ANNUAL REPORT

2017 -2018

Molecular Biology Institute

( 3 1 0 ) 8 2 5 - 1 0 1 8

m b i . u c l a . e d u

U C L A B o y e r H a l l

m b i a s s t @ l i f e s c i . u c l a . e d u

MOLECULAR BIOLOGY INSTITUTE

REMEMBERING PAUL BOYER

MBI DIRECTOR’S REPORT MBI COMMITTEES

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MBI ADMINISTRATIVE SUPPORT STAFF ACTIVITIES Administrative Services Building Management

MBI PROGRAMS & EVENTS

The David S. Sigman Memorial Lectureship & Symposium The Audree Fowler Fellows in Protein Science The Jules Brenner Achievement Fellowship in Molecular Biology Boyer/Parvin Postdoctoral Research Awards Thursday Seminar Series MBI Interdisciplinary Faculty Seminars MBI Annual Retreat & Research Conference Biotechnology Edge Workshop Focus on Imaging Workshop Mouse Genome Informatics Workshop

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MBI FACULTY RESEARCH & PROFESSIONAL ACTIVITIES Newly Appointed Members Honors & Professional Awards Service on UCLA Committees Service on External Committees Patents Issued Visiting Faculty & Scholars

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MBI PARTNERS IN BOYER HALL Institute for Quantitative & Computational Biology (QCBio) The QCBio Collaboratory UCLA-DOE Institute Fermentation Core Facility

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GRADUATE PROGRAMS Molecular Biology Interdepartmental Ph.D. Program (MBIDP) Whitcome Pre-doctoral Training Program

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MEMBER PUBLICATIONS MBI Faculty Publications

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PAUL D. BOYER 1918 - 2018

REMEMBERING WITH GRATITUDE

PAUL D. BOYER 1918 - 2018

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DearColleagues,Thisyearwillbeforevermemorableinthehistoryof our Institute because itmarks the passing ofourbelovedPaulBoyer.Hismanyscientificandacademic accomplishments have beenhighlighted in several journals and it has beenwonderful to hear so many colleagues speakabouthowmuchDr.Boyermeanttothem.Wearegrateful for his vision, his collegiality, hiscommitment to scientific excellence and hisoptimisticspirit,allofwhichbecamepartofthecultureofourinstitute.Thankyou,Paul!ThelastyearwasalsomarkedbyseveralchangesintheMBIDPofficeandbuilding.TwonewSAOs,StephanieCuellarandAshleyTerHorst joinedourofficeandhavesmoothlytakenovertheadministrationoftheMBIDPandhavequicklybecome familiarwithourbodyof students and faculty.Anewadministrator assistant,AltagraciaAlvaradoisnowthefacebehindtheMBIemails,workshops,eventsandinteractionswithourbodyofstudents.BigkudostoHelenHouldsworthfor“fillingtheblanks”aswecompletedsearchesandrecruitedthisgreatteam.WealsowelcomeMikeKane,ournewbuildingmanagerwhohassoefficientlyadaptedtoUCLAandBoyerHallandcontinuedtotakecareoftheInstituteandBoyerHalloccupants.MuchofourattentionhasbeenplacedontherenovationsofBoyer159,ourpremierconferenceroom.ThemuchneededupgradewasonlypossiblebecauseofthecommitmentandsupportoftheDeansofLifeSciences,DGSOMandPhysicalSciencesaswellastheChairofChemistryandBiochemistry.Wecouldnothavedoneitwithoutyou!Thepatio adjacent to the conference roomwill also be renovatedby the endofNovember andwill provide anoutstanding space for events, meetings, student recruitment, informal discussions and celebrations. We areextremelyexcitedtohavethisgreatspaceavailableforalltheevents,thesisdefensesandscientificseminars.Thankyouallforyourpatienceandtrust.HighlightsofthepastyearfortheMBIincludedtheSigmanSymposiumhonoringProfessorYigongShiwhodeliveredamemorablelectureentitled“Mechanismofpre‐mRNAsplicingbytheSpliceosome”.Asinpreviousyears,thiswasawonderfuleventandImustacknowledgetheMBISigmanLectureshipCommitteethatincludesFengGuo,ReidJohnsonandJimBowie(chair).Thankyoufortheoutstandingselectionandyourcontinuouscommitmenttothisevent.Alongtheselines,theflagshipoftheinstitute,MBIThursdaySeminarSerieshasbroughtinfantastictalksandimpressivescientists.ThankyoutoMargotQuinlanandTracyJohnsonandtheircommitteefortheirhard,hard,hardworkonthisendeavor.AscanbeeasilynotedintheNewsletter,themembershipcontinuestothriveandthescientificcaliberofourfacultyisunquestionable.HereImusthighlightafewhonorsreceivedbyourmembers:theelectionofUtpalBanerjeetotheNationalAcademyofSciences,HHMIinvestigatorawardtoTamirGonen,theWilliamC.RoseAwardgivenbytheASBMBtoStevenClarke,thePaulSiglerPrizegivenbyYaleUniversitytoDavidEisenbergandtheAmericanHeartAssociationRusselRossMemorialLectureshiptoKarenReue.Congratulations!Ourgraduateprogramisexpanding,withatotalof145students.Wejustwelcomedourincomingclassof2018‐2019with23students.Duringthisacademicyear,14studentsreceivedtheirdoctoratesandcombinedtheyproduced119scientificpublications.Theyareour legacyandweare fullycommitted toconstantly improve their trainingandresearchexperience.Iwouldtaketheopportunitytothankourhomeareadirectors:FengGuo(BBSB),JeffLong(CDB),MichaelCarey(GREAT)andPeterBradley(IMMP)whohaveplacedalotofenergyintotherecruitmentoftheincomingclassandtheguidanceofcurrentstudents.Ourmissiontoreconnectwithourlargebodyofgraduateshascontinued,throughalumninewslettersandotheroptionstoconnectwiththeprogram.Duringthiscomingyear,alumnilocatedintheLAareawillbeinvitedtoattendtheupcomingMBIretreatwhichwillbeinLakeArrowhead.It

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hasbeennicetoreceivefeedbackfromsomeofthemstatinghowmuchtheinstitution,andtheMBIinparticular,meanttothematacriticaltimeintheircareers.ThroughthegenerosityofourdearAudreeFowler,theMBIhasbeenabletoawardfourAudreeFowlerFellowshipsin Protein Science this past year. This has become a wonderful tradition and our graduate students are veryappreciativefortheopportunitytocompeteforthisaward.Thisyear’sawardeesare:MichaelHughes(Eisenberglab),Kanishk Jain (Clarke lab),WilliamBarshop(Wohlschlegel lab)andYuxiLiu (Yeates lab).The JulesBrennerAchievement Fellowship in Molecular Biology went to Aimee Flores (Lowry lab). Congratulations to all theseoutstandinggraduatestudents!Finally,the18thannualBoyer‐Parvinrecognitionawardshavecontinuedtoprovideastand‐upsalutetoourbodyofpost‐doctoraltrainees.Thisyear,from9exceptionalnominees,3wereselected.ThewinnerswereFrancisMercer(PatriciaJohnson’slab),MarcusSeldin(JakeLusis’lab)andMichaelHicks(AprilPyle’slab).ThishasbeenaspecialsignatureoftheMBI,initiatedbyourfounder,andwearecommittedtoseekadditionalfundstocontinuethesupportofthisimportantevent.Asinpreviousyears,theImagingWorkshopandtheBiotechnologyWorkshopswereasuccesswithattendancetofullcapacity.WearepreparingsomeslightmodificationstotheImagingworkshoptobettersupportourcommunitywithmorestratificationintraining(beginner,intermediate,advanced).Hopetoseeyouatourevents,symposiaandseminars!Hastapronto.LuisaLuisaIruela‐Arispe,Ph.D.Director,MolecularBiologyInstitute

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EXECUTIVEADVISORYCOMMITTEEAmanderClark,CatherineClarke,AlexanderHoffmann,SiavashKurdistani,SabeehaMerchantand

JeromeZack

MBIMEMBERSHIPArnoldBerk(Chair),AlisonFrand,BennettNovitch,ThomasVondriskaandMeganMcEvoy

THURSDAYSEMINARSMargotQuinlan(co‐Chair),TracyJohnson(co‐Chair),DouglasBlack,HilaryColler,David

