Research & Development of Modern Biotechnology...
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Transcript of Research & Development of Modern Biotechnology...
Research & Development of Research & Development of Modern Biotechnology in Modern Biotechnology in
BangladeshBangladesh
Fourth Asian Conference on Fourth Asian Conference on Biotechnology AndBiotechnology And DevelopmentDevelopment
Organized by Organized by ––RIS NARC UNESCO RIS NARC UNESCO
February 12 February 12 --13,Kathmandu,Nepal13,Kathmandu,Nepal20092009
Ferdousi Begum Ph. DFerdousi Begum Ph. DExecutive DirectorExecutive Director
DEBTECDEBTEC--Development of Biotechnology & Development of Biotechnology & Environmental Conservation Environmental Conservation CentreDhakaCentreDhaka, ,
Phone: 8114827, Fax: 8115155Phone: 8114827, Fax: 8115155Website: Website: www.debtec.orgwww.debtec.org, , www.mapbd.comwww.mapbd.com
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Bangladesh, in full, People’s Republic of Bangladesh, republic of southern Asia, in the northeastern portion of the Indian subcontinent, bordered on the west, north, and east by India, on the southeast by Myanmar (formerly known as Burma), and on the south by the Bay of Bengal. The area of the country is 147,570 sq km (56,977 sq mi). The capital and largest city of Bangladesh is Dhaka.
Ancient Biotechnology
““We have to duplicate what has been We have to duplicate what has been achieved on the production front during past 12,000 achieved on the production front during past 12,000 years in the next 40 years. This cannot be done without years in the next 40 years. This cannot be done without the help of new technologies and management tools.the help of new technologies and management tools.’’
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Prof. M.S. SwaminathanFather of Green Revolution
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Bangladesh PerspectiveExplore genetic resources to improve the quality of Agriculture productsCompounds from natural products could be purified, optimized, and synthesized by biochemists, chemist and medicinal chemistsApproach of exploiting natural products from our largely unexplored flora and fauna for drug discoveryby many a multidisciplinary approach must be a priority
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BiotechnologyBiotechnology ::
Tissue CultureTissue CultureFermentationFermentationVermicultureVermiculture
Soft core BiotechnologySoft core Biotechnology
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Hardcore BiotechnologyHardcore BiotechnologyGenetic EngineeringGenetic Engineering
Recombinant DNA TechnologyRecombinant DNA Technology
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CONDUCTED WHICH WILL BE FOUND IN THE CONDUCTED WHICH WILL BE FOUND IN THE BIOSAFETY CLEARING HOUSE FOR PUBLIC BIOSAFETY CLEARING HOUSE FOR PUBLIC
INFORMATIONINFORMATIONGovernment Institute
Bangladesh Government has set up National Biotechnology Institute at Savar under SICT Ministry
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National Biotechnology Policy, Fisheries Biotechnology Policy, MedicalBiotechnology Policy & Crop Biotechnology Policy approved by
PM Oct’06Biosafety Guideline Approved Biosafety framework
Public UniversitiesNGOs
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Supporters of the technology are those that Supporters of the technology are those that believe: believe:
1. Its potential to enhance food security1. Its potential to enhance food security
2. Economic development2. Economic development
3. Increase productivity and reduce environmental 3. Increase productivity and reduce environmental pressures.pressures.
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Few scientific developments have given rise to as Few scientific developments have given rise to as much controversy as biotechnology.much controversy as biotechnology.Numerous group are united in their opposition, Numerous group are united in their opposition, expressing concern overexpressing concern over: :
