lavage of patients with, 1060

Scans abnormal , ventilation in middle-aged smokers, 148 gallium-67

lung, evaluation of, in prediction of therapeutic response in steroid-treated pulmonary sarcoidosis, 65

value of, in pulmonary tuberculosis, 746 Scintigraphy, gallium-67, utility of, in diagnosis and treatment

of Pneumocystis carinii pneumonia in patients with AIDS, 1086

Sea urchins to chromosomes and cancer, from (editorial), 935 Sepsis, pneumococcal, alcoholism, and leukopenia, 757 Serotonin

levels, increased lung, relationship of, to endotoxin-induced pulmonary hypertension in sheep, 1257

pulmonary extraction of, in patients with ARDS, 479 Serum

alpha-l-proteinase inhibitor, smoking does not reduce functional activity of, 818

angiotensin-converting enzyme levels, evaluation of, in predic­tion of therapeutic response in steroid-treated pulmonary sarcoidosis, 65

antiproteases in smokers and nonsmokers , 1162 samples from patients with ARDS, neutral endopept idase in,

compared with angiotensin-converting enzyme, 1262 usefulness of tumor markers in, of patients undergoing fiber­

optic bronchoscopy, 60 Sheep

influence of alveolar oxygen on pulmonary vasoconstriction in newborn lambs versus, 326

relationship of increased lung serotonin levels to endotoxin-induced pulmonary hypertension, 1257

unanesthetized, effects of OKY-046, a selective thromboxane syn­thetase inhibitor, on endotoxin-induced lung injury in, 494

Single-breath diffusing capacity, reference equat ions for, 806 Sleep apnea. See Apnea Sleep

breathing during, in patients with interstitial lung disease, 224 and oxygenation during, are similar in normal men and nor­

mal women, 86 deprivation, effect of, on activity of genioglossus, 1242 effects of nasal anesthesia on breathing during, 972 respiratory muscle activity and thoracoabdominal motion dur­

ing acute episodes of as thma during, 999 -wake complaints in patients with sleep-related respiratory dis­

turbances, 520 Smoke

cigarette augmentat ion of elastase-induced emphysema by, 885 changes in rat pulmonary clearance of " m T c D T P A induced

by, 1170 exposure, acute, increases alveolar permeabili ty in rabbits ,

321 impairs elastin resynthesis in lungs of hamsters with elastase-

induced emphysema, 640 tobacco, pattern of inhalation of, in pipe, cigarette, and never

smokers, 628 Smokers

abnormal ventilation scans in middle-aged, 148

I N D E X - S U B J E C T S 1399 asymptomatic, disassociation in mucociliary function of cen­

tral and peripheral airways of, 633 loss of alveolar a t tachments in, 894 nor.-, domain spirogram indices and their variability and ref­

erence values in, 1041 and nonsmokers , serum antiproteases in, 1162 patterns of spirogram abnormal i ty in, 1034

Smoking cigarette, and health (ATS statement) , 1133 does not reduce function activity of serum alpha-l-proteinase

inhibitor, 818 and nonsmoking asbestos-exposed workers, lung function and

exercise performance in, 612 Snoring subjects with and without obstructive sleep apnea,

pharyngeal compliance in, 211 Spirogram(s)

abnormality, patterns of, in smokers, 1034 how many, for a histamine challenge? 268 indices, domain , variability and reference values in nonsmok­

ers of, 1041 Spirometry

effect of anticholinergic t reatment on postexertional wheezing in as thma studied by phonopneumography and, 16

standards effects of, on two occupat ional cohorts, 120 Sputum, cystic fibrosis, aminoglycoside penetration, inactivation,

and efficacy in, 761 S T A T E O F A R T

Bronchopulmonary dysplasia: unresolved neonatal acute lung injury, 694

Elastases and emphysema: current assessment of protease-anti-protease hypothesis, 417