Eisenberg,SriKosuri,MichaelTeitellandTomVallim

SIGMANAWARDSELECTIONJamesBowie,FengGuo,LuisaIruela‐ArispeandReidJohnson

AUDREEFOWLERFELLOWSHIPINPROTEINSCIENCEJoseRodriguez,SiavashKurdistani,KathrinPlathandGregoryPayne

JULESBRENNERSCHOLAR’SACHIEVEMENTFELLOWSHIPINMOLECULARBIOLOGYJulesBrenner,AmanderClark,DonKohnandTimothyLane

PHILIPJ.WHITCOMEFELLOWSHIPFengGuo,JeffreyLong,PeterBradleyandMichaelCarey

BOYER/PARVINPOSTDOCTORALAWARDSKarenReue,JoseRodriguez,OliverFregosoandHilaryColler

MOLECULARBIOLOGYINTERDEPARTMENTALPH.D.PROGRAMLuisaIruela‐Arispe,PeterBradley,MichaelCarey,JeffreyLongandFengGuo

2017‐2018ANNUALRETREATGeoffreyProvonost(Chair),AaronVanLoon,BrendaMolgora,GuillaumeUrtecho,Samantha

Edwards,AlexSercelandJessicaOchoa

ANNUALRETREATPOSTERJUDGESPeterBradley,MichaelCarey,HilaryColler,AndrewGoldstein,FengGuo,LuisaIruela‐Arispe,

TracyJohnson,JeffreyLong,MargotQuinlanandMelissaSpence

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ADMINISTRATIVESERVICESHelenHouldsworth,BoyerHallManagementServicesOfficer

It’s a pleasure to update you on the administrative team thatmade the activities you read about in this reportpossible.I’mconsistentlyimpressedbytheenergytheybringtotheirroles,aswellastheircommitmenttoserveourFacultyandstudentsandtheteamworktheyshoweachother.InOctoberwewelcomedAltagraciaAlvaradoasournewOfficeCoordinator,replacingMeganWeitzelwhomovedontoanSAOpositioninnorthcampus.Altagracia(“Gracie”)isarecentgraduatefromUCLAandapassionateBruin.Althoughnewtothesouthcampussciencecommunityandtomanyofthetasksshewasfacedwith,shethrewherselfwhole‐heartedlyintolearningandadaptingtohernewrole.Shealsobroughthercreativeskillswhichhavegivenouradvertisingmaterials,websiteandsocialmediaamuchneededboost.She’smade thepositionherownandbecomeavaluedmemberoftheteam.Ataroundthesametime,wehiredStephanieCuellar,andshortlyafterthatAshleyTerHorstasnewSAO’sfortheMolecularBiologyIDP.(Yes,itwasabusyfallquarter!).Inaneworganizationalarrangementforus,Stephanienowtakesprimaryresponsibilityforstudentrecruitment,admissionsandalumnirelationsandAshleyisresponsibleforcontinuingstudentactivitiesandtime‐to‐degreeprogress.BothAshleyandStephaniejoinedusfromotherpositionsatUCLA,whichhelpedthemadapttotheirnewroles.Nevertheless,theyworkedtirelesslytobecomefamiliarwithourMBIcommunityandthenuancesofanIDP,atatimewhentheacademicquarterwasalreadyinfull‐swing.Theirwillingnesstosupporteachotherandworkasateamisahugebenefittotheprogramandgivesusagreatercapacitytosupportallaspectsofourstudents’education.IntheabsenceofanyMBIDPSAO’sduringthesummer,newBioinformaticsSAOMandyMcWeeneyhelddownthefortforbothprograms.Wecouldnothavesurvivedthishectictimewithouther!ShealsogenerouslysharedherknowledgeandexperiencewithStephanieandAshleywhentheyarrived,helpingthemgetuptospeed.As a final summer challenge in theGraduate Programs office,we decided to initiate a remodel, to improve theawkwardconfigurationandcreatethreeentirelyseparateandprivateofficesforourSAOs.TheworktookmuchlongerthanhopedandAshleywasconfinedtotemporaryofficespaceforseveralmonthsaftershestarted.However,I’mhappytoreportthatallthreeSAOsarenowinplaceandwehaveamuchmorefunctionalsuite!Long‐timeBuildingManager,ShawnLockard,retiredfromUCLAattheendof2018.ShawnhadalongandsuccessfulcareeratUCLAandadeepknowledgeofBoyerHall,boththepersonnelandtheinfrastructure.Heleftbigshoestofill.Afteranextensivesearchforhisreplacement,wewerefortunatetofindMichaelKane.MikecameonboardinlateJanuary,bringinghisexperienceinuniversitybuildingmanagementfromMITandabackgroundinconstructionprojectmanagementwhich isproving tobe invaluable inBoyerHall at this time (seehis firstmanagers’ reportbelow!).Mike’sattentiontodetail,enthusiasmtolearnaboutBoyerHallandhiseasy‐goingpersonalityhaveallbeengreatlyappreciatedbyouradminteamandtheFaculty.WealsoappreciatedOrenSaig,ourFacilitiesCoordinatorwhosteppedinasBuildingManageruntilMikewashired.OrencoveredforShawnwiththesameleveloffocusanddedicationhebringstohisownrole,makingsuretherewasminimalimpacttotheresearchersofBoyer.AsaresultwewerehappytorecommendhimforapromotiontoAssistantBuildingManager,arequestwhichwasapprovedrecently.OrenandMikehavedevelopedagreatworkingrelationshipandtheoccupantsofBoyerarefortunatetohavebothofthesededicatedguysintheBuildingManagementoffice.IwouldberemissatthispointtonotmentionLuzTorres,whohaskeptourfinancesonanevenkeelthroughouttheyear.LuzsuccessfullymanagesinternalandexternalfundsfortheMBI,MBIDP,QCBioandBioinformatics,whichrepresents hundreds of payments, reimbursements, transfers and overall budgeting oversight. Luz also plays aleadingroleintrainingjunioradministratorsinfinancialtransactionsandansweringtheirquestionsastheybecomefamiliarwiththeUCLAsystems.ThishasbeenaverybusyyearforLuzandweappreciatehercalmleadershipandoversightofallofouroperations.Luzwillbeinevenhigherdemandnextyear,astheMBIofficemovesintointer‐departmentalgrantssubmissions.Webelievethisisamuch‐neededservicetoourmembersandoneweareuniquelyplacedtoprovide.Moreonthisinnextyear’sreport!

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Finally, a note about QCBio, which continues to grow and evolve. BIG summer, the undergraduate program tointroduceyoungstudentstobioinformaticswelcomedaround40participantsthisyear,fromacrossthecountry.QCBioProgrammanagerJessicaJimenezhastakentheleadinthisinnovativeprogramand,duetoafamilymove,she’snowhandingoverthereinstoLanaMartin.LanajoinedusattheendofJulyandwilltakeoverbothBIGSummerandtheQCBiocollaboratorypostdoctoralteachingprogram.QCBioadministratorMarieGrossettspentalargepartofheryearplanningandrunningtheInternationalSystemsBiologyofHumanDiseasesConference,whichwashosted atUCLA this year.Marie arranged all the conferencelogistics,meals,accommodationandguestspeakers.TheconferencewasabigsuccessandMarie’swarm,hospitableapproachwascommentedonbymanyoftheguests.Asyoucansee,wehadaveryfullyearwithlotsofchanges!We’lllookforwardtoseeingwhatthenewacademicyearbringsourway.

BUILDINGMANAGEMENTMichaelKane,BoyerHallBuildingManager

ProjectsWehadtwoprojectscommenceduringthe2017‐2018academicyearinBoyerHall.(1)LabRenovationinBoyer332forDr.Allard(ISGDept),whichwascompletedinJune,and(2)ConferenceRoomRenovationinBoyer159,whichwillbecompletedbyFallQuarter2018.Thefollowingprojectsareinthedesigndevelopmentphases,andwilllikelybecompletedinthe2018‐2019academicyear:

ElevatorUpgrades–BothBoyerHallelevatorswillhavetheirmechanicalsystemsreplacedandbothcabswillreceiveinteriorrefreshes.ItlookslikeourelevatorupgradewillcommenceintheFallQuarterof2018.Staytuned…

BoyerHallPatioRefresh–Wewillbesprucingupthepationowtheconferenceroomprovidesmoreaccessandvisibility.Improvementswillincludenewfurnitureandlandscapingfeatures.

