REGIONAL CENTRE OF ADVANCED TECHNOLOGIES AND MATERIALS
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BROKERAGE FOR HEALTH September 3-4 2018, Oslo HEALTH-NCP-NET 2.0 project is funded by the European Commission REGIONAL CENTRE OF ADVANCED TECHNOLOGIES AND MATERIALS Andrea Nogova Palacky University Olomouc session (edit)
Transcript of REGIONAL CENTRE OF ADVANCED TECHNOLOGIES AND MATERIALS
BROKERAGE FOR HEALTH September 3-4 2018, Oslo
HEALTH-NCP-NET 2.0 project is funded by the European Commission
REGIONAL CENTRE OF ADVANCED TECHNOLOGIES AND MATERIALS
Andrea Nogova
Palacky University Olomouc
session (edit)
HEALTH-NCP-NET 2.0 project is funded by the European Commission
Expertise:
Interactions of drugs, antioxidants, and cytochrome P450 with biomembranes.
Software projects for analysis of molecular channels MOLE and ChannelsDB.
Molecular dynamics of biomolecules and complex molecular systems, force field development, QM/MM methods and their applications in biomolecular research.
Modelling of above mentioned systems and processes.
RCPTM EXPERTISE – Molecule/Membrane Interactions
ERC Consolidator grant 2D-CHEM: Two-Dimensional Chemistry towards New Graphene Derivatives (Project ID: 683024)
HEALTH-NCP-NET 2.0 project is funded by the European Commission
MOLE 2.5 is an universal toolkit for rapid and fully automated location and characterization of channels, tunnels and pores in (bio)macromolecular structures, e.g., proteins, RNA, DNA and biomacromolecular assemblies.
molmedb.upol.cz
RCPTM EXPERTISE – Molecule/Membrane Interactions
HEALTH-NCP-NET 2.0 project is funded by the European Commission
Result: Silver nanoparticles strongly enhance and restore bactericidal activity of inactive antibiotics against multi-resistant Enterobacteriaceae.
Patent: EP2950804
RCPTM EXPERTISE – Nanotoxicology
Result: Bacterial resistance to silver NPs and a way how to overcome it.
Panacek, A, et.al: Nature Nanotechology, 2018
HEALTH-NCP-NET 2.0 project is funded by the European Commission
Result: Silver containing nanocomposites.
One/Two-step synthesis: PCT: CZ2017/050002, US patent No. 9,505,027 B2
Immobilization of nanoparticles into solid materials: CZ patent: 2017 – 806 (Preparation of tubes / urinary catheters)
230 mg/g
760 mg/g
MMT@AgNPs dorsilit@AgNPs Filtration
membranes Functionalisation
of textile
RCPTM EXPERTISE – Nanotoxicology
HEALTH-NCP-NET 2.0 project is funded by the European Commission
In 2004 we have synthesized carbon quantum dots and understood its fluorescence.
We applied positively charged carbon dots (CDs) for mesenchymal stem cells (MSC) labeling under the skin of mice.
Highly sensitive and reliable nanothermometer based on photoluminescence lifetime thermal sensing (independent of concentration, size, or geometry of a probe).
RCPTM EXPERTISE – Nanosensors: Carbon quantum dots
CD-labeled MSC CDs
Under the skin of mice
Kalytchuk S., et.al.: ACS Nano, 2017
HEALTH-NCP-NET 2.0 project is funded by the European Commission
RCPTM EXPERTISE – Nanosensors based on Raman spectroscopy
Result: MA-SERS nanosensors for a detection of potential biomarkers and bacterial infections.
Detection of bacteria in cerebrospinal fluid. Based on the already established platform utilizing Fe3O4@Ag@Streptavidin@Antibody nanocomposite.
Detection of IgG, Dopamine, PSMA, nucleic acids
Topic
HEALTH-NCP-NET 2.0 project is funded by the European Commission
Possible topics:
sc1-bhc-02-2019
sc1-bhc-31-2019
imi2-2018-15-01
imi2-2018-16-05
Keywords:
Markers, biomolecules, silver nanoparticles, antibiotics
resistance, nanocomposites, wound cover, nanosensors, MA-
SERS nanosensors
Thank you!
Contact details
HEALTH-NCP-NET 2.0 project is funded by the European Commission
Andrea Nogova
Grant policy coordinator
Palacky University Olomouc, RCPTM
+420 585 634 521
https://www.rcptm.com/