Nutrition and chronic lung disease, 1347 Steroid

therapy, long-term, in vitro resistance to dexamethasone of basophils from patients receiving, 1015

-treated pu lmonary sarcoidosis, prediction of therapeutic re­sponse in, 65

(correspondence), 1139 Sulfur oxide exposure, long-term ambient , prevalence of persistent

cough and phlegm in young adults in relation to, 261 Superoxide dismutase, l iposome-encapsulated, protection against

pulmonary oxygen toxicity in rats by intratracheal admin­istration of, 164

Surfactant-deficient lambs, normal izat ion of arterial blood gases after t reatment of, with Tween 20, 1313

Swallowing, effects of, on pat tern of continuous respiration in adults , 1219

Syndrome acquired immune deficiency, utility of gallium-67 scintigraphy

and bronchial washings in diagnosis and treatment of Pneumocystis carinii pneumonia in, 1087

adult respiratory distress causes of mortali ty in pat ients with, 485 chemotactic activity in bronchoalveolar lavage fluid from

patients with, 490 indicators of risk, course, and prognosis (editorial), 471

neutral endopept idase in serum samples from patients with, compared with angiotensin-converting enzyme, 1262

neutrophil elastase-releasing factors in bronchoalveolar lavage from patients with, 1098

prognosis after onset, 472 pulmonary extraction of serotonin and propranolol in patients

with, 479 regulation of tissue oxygen extraction is disturbed in, 109

Systemic lupus erythematosus , shrinking lung, diaphragmatic dysfunction, and (case report) , 926

" m T c D T P A , cigarette-smoke-induced changes in rat pulmonary clearance of, 1170

Tetraplegia, relationship between respiratory muscle electromyogram

and rib cage mot ion in, 53 Theophylline

responses to large doses of, in pat ients with C O P D , 871 sustained-release, reduces dyspnea in nonreversible obstructive

airway disease (correspondence), 195 Thrombin-induced microembolism, pulmonary transvascular fluid

and protein exchange after, 70 Thromboxane synthetase inhibitor (OKY-046), selective, effects of,

on endotoxin-induced lung injury in unanesthetized sheep, 494

Tissue distribution, influence of hypoxemia on, in conscious dog, 504 lung

connective, biochemical and pathologic evidence for proteo­lytic destruction of, in cystic fibrosis, 529

neutral metal loendopept idase in, 564 oxygen extraction, regulation of, is disturbed in ARDS, 109 shrinkage, lung, effects of 10% formalin fixation on, 1078

Toluene diisocyanate airway hyperresponsiveness and inf lammat ion induced by, in

guinea pigs, 1106 prednisone inhibits late as thmat ic reactions and associated in­

crease in airway responsiveness induced by, 1010 Trachea, increase in size of, with age, 784 Transplantation, allogeneic bone marrow, diagnostic yield of bron­

choalveolar lavage in pneumoni t i s occurring after, 1118 Trauma, cutaneous, and blastomycosis (correspondence), 931 Trudeau medal for 1985, 719 Tubercule bacilli within cultured h u m a n macrophages, effect of

e thambutol on, 742 Tuberculin

conversions in Indochinese refugees, assessment of boosting and anergy in, 516

skin testing, annua l , choosing appropr ia te cutting point for conversion in, 379

test re-emphasis on clinical judgment (commentary) , 177 variability with Mantoux procedure (commentary) , 175

Tuberculosis cases with drug-resistant and drug-susceptible bacilli, infection

and disease among contacts of, 125 epidemiology of, in chronic care popula t ion , 133 experimental, anti tuberculosis activity of ofloxacin (DL 8280)

on, in mice (Note), 915 and HLA-A, -B, and -DR phenotypes , 382 operational evaluation of t reatment for, and results of 8- and

12-month regimens in Peru, 737 Pneumocystis carinii pneumonia radiographically simulating,