QCBioWallRelocation–Weareinthedesignphaseforthiswallrelocationproject.Thisminorrenovationwillhelpopenupthecorridoronthe5thfloorandcreatemoreofacollaborativespaceforthe5thfloorlabs.

NewFacultyWeareexcitedtowelcomeDr.PatrickAllardfromTheInstituteforSocietyandGenetics.Dr.AllardjustcompletedhismovefromCHStoBoyerHallinJuneof2018.Dr.AllardandhislabgroupnowresideinBoyerHallRoom332wheretheyresearchenvironmentalimpactsongeneexpressionandtheirrelevancetohealth.BuildingPersonnelChangesIwashiredonasBuildingManagerlateJanuaryof2018.Ithasbeengreatgettingtoknoweveryoneinthebuilding,andIlookforwardtoservingtheBoyerHallresidents.IwouldalsoliketocongratulateOrenSaigonhiswell‐deservedpromotiontoAssistantBuildingManager.OrenhasbeenanexemplaryemployeefromthetimeI’veknownhimandwe’reexcitedtoseehimgrowintohisnewrole.BuildingServicesTherefrigerationunittocoldroom324wasreplaced,thiswasa$20,000maintenanceproject.Wearecurrentlylookingtoadda–20toourfreezerbackupprogramlocatedinthebasementofBoyerHall.BuildingMaintenanceWearecurrentlyworkingwithAssociateViceChancellor,KellySchmader,tomodernizethegeneraluseareasinBoyerHall.Wearehopingtomakeaestheticimprovementstogeneralbuildingareas(corridors,smallconferencerooms,andrestrooms).WearealsoseekingdeferredmaintenancefundsfromthestatetoupgradeDIwaterand

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buildinglabwastelines.Inadditiontothesedeferredmaintenanceprojects,weareworkingtosetupapreventativemaintenanceprogramforthegeneral/sharedareasofBoyerHall.ThiswouldincludeactivitiessuchasregularlyscheduledstrippingandwaxingofthecorridorfloorsandtouchuppaintingthroughoutthesharedspacesofBoyerHall.

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DAVIDS.SIGMANMEMORIALLECTUREThursday,October19,2017

DavidS.SigmanProfessor,BiologicalChemistryandChemistry&BiochemistryThe SigmanLectureshipAwardwas established in2002 tohonor thememory ofDavidSigman,ProfessorintheDepartmentsofBiologicalChemistryandChemistry&Biochemistry,andafoundingmemberandformerAssociateDirectoroftheMBI.Hewasa leader in the fieldofchemicalbiologyatUCLAanddiscoveredchemicalnucleases in a career that illuminated the molecular mechanisms of catalysis. Apermanentlyendowedfundwasmadepossiblebycontributionsfromover200ofProfessor Sigman’s colleagues, friends, and family, as well as corporate donorsincluding theAmgenFoundation,EliLillyandCompany, theBristol‐MyersSquibbFoundation,andRaytheonSystemsCompany.

2017SigmanLectureshipHonoreeYigongShi,Ph.D.VicePresident,TsinghuaUniversityDean,SchoolofLifeSciences,TsinghuaUniversityCo‐Director,Tsinghua‐PekingJointCenterforLifeSciences,BeijingKeynotePresentation“Mechanismofpre‐mRNASplicingbytheSplicesome”AbstractPrecursormessengerRNA(pre‐mRNA)splicing,discovered40yearsago,isanessentialstepintheinformationflowfromDNAtoproteininall eukaryotes.Research efforts of thepast fourdecadeshave led tomoleculardelineationof thesplicingpathway, includingdiscoveryofthenatureandspecificsofthesplicingreaction,definitionofthespliceosomeandidentificationofitscomponents,andbiochemicalanalysisofthevarioussplicingcomplexesandtheirregulation.Structuralinformationiscentraltomechanistic understanding of pre‐mRNA splicing by the spliceosome. X‐ray crystallography of the spliceosomalcomponentsandsubcomplexesiscomplementedbyelectronmicroscopy(EM)oftheintactspliceosome.Inthepasttwoyears,aburstofatomicstructuresontheintactspliceosomeatdifferentstagesofthesplicingcyclehasrevealedunprecedentedmechanisticinsightsintopre‐mRNAsplicing,corroboratingandexplainingalargebodyofgeneticandbiochemicaldata.Thespliceosomeisproventobeaprotein‐directedmetalloribozyme.Inthispresentation,Iwillsummarizemechanisticrevelationsfromrecentstructuraladvancesontheyeastandhumanspliceosomes.Atalunchtimeevent,thefollowingtraineespresentedtheirresearchtoDr.Shi:Presenter PI/Mentor TitleofPresentation

MimiHo PascalEgea/JasmineZhou

“InteractionsandepitopemappinginHumanCytomegalovirusgH/gLPentamercomplex”

DuyoungMin

JimBowie “HowCLCchloridetransporterfolds”

YuxiLiu ToddYeates “ASymmetricMolecularScaffoldforProteinImagingbyCryo‐ElectronMicroscopy”

YiYing DougBlack “SplicingactivationbyanRbfoxproteinrequiresself‐aggregationthroughitstyrosine‐richdomain”

KevinMurray

DavidEisenberg “ComputationalDesignofAmyloidFibril Inhibitors

Honoree Yigong Shi with Sigman Chair Jim Bowie

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AUDREEFOWLERFELLOWHIPSINPROTEINSCIENCE

Dr.AudreeV.FowlerhasbeenadedicatedBruinformorethan60years.Astrongsupporterofthebasicsciences,theperformingarts,andmedicineatUCLA,sherecentlydemonstratedherdevotiontotheCollegeofLettersand Science again by establishing the Audree V. Fowler GraduateFellowshipinProteinScience,tobeadministeredbytheMolecularBiologyInstitute.Since2008,30talentedgraduatestudentshavereceivedthesefellowships.AudreereceivedherB.S.inchemistryfromUCLAin1956andwentontoearn a Ph.D. in biochemistry in 1963, when that field was almostexclusivelymale. She served as aNIHpostdoctoral fellow at theAlbert

EinsteinCollegeofMedicine inNewYorkand inUCLA’sDepartmentofBiologicalChemistrybeforebecomingaresearchbiologicalchemistintheDavidGeffenSchoolofMedicineatUCLA.Shebuiltaneminentresearchcareerwhich includesover80publications. Shealsobuilt strong connectionswith theMolecularBiology Institute, theDepartment of Biological Chemistry in theDavidGeffen School ofMedicine, theUCLAProteinMicrosequencingFacility—wheresheservedasdirectorfor15years—andtheJonssonComprehensiveCancerCenter.SheisoneoffivefoundingmembersoftheAssociationofBiomolecularResourceFacilities(ABRF),whichisnowaninternationalorganizationof1,100members.Shewasnamedthefirstlifetimememberoftheorganizationin2008.AlthoughsheretiredfromUCLAin1999,Fowlerisdeterminedtoremainactive.SheisanavidBruin,maintainingher emeritimembership in theMolecular Biology Institute and serving on the board of directors ofWomen&Philanthropy.ShealsoisontheexecutiveboardofDesignforSharingandtheIrisCantorUCLAWomen’sHealthCenter,andshevolunteeredattheSantaMonicaPierAquarium—formerlytheUCLAOceanDiscoveryCenter.SheexpandedherinvolvementbygivingtoursofthePalisadesParkhostedbytheSantaMonicaconservancyandoftheMarionDaviesBeachHouse.The Audree V. Fowler Graduate Fellowships in Protein Science serves as a fitting testament to Dr. Fowler’scommitmentanddedicationtoherresearchandtoUCLA.ThefellowshipsareawardedtopromisingPh.D.candidatesworkinginproteinscience.ThecrucialresourcesprovidebytheawardadvancetheeducationoftheFowlerFellowsbyenablingthemtoconcentrateontheirinnovativeresearch.

“ThesciencesgavemeagreatlifeandnowIwanttohelpotherstohavethesameopportunitiesIenjoyed.”2017‐18Recipients

Michael Hughes (Eisenberg Lab) “Structural insights into low-complexity domains & non-membrane bound organelles”

KanishkJain(ClarkeLab)“Understandingproteinargininemethyltransferasesandtheirbiochemicalmechanisms”

WilliamBarshop(WohlschlegelLab)“MilkyWay:AProteomeBioinformaticsPlatform,anditsApplicationinDevelopmentofProteolyticDigestionResistantAffinityPurificationBeads”

YuxiLiu(YeatesLab)“CharacterizationofNaturalandEngineeredSymmetricProteinOligomers”Moreinformationaboutthisyear’srecipientsandtheirresearchcanbefoundwww.mbi.ucla.edu/fowler‐fellows.

