Cell  Maintanance    Factors  

Repilac1on    Factors  

Cell  Mortality    Factors  

Interac1ng  vectors  push  body  systems  in  different  direc1ons  forming  a  stable  ballanced  regulatory  plane  of  system  states.  

Outside  the  stable  regulatory  plane  body  systems  behave    chao1cally  and  1ssue  can    destablize  (e.g.  illness/death).  

80  Yr.    Life  Span  

New  Regulatory    Plane  >  Life  Span  >  160  Yr.  ???    

Change  in  Regulatory  Vectors  

Tissue  Spacific    Life  Span  Regula1on  

Stable    Regulatory    

Plane  Tissue  Spa.  Stable    

Regulatory    Plane  

Tissue  Spa.    Stable    

Regulatory    Plane  

Mul1ple  Body    

Systems    Co-­‐regulate  Crea1ng  a  Global  

Regulatory  Complex  Defining  a  Plane  

of  Life-­‐Span  Regula1on  for  the  Body  as  a  whole.    

Adverse  Childhood  Experiences  

(ACEs)  

Autonomic    Dysregula1on  

Allosta1c    Load  

Telomerase  Telemeres  

ROS,  CASP9,  CREB,  Bcl2  etc.  

Apoptosis  Regulators  

Cell  Markers  of    Cell  Health    and  Self  

Removal  of    Healthy  Cells  

Neuroplas1c    Immunofunc1ons    

Neuroplas1c  Changes  

Remove  Brake  On  Plas1city  

Increase  Rate    of  Brain  Tissue    Change  

Glial  Func1oning  •     Glutamate  Reuptake  •     Immune  Barrior  •     Synap1c  Plas1city  •     Apop1c  Signal  

Rapid  Tissue    Loss  

Cell  Repair  Cycles  •  Neurogenesis    •  LTP  •  Cell  Repair  

Lesion    Regrowth  

Metabolic  Changes  

(e.g.  Sugar/Insulin,    Mitochondria  fxn)  

Model  of  Mul1ple  Sclerosis  

Balance    

Decrease  Cell  Replacement  And  Reduced  Cell  Health  

Gene1c  &  Other    Factors