RADIUM COMMISSION
Transcript of RADIUM COMMISSION
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RADIUM COMMISSION.
FIRST ANNUAL REPORT.1
THE period covered by the first annual report ofthe Radium Commission, dated August 31st, 1930,is nearly a year, since the Commission started workon Sept. 26th, 1929. It is recorded that the firstdecision of the Commission were to accept theoffer of the loan of a four-gramme " bomb " for aperiod of three months, free of charge ; and to entrustthis " bomb," provisionally, to the WestminsterHospital to carry out a special programme of radiumtherapy suggested by the Commission. Moreover,the first 5 grammes of radium were ordered andplaced in containers in anticipation of the require-ments of national centres. The Commission thenaddressed itself to the task of framing and creatinga national organisation, with the primary objectivesof (a) " treatment of the sick " as prescribed by theRoyal Charter, and (b) the evaluation of radium inthe treatment of cancer as determined by resultsover a period of years. To this end it was decidedto concentrate the available radium at 12 nationalcentres outside London, and in London to combinea centre for treatment with a post-graduate schoolof radiotherapy for the service of the whole country.The selected centres were required to furnish detailedreplies to two questionaires prepared by the Com-mission-No. 1. dealing with the staffing, organisa-tion, equipment, and experience in radium therapyof the hospital nominated; and No. II. with themethods of technique in radium therapy proposedto be followed. The centres were also asked to formu-late and submit a schedule of their requirements,and were urged to avoid abnormal demands, to adoptproved methods of technique, and where possible tobring patients to fully equipped clinics rather thanto take radium to the patients.
Rental charges are made for radium loaned tocentres in order to avoid drawing upon the capitalof the National Radium Fund to defray administra-tive or overhead expenses, and to preserve undimi-nished the sum of money available for the purchaseof radium. The Commission expresses the beliefthat this policy will commend itself to Parliamentand the public, even though it may not always bewelcomed by the financial authorities of the centresconcerned. The rate of rental at present fixed-i.e.,2 per cent. per annum of the capital value of theradium and containers-is provisional and is subjectto revision. It is not, of course, desired to makeany financial profit from the loan of national radium.Radium Supply.-A total of 18 grammes has been
ordered by the Radium Trust. Of this amount some18 grammes have been provisionally allocated tonational centres, and it is hoped that the whole ofthis amount will be in full clinical use by the end of1930. At the end of August 14 grammes had beenreceived from the manufacturers and 8 grammes had ’’,been actually delivered to centres.
Outside Demands for Radium.-The Commissionhas received many applications for grants of radiumfrom institutions throughout the country. Even ifan unlimited stock of radium had been available, theCommission hold that, in the present state of know-ledge of radiotherapy, an indiscriminate or even awider distribution of national radium would beTindesirable. The dangers, both to operator andpatient, attendant on the use of this new and potentweapon are not only real and serious but there is much
1 H.M. Stationery Office, 1930, Cmd. 3678. 1s. 3d.
popular misconception (extending sometimes even tothe medical profession) with regard to the efficacy ofradium and the technical difficulties of its clinical use.
Inability to meet demands for radium does not,however, signify any lack of sympathy on the partof the Commission with non-selected hospitals whichare adequately equipped and staffed to undertake,and which are anxious to practise, radiotherapy.They have been urged to comply with the rules andprecautions for the use of radium adopted by nationalcentres, and to make use of the national forms ofclinical case records (of which specimens are givenin this report) in order that statistics may be basedupon as wide an experience as possible.
A NATIONAL POST-GRADUATE SCHOOL.
Since the need of practitioners fully qualified topractise radiotherapy is urgent, the Commission
drew up a scheme for the creation of a post-graduateschool of radiotherapy. They suggested the coöpera-tion of the Mount Vernon Hospital at Northwood,Middlesex, which had recently decided to devoteits energies to the study and treatment of cancer,with the Radium Institute in Portland-place, London,in the establishment of such a school, and eventuallya joint scheme was worked out. Under a schemeprepared by the Director of Medical Services of theHospital and Institute (Sir Cuthbert Wallace), themain clinical and .pathological work of the jointinstitution will be carried out at Mount Vernon,whilst the diagnostic and out-patient department,with a proportion of the surface therapy work, willbe centred at the Radium Institute, which will alsobecome the Commission’s principal centre for thesupply of radon (radium emanation). Three grammesof national radium is being allocated to Mount VernonHospital for clinical work, and 1 gramme to theRadium Institute for radon. The post-graduateschool is being inaugurated this autumn (October, 1930).The Commission note that satisfactory cooperation
has been established with other bodies, notably theMedical Research Council, King Edward’s HospitalFund for London, the British Empire Cancer Cam-paign, the Cancer Commission of the League ofNations, and the National Physical Laboratory.
TECHNIQUE OF RADIUM THERAPY.
Although much experimental work is being con-ducted in many countries, it cannot be claimedthat the methods of technique have yet becomestandardised or are incapable of improvement. Itis therefore the policy of the Commission to encouragoand try out all approved methods, as well as thosewhich, in the judgment of its advisers, afford goodpromise of success. At present there are four maintechniques :-
(1) The use of radium in containers (i.e., needles, tubes,&c.) which are inserted surgically into the diseased tissuesor placed in natural cavities of the body.
(2) Surface therapy, the radium containers being placed inexternal contact with the body or very close to it.
(3) Distance radium therapy (or mass irradiation) bymeans of a " bomb " containing a large quantity of radium,which is placed at a distance of some inches from the body.
(4) Radon therapy. Similar to No. (1) except’ that,instead of radium being used, " radon " (i.e., the gasemanating from it) is collected and sealed in small tubesor
" seeds " which are inserted in the tissues.