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JULESBRENNERACHIEVEMENTFELLOWSHIPINMOLECULARBIOLOGY

Jules Brenner has worked in thecinematography division of themotionpictureindustryfromtheendofhismilitaryservicein1959totheday of his retirement in 1996,startingasacameraassistant/loaderat Warner Bros up to Director ofPhotography(1968‐1991)withsuchfilm credits as Dalton Trumbo's“Johnny Got His Gun,” John Milius’“Dillinger,”twoearlyepisodesoftheMacGyverTVseriesandthecultfave,“TheReturnoftheLivingDead.”(Hisfullcredit list isavailableonIMDB).He is a voting member of theAcademyofMotionPictureArts&Sciences(AMPAS)andservesasajudgeintheirNichollFellowshipScreenwritingCompetition.Since retirement he has been active as a motion picture and book reviewer, accredited by theMotion PictureAssociationofAmerica(MPAA)asaprintandonlinefreelancejournalist.HisreviewshavebeenpublishedinprintpublicationssuchasMysterySceneMagazine,andallaroundthewebonsuchsitesas filmcritic.com,Paste.com,About.com,andothers inaddition tohisownsites,CinemaSignalsandCriticalMysteryTour.HisreviewblurbsappearonRottenTomato.HehaslecturedonScreenwritingforColumbiaCollegeofChicago,StudioCitycampus.HewritescodeinHTML,VisualBasicandASMandlovesswimming,scubadiving,andweighttraining.Hisaddictionsaremoviesandreadingandhehasanintenseinterest,strictlyasalayman,inthesciences.

Awardees (L-R) Michael Hughes, Yuxi Liu, Kanishk Jain and William Barshop, with Dr Fowler.

Past and present Brenner Fellows: Lulan Wang (2016), Courtney Young (2017) and Aimee Flores (2018) with Mr. Brenner

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Mr. Brenner believes that Molecular Biology is where thefuture lies and has provided a gift to recognize oneoutstanding student that has advanced the discipline. Theawardee was selected by a committee of distinguishedfacultyandbyMr.Brenner,whoalsointroducedtheawardin a video presentation at the Annual MBI Retreat, April,2017.2018Recipient AimeeFlores(LowryLab)

BOYER/PARVINPOSTDOCTORALRESEARCHAWARDSMBIFoundingDirectorPaulBoyerhadadeepregardforpostdoctoralresearchers.Heappreciatedthededication,intellectandskilltheybringandtheimpactoftheirresearchonscientificprogress.ItwasinthisspiritthatDrBoyerdonatedaportionofhis1997NobelPrizetoestablishthePostdoctoralAwards.Additionalsupportfromhislong‐timecolleagueJamesPeter,fromPhyllisParvinonbehalfoftheParvinFoundationandfromAmgenInc.createdanopportunitytorecognizeover100exceptionalresearchersinChemistry,BiochemistryandMolecularBiology,forthepast16years.TheParvinFoundationhasbeenatirelesssupporterofmolecularbiologyresearchsincethegiftof$1millionmadetheMolecularBiologyBuilding(nowPaulD.BoyerHall)possible.FoundationPresidentPhyllisParvincontinuestobeanavidsupporterofthepostdoctoralawards.ThankstotheParvinFoundation,AmgenIncandindividualdonorswho believe in the value of postdoctoral research, we are able to continue the tradition of recognizing theseexceptionalscientists.

Therecipientsofthesethreeawardswere:

FrancisMercer,Ph.D.Mentor:Prof.PatriciaJohnson;Microbiology,Immunology&

MolecularGenetics

MarcusSeldin,Ph.D.Mentor:Prof.A.JakeLusis;Cardiology

MichaelHicks,Ph.D.

Mentor:Prof.AprilPyle;Microbiology,Immunology&MolecularGenetics

ThanksgotothemembersoftheSelectionCommittee,KarenReue,JoseRodriguez,OliverFregosoandHilary

Coller,fortheirextensiveeffortsinselectingthewinners.

Aimee receiving her award from Mr. Brenner

(L-R) Awardees Marcus Seldin, Francis Mercer and Michael Hicks

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RESEARCHSEMINARSERIES

ThisseminarseriescontinuestobeafocalpointofMBIactivities.The2017‐2018scheduleincludednationalandinternationallyrenownedspeakers,invitedandhostedbyMBIFacultyandstudentsfromtheMBIDPprogram.

Date Speaker Institution(s) Title Host

10/5/2017 LianaLareau,Ph.D. CaliforniaInstituteforQuantitativeBiology,UniversityofCalifornia,

Berkeley

“RibosomeDynamicsCapturedbyDeepSequencingandDeepLearning”

MBIDPstudents(GREATHomeArea)

10/12/2017 ElcinUnal,Ph.D. UniversityofCalifornia,Berkeley

“MeioticDifferentiation:UncoveringUniqueModesofGeneRegulationand

OrganelleRemodeling”

SriKosuri

10/19/2017 YigongShi,Ph.D. TsinghuaUniversity,Beijing

"Mechanismofpre‐mRNASplicingbytheSpliceosome"

JimBowie/ReidJohnson

10/26/17 RaymondDeshaies,Ph.D.

AmgenandCaliforniaInstituteof

Technology

"TheAdaptiveExchangeHypothesis:DynamicSpecificationoftheSCFUbiquitinLigaseRepertoireby

Substrate"

SteveYoung

11/2/2017 PeterJackson,Ph.D.

StanfordUniversitySchoolofMedicine

"Reformulatingadipogenesis:CilarytraffickingofafattyacidGPCRactivatescAMP‐dependent

differentiationofmesenchymalstemcells"

JorgeTorres

11/9/2017 LeonardZon,M.D. Children'sHospitalBoston,HarvardMedicalSchool

HowardHughesInvestigator

"Pathwaysregulatinghematopoieticstemcellself‐renewalandmigration"

CarlaKoehler

11/16/2017 TamirGonen,Ph.D. Investigator,HowardHughesMedicalInstituteDepartmentofBiological

Chemistry

"MicroEDopensaneweraforbiologicalstructuredetermination"

DougBlack

11/30/2017 RaymondStevens,Ph.D.

UniversityofSouthernCalifornia

"Anewapproachtowardsdiabetesstructurebaseddrugdiscovery"

RonKaback

12/7/2017 ChristopherLima,Ph.D.

MemorialSloanKetteringCancerCenter

"NuclearqualitycontrolandtheRNAexosome"

TracyJohnson&DougBlack

1/11/2018 DavidRawlings,M.D.

SeattleChildren'sHospitalUniversityofWashington

"Engineeringhumanlymphoidcellsfornovelclinicalapplications"

MBIDPstudents(IMMPHomeArea)

1/18/2018 KarenAdelman,Ph.D.

HarvardMedicalSchool "TranscriptionasaCentralHallmarkofActiveEnhancers"

TracyJohnson

1/25/2018 VamsiMootha,M.D.

HarvardMedicalSchool,

"GenomicsApproachestoMitochondrialBioenergetics"

SteveYoung&SabeehaMerchant

2/1/2018 ScottKeeney,Ph.D. HHMIMemorialSloanKetteringCancerCenter

HowardHughesInvestigator

"BreakingPar:SexChromosomeRecombinationinMaleMeiosis"

TracyJohnson

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2/8/2018 MichelGoedert,M.D.,Ph.D.

MedicalResearchCouncil,UniversityofCambridge

"SynucleinopathiesandTauopathies" DavidEisenberg

2/22/2018 WilliamA.PetriJr.,M.D.,Ph.D.

UniversityofVirginia

"RoleofHumanGenetics,environmentandmicrobiomeinsusceptibilityto

amebiccolitis"

PatriciaJohnson

3/1/2018 EmanuelaGussoni,Ph.D.

HarvardMedicalSchool "TetraspaninCD82inMuscleStemCellsandMuscularDystrophy"

MBIDPstudents

(CDBHomeArea)

3/8/2018 OlgaBoudker,Ph.D.

CornellUniversity "GlutamateTransporterDynamics:HowFastCanItGo?"

JimBowie

3/15/2018 StevenBoxer,Ph.D. StanfordUniversity "Reactions,Interactions,DynamicsandMassSpecImagineinModelBiological

Membranes:VirusesandRafts"

SteveYoung

4/12/2018 SophieDumont,Ph.D.