1124 pulmonary

clinical trial of three 6-month regimens of chemotherapy given intermittently in cont inuat ion phase of t reatment of, 374

value of gallium-67 scanning in, 746 regimens

anti-, pharmacokinet ic studies on, 510 short-course anti- , absorpt ion and metabolism of compounds

used in initial intensive phase of, 510 Tumor markers, usefulness of, in serum and bronchoalveolar la­

vage of pat ients undergoing fiberoptic bronchoscopy, 60 Tween 20, normalizat ion of arterial blood gases after t reatment of

surfactant-deficient lambs with, 1313 Twins, monozygotic, age-related variation of respiratory chemo-

sensitivity in, 89 Ultrastructure and product ion of chemotact ic factors by alveolar

macrophages in modification by hyperoxia in vivo of endo­toxin-induced neutrophil alveolitis in rats, 152

Urinary excretion of desmosine in subjects with P iZZ alpha-1-antitrypsin deficiency, 821

1400 Vanadium pentoxide inhalat ion, pu lmonary effects of acute, in

monkeys, 1181 Vasculature, pulmonary, nifedipine dilates, without producing

symptomatic systemic hypotension in upright resting and exercising patients with pu lmonary hypertension secondary to C O P D , 963

Vasoconstriction hypoxic pulmonary, high-frequency ventilation at tenuation of,

and role of prostacyclin, 99 pulmonary, influence of alveolar oxygen on, in newborn lambs

versus sheep, 326 Ventilation

at tenuat ion, high-frequency, of hypoxic pu lmonary vasocon­striction, role of prostacyclin in, 99

intermittent mandatory, does it correct respiratory alkalosis in patients receiving assisted mechanical ventilation, 1071

mechanical , effect of gas leak a round endotracheal tube on mean tracheal pressure during, 339

prediction of, at maximal exercise in chronic air-flow obstruc­tion, 230

scans, abnormal , in middle-aged smokers, 148 Ventilator mode, mechanical , effect of, on tendency toward respi­

ratory alkalosis in, 1075 Ventilatory

response to hypercapnia, premorbid , is not related to resting arterial

C 0 2 tension in hamsters with elastase-induced emphysema, 1055

steady-state hypoxic, almitrine increases, in hypoxic chronic air-flow obstruct ion, 1233

Ventricular end-diastolic pressure, left, that occurs during exer­cise in patients with C O P D , increases in intrathoracic pres­sure do not explain rise in, 623

Verapamil, differential inhibition of bronchoconstr ic t ion by, 666

I N D E X - S U B J E C T S

Vermont granite workers, healthy, mineral dust and cell recovery from bronchoalveolar lavage of, 393

Virus-provoked airway hyperreactivity, use of guinea pig as model for, 305

Volume, instilled, effect of changing, for bronchoalveolar lavage in patients with interstitial lung disease, 390

Walking performance, effects of large carbohydrate load on, in chronic air-flow obstruction, 960

Wheezing, postexertional, effect of anticholinergic treatment on, in as thma studied by phonopneumography and spirometry, 16

Will Ross medal for 1985, 719 Workers

asbestos comparison of ferruginous body and uncoated fiber content

in lungs of former, 143 -exposed, lung function and exercise performance in smoking

and nonsmoking, 612 lymphocyte subpopulat ions in bronchoalveolar lavage fluid

in, 824 blue collar, prevalence of radiographic appearance of pneumo­

coniosis in unexposed (correspondence), 1139 grain, rapid decline in FEV, in, in relation to level of dust

exposure, 814 healthy Vermont granite, mineral dust and cell recovery from

bronchoalveolar lavage of, 393 Workshop

of the Division of Lung Diseases: definition of emphysema (workshop summary) , 182

on investigative use of fiberoptic bronchoscopy and broncho­alveolar lavage in asthmatics (workshop summary), 180

Zinc, prevention by, of rat lung collagen accumulation in carbon tetrachloride injury, 536