The Commission has arranged that all nationalcentres shall be equipped to practise methods (1)and (2); that some of them (five at present) shall inaddition be equipped for the production of radon,and one hospital (Westminster) shall be speciallycharged to try out No. (3). This position is subjectto modification as and when further experienceindicates the desirability of introducing new methods
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or possibly discarding others which are alreadyin use.
The Westminster "Bomb."-The four-gramme" bomb," originally on loan, was purchased. This" bomb " was acquired in order to enable the Com-mission to try out the method of " distance radiumtherapy," or " mass irradiation," which has beenpractised for some time past in other countries (withundetermined results), and which, if proved successful,might, in many cases, obviate the need for surgicalinterference. It is too soon to formulate or publishany considered conclusions. As at present advised,however, the Commission is of opinion that the
experience so far gained is not sufficiently encouragingto justify the acquisition of any more large " bombs "at the present time.
Appendices.The report contains, as appendices : (1) a balance
sheet; (2) a specimen of agreement with national iradium centres; (3) a summary of the present stage Iof development of the 12 national radium centres; I(4) a reprint of memorandum published by theCommission in November, 1929, deprecating extra-vagant claims for the healing properties of radium,and setting out a considered view of the true position; i(5) specimen " national radium forms" for case-records of malignant disease affecting various regions Iof the body, with reproductions.of the charts devised Iby Prof. Regaud; (6) a memorandum on the policyto be adopted by the Commission towards hospitalsor medical groups (other than the national radium I
centres) who may apply for advice, guidance, orloan of radium; (7) a memorandum furnished to Ithe National Radium Commission on the relation.between the Mount Vernon Hospital and the Radium IInstitute; (8) a note on the care and custody of iradium ; (9) a memorandum on radon departments iat national centres.
Conclusion.The Commission again emphasise that great i
caution is necessary in estimating the value and
effica,cy of radium in the treatment of malignantdisease and they strongly deprecate the creation of
false hopes by means of sensational, or even optimistic,statements. As a result of world experience, extend-ing now over many years, the best that can be saidis that some results, under certain conditions, are
very satisfactory ; that others, for no clearly estab-lished reasons, are less so, and that in a considerable
proportion of cases the results are either inconclusiveor definitely disappointing. They hold that this does.not justify a pessimistic outlook, as many problemswhich yet remain unsolved may yield to experienceand research. But time is an essential condition of
success and it can only be after several years of pioneerwork that there can be a sufficient supply of statisticaland scientific data to enable positive conclusions tobe reached and published to the world. The Com-
mission have therefore made it their first duty toorganise a concentrated and controlled nationalradium service, with a definite and coordinated pro-gramme which will be carried out at selected centresunder the supervision of recognised experts, and ofwhich the progress and results will be recorded on auniform system. By this means the treatment ofthe sick, which is enjoined in the Royal Charter,will proceed pari passu with’ the advancementof knowledge of the best methods of radiumtherapy, whilst due economy will be securedin the utilisation of the limited stock of nationalradium.
Finally, the Commission repeat their warning that,radium is not yet established as a
" cure for cancer ; ;.that whilst it holds out a good promise of beneficialresults, and certainly of alleviation of suffering, it isat present a very dangerous weapon and one whichunless used with the greatest skill, care, and pre-caution may easily be productive of more harm thangood. This is the Commission’s considered opinion,as the result of its first year’s work, but it is noted.that at least five years of further experience andcoordinated research will probably be required beforeany final verdict can be anticipated.
REVIEWS AND NOTICES OF BOOKS
Cancer of the Larynx.By Sir STCLAIR THOMSON, M.D., F.R.C.S.,F.R.C.P., Emeritus Professor of Laryngology inKing’s College Hospital; and LIONEL CoLLEDGE,M.B., F.R.C.S., Surgeon to the Throat Depart-ment, St. George’s Hospital. London: KeganPaul, Trench, Triibner and Co. ; Anglo-FrenchLibrary of Medical and Biological Science. 1930.
Pp. 244. 25s.
THE treatment of cancers of the throat has madeconsiderable progress during the last decade and thiscareful and up-to-date exposition by two of the
surgeons who have taken a leading part in thisadvance is opportune. The greater part of the bookis occupied by the discussion of operative treatment,but a later chapter deals with treatment by radiumand X rays. This chapter is largely a record of
disappointments, but some of the unfavourableopinions quoted date from the earlier part of thedecade; somewhat better results, which are alsoquoted, have been obtained during the last two orthree years, and it should be remembered that theearly results of surgical treatment were also very dis-couraging. The authors do well to point out that
radiation cannot be advised indiscriminately for
inoperable cases on the ground that it may do goodand will do no harm, for it is quite as likely to
aggravate the symptoms as to give relief in thecases under discussion.The earlier chapters are concerned with pathology,
symptoms, and diagnosis; Sir StClair Thomson’s.long experience gives great value to this part of the,book. In the diagnosis of post-cricoid cancer the:difficulty of inspecting this region is noted, togetherwith the risk of damage by an cesophagoscope; the;value of palpation through the mouth is mentioned,,but not von Eicken’s method of inspection, aided bypulling forward the larynx with a probe in the anteriorcommissure ; this procedure is easy, causes no damage.or discomfort, and often affords a good view of the.hypopharynx. The authors’ advice that there is noneed to be in haste to settle a diagnosis, if there is.insufficient evidence, is only safe if it is confined, as.they intend, to genuinely early cases where neither-extremity of the cord nor the subglottic region is.invaded ; otherwise any long delay may well end indisaster.A clear and complete discussion ef the operations
of laryngofissure and laryngectomy occupy about