UniversityofCalifornia,SanFrancisco

"CellDivision:MechanicalIntegritywithDynamicParts"

MargotQuinlan

4/19/2018 HanaElSamad,Ph.D.

UniversityofCalifornia,SanFranciscoSchoolof

Medicine

"CellularFeedbackControl‐WhatDoAlltheLoopsDo?"

MargotQuinlan(MBI)&

VanSavage(QCB)

4/26/2018 RoyParker,Ph.D. UniversityofColorado,Boulder

"RNPGranulesinHealthandDisease" MingGuo

5/3/2018 GregoryAlushin,Ph.D.

TheRockefellerUniversity "Cytoskeletalstructuralplasticityinforcegenerationandmechanosensation"

HilaryColler

5/10/2018 PhotiniSinnis,M.D. JohnsHopkinsBloombergSchoolofPublicHealth

"Establishment ofMalariaInfection:ParasiteBottleneck&Pointfor

Intervention

PeterBradley

5/17/2018 TimStearns,Ph.D. StanfordUniversity "CentrosomesandCilia:FromSingleMoleculestoNewModelOrganisms"

MargotQuinlan

5/24/2018 JayKeasling,Ph.D. UniversityofCalifornia,Berkeley

"EngineeringMicroorganismsforProductionofIsoprenoidNaturalProductsandSomeNot‐So‐Natural

Products"

MBIDPstudents(BBSBHomeArea)

5/29/2018 AngeliqueBordey,Ph.D.

YaleSchoolofMedicine "UnderstandingHowMTORHyperactivityLeadstoEpilepsyand

BehavioralDeficits"

YeZhang(MBI)&

ChrisEvans(BRI)

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FACULTYRESEARCHSEMINARSERIES

Theseinformalpresentationscontributetoourscientificprogressandenableourmembershiptokeepup‐to‐dateoncurrentresearchdevelopmentsbytheMBIfaculty.

Date MBIFacultyMember Department Title

10/3/2017 LuisaIruela‐Arispe,Ph.D.

MCDB "StateoftheMBI2017:Agrowingmembership,newstaff,facilityrenovationsandmore..."

10/10/17 PatrickAllard,Ph.D. InstituteforSocietyandGenetics

"MechanismsoftransgenerationalinheritanceofenvironmentalexposuresinC.elegans"

10/17/17 ManishButte,Ph.D. PedAllergy/Immunology

"PullingouttheStopsinT‐cells"

10/24/2017 DonPuppione,Ph.D. EmeritusProfessor "CombiningproteomicswithgenomicstolookattheevolutionofmammalianapoC‐I"

10/31/2017 GeraldLipshutz,M.D.,D.D.S.

Surgery,Endocrinology,DiabetesandHypertension,

Molecular&MedicalPharmacology

"TrialsandTribulationswithArginase:ProgressinGeneandCellTherapyforitsDeficiencyandDefiningitsPossibleCellAutonomousRolein

NeuronalDevelopment"

11/7/2017 AliceSoragni,Ph.D. Hematology‐Oncology "Proteinaggregationincancer:p53andbeyond"

11/14/2017 MatteoPellegrini,Ph.D. MCDB "WhatcanDNAmethylationtellusaboutmetabolicsyndrome?"

11/28/2017 JoseRodriguez,Ph.D. Chemistry&Biochemistry

"StructuresofMammalianPrion"

12/05/2017 BrigetteGomperts,M.D.

Pediatrics,Hem/Onc "MaintainingMucociliaryClearance‐ theCriticalRoleofAirwayBasalStemCells"

1/9/2018 GraceAldrovandi,M.D. Pediatrics‐InfectiousDiseases

"Moms,MilkandMicrobes:HowtoBuildHealthyBabies"

1/30/2018 HongZhou,Ph.D. MIMG "StructuralstudiesofHumanHerpesViruses"

2/6/2018 MargotQuinlan,Ph.D. Chemistry&Biochemistry

"CytoskeletalControlofCellPolarityintheDrosophilaOocyteandOtherActinNews"

2/13/2018 AmanderClark,Ph.D. MCDB "MolecularRegulationofHumanGermCellFormation"

2/20/2018 FengGuo,Ph.D. BiologicalChemistry "RNAStructuresandmicroRNABiogenesis"

2/27/2018 LilyWu,M.D.,Ph.D. Molecular&MedPharmacology

"Tumorheterogeneityandmetastaticprogressioninrenalcellcarcinoma"

3/6/2018 ToddYeates,Ph.D. Chemistry&Biochemistry

"GiantProteinAssembliesinNatureandByDesign"

3/13/2018 YousangGwack,Ph.D. Physiology "CalciumSignalingComponentsinInnateImmunity"

3/20/2018 LouisBouchard,Ph.D. Chemistry&Biochemistry

"TechnologyDevelopmentforPreciseModulationofT‐CellsFate,TissueEngineering,Mechanosensing

andOtherStories"4/3/2018 ElissaHallem,Ph.D. MIMG "Host‐SeekingBehaviorsofParasiticNematodes"

4/10/2018 SriKosuri,Ph.D. Chemistry&Biochemistry

"SyntheticApproachesforUnderstandingBiology"

4/17/2018 LuisaIruela‐Arispe,Ph.D.

MCDB "MBIDPUpdate‐ReporttotheFaculty"

4/24/2018 RenSun,Ph.D. Molecular&MedPharmacology

"RationalVaccineDesignEnabledbyHighResolutionGeneticMapsofViralGenomes"

5/1/2018 JosephLoo,Ph.D. Chemistry&Biochemistry

"Pushing(andImaging)theBoundariesofProteinMassSpectrometryBeyondSequencingtoStructural

Biology"5/8/2018 JeromeZack,Ph.D. Hem‐ Onc/MIMG "DevelopinganApproachtoPurgeHIVReservoirs"

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5/15/2018 PeterTontonoz,M.D.,Ph,D.

Path&LabMed "LipidTransportPathwaysinPhysiologyandDisease"

5/22/2018 MichaelCarey,Ph.D. BiologicalChemistry "GeneUnitSub‐Tads:HowESCellEnhancersInteractwithPromoterswithinthe3DGenome"

MBIANNUALRETREAT&RESEARCHCONFERENCE

The MBI Retreat is organized each year bystudent representatives from the MolecularBiology Interdepartmental Ph.D. Program, theCellular&MolecularBiologyTrainingProgramand the Cell‐Biology Interface TrainingProgram. The program offers the opportunityfortheMBIcommunity;students,postdocsandfaculty, to gather together to celebrate thediversityof intellectualpursuits thatcomprisemodernmolecularbiologyatUCLA.The40thMBIAnnualretreatwasheldonMarch17‐18,2017theCrownePlazaVenturaBeach.169peopleattendedtheretreat,including146graduatestudentsand23facultymembers.44students presented posters and 10 studentsgaveoralpresentations.Oneofthehighlightsofthisyear’sretreatwasthepresentationbyourKeynote Speaker, Dr. Michael Snyder from

StanfordUniversity.Anotherhighlightof theretreatwastheCareerPanel,whereprofessionals fromacademiaandindustryoutlinedtheircareerpathsandgaveprofessionaldevelopmentadvicetothestudents.

Panelists with student host Jessica Ochoa

Thepaneliststhisyearwere:

EdwinSaada(SandiaNationalLaboratories) JenniferLovick(SAGEPublishing) DavidLeibly(ADRx)

Retreat Committee Chair Geoff Pronovost talks to fellow students at the retreat poster session.

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EmilyLowe(KitePharma/Gilead)

Theretreatprogramalsoincludedtimetorelaxandenjoythebeautifullocation.TheHomeArea“HouseCup”wasextremelypopular,which includedagameof tug‐o‐waronthebeach,withGeneRegandIMMPtyingtoendtheevents.We were grateful for the financial support of several UCLA Departments: Biological Chemistry; Chemistry andBiochemistry;MCDB;MIMG;PathologyandLaboratoryMedicine,andtheDavidGeffenSchoolofMedicine,BroadStemCellResearchInstitute,andJonssonComprehensiveCancerCenter,whomadethisretreatpossible.Also, avery specialTHANKYOU toourbenefactorsDr.AudreeFowler,Dr.GarryMiyadaand JulesBrenner, forbelievingthatinvestingingraduateeducationisthepathtoabetterfutureforall.

