Research RetreatCurrent Overview

Tom Hostetter

Vice Chairman for Research

Some Outcomes of Last Retreat 2009

• Agre Society solidified

• Annual Research Day

• Distribution of CTSC resources

• Meeting with SOM and UH leaders regarding research issues

Research Award Costs ( $ millions)

Year 07- 08 08- 09 09- 10 10- 11 11- 12

DOM 47.2 51.0 64.4 62.5 55.2

SCC 5.3 5.2 4.9 4.9 6.5

Research Cost 2011- 2012

Federal StateFoundatio

n Industry Total

CV Medicine 7,046,710 0 2,515,492 1,080,523 10,642,725

Clinical Pharm 446,135 0 0 0 446,135

Endocrinology 1,175,716 0 2,500 49,005 1,227,221

GI 3,635,636 0 0 238,013 3,873,649

Gen Med 313,600 0 0 0 313,600

Geriatrics 70,229 0 0 0 70,229

Heme/Onc 4,574,093 0 781,040 998,973 6,354,106

ID/HIV/Medicine 23,857,151 192,541 636,169 107,611 24,793,472

Nephrology/Hyp 4,837,604 0 0 70,302 4,907,906

Pulmonary/CC/Sleep 2,238,545 0 100,000 260,480 2,599,025

Rheumatology 0 0 0 0 0

Sources of Awards 2011- 2012($ millions)

Federal State Foundation Industry

48.2 .2 4.0 2.8

Selected Highlights 2012

• VAMC- Highly Funded Programs in Implementation, Quality and Education Research Basic and applied studies of antibiotic resistance GREC revitalized• CV- High impact papers in Science and Nature 6 new RO1s and a DARPA grant Mukesh Jain elected VP of ASCI• Endo- NIH trials ACCORDION,EDIC Studies in diabetic retinopathy• GI- NIH funded Network for study of Barrett’s PPG for IBD

Over 40 new or competing renewal grants, one half from NIH

Selected Highlights 2012

• Heme/Onc- Cancer Center renewed High impact papers in NEJM, PLOS Genetics, JBC, PNAS• ID- Progress in HIV and TB research Creation of ID and Immunology Institute Expansion of work in Uganda including CV Neuro, & Genetics• Renal/Htn- Leadership in NIH SPRINT and CRIC trials Ongoing participation in NIH Clinical Trials in Organ Transplantation 2 endowed faculty positions from Centers for Dialysis Care

Underrepresented Areas

• Topics

- Human/Population Genetics

- Outcome/Health Care Delivery - Comparative Effectiveness Research - Geriatrics

• Grant Types - K grants - for early career - P and U grants – for multiple investigators - Industry

Threats to Funding

•NIH budget has been declining in constant dollars about 10 years ( ARRA funds in 2009 and 2010 excepted)•Sequestration of 5- 10% of NIH budget will lead to about 2500 fewer new grants funded

FASEB

Responses To Funding Threats

• Industry support- now about 6 % of total

Responses To Funding Threats

• Industry support

• Philanthropy

Examples: Harrington Discovery Institute

Centers for Dialysis Care

Responses To Funding Threats

• Industry support

• Philanthropy

• Widen range of Federal Sources CTSC cores and pilot grants

AHRQ

DOD

PCORI

Patient Centered Outcomes Institute (PCORI)

• Part of the Affordable Care Act

• 2013 Budget $390 million

• PCORI approved 25 awards, totaling $40.7 million over three years, to fund patient-centered comparative clinical effectiveness research projects

PCORI’sResearch Budget Distribution

Responses To Funding Threats

• Industry support• Philanthropy• Widen range of Federal Sources CTSC cores and pilot grants AHRQ DOD PCORI

• Better grants to Traditional Federal Sources Multi PI / Team

Collaboration with other departments / institutions

Training

• Med Students Theses

• Residency short track

• Grad Students Tuitions

• F, T and K NIH Grants

Medical Student Theses

• Students are required to write a thesis.• They have 4 months of committed time and an

optional summer block after 1st year.• About 8% work in the DOM for their theses• To let students know of your research, update

your info on the ePortfolio site. https://casemed.case.edu/ePortfolioFaculty08/

• Also send email to Todd Fennimore, Director of the Office of   Medical Student Research, txf80@case.edu.

Arrive at CWRU

School of Medicine

Year 1 Year 2 Year 3 Year 4

Begin investigating

areas of research interest

Contact potential mentors for the

summer with the idea of a project

that leads into the research block in

year 3.

Decide on a mentor for

the summer and submit

IRB applications & funding

applications.

Medical Student Research Timeline

SUMMER RESEARCH

Schedule Yr 3 including the

research block

Submit the research proposal

and submit IRB

application

4 mo.

Research progress

reports due at 1 and 2 month

points

Research summary due

the Friday after the end of the research block

Work on M.D. thesis

M.D. thesis due by

January 15th of the 4th

year

Lepow Medical Student

Research Day

Lepow Medical Student

Research Day

RESEARCH BLOCK

Lepow Medical Student

Research Day

29%

48%

The value of a research continuum including the summer between years 1 & 2 as well as the research block in year 3.

Courtesy of Jim Bruzik

Percent of Published Student Research

Training

• Med Students Theses

• Residency Short Track

• Grad Students Tuitions

• F, T and K NIH Grants

Graduate Student Support by DOM

•Selected PhD students enrolled in SOM with a DOM PI

•DOM will pay their tuition

•PI must pay their stipend from grant, etc and division guarantee support for the term of the student’s course.

•About 20 students are being supported

Break Outs• Breakout #1: Evolving NIH/Federal Funding Landscape     Leaders: Richard Walsh, MD & Fabio Cominelli, MD

• Breakout #2: Mentoring and Career Development                  Leaders: Mukesh Jain, MD  & Aaron Proweller, MD

• Breakout #3: Team Science and Multidisciplinary Research       Leaders: Amitabh Chak, MD, Stanton Gerson, MD & Robert Salata, MD

• Breakout #4: Enhancing Industry-sponsored Research Opportunities       Leaders: Neal Meropol, MD,  & Marco Costa, MD, PhD