Notes The Concentration of Leukocyte Elastase-ol-Proteinase Inhibitor Complex in Bronchoalveolar Lavage Fluids from Healthy Human Subjects 1 3

MARIANNE JOCHUM, ANTOINE P E L L E T I E R , CHRISTIAN BOUDIER, G A B R I E L L E PAULI, and J O S E P H G. BIETH

SUMMARY Although a1-proteinase inhibitor (a1-antitrypsin) is widely thought to protect lung elastin against the elastolytic action of leukocyte elastase, there is only circumstantial evidence for such a protective role. We have demonstrated and quantified elastase-ol-proteinase inhibitor complex in bronchoalveolar lavage fluids from healthy smokers and nonsmokers using a new enzyme-linked immunosorbent assay. The relative concentration of complex is 0 .36 ± 0.48 mmol/mol albumin in nonsmokers and 0 .33 ± 0 .29 mmol/mol albumin in smokers. Less than 1% of lavage fluid a1-proteinase inhibitor is complexed with elastase (0 .31% in nonsmokers and 0 . 34% in smokers). This proportion is, however, much higher than in normal plasma where only approximately 0 . 0 0 6 % of inhibitor is bound to elastase. Our data confirm that a1-proteinase inhibitor efficiently acts as an antielastase barrier in the lower respiratory tract. AM REV RESPIR DIS 1985; 132:913-914

The protease-antiprotease theory of pulmo­nary emphysema holds that alveolar struc­tures may be destroyed by proteases such as neutrophil elastase but are normally protected from destruction by elastase inhibitors such as al-proteinase inhibitor (a lPI ) . There is, however, only circumstantial evidence in fa­vor of this theory. For instance, emphysema may be induced in animals with large doses of neutrophil elastase (1), and inherited defi­ciency of a l P I is linked to a high frequency of this disease (2). By contrast, demonstra­tion of elastase-alPI complex in the lower res­piratory tract would provide direct evidence tha t elastase is released and inhibited at the alveolar level. Recently, 2 groups of investi­gators have developed enzyme-linked im­munosorbent assays for the quanti tat ion of human leukocyte elastase-alPI complexes (3, 4). We therefore decided to use one of these methods (3) to measure the amount of elastase-alPI complex in bronchoalveolar la­vage fluids from healthy human smokers and nonsmokers .

The 17 lavage fluids used in this study are part of the 20 samples collected and described previ­ously (5). Briefly, a B3 fibroscope (Olympus Corp. of America, New Hyde Park, NY) was wedged into the distal branch of the lingula, and five 60-ml por­tions of saline were infused into the lung and re­covered in a vacuum trap (mean recovery, 50 ± 10%). The 5 samples were pooled, centrifuged, and frozen until used. After thawing, they were con­centrated 5-fold by Amicon UM2 ultrafiltration (Amicon Corp., Lexington, MA).

The mean age of the 8 nonsmokers and of the 9 smokers was 27.8 ± 10.8 yr and 25 ± 2.9 yr, respectively. The smokers (smoking rate, 8.5 ± 4.9 pack-years) did not smoke for at least 24 h before lavage. The nonsmokers' and the smokers' fluids contained 12.1 ± 7.2 x 106 and 28.7 ± 18.5 x 106 alveolar macrophages and 0.28 ± 0.14 x 106 and 0.28 ± 0.51 x 106 polymorphonuclear neu­trophils per lavage, respectively.