RETREATSCHEDULE

Saturday,March17,2018KeynoteAddressIntroduction

GuillaumeUrtecho

1:30–2:30PM MichaelSnyder,Ph.D.StanfordUniversity”BigDataandHealth”

SessionIChair:ManishButte,M.D.,Ph.D.2:30–2:50PM AanandPatel(QuinlanLab)2:50–3:10PM AdewunmiAdeleja(HoffmannLab)3:10–3:40PM DonaldKohn,M.D.CareerPanelModerator:JessicaOchoa4–5PM Q&AwithPanelists:

EmilyLowe(KitePharma/Gilead)EdwinSaada(SandiaNationalLaboratories)DavidLeibly(ADRx)JenniferLovick(SAGEPublishing)

5:30–7PM DinnerandPresentationofStudentAwards7–8:30PM PosterSession8:30–11PM PubTrivia

Sunday,March18,2018SessionIIChair:AndrewGoldstein,Ph.D.9:30–9:50AM GuillaumeUrtecho(KosuriLab)9:50–10:10AM ThangNguyen(TeitellLab)10:10–10:40AM SiavashKurdistani,Ph.D.SessionIIIChair:OliverFregoso,Ph.D.10:50–11:10AM JaspreetSandhu(TontonozLab)11:10–11:40AM StephanieDemarco(HillLab)

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11:40–12:10PM MargotQuinlan,Ph.D.GraduateStudentAwards1:30PM PosterAwardPresentationsFowlerFellowshipAwardPresentationsIntroduction AudreeFowler

1:40–2PM MichaelHughes(EisenbergLab)2–2:20PM KanishkJain(S.ClarkeLab)2:20–2:40PM WilliamBarshop(WohlschlegelLab)2:40–3:00PM YuxiLiu(YeatesLab)3–3:30PM KathrinPlath,Ph.D.

ClosingRemarks DirectorLuisaIruela‐Arispe,Ph.D.

MB‐IDPHouseCup3:40–4:45PM WaterBalloonToss,TugofWar,FlagTag,

Cornhole

BIOTECHNOLOGYEDGEWORKSHOPMBI&AmgenInc.

March26th‐30th,2018theMBIcollaboratedwithresearchersatAmgentoholdthe3rdAnnual“BiotechnologyEdge”Workshop. Theworkshop provided an opportunity to learn firsthand about the biotechnology industry,

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includingallaspectsofthedrugdiscoveryprocessandthewaysinwhichtraineescanprepareforacareerintheprivatesector.Duringthefirstfourdays,seniorAmgenscientistscametoUCLAtogivepresentationsonvariousaspectsofdrugdesignandtesting.Theyalsospoketotheaudienceaboutpreparingforcareersinbiotechnology.OnthelastdayoftheworkshopthetraineestraveledtoThousandOakstotourAmgenlabstointeractwithdirectlygroupleadersandjuniorresearchersandseefirst‐handhowthelatesttechnologiesarebeingusedtomovepotentialtherapeutics through the pipeline. The entire workshop was extremely popular and only 30 trainees could beaccommodatedduetospacelimitationsontheAmgentour.

FOCUSINIMAGINGWORKSHOPMBI,CNSI,CarlZeissMicroscopy&Bitplane

HeldAugust1stthrough4th,the“FocusonImagining”workshop,providedessentialhands‐ontraininginthebasicprinciplesofmicroscopy,confocal,electronmicroscopyandImaris3D/4Dvisualizationandanalysis.ThiswasthethirdworkshoporganizedincollaborationwithpartnersatZeissandBitplane,whoprovideequipmentandexperttrainingpersonnel.Eachsessionwas2hourslongandwasofferedonmultipledaysandtimestoaccommodateasmanyaspossible.BitplaneSpecialistLynseyHamilton,Ph.D,gaveanintroductoryseminarfortheIMARISTrainingonthefinalday.55traineesandfacultyattended.

TRAININGSESSIONSCHEDULE

Tuesday–August1stPrinciplesofMicroscopy1pmand3:30pmConfocalMicroscopy1pmand3:30pmElectronMicroscopy1pmand3:30pmWednesday–August2ndPrinciplesofMicroscopy9:30am,1pmand3:30pmConfocalMicroscopy9:30am,1pmand3:30pmElectronMicroscopy9:30am,1pmand3:30pmThursday–August3rdPrinciplesofMicroscopy9.30am,1pmand3.30pmConfocalMicroscopy9.30am,1pmand3.30pmElectronMicroscopy9.30am,1pmand3.30pmFriday–August4thBoyerHall130IntroductorySeminar 10am“Exploreyour3DdatawithImaris”LynseyHamilton,Ph.D.BitplaneSpecialistIMARISTrainingSessionsIntroductorySessionsFridayAugust4th1pm–2pm:Imaris3Drendering&animationsFridayAugust4th2pm–3pm:ImarisAutomatedobjectdetection,countingandvolumetricstatistics

AdvancedSessionsFridayAugust4th3.30pm–4.30pm:ImarisColocalizationanalysistechniquesFridayAugust4th4.30pm–5.30pm:ImarisNeuronTracing,Q&A

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MOUSEGENOMEINFORMATICSWORKSHOP

Afterashorthiatus,theMBIreconveneditspopularmousegeneticsandgenomeinformaticsworkshop.The2hourworkshopwasheldonTuesdayMarch20,2018andleadbyDr.MeiyeeLaw,OutreachCoordinatoratJacksonLabs.Dr.Lawbeganbycoveringbasicconceptsofmousegenetics,datastructures,pagenavigationintheMGIdatabase(www.informatics.jax.org)andbatchdatamining/analysis.Inthesecondhalfoftheworkshop,sheleadparticipantsthroughpracticalexamples todemonstratehowtheMGIdatabasecouldbeused toanswerbiologicalquestions.Attendeesalsoreceivedone‐on‐oneassistancewithanalyzingtheirowndata.Theworkshopwasextremelypopularandregistrationreachedtheroomcapacityof60,withawaitinglistforopenspots.Giventheinterestinthisarea,andwiththesupportofJacksonLabswehopetoofferthisworkshopannually.

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NEWMBIMEMBERS

JustineC.Lee,MD,Ph.D.,FACSAssociateProfessor,PlasticandReconstructiveSurgerywww.uclahealth.org/JustineLeeDr.Leeisacraniofacialsurgeon‐scientist.Herresearchprogramincludesabasicscienceandclinicalcomponentfocusedoncraniofacialreconstructionandinvestigatingpracticalsolutionsfordefectsofthecraniofacialskeleton.Herbasicworkisfocusedonunderstandinganddevelopingmaterials‐basedcalvarialboneregenerationstrategiesforrapidtranslation.Herclinicalworkisfocusedonoutcomesofcraniofacialsurgerywithaparticularemphasisonpediatriccongenitalanomalies.SheisfundedbytheJeanPerkinsFoundation,theBernardG.SarnatEndowment,thePlasticSurgeryFoundation,andtheUSDepartmentofVeteransAffairs.Dr.LeegraduatedsummacumlaudefromUCLAwitha

BachelorsofScienceinMolecular,Cell,andDevelopmentalBiology.Subsequently,shereceivedherMDandPhDfromtheUniversityofChicago.ShecompletedherplasticandreconstructivesurgeryresidencyattheUniversityofChicagoandreturnedtoUCLAforhercraniofacialsurgeryfellowship.SheistheBernardG.SarnatEndowedChairforCraniofacialBiology.InadditiontoherworkatUCLA,sheishighlyactiveinbothnationalandinternationalreconstructivesurgeryorganizations.SheservesasAssociateEditorforAnnalsofPlasticSurgery,SectionEditorinCraniofacialSurgeryfortheCleftPalate‐CraniofacialJournal,andSectionEditorinPlasticandReconstructiveSurgeryfortheCleftPalate‐CraniofacialJournal.