1.1. Environmental and health risks Environmental and health risks
2.2. Impacts on rural livelihoods Impacts on rural livelihoods
3.3. Economic dominance of multinational companies Economic dominance of multinational companies
4.4. Ethical implications of crossing species boundaries.Ethical implications of crossing species boundaries.
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Each Contracting Party shall, as far as possible and Each Contracting Party shall, as far as possible and as appropriate:as appropriate:–– Establish or maintain means to Establish or maintain means to regulate, mange or regulate, mange or
control the risks associatedcontrol the risks associated with the use and release of with the use and release of living modified organisms resulting from biotechnology living modified organisms resulting from biotechnology which are likely to have which are likely to have adverse environmental impactsadverse environmental impactsthat could affect the that could affect the conservationconservation and and sustainable use of sustainable use of biological diversitybiological diversity, taking also into account the , taking also into account the risks to risks to human healthhuman health
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Risk:Risk:
The convention recognizes the need The convention recognizes the need to protectto protect human human health and the environmenthealth and the environment from the from the adverse effectadverse effectof the product of modern biotechnology (of the product of modern biotechnology (Living Modified Living Modified OrganismsOrganisms-- LMOsLMOs))
Benefit:Benefit:
The convention also recognize biotechnology has The convention also recognize biotechnology has great great potentialpotential for the promotion of the human wellfor the promotion of the human well--being, being, meeting critical food for agriculture and healthcare.meeting critical food for agriculture and healthcare.
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Under this project, a survey has been Under this project, a survey has been conducted which will be found in the conducted which will be found in the BiosafetyBiosafety Clearing House for Public Clearing House for Public
InformationInformation
Government InstituteGovernment InstitutePublic UniversityPublic UniversityNGOsNGOs
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Current Research Activities in Current Research Activities in Government InstitutesGovernment Institutes
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Golden rice:Golden rice:Vitamin A rich developed by the Monsanto, Vitamin A rich developed by the Monsanto, SyngentaSyngenta, etc at IRRI., etc at IRRI.
BR29 Medicinal Rice
Daffodil
Beta carotene, (vitamin A)
Backcrossing with parents in BRRI to yield to enhance the yield of the rice and also adaptation.
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Indigenous Fruits & VegetablesIndigenous Fruits & Vegetables
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Late blight resistance of potato
Contained trial in glass house BARI collaboration with University of Winkinsons, USA
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Bringal (Eggplants)
Fruit a
nd Shoot b
orer
Insec
t resi
stance
develo
ped by M
ahyc
o, In
dia
Backcro
ssing w
ith par
ents
for en
hance
the
yield an
d adap
tation
at B
ARI, Ban
gladesh
,
Under the s
upervisi
on of
BARC
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PRSV – Papaya Ringspot Poty Virus resistance papaya development under CIMMYT Program, 2002-05
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•Viral strains have been collected and identified.
•Reconstructed gene inserted into 3 Thailand and 2 Hawaiian Verities offering resistance to Bangladeshi viral strains.
•Application for net house/field testing written and submitted through BARI to BARC and MoA
•Awaiting decision from the application
•The 5 transgenic are being tested at Cornell University for their resistance to Bangladeshi viral strains.
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POD BORER resistance chick POD BORER resistance chick peas develop by ICRISATpeas develop by ICRISAT--at at BARI for filter in containment, BARI for filter in containment, all these are supported by BAU, all these are supported by BAU, MOAMOA
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Research on Research on Micro BiologyMicro Biologyfisheries andfisheries andlive stock is lesslive stock is lesssignificant. Mostsignificant. MostOf the worksOf the worksare on plantare on plantrelated.related.
Embryo transformation is trying in BLRI
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Transformation Technique of Jute is being trying many
year seen IFRB, Bangladesh Atomic Energy Commission.
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Public UniversitiesPublic UniversitiesDNA isolation and PCRDNA isolation and PCR--Polymerase Chain Polymerase Chain Reaction technique Reaction technique also work in routine basis in DU, RU, also work in routine basis in DU, RU, BRRI, BARI, and BLRI,BRRI, BARI, and BLRI,to educate and trained the student
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to educate and trained the student
Salinity tolerance rice, is trying to develop by Biochemistry
Department University of Dhaka, last few years. Supported by USAID
Programme.
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DNA isolation and PCR
Polymerase Chain
Reaction technique also work in routine basis in DU, RU, BRRI,
BARI, and BLRI,
to educate and trained
the student.
DNA finger printing of some DNA finger printing of some important crop is being processimportant crop is being processunder the supervision of BARC.under the supervision of BARC.
Agrobactarium mediated transformation is trying to
develop in many institution, BINA, BRRI, BARI, DU, BAU.
Etc.
