Reduced Transition between Open and Inactivated Channel States Underlies 5HT Increased INa+ in Rat...

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Reduced Transition between Open and Inactivated Channel States Underlies 5HT Increased INa+ in Rat Nociceptors Pablo d’Alcantara, Luz M. Cardenas, Stéphane Swillens, Reese S. Scroggs Biophysical Journal Volume 83, Issue 1, Pages 5-21 (July 2002) DOI: 10.1016/S0006-3495(02)75146-1 Copyright © 2002 The Biophysical Society Terms and Conditions

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Page 1: Reduced Transition between Open and Inactivated Channel States Underlies 5HT Increased INa+ in Rat Nociceptors Pablo d’Alcantara, Luz M. Cardenas, Stéphane.

Reduced Transition between Open and Inactivated Channel States Underlies 5HT Increased INa+ in Rat Nociceptors 

Pablo d’Alcantara, Luz M. Cardenas, Stéphane Swillens, Reese S. Scroggs 

Biophysical Journal Volume 83, Issue 1, Pages 5-21 (July 2002)

DOI: 10.1016/S0006-3495(02)75146-1

Copyright © 2002 The Biophysical Society Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 2: Reduced Transition between Open and Inactivated Channel States Underlies 5HT Increased INa+ in Rat Nociceptors Pablo d’Alcantara, Luz M. Cardenas, Stéphane.

Figure 1

Biophysical Journal 2002 83, 5-21DOI: (10.1016/S0006-3495(02)75146-1) Copyright © 2002 The Biophysical Society Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 3: Reduced Transition between Open and Inactivated Channel States Underlies 5HT Increased INa+ in Rat Nociceptors Pablo d’Alcantara, Luz M. Cardenas, Stéphane.

Figure 2

Biophysical Journal 2002 83, 5-21DOI: (10.1016/S0006-3495(02)75146-1) Copyright © 2002 The Biophysical Society Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 4: Reduced Transition between Open and Inactivated Channel States Underlies 5HT Increased INa+ in Rat Nociceptors Pablo d’Alcantara, Luz M. Cardenas, Stéphane.

Figure 3

Biophysical Journal 2002 83, 5-21DOI: (10.1016/S0006-3495(02)75146-1) Copyright © 2002 The Biophysical Society Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 5: Reduced Transition between Open and Inactivated Channel States Underlies 5HT Increased INa+ in Rat Nociceptors Pablo d’Alcantara, Luz M. Cardenas, Stéphane.

Figure 4

Biophysical Journal 2002 83, 5-21DOI: (10.1016/S0006-3495(02)75146-1) Copyright © 2002 The Biophysical Society Terms and Conditions

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Page 6: Reduced Transition between Open and Inactivated Channel States Underlies 5HT Increased INa+ in Rat Nociceptors Pablo d’Alcantara, Luz M. Cardenas, Stéphane.

Figure 5

Biophysical Journal 2002 83, 5-21DOI: (10.1016/S0006-3495(02)75146-1) Copyright © 2002 The Biophysical Society Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 7: Reduced Transition between Open and Inactivated Channel States Underlies 5HT Increased INa+ in Rat Nociceptors Pablo d’Alcantara, Luz M. Cardenas, Stéphane.

Figure 6

Biophysical Journal 2002 83, 5-21DOI: (10.1016/S0006-3495(02)75146-1) Copyright © 2002 The Biophysical Society Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 8: Reduced Transition between Open and Inactivated Channel States Underlies 5HT Increased INa+ in Rat Nociceptors Pablo d’Alcantara, Luz M. Cardenas, Stéphane.

Figure 7

Biophysical Journal 2002 83, 5-21DOI: (10.1016/S0006-3495(02)75146-1) Copyright © 2002 The Biophysical Society Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 9: Reduced Transition between Open and Inactivated Channel States Underlies 5HT Increased INa+ in Rat Nociceptors Pablo d’Alcantara, Luz M. Cardenas, Stéphane.

Figure 8

Biophysical Journal 2002 83, 5-21DOI: (10.1016/S0006-3495(02)75146-1) Copyright © 2002 The Biophysical Society Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 10: Reduced Transition between Open and Inactivated Channel States Underlies 5HT Increased INa+ in Rat Nociceptors Pablo d’Alcantara, Luz M. Cardenas, Stéphane.

Model 1

Biophysical Journal 2002 83, 5-21DOI: (10.1016/S0006-3495(02)75146-1) Copyright © 2002 The Biophysical Society Terms and Conditions

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Page 11: Reduced Transition between Open and Inactivated Channel States Underlies 5HT Increased INa+ in Rat Nociceptors Pablo d’Alcantara, Luz M. Cardenas, Stéphane.

Model 2

Biophysical Journal 2002 83, 5-21DOI: (10.1016/S0006-3495(02)75146-1) Copyright © 2002 The Biophysical Society Terms and Conditions

http://www.elsevier.com/termsandconditions
Page 12: Reduced Transition between Open and Inactivated Channel States Underlies 5HT Increased INa+ in Rat Nociceptors Pablo d’Alcantara, Luz M. Cardenas, Stéphane.

Model 3

Biophysical Journal 2002 83, 5-21DOI: (10.1016/S0006-3495(02)75146-1) Copyright © 2002 The Biophysical Society Terms and Conditions

http://www.elsevier.com/termsandconditions

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