Rebirth Flyer
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Transcript of Rebirth Flyer
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From RegenerativeBiology
to ReconstructiveTherapy
Hannover Medical School& Partners
Cluster of Excellence
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The goal o the Excellence Initiative
is to strengthen cutting-edge researchin Germany and to improve its inter-national competitiveness. Outstan-ding projects are unded as Clusterso Excellence which ocus the research
potential at university locations in Germany and, hence, streng-
then their international visibility.With the enthusiastic support o six important partner institu-
tions, Hannover Medical School (MHH) has estab-lished a Cluster o Excellence in the area o
Regenerative Biology and Reconstruc-tive Therapies , acronym REBIRTH.
REBIRTH receives unding over a peri-od o ve years with an average bud-get o 6.5 million euros per year.
REBIRTH - Optimal partner
Our programme integrates excellenttraining with innovative science and ex-perimental as well as clinical medicine.Interactive basic research projects aredesigned to identi y and evaluate cellularand molecular mediators that stimulateregeneration.
We test new approaches or regenerativetherapies using novel (i possible somatic) cell sources which weengineer applying genetic, epigenetic, as well as sca old-basedprinciples. Expertise in various elds o engineering, chemistry,
biophotonics and nanotechnology supports and supplements ourresearch and development.
Toward patient- ocused, applied studies, the existing wide ran-ge o certi ed/accredited acilities or Good Practice (laboratory,
The Hans Borst Center or Heart and Stem Cell Research was unded with13.5 million euros by theBraukmann-WittenbergHeart Foundation.Since May 2008 13 o 40working groups are based in the new building.
Establishing an excellentcluster
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manu acturing and clinical) and close industrial collaborations
will be urther expanded. Upscaling technologies and pro-activebiosa ety assessment complete our translational activities.
Based upon MHHs recent key achievements and priorities weocus on disorders o blood (including immunity), heart , lung
(respiratory tract), liver, and pancreatic beta cells.
REBIRTH - Cluster o Excellence in the area o Regenerative Biologand Reconstructive Therapies. We ocus on disorders o blood (including immunity), heart, lung (respiratory tract) and liver in a disease speci c way.
Human Resources
Established Therapy
Area A Regenerative
Biology Phylogeny Ontogeny Milieu Cell Proliferation (Epi) Genetics
Blood Heart Lung Liver
FunctionStemness
Area BReconstructive
Therapy Tissue Engineering/
FunctionalizedImplants
Cell Therapy Regenerative Agents
Approval
Reprogramming Differentiation
Area C GLP, GMP, GCP Upscaling MolTox/ Pathology Imaging
Good practice and Pharmacovigilance
Clinical trials
Feedback
Area D Education
Ethics Public Relations
Disease models
Cultural Diversity
Gender Equity
Thereby, REBIRTH represents an optimal partner or other dome-stic and international centres in regenerative medicine.
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Rational drug design produces
iso orm-speci c inhibitorsthat target a novel allosteric binding site in myosin.
Hannover Medical School Max Planck Institute or Molecular Biomedicine, Mnster
Our basic research activities in Area
A are conducted by two collaborati-ve research units that ocus on StemCell Biology and Regeneration andOrganogenesis . Key objectives o our work programme are to obtaindeeper insights into the basic mecha-
nisms o genetic and epigenetic re-programming, allowing us to develop
novel pluripotent cell sources potentially derived rom postnatal tis-sues, and to control their di erentiation with subsequent robust unc-tional tests.
Discovering novel therapeutic targetsThe eld o stem cell biology will receive a new twist by addressing thebiochemical and genetic basis that orms the sweet sur ace o stem
cells, with potentially immense implicationsor their homing, migration, di eren-
tiation and labeling. Furthermore,we wish to identi y key players
o organogenesis and compa-re these to the regulators o milieu-dependent regene-ration. Finally, we exploreintrinsic and extrinsic limi-tations o regeneration by
studying mechanisms o cellcycle control, senescence and
ageing. This work is designed todiscover novel therapeutic targets
and methods. Area A has multiple in-teractions with Area B.
Area A:RegenerativeBiology andRelated
Sciences
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Helmholtz Centre or In ectionResearch, Braunschweig
Federal Research Centre or Animal Health, Mariensee
C
h r i s t i a n R
i c h t e r s
, M n s t e r
Area B connects insights rom
Area A with input rom clinicalpractice and translational plat-orms (Area C). To replace dys-unctional organs and tissues or
to restore their unction, we o-cus on cell therapy and tissue
engineering .The search or novel regenerative
agents and biomaterials is embedded in these activities.
In preclinical models o human diseases a ecting lymphohaema-topoietic system, heart, lung, liver and pancreatic beta cells, we
address the therapeutic options provided by di erent cell sources(adult vs. embryonic) and the combination o cell therapy with rege-nerative agents.
Therapeutic initiatives conducted in networksThis research is fanked by programmes investigating modes o indu-
cing tolerance to cells that are not entirely sel . Most o our thera-peutic initiatives are coupled to ongoing clinical trials, some o whichare conducted in national and international networks. Especially orcardiovascular and pulmonary indications, we will study the potentialo clinically applicable 3-dimensional bioarti cial tissue composed o cell-seeded biological or synthetic matrices.
This includes the unctionalization o synthetic (and biodegradable)implants by nanostructuring, coating with bioactive compounds andpre-implantation cell seeding. Novel technologies based on biome-chanics and photonics connect regenerative medicine with physical,mechanical and chemical sciences .
Area B:ReconstructiveTherapy inPreclinical
Models
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Leibniz University o Hannover University o Veterinary Medicine Hannover
For mammalian cell cultivation pro-
cesses, main research topics arethe infuence o environmental para-meters such as shear stress, tempe-rature and toxic metabolites on cell
behaviour and productivity.
Area C will supply important tech-
nological platforms or Areas A andB and will be essential or translati-on o developments rom Area B intoclinical application. To ollow the e -
ects o recombinant agents andmodi ed cells or tissues in vivo, we will urther strengthen our invest-
ments in bioimaging and cell marking (genetic and phenotypic), andstudy the long-term integrity o engineered and clonally expanded cellpopulations in the homeostatic, stressed and ageing organism (inter-action with Areas A & B).
Including integrated concept for GXP
Included in this global assessment are the derivation, expansion, ma-nipulation, and characterization o human stem cell lines, as well aspreclinical e cacy and toxicity testing in appropriate animal models.Large-scale cell expansion and biocompatibility testing are urtherimportant translational topics. Potential toxicity will be primarilyaddressed by investigating genetic and epigenetic instability and in-appropriate di erentiation. Our translational activities include an
integrated concept orGXP: good practice
or laboratory, manu ac-turing and clinical work(GLP GMP GCP).Clinical projects are su-pervised to guaranteehighest quality alreadyin preclinical data collec-tion, product design,biocompatibility testing
and nally the conception, conductand data management o clinicaltrials.
Area C:Translation
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Laser Zentrum, Hannover Fraunho er ITEM, Hannover
REBIRTH considers the promotion and
integration o young scientists andthe gender equality programme askey indicators o its per ormance. Theemphasis on education and equality is an integral component o our scien-
ti c programmes, and we believe that an own Area dedicated to these
important topics is as relevant or the long-term success o REBIRTHas the quality o our research activities.
Establishing an interdisciplinary PhD programmeThe rst step in this direction was the establishment o an interdisci-plinary international PhD programme Regenerative Sciences. It co-
vers all crucial topics ranging rom basic biology o regeneration overprinciples o engineering technologies (materials, cells, tissues) to cli-nical study design and related questions (good practice, process de-velopment, regulatory, economical and ethical issues). As part o allactivities, REBIRTH will also strengthen the investment o its partici-pating institutions to promote gender equality.
Supporting career developmentOne component o this task is to implement e ective career develop-ment measures. These shall be urther expanded to include long-termcareer perspectives o international colleagues in Germany. An inte-grated approach to increase diversity and obtain long-term eedbacko alumni is thus a logical consequence o our work.
Area D:HumanResources
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We envision that REBIRTHwill reach the ollowing goals:
n to orm a centre or basic and translational studies on stemcells and tissue engineering in hematopoietic, cardio-vascu-lar, respiratory and hepatopancreatic medicine, leading toinnovative therapeutic strategies
n to create an internationally renowned major player in the
design and implementation o regenerative clinical studieswith a strong emphasis on biosa ety and predictability
n to realise trans- and intrainstitutional networking by orming dual leaderships o clinical departments and technical/natu-ralscientifc institutes with a regenerative ocus
n to strengthen our position as an attractive national and inter-national networker, characterized by an interdisciplinaryculture o open-minded, hypothesis-driven and innovativeresearch.
REBIRTH - Cluster o ExcellenceHannover Medical SchoolCarl-Neuberg-Str. 130625 Hannover, Niedersachsen, GermanyCoordinator: Pro essor Dr. Axel HaverichBusiness Manager: Tilman Fabian
Tel: +49 511 532 - 5204Fax: +49 511 532 - 5205in [email protected]
Long-termobjectives
Cluster of ExcellenceFrom Regenerative Biology to Reconstructive Therapy
M a r c
h 2 0 0 9