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Semi ConservativeGovernment Institutions and NGO activities on Government Institutions and NGO activities on
modern Biotech in Bangladesh.modern Biotech in Bangladesh.
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11 22 33 44 55 66
Institute/Institute/OrganizationOrganization
Biotech Biotech Experts Experts PhD.+ PhD.+ M.S.M.S.
No. Biotech R&D No. Biotech R&D projects Ended + projects Ended +
RunningRunning
Any plan Any plan for Biotech for Biotech
researchresearch
BiosafetyBiosafetymeasures measures
documented documented ––authorityauthority
Future capacity Future capacity building areabuilding area
BARIBARI 5+55+5 YESYES--IBCIBC LMO, TrialLMO, Trial
BCSIRBCSIR 3+73+7 YESYES--IBCIBC LMO, MicrobialLMO, Microbial
BFRIBFRI 1+01+0 1+11+1 YESYES--IBCIBC DFDF
BINABINA 6+06+0 1+31+3 YESYES--IBCIBC LMOLMO
BJRIBJRI 2+12+1 YESYES--IBCIBC LMOLMO
BLRIBLRI 1+41+4 YESYES--IBCIBC LMO, TrialLMO, Trial
BRRIBRRI 5+15+1 YESYES--IBCIBC LMOLMO
BSRIBSRI 1+11+1 2+12+1 YESYES--IBCIBC TCTC
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BTRIBTRI 0+10+1
DAEDAE 0+10+1 YESYES TC, MushroomTC, Mushroom
DLSDLS 1+11+1 YESYES
DoEDoE BiosafetyBiosafety
FRIFRI 1+01+0 YESYES YESYES--IBCIBC TCTC
NHNH TC,DFTC,DF
NIBNIB 1+71+7 YESYES YESYES--IBCIBC All Biotech All Biotech sectorssectors
WRCWRC 1+01+0 YESYES YESYES--IBCIBC TC, LMOTC, LMO
NICVDNICVD 1+01+0 YESYES Medical Medical BiotechBiotech
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Public/Private Educational InstitutePublic/Private Educational Institute
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Institute/Institute/OrganizationOrganization
BiotechBiotechExpertsExpertsPhD.+ PhD.+ M.S.M.S.
No. Biotech No. Biotech R&D projectsR&D projects
Ended +Ended +RunningRunning
Any plan Any plan For For
BiotechBiotechresearchresearch
BiosafetyBiosafetymeasuresmeasures
documented documented –– authorityauthority
FutureFutureCapacityCapacity
building areabuilding area
BAUBAU 42+642+6 9+139+13 yes yes -- IBCIBC LMO, DF, LMO, DF, BiosafetyBiosafety
BSMRAUBSMRAU 4+14+1 yes yes –– IBCIBC LMO, DFLMO, DF
CUVASCUVAS 1+31+3 DFDF
CUCU 5+55+5 yes yes –– IBCIBC LMO, DFLMO, DF
DUDU 16+1016+10 yes yes -- IBCIBC LMO, DF, LMO, DF, BiosafetyBiosafety
JUJU 4+14+1 LMO, DFLMO, DF
KUKU 2+52+5 yes yes -- IBCIBC LMO, DFLMO, DF
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RURU 12+412+4 yes yes -- IBCIBC LMO, DF, LMO, DF, BiosafetyBiosafety
SAUSAU 2+32+3 LMO, DFLMO, DF
SUSTSUST 1+51+5 LMOLMO
SVCSVC 1+41+4 TCTC
BBMUBBMU 0+10+1 MB, MB, BiosafetyBiosafety
GBGB 1+31+3 LMOLMO
BRACUBRACU LMOLMO
UODAUODA 1+41+4 LMOLMO
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Most of the NGOs are trying to develop Most of the NGOs are trying to develop commercialization of Tissue Culture commercialization of Tissue Culture
productsproducts
BRACBRAC
ProsikhaProsikha
Tissue Culture of Tissue Culture of Orchid, Banana, Orchid, Banana, Potato, Potato, SteviaStevia and and some ornamentalssome ornamentalsTissue Culture of Tissue Culture of Orchid, Banana, Orchid, Banana, Potato and some Potato and some ornamentalsornamentals
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1998 1998 –– First Non Governmental Research First Non Governmental Research Organization Organization Students Students –– KhulnaKhulna UniversityUniversityAwarenessAwarenessPolicy MakingPolicy MakingMedia CampaignMedia CampaignTissue Culture Training and TC of threatened Tissue Culture Training and TC of threatened SpeciesSpeciesBiosafetyBiosafety Issues Issues –– GMOs/LMOsGMOs/LMOsFerdousi Biotech (sister concern) for Ferdousi Biotech (sister concern) for Commercialization Commercialization
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The book The book -- Ami keno Baba Mayer Ami keno Baba Mayer MotoMotowritten by Dr. Ferdousi Begum, written by Dr. Ferdousi Begum,
which got which got BanglaBangla Academy Science Award 2006Academy Science Award 2006
