Ferran Sanz – GRIB

Research Programme on Biomedical Informatics

(GRIB)

Ferran Sanz – GRIB

What is the GRIB?

• GRIB is a research programme of both Universitat Pompeu Fabra (UPF) and IMIM.

• IMIM is the research institute ofHospital del Mar (PSM)and it is academically affiliated to the UPF.

• GRIB is located in the Biomedical Research Park of Barcelona (PRBB).

• GRIB is also the Biomedical Informatics node of the Spanish Institute of Bioinformatics (INB).

TICs and computational approaches are mandatory tools for managing and exploiting the immense amounts of data that are currently generated in the biomedical research (experimental, clinical, epidemiological).

Mission:

To invent, develop and apply computational methods that, through an intensive use of and information technologies, allow a better understanding and prediction of biological phenomena, giving especial emphasis to those related to the human diseases and their treatment.

GRIB Mission

Ferran Sanz – GRIB

GRIB themes and organisation

GRIB is organised in six thematicin silico labs:

Computational Genomics: Computational analysis of genomic sequences and information. PIs: M. Albà, E. Eyras, N. Lopez-Bigas & R. Castelo.Structural Bioinformatics:Analysis and modelling of protein structures and interactions. PI: B. Oliva.Computational Biochemistry and Biophysics:Modelling and simulation of biophysical and biochemical phenomena at molecular and systemic scales. IPs: J. Villà-Freixa and G. de Fabritiis.Chemogenomics: Computational annotation and analysis of massive molecular DBs vs. protein families showing therapeutic interest. IP: J. Mestres.Computer-Assisted Drug Design:Molecular modelling and multivariate statistical analysis in the drug R&D. IPs: M. Pastor, J. Selent & I. Zamora (part time)Integrative Biomedical Informatics:Integrative knowledge management in biomedical research. IP: F. Sanz.+Management office.Manager: C. Donlo

Ferran Sanz – GRIB

The GRIB team

The GRIB staff is a multidisciplinary team of +70 professionals (+20PhDs), which includes:

• biologists,• pharmacists,• chemists,• physicians,• computer scientists,• mathematicians• research management staff

Ferran Sanz – GRIB

GRIB publications in SCI journals 2005-2009

27 29 27

3834

0

5

10

15

20

25

30

35

40

2005 2006 2007 2008 2009

Total no. of the period: 155

GRIB research outcomes

* Without including Complex System Lab. publications

Ferran Sanz – GRIB

GRIB research outcomes

Quartil distribution of the journals of GRIB publications(SCI classification)

2005 - 2009

2231

26

1 1 0

11

2326

0

5

10

15

20

25

30

35

40

2005 2006 2007 2008 2009

Q1 Q2 Q3 Q4

• Average IF of the journals of GIB publications (2005-09): 5.33

• No. of citations of papers published in 2005-07: 1668

Ferran Sanz – GRIB

• GRIB develops open source and proprietary software that is internationally recognised.

• GRIB research has generated two spin-off:

• Pharmatools

• Chemotargets

GRIB research outcomes

Integrative knowledge management in pharmacovigilance

• Literature mining• in silicosimulation• Pathway analysis• Genetic

polymorphisms

30M EHRs from 4 EU countries !

www.alert-project.org

Possible drug – AE relationship to be assessed

Biological

pathways

Genetic variants (SNPs)

Drug Adverse event

Similardrugs-ligands

Drugmetabolit

esInvolved proteins

Workflows for chemo- & bio-informatics signal substantiation

Ferran Sanz – GRIB

GRIB’s strategic priority• The GRIB aims to enhance its biomedical focus, putting the emphasis in

the clinical application of the bioinformatics and knowledge management approaches that it develops.

• In particular, we are currently developing a strategic collaboration with Hospital del Mar (PSM)on the research exploitation of its clinical information system (IMASIS).

Ferran Sanz – GRIB

grib.imim.es