The elastase-crlPI concentration was determined on the concentrated fluids using the enzyme-linked immunosorbent assay described in detail by Neu­mann and coworkers (6). Briefly, the samples were added to microtitration plates coated with sheep antielastase IgG. This antibody does not cross-react with cathepsin G and other neutrophil proteinases. After incubation and washing, the solid phase-bound elastase-alPI complexes were reacted with alkaline phosphatase-labeled rabbit anti-alPI IgG. After further washings, p-nitrophenylphosphate was added to measure the amount of solid phase-bound elastase-alPI complexes. The assay was calibrated using a standard solution of known

elastase-alPI concentration. The preparation of this solution is described in detail in the report by Neu­mann and coworkers (6). Calibration curves iden­tical to those reported by these investigators were always obtained. To determine whether ultrafiltra­tion impairs the measurement of elastase-alPI, we used 3 lavage fluids collected from polytraumatized patients, and we measured the concentration of complex before and after 5-fold fluid concentra­tion by ultrafiltration (in these fluids the elastase-alPI concentration was sufficiently high to allow the assay to be performed on unconcentrated sam­ples). The 3 concentrations of complex expressed as microgram of elastase per milliliter of uncon­centrated fluid, were 0.81, 1.04, 6.38, and 0.86, 1.01, 6.14 before and after ultrafiltration, respectively. These data show that the concentration process does not significantly distort the data. All lavage fluids except 1 contained detect­able amounts of elastase-alPI complex. The absolute concentrations ranged from 0 to 15.6 ng elastase/ml in nonsmokers and from 0.6 to 7 ng elastase/ml in smokers. The relative concentrations (mean ± SD) were 0.36 ± 0.48 mmol e las tase-a lPI /mol albumin in non-smokers and 0.33 ± 0.29 mmol elastase a l P I / m o l albumin in smokers. The relative concentrations of immunoreactive (total) a lPI were 88 ± 34 mmol a l P I / m o l albumin in nonsmokers and 92 ± 27 mmol a l P I / m o l albumin in smokers (5). Hence, the percent­age of elastase-bound a l P I was 0.31 ± 0.31 in nonsmokers and 0.34 ± 0.24 in smokers. The individual values obtained for the 2 groups of subjects are shown in figure 1; this confirms that both relative concentrations of elastase-alPI complex are very scattered. Thus, smokers and nonsmokers have very similar levels of complex. In addition, the con­centration of elastase-alPI complex does not significantly correlate with the smoking rate (pack-years) or with the concentration of poly­morphonuclear leukocytes present in the la­vage fluids.

In vitro studies have shown that cigarette smoke condensate releases elastase from neu­trophils (7). It is therefore surprising that the smokers did not have higher amounts of elastase-alPI complex than did the nonsmok­ers. This might in part be due to the short smoking history of the volunteers (8.5 ± 4.9 pack-years). It is also possible that some of the elastase-üTPI complexes formed during smoking disappeared from the lung surface during the 24-h nonsmoking period that preceded the smokers' lavages. Further experi­ments are required to clarify this point.

* * *

The mean absolute concentration of com­plexed elastase in the 17 samples is 4.2 ng/ml . Taking into account the mean volume of la­vage fluids (150 ml), we get an average of ap­proximately 600 ng of a l P I - b o u n d elastase per lavage. Because neutrophils contain about 3.5 \xg elastase per 106 cells (8), the aforemen­tioned amount of elastase corresponds to 0.17 x 106 neutrophils, i.e., to 60% of the neu-

(Received in original form September 24, 1984 and in revised form April 24, 1985)

1 From INSERM Unite 237, Faculte de Phar-macie, Universite Louis Pasteur, and Service de Pneumologie, Centre Hospitalier Universitaire, Strasbourg, France, and Abteilung für Klinische Chemie und Klinische Biochemie in der Chirur­gischen Klinik der Universität München, D 8000, München, FRG.

2 Supported by grants from the INSERM (CRL 815021, CRL 815030, and CP 810121), from the Fon-dation pour la Recherche Medicale, and from the Deutsche Forschungsgemeinschaft München (Son­derforschungsbereich 0207, LP8).

3 Requests for reprints should be addressed to Dr. Joseph G. Bieth, INSERM Unite 237, Faculte de Pharmacie, B.P. 10, 67048 Strasbourg-Cedex, France.