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FERDOUS BIOTECH FERDOUS BIOTECH -- A facility of 11000 Sq feet A facility of 11000 Sq feet has been established in a 5 has been established in a 5 BighaBigha area near area near SavarSavar
Commercialization of Tissue CultureCommercialization of Tissue CultureDNA Finger printing of indigenous DNA Finger printing of indigenous varietiesvarietiesMolecular TaxonomyMolecular TaxonomyTesting facilities for Testing facilities for GMOsGMOs and and LMOsLMOs
IUCN IUCN –– Awareness BuildingAwareness BuildingUBNIGUBNIG-- Awareness Building Awareness Building especially concerned on GMO/especially concerned on GMO/LMOsLMOsCFSD CFSD –– Awareness BuildingAwareness BuildingBELA BELA –– Awareness BuildingAwareness BuildingICDDRBICDDRB-- Microbial Biotechnology Microbial Biotechnology
Private SectorPrivate Sector
East West Seed East West Seed –– Containment for Containment for GMOs/LMOsGMOs/LMOsSquare BiotechSquare Biotech
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What are the potential risk on biodiversity What are the potential risk on biodiversity of Bangladesh in terms of on going of Bangladesh in terms of on going
Research and Development Activities with Research and Development Activities with GMOsGMOsGenetic Genetic transformation transformation activities are activities are going in different going in different university and university and research institute research institute not done as not done as required required precautions.precautions.
Transform micro Transform micro organism organism recombined DNA recombined DNA containing containing vectors are vectors are released very released very unsafe way. unsafe way.
These maybe These maybe contaminated the contaminated the environment environment which may cause which may cause the serious the serious healthhealth hazard.
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Genetic Engineering of Bacteria
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On the other On the other hand the hand the research on research on four crops is four crops is conducted conducted under contain under contain condition, it is condition, it is there fore too there fore too early too asses early too asses the impact of the impact of this crop on this crop on biodiversity.biodiversity.
Impact of Impact of biodiversity biodiversity can only be can only be assessed when assessed when these crops will these crops will be released be released and cultivated and cultivated for few for few generations.generations.
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BiosafetyBiosafety facility exists in the institute and NGOsfacility exists in the institute and NGOsinvolving Biotechnological activities.involving Biotechnological activities.
In Bangladesh modern biotechnological research is in In Bangladesh modern biotechnological research is in insignificant stage some activities are just now started insignificant stage some activities are just now started and and biosafetybiosafety framework is under going to developframework is under going to develop
Under the MOA and direct supervision of BARC at Under the MOA and direct supervision of BARC at BARI and BRRI containment has been developed & BARI and BRRI containment has been developed & ABSP II project they have supported to develop ABSP II project they have supported to develop biosafetybiosafety facilities.facilities.
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““Recall the face of the poorest and the weakest Recall the face of the poorest and the weakest man whom you have seen, and ask yourself, if theman whom you have seen, and ask yourself, if thesteps you contemplate are going to be of any usesteps you contemplate are going to be of any useto him. Will he gain anything by it? Will itto him. Will he gain anything by it? Will itrestore to him control over his own life and restore to him control over his own life and destiny?destiny?””
Mahatma Gandhi.Mahatma Gandhi.
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THANK YOU
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Thank youThank you
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