MelodyLi,Ph.D.AssistantProfessor,Microbiology,ImmunologyandMolecularGeneticswww.melodylilab.orgDr.Liisamolecularvirologistandherlaboratorystudieshostdefensestrategiesthatcontrolinfectionswitharthropod‐borneviruses(arboviruses),whichhavecauseddevastatingoutbreaksinrecentyears.Viralinfectionstimulatestheproductionofinterferon,resultingintheexpressionofalargeanddiverserepertoireofinterferon‐stimulatedgenes.However,mostofthesegeneshavenotbeencharacterized.Ingraduateschool,Dr.LielucidatedthefunctionalconsequencesofhumanpolymorphismsintheAPOBEC3Hgene.Herworkwasamongthefirststudiestoestablishananti‐HIV‐1roleforhumanAPOBEC3Hinvivo.Herpostdoctoralworkontwointerferon‐inducedproteins,ZAPandIRF2,

advancesourunderstandingofhostmechanismsthatinhibitviraltranslationandpromoteclearanceinthecentralnervoussystem.Herlaboratoryiscurrentlyinvestigatingthemechanismandregulationofbroad‐spectrumantiviralfactorswiththehopethattheywillinformdevelopmentofnoveltherapeuticsagainstre‐emergingarboviruses.Dr.LireceivedherPhDinMicrobiologyfromUniversityofWashington,Seattlein2011.ShesubsequentlycompletedherpostdoctoralworkatRockefellerUniversityin2017andstartedherowngroupatUCLAinthefallof2017.

TheodorosKelesidis,M.D.,Ph.D.,M.Sc.AssistantProfessor,Medicine–InfectiousDiseaseshttps://www.uclahealth.org/theodoros‐kelesidisDr.Kelesidisisatranslationalphysician‐scientistfocusingonimmunopathogenesisofinfectiousdiseases.HislaboratoryusesavarietyofinvitroandinvivomodelstoinvestigatenovelmechanismsofHIV‐relatedinflammationandimmunedysfunctionandhowtheydriveendorgandiseasesuchasatherosclerosis.InadditiontoHIV,Dr.Kelesidis’researchinterestsincludeinfectionsinimmunocompromisedpatientsandantimicrobialresistance.Dr.KelesidisreceivedhisMDfromUniversityinAthens,GreeceandhisPhDfromUniversityofCaliforniaLosAngeleswherehealsodidhisfellowshipininfectiousdiseases.HehasalsoreceivedanM.ScintranslationalresearchfromUCLA.Heis

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currentlyanAssistantProfessorofMedicineattheDepartmentofMedicine,DivisionofInfectiousDiseasesatUCLA.

SiobhanABraybrook,Ph.D.AssistantProfessor,Molecular,Cell,andDevelopmentalBiologyhttps://www.mcdb.ucla.edu/faculty/siobhanbDr. Braybrook is a developmental biologist who specializes in themechanicalproperties of cells and tissues as they relate to growth. She collaborateswithmathematicians, computer modellers, and engineers in order to addressthephysicalbiologyofgrowth.Hermajorstudysystemsareplantsandbrownalgae,with recent forays into immunology and cancer. The lab currently focuses onmechanisms of pH‐induced growthmechanics, anisotropic cell elongation, thebiomechanics of biological gels, andmorphometric analysis of cell shapes. Dr.BraybrookreceivedherPh.D.fromUCDavis.ShecompletedaresearchfellowshipattheUniversityofBern(CH)beforestartingaresearchgroupatTheUniversity

ofCambridge(UK).In2017,thelabmovedtoUCLA.

TamirGonen,Ph.D.Professor,BiologicalChemistryhttps://cryoem.ucla.edu/Dr.GonenisanexpertinelectroncrystallographyandcryoEM.Hedeterminedthe1.9Åresolutionstructureofthewaterchannelaquaporin‐0byelectroncrystallography,thehighestresolutionforanyproteindeterminedbycryoEMtechniquesatthetime.DrGonenestablishedhisownlaboratoryattheUniversityofWashingtonin2005togetherwiththeveryfirstcryoEMlaboratoryinthePacificNorthwest,aresourcethatcontinuestobenefitmanyresearchersattheUWSchoolofMedicineandbeyond.MorerecentlyDrGonenwashonoredwithaCareerDevelopmentawardfromtheAmericanDiabetesAssociation,becameaMemberoftheRoyalSocietyofNewZealand,aswellasbeingchosenoneofonly50HowardHughesMedicalInstituteEarlyCareer

Scientistsaroundthecountry.In2011DrGonenacceptedapositionasaGroupLeaderattheHHMIJaneliaResearchCampuswherehebegandevelopingMicroEDasanewmethodforstructuralbiology.WiththismethodDrGonenhaspushedtheboundariesofcryoEManddeterminedseveralpreviouslyunknownstructuresatresolutionscloseto1Å.In2017DrGonenmovedhislaboratorytotheDavidGeffenSchoolofMedicineoftheUniversityofCalifornia,LosAngelesasanInvestigatoroftheHowardHughesMedicalInstituteandaProfessorofBiologicalChemistryandPhysiology,wherehecontinuesstudyingmembraneproteinstructureandfunctionusingcryoEMandMicroED.DrGonenauthoredmorethan100publicationsandseveralofhispasttraineesarenowfacultyaroundtheworldattopuniversities.

TimO’Sullivan,Ph.D.AssistantProfessor,Microbiology,Immunology,andMolecularGeneticshttp://www.mbi.ucla.edu/faculty/tim‐osullivan/Dr. O’Sullivan is an Assistant Professor of Microbiology, Immunology, andMolecular Genetics. He received his Bachelors of Science Degree (B.S.) fromCornell University and his Doctor of Philosophy Degree (Ph.D.) in BiomedicalSciencefromtheUniversityofCaliforniaSanDiego.Dr.O’Sullivan’sthesisworkfocusedontheinteractionsbetweentheinnateimmunesystemandcancer.Dr.O’Sullivan subsequently completed his American Cancer Society postdoctoralfellowshipatMemorialSloanKetteringCancerCenterwherehestudiedtheroleofcirculatingandtissue‐residentinnatelymphoidcells(ILC)duringviralinfectionanddiet‐inducedobesity.Dr.O’SullivanestablishedhisownlaboratoryatUCLA

in2017.TheO’Sullivanlabisdedicatedtounderstandingthemolecularmechanismsresponsibleforprotectiveorpathologicimmuneresponsesduringcancer,viralinfection,andobesity.

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TamerSallam,MDPh.D.AssistantProfessor,MedicineDr.Sallamisacardiovascularphysician‐scientistinvestigatingtherelationshipbetweengeneticdiversityandcommoncardiovascularproblemssuchasdyslipidemia,obesityandheartdisease.Dr.Sallam’spreviousworkhasprovidedfundamentalinsightsintomechanismscontrollingcholesterollevelsandphysiologicrolesofnewlyrecognizedgenesknownaslongnon‐codingRNAincardiovasculardisease.ThroughmultipleindependentgrantshislabiscurrentlyinvestigatingthecontributionsoflongnoncodingRNAsincardiovascularriskfactorsanddisease.Dr.SallamcompletedresidencyandchiefresidencytrainingatYale,followedbycardiologyfellowshiptrainingatUCLA.Dr.SallamgraduatedfromtheSTARprogramatUCLAearningaPhDintheLab

ofPeterTontonoz.Dr.SallamhasbeenawardedtheLaurenB.LeichtmanandArthurE.LevineinvestigatorshipatUCLA.HeistherecipientoftheAmericanCollegeofCardiologyPresidentialCareerDevelopmentAward,BurroughsWellcomeFundCareerAwardforMedicalScientists,andAmericanSocietyforClinicalInvestigationYoungInvestigatorAward.Dr.Sallamcurrentlyservesasco‐directoroftheUCLAcenterforCholesterolManagementandAssistantDirectoroftheUCLASpecialtyTrainingandAdvancedResearch(STAR)Program.

JesseZamudio,Ph.D.AssistantProfessor,Molecular,Cell,andDevelopmentalBiologyJesse Zamudio received his bachelor's degree from UCLA in Chemistry &Biochemistry. He received his Ph.D. from UCLA in the Department ofMicrobiology,ImmunologyandMolecularGeneticsworkinginthelaboratoryofDr.DavidCampbellandDr.NancySturm.Forhisthesiswork,hecharacterizedthe first eukaryotic messenger RNA (mRNA) ribose cap methyltransferases.AlthoughpresentinboththeuniquemRNAcapstructureofhumanpathogenicKinetoplastidprotozoaandhumanmRNA,theproteinsresponsibleforeachhadnot been discovered. Based on evolutionary sequence conservation to knownviral proteins, they were able to characterize a conserved eukaryotic proteinfamily responsible for thesemodifications and determine their role inmRNAbiogenesisandproteintranslationinkinetoplastids.Thesestudieshaveaidedthe

investigation of the human cap ribose methyltransferases implicated in early development. Jesse pursued hispostdoctoral research in the laboratory of Dr. Phil Sharp at the MIT Cancer Center. His research focused onquantitativeapproachestocharacterizeRegulatoryRNAsinembryonicandadultstemcells.HeaimedtoconfidentlyassayregulationbythemammalianRNAinterference(RNAi)pathwayandindoingsodiscoverednewclassesofmammaliansmallRNAsandprinciplesdeterminingregulatoryactivity.Currentresearchinthelabis focusedoncharacterizingfunctionalRNAsinthecontrolofcellstatetransitionsduringdevelopmentandcancerprogression.