913

914 NOTES

E-o^PI /albumin ( mmole/mole )

o Ol

SN

" 1

. . . 1 > CO - • •

SN

• J • CD

CO • ••! • • • • 1 •

1 1

• •

O Ol

E - ^ P I / ^ P I ( mole/molexlOO )

Fig. 1 Relative concentrations of elastase-olPI complex (E-a1PI) in bronchoalveolar lavage fluids from 8 non-smokers (NS) and 9 smokers (S). Horizontal bars indi­cate mean values. A. The data are expressed relative to the concentration of albumin (5). Mean ± SD = 0.36 ± 0.48 mmol elastase-a1PI/mol albumin in nonsmok-ers and 0.33 ± 0.29 mmol elastase-a1PI/mol albumin in smokers. B. The data are expressed relative to the concentration of immunoreactive (total) a1PI (5). Mean ± SD = 0.31 ± 0.31% elastase-bound olPI in non-smokers and 0.34 ± 0.24% elastase-bound alPI in smokers.

trophils recovered per lavage in our popula­tion of healthy subjects. The amount of elastase-alPI complex must therefore be con­sidered as high despite the fact that it represents only 0 . 3 % of total a l P I . It must also be emphasized that in normal plasma only about 0.006% of a l P I is complexed to neutrophil elastase (4, 6). Our data therefore suggest that even in healthy persons there is massive liberation of neutrophil elastase in the lower respiratory tract and that a lP I effi­ciently acts as an antielastase barrier.

The present data also show that in vivo complex formation between a l P I and neu­trophil elastase does not account for the high proportion of functionally inactive a lPI pres­ent in lung lavage fluids (5). Other factors such as proteolytic degradation (9) might be responsible for the partial inactivity of a lP I .

Ackno w ledg men t The writers thank Dr. S. Neumann and H. Lang, Biochemical Research Institute, Merck, Darmstadt, FRG for supplying the reagents for the immunoas­say of elastase-olPI complex.

References

1. Janoff A, Sloan B, Weinbaum G, et al Ex­perimental emphysema induced with purified hu­man neutrophil elastase. Tissue localization of the instilled protease. Am Rev Respir Dis 1977; 115:461-78.

2. Laurell CB, Eriksson S. The electrophoretic al-globulin pattern of serum in al-antitrypsin defi­ciency. Scand J Clin Lab Invest 1963; 15:132-40. 3. Neumann S, Hennrich N, Gunzer G, Lang H. Enzyme-linked immunoassay for elastase from leu­kocytes in human plasma. J Clin Chem Clin Bio-chem 1981; 19:232. 4. Brower MS, Harpel PC. Alpha-l-antitrypsin-human leukocyte elastase complexes in blood:quan-tification by an enzyme-linked differential antibody immunosorbent assay and comparison with alpha-2-plasmin inhibitor-plasmin complexes. Blood 1983; 61:842-9. 5. Boudier C, Pelletier A, Pauli G, Bieth JG. The functional activity of o-l-proteinase inhibitor in bronchoalveolar lavage fluids from healthy human smokers and non-smokers. Clin Chim Acta 1983; 132:309-15. 6. Neumann S, Hennrich N, Gunzer G, Lang H. Enzyme-linked immunoassay for human granulo­cyte elastase-crl-proteinase inhibitor complex. In: Goldberg DM, Werner M, eds. Progress in clinical enzymology. II. New York; Masson Publishers, 1983; 293-8. 7. Blue ML, Janoff A. Possible mechanisms of emphysema in cigarette smokers. Release of elastase from human polymorphonuclear leukocytes by cig­arette smoke condensate in vitro. Am Rev Respir Dis 1978; 117:317-25. 8. Ohlsson K. Interactions between granulocyte proteases and protease inhibitors in the lung. Clin Respir Physiol 1980; 16(Suppl):209-22. 9. Travis J, Salvesen GS. Human plasma proteinase inhibitors. Annu Rev Biochem 1983; 52:655-709.