Replikonski modelElongation. removal of RNA pruner by RNase HI and MFI Gap-filling Polymerase and...
Transcript of Replikonski modelElongation. removal of RNA pruner by RNase HI and MFI Gap-filling Polymerase and...
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Replikonski model
Nature Reviews Genetics 8, 588-600 (2007)
replikator … genetski element, na katerem pride do iniciacije podvojevanja DNA
replikon …. tisti del kromatina, ki se podvoji pod kontrolo določenega replikatorja
iniciator …. proteini (kompleks), ki se vežejo na replikator in sprožijo podvojevanje
iniciacijsko mesto (ori) …. mesto na kromatinu, kjer se pojavijo replikacijske vilice (lahko sovpadajo z replikatorjem, niso pa vsi replikatorji aktivni v vsakem celičnem ciklu)
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http://www.web-books.com/MoBio/Free/Ch7A.htm
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prediniciacija iniciacija
ORC: origin recognition complexCdc, Cdt: helicase loading proteinsMcm2-7: helicase
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http://biochemie.web.med.uni-muenchen.de/Yeast_Biology/10_Cellcycle.htm
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http://www.biochem.mpg.de/en/rg/pfander/Research/index.html
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http://nersp.nerdc.ufl.edu/~arabian/mcb3020s/lecture3.pdf
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Cooper 2
RFC: podajalec drsne vponke(clamp-loading protein)
PCNA: drsna vponka(sliding-clamp protein)
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http://www.biochem.mpg.de/en/rg/pfander/Research/index.html
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http://cmgm.stanford.edu/biochem201
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http://ftp.uke.uni-hamburg.de/kliniken/medizinische-klinik-1/index_43074.php
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Hayflickov fenomen
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http://barleyworld.org/css430_09/lecture%207-09/figure-07-25.JPG
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Alberts 4
http://cechlab.colorado.edu/telomodel.html