Radioembolization induced liver disease, a brief and limited description

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RADIOEMBOLIZATION INDUCED LIVER DISEASE! Aaron Shiloh, MD Section Chief, IR Diagnostic Imaging, Inc. Philadelphia

Transcript of Radioembolization induced liver disease, a brief and limited description

Page 1: Radioembolization induced liver disease, a brief and limited description

RADIOEMBOLIZATION INDUCED LIVER DISEASE!

• Aaron Shiloh, MD• Section Chief, IR

• Diagnostic Imaging, Inc.• Philadelphia

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73 YO S/P PRIOR LEFT HEPATECTOMY WITH MULTIPLE RIGHT HEPATIC HCC

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• ECOG O, Childs Pugh A• Left Hepatectomy 2007• T Bili 0.5, Alk Phos 81, AST 56, ALT 42• Non alcoholic• No prior chemotherapy

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Two months later…

• Pt presents with ascites, jaundice, fatigue• MRI performed • Labs obtained

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REILD

• Presents as jaundice and ascites 1-2 months post RE in the absence of tumor progression or bile duct occlusion

• Cirrhosis and exposure to prior chemotherapy have been shown to be predictors of REILD

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Hepatology. 2012 Dec 10. doi: 10.1002/hep.26191. [Epub ahead of print]

Prognostic factors and prevention of radioembolization-induced liver disease.

Gil-Alzugaray B, Chopitea A, Iñarrairaegui M, Bilbao JI, Rodriguez-Fraile M, Rodriguez J, Benito A, Dominguez I

, D'Avola D, Herrero JI, Quiroga J, Prieto J, Sangro B.

Complications following radioembolization with yttrium-90 microspheres: a comprehensive literature reviewA Riaz, RJ Lewandowski, LM Kulik, MF Mulcahy… - Journal of Vascular and …, 2009 - Elsevier