De‐ChenLin,Ph.D.AssistantProfessor,Cedars‐SinaiMedicalCenterAdjunctAssistantProfessor,UCLASchoolofMedicineDr.Linhasabroadbackgroundincancergeneticsandbiology,withspecifictrainingandexpertiseinfunctionalgenomicstudyaswellastranscriptionalregulation.Themajorfocusofhisworkisidentifyingkeygenomicandepigenomicabnormalitiesinhumanmalignanciesandtranslatingthesefindingsintonovelclinicalmanagements.Tofacilitatethisresearch,hehasestablishedanddevelopedavarietyoffunctionalgenomicapproachesaswellascomputationalalgorithms.Withthesetoolsandcomprehensivebiologicalstudies,Dr.Linuncoveredimportantgenomicandepigenomicaberrationswhichpromotemalignantphenotypes.

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MBIFACULTYHONORS&PROFESSIONALAWARDS

Bannerjee,Utpal ElectedMember,NationalAcademyofSciences

Bitan,Gal UCLAInauguralUndergraduateResearchWeekFacultyMentorAward

Bowie,James ElectedFellowoftheBiophysicalSociety,AcademiaSinicaChohHaoLiMemorialLecture

Clarke,Steven WilliamC.RoseAwardoftheAmericanSocietyofBiochemistryandMolecularBiology

Coller,Hilary CancerResearchInstituteClinicalandLaboratoryIntegrationProgramAwardDepartmentalNomineeforUCLADistinguishedTeacherAwardAnna‐MariaandStephenKellenFoundation‐MelanomaResearchAllianceTeamScienceAwardUCLAUndergraduateResearchFacultyMentorAward

DeRobertis,Edward 50thAnniversaryLectureoftheJapaneseSocietyofDevelopmentalBiology90thAnniversaryLectureforInstitutoClementeEstable

Eisenberg,David PaulSiglerPrize,YaleUniversity

Ernst,Jason NIH/NIDAAvenirAward, RoseHillFoundationInnovatorAward

Goldstein,Andrew AmericanCancerSociety2018GiantsofScienceHopeAward

Gonen,Tamir HHMIInvestigator

Guo,Ming GlennFoundationforMedicalResearchAward

Hoffmann,Alexander KeynoteSpeaker,InternationalConferenceonIntelligentBiologyandMedicine

Iruela‐Arispe,Luisa NIH/NHLBIOutstandingInvestigatorAward(R35)

Johnson,Tracy Chair,KeithandCeciliaTerasakiEndowed;LifeSciencesAwardforExcellenceinPromotingDiversityandInclusionThroughService,Teaching,MentoringandResearch

Kohn,Donald LifetimeAchievementAward,thePediatricBlood&MarrowTransplantConsortium

Kurdistani,Siavash W.M.KeckFoundationAward

Lipshutz,Gerald EndowedChair

Novitch,Bennett EthelScheibelChairinNeuroscience;AblonScholarsAward(JCCC/BSCRC)

Pyle,April AblonAward

Quinlan,Margot UndergraduateResearchWeekFacultyMentorAward

Reue,Karen AmericanHeartAssociationRussellRossMemorialLecture

Rodriguez,Jose PewBiomedicalScholar

Sallam,Tamer BurroughsWellcomeFundCareerAwardforMedicalScientistsFellowofAmericanCollegeofCardiology

Soragni,Alice Lynda'sFundPilotStudyAward

Spencer,Melissa GoldenTestTubeAward,UCLADept.ofNeurology

Tarling,Elizabeth IrvineH.PageYoungInvestigatorResearchAwardPromotedtoAssociateProfessorinResidence

Teitell,Michael AppointedDirector,UCLAJonssonComprehensiveCancerCenterPresident,JonssonCancerCenterFoundationDirector,DGSOMCancerResearchThemeLydaandHarrisonLattaEndowedChairinPathologyJeromeB.BlockMemorialLecture,LABioMed

Torres,Jorge 2019RuthKirschsteinDiversityinScienceAwardAmericanSocietyforBiochemistryandMolecularBiology

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Yeaman,Michael SpiritofInnovationAward(LABioMed);GlobalTechnologyCommunity(CNSDiseases)DistinguishedPrimaryInvestigator(U.S.DepartmentofDefense)Chair,SummitonImmuneTolerizationVaticanCouncilonMedicine&Society

MBIFACULTYSERVICEONUCLACOMMITTEES

Adams,John MemberandAdvisor,CTSIKL2GrantProgram

Chair,UCLA‐UCIAlphaStemCellClinicInternalAdvisoryBoardChair,UCLAScientificReviewCommitteeMember,ExecutiveOversightCommmittee,ClinicalandTranslationalScienceInstituteMember,OperationsCommitteeandExecutiveActionCommittee,ClinicalandTranslationalScienceInstitute,DavidGeffenSchoolofMedicineatUCLAMember,UCLAClinicalandTranslationalScienceInstituteProgramAreaLeaderCommitteeMember,ExecutiveAcademicActionsCommittee,OrthopaedicSurgeryMember,CTSIInstitutionalSteeringCommitteeMember,CTSISeminar(formerlyIMED)CommitteeMember,ClinicalResearchGovernanceCommitteeDGSOMSeedGrantReviewCommitteeDGSOMOppenheimGrantReviewCommittee

Allard,Patrick LifeScienceDiversityAdvisoryCommitteeUCLAFacultyGrantProgramCommittee

Ardehali,Reza Co‐DirectoroftheUCLAVascularBiologyTrainingGrantMember,DGSOMScholarshipSelectionCommitteeMember,UCLAMedicalinstitutionalReviewBoard

Berk,Arnold Chair,MBIMembershipCommittee

Bitan,Gal Judge,UndergraduateResearchPosterDayDean'sPrizeBBSBPh.D.HomeAreaAdmissionsCommitteeJudge,CollinsDayPosterSession(Neurobiology)

Black,Douglas MIMGViceChairforAcademicPersonnelChair,MIMGMeritReviewCommitteeMember,SpecialCommitteeforViceChancellorforResearchMember,MBISeminarCommitteeChair,HonorsandAwardsCommitteeofUndergraduateCouncil

Bowie,James UCLACouncilofAdvisors;SigmanLectureCommittee

Bradley,Peter IMMPCurriculumandAdmissionsCommitteeIntercollegiateAthleticsCommittee

Braun,Jonathan UCLAHealthSystemExecutiveCommitteeUCLAHealthSciencesDataStrategyandGovernanceCommittee

Braybrook,Siobhan Member,MCDBFacultyRecruitmentCommittee(PlantBiology)Member,LifeSciencesDiversityAdvisoryCommittee

Butler,Samantha Member,NeurobiologyAcademicReviewCommitteeReviewer,UCLAInnovationFund(DGSOM)Member,MCDBPlantJobSearchCommittee

Butte,Manish Co‐DirectorofI3T:Immunity/Inflamation/Infection/TransplantationCo‐DirectorofCancerNanoThemeoftheJonssonComprehensiveCancerCenter

Chen,Irvin Member,UCLADualUseReviewEntityMember,AdHOCPromotionCommitteeChair

Chen,Jau‐Nian Member,UCLAAcademicSenateCouncilonResearch

Chow,Samson Chair,InstitutionalBiosafetyCommitteeMember,EmbryonicStemCellResearchOversightCommittee

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Clarke,Catherine Member,UndergraduateStudyandCurriculumCommittee(Chem&Biochem)Member,DiversityandLeadershipCommittee(Chem&Biochem)Member,DevelopmentCommittee(Chem&Biochem)

Colicelli,John UCLASPOREinProstateCancerInternalAdvisoryCommitteeFacultyAdvisoryCommittee,MinorinBiomedicalResearchDiversityOversightCommittee,SchoolofMedicineDGSoMMedicalEducationCommitteeJCCCIntramuralