Rate Adaptive Pacing: Sensors and Programming ...2009.cardiorhythm.com/pdf/19/87.pdf · Minimum...
Transcript of Rate Adaptive Pacing: Sensors and Programming ...2009.cardiorhythm.com/pdf/19/87.pdf · Minimum...
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Rate Adaptive Pacing:Sensors and Programming ApproachesSensors and Programming Approaches
Basics of Cardiac Pacing CCardioRhythm 2009, Hong Kong
Euljoon Park, PhDj ,St. Jude Medical
Cardiac Rhythm Management Division
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Rate Adaptive PacingRate Adaptive Pacing
●Use of sensor or combination of sensors (besides the sinus node) to adjust the pacing rate to meet t e s us ode) to adjust t e pac g ate to eetthe patient’s metabolic needs
● Indicated for chronotropic incompetence
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A dAgenda
● Definition of chronotropic incompetence● Sensors for rate adaptive pacing● Rate adaptive pacing parameters and programming
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Chronotropic Incompetence
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Cardiac Output● Cardiac output is the volume of blood (in liters) ejected by
the heart in one minute● Stroke volume is the volume of blood (in liters) ejected by
the heart in one beat● When the body is under stress (physical, emotional), the
heart tries to increase cardiac output … by increasing the t d t k l di t thi f lrate and stroke volume according to this formula
C di O t t H t R t St k V lCardiac Output = Heart Rate x Stroke Volume
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Normal Chronotropic Response
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Chronotropic Incompetence● If the patient’s heart cannot increase its rate appropriately
in response to increased activity, the patient is p y, pchronotropically incompetent
● Chronotropic incompetence definitions:○ Maximum heart rate < 90% x (220 - Age)○ Maximum heart rate < 120 bpmp
● Causes○ Agingg g○ Drugs○ Heart disease
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Diagnosing Chronotropic IncompetenceDiagnosing Chronotropic Incompetence
● Patient history● Patient history● Holter or telemetry
monitoringg● Exercise testing
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Sensors for Rate Adaptive Pacing
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Sensors
● Rate adaptive pacemakers rely on sensors to detect patient activitypatient activity
● The ideal sensor should bePhysiologic○ Physiologic
○ Quick to respondAbl t i th t ti ll t th ti t’○ Able to increase the rate proportionally to the patient’s need
○ Able to work compatibly with the rest of the pacemaker○ Able to work compatibly with the rest of the pacemaker○ Able to work well with minimum energy demands or
current draincurrent drain○ Easy to program and adjust
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Types of Sensors● Activity sensors
○ Accelerometers○ Accelerometers○ Vibration sensors (piezoelectric sensors)
● Physiologic sensors● Physiologic sensors○ Impedance
• Minute ventilation (MV)Minute ventilation (MV)• Closed loop system (CLS)
○ Peak Endocardial Acceleration (PEA)( )○ Temperature○ Evoked responsep○ QT interval
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Acti it / AccelerometerActivity/ Accelerometer
● Responds rapidly● No special pacing leads required● No special pacing leads required● Easy to manufacture and program● Cannot be “fooled” by pressure on the cany p● Non-physiologic
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Activity Sensor/VibrationActivity Sensor/Vibration
● Responds rapidly● No special pacing leads required● No special pacing leads required● Easy to manufacture and program● Can be “fooled” by pressure on the can or footfallsy p● Non-physiologic
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Minute Ventilation
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Minute Ventilation
● Uses low-level electrical signals to measure resistance across the chest (“transthoracic impedance”)across the chest ( transthoracic impedance )○ Impedance (resistance) increases during inhaling, and
decreases during exhalingdecreases during exhaling○ Detect respiration rate and relative change in tidal
volume○ MV = RR x TV
● Requires no special sensorq p● Metabolic● Slow due to processing in pacemakerp g p
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Closed Loop System (CLS)p y ( )
M h i di● Measures changes in cardiac contractility (inotropy)
● Impedance (resistance) p ( )increases during systole and decrease during diastole
● May be affected by changes● May be affected by changes in posture
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Endocardial Acceleration sensorEndocardial Acceleration sensor
● A microaccelerometer sensor inserted in the tip of a pacing lead for the chronic measurement of the Endocardial Acceleration (EA)
● PEA is related to the first HS, which reflects cardiac contractility
PACING TIPELECTRONICSRIGID AND HERMETIC CAN
MICRO MASS FORCE TRANSDUCER
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Endocardial Acceleration and Heart Sound
PEA I0 5 EJECTION TIMEPEA I
0
0.5
EA (g)
ET= t(PEAI,PEAII)
PEA II-0.5
PHONO
100
200PHONO
BP (mmHg)
0
( g)
ECG
0 1 2
ECG
t (s)
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PEA
● Measures changes in cardiac contractility● Proportional to metabolic demand● Fast● Require special sensor● Large lead body
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Evoked ResponseEvoked Response
● Measures the QRS Qdepolarization area
● Theory: the QRS depolarization decreases indepolarization decreases in area with exercise
● Requires no special leads● May be affected by changes
in posture● Only works when the device● Only works when the device
is pacing
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QT IntervalQT Interval
● Measures the interval between the pacing spike and the evoked T-wave
● Theory: This interval shortens● Theory: This interval shortens with exercise
● Requires no special pacing lead
● Works only when the device is pacingis pacing
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TemperatureTemperature
● A thermistor is mounted in the lead (not the can)● Requires a special pacing lead● Requires a special pacing lead● Metabolic● Response time can be slowp
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Rate Adaptive Pacing Parameters:Rate Adaptive Pacing Parameters:How to Program
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Rate Adaptive Programming ParametersRate Adaptive Programming Parameters
● Base rate / Rest Rate● Base rate / Rest Rate● Maximum sensor rate● Threshold● Threshold● Slope● Reaction time● Reaction time● Recovery time
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Rate Adaptive Pacing
rate
Max Sensor RateH
ear r
Reaction Time Recovery Time
Base RateSlope
Rest Rate
Work load (Activity, MV, PEA . . .)Threshold
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Maximum Sensor Rate
● Maximum Sensor Rate is the fastest possible rate the pacemaker will pace in response to sensor inputpacemaker will pace in response to sensor input
● The Maximum Sensor Rate must be a rate that the patient can toleratepatient can tolerate○ Maximum heart rate formula (220-age) x .90 is highest
possible settingpossible setting○ But if patient cannot tolerate the maximum heart rate,
set the Maximum Sensor Rate to a rate s/he can tolerate
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Base Rate● Minimum heart rate the pacemaker allows.● When a patient’s intrinsic heart rates (when in rest) fall p ( )
below the base rate, the pacemaker will pace at the base rate
Rest Rate● Few companies provide the rest ratep p● When a patients takes a prolonged rest, the pacemaker
lower the base rate to the rest rate● Fixed or Dynamic
● Static: programmed by time (10 pm – 7 am, for example)
● Dynamic based upon activity
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Threshold
● Threshold is the amount of activity needed to cause sensor activitysensor activity
● Programmable from low (least activity required to generate sensor signals) to high (most activity)generate sensor signals) to high (most activity)
● Can also be set to AUTO
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Threshold
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Threshold Programming Considerations
● AUTO allows the pacemaker to automatically adjust to the patient’s changing activity levelsthe patient s changing activity levels○ Updates automatically (i.e., every 18 hours)
● AUTO with Offset can further fine-tune the settings● AUTO with Offset can further fine-tune the settings○ A negative value makes it more sensitive (less activity
is needed to start rate response)is needed to start rate response)○ A positive value makes it less sensitive (more activity
is needed to start rate response)p )● Considerations
○ Patient age, lifestyle, everyday activitiesg , y , y y○ Patient’s fitness level (how likely is he to go jogging?)
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Slope
● Slope describes the sensor-drive pacing rate for a given level of activitylevel of activity
● It is programmable from low to high (i.e., 1-16)● All other things being equal a slope of 1 will increase the● All other things being equal, a slope of 1 will increase the
rate less than a slope of 16● AutoSlope● AutoSlope
○ Based on recent activity levels○ Offset values can be programmed to further fine tune○ Offset values can be programmed to further fine tune
rate response
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Slope
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Slope Programming Considerations
● Slope determines “how much” rate response is given for a specific activitya specific activity
● When selecting a slope, considerThe patient’s age activities lifestyle○ The patient’s age, activities, lifestyle
○ How well patients can tolerate rapidly paced activityH h t th d○ How much rate response they need
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Reaction Time
● When the sensor determines the patient needs rate response the Reaction Time parameter regulates howresponse, the Reaction Time parameter regulates how quickly rate response is delivered
● Programmable to: Fast, Medium, SlowProgrammable to: Fast, Medium, Slow● Consider the patient’s age, lifestyle, activities, and how
quickly patients would need rate responseq y p p
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Reaction Time
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Recovery Time● Recovery time determines the minimum time it will take
the sensor-driven rate at the maximum sensor rate to go back down to the programmed based rate
● Similar to Reaction Time● Programmable as Fast, Medium, Slow, and Very Slow● Programming considerations are the usual:
○ Patient age, lifestyle, activity levels○ Tolerance of rate transitions
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Recovery Time
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Programming Rate Response
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PASSIVE Sensor Setting
● Patients do not receive any rate response (the sensor does not control the rate) but the sensor reports what itdoes not control the rate) but the sensor reports what it would have done in a diagnostic report
● Benefits of PASSIVE● Benefits of PASSIVE○ Test sensor parameters before they are programmed○ Check how changes in sensor settings will work for a○ Check how changes in sensor settings will work for a
particular patient without exposing the patient to possibly uncomfortable sensor settingsp y g
○ Makes it easier to fine-tune the sensor
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Rate Response Optimization● A two-minute exercise test and the programmer can
gather enough data to recommend optimal rate-responsive parameter settings
● Allows the clinician to fine-tune rate response for an individual patient○ Without difficult exercise testing○ Quick and easy○ Recommends settings for better decision making
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Rate Response Optimization
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Sensor Indicated Rate Histogram
Sensor “Threshold” Sett S itito Sensitive
(Number to Low)
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Conclusion● Rate adaptive pacing is almost a “standard feature” today● Pacemaker patients often suffer from varying degree of● Pacemaker patients often suffer from varying degree of
chronotropic incompetence○ Many who are not chronotropically incompetent nowMany who are not chronotropically incompetent now
will become chronotropically incompetent with disease progression
● Automated options make programming easier● There is no “perfect” sensor
○ Combination of sensors● Rate response optimization is a valuable and actually
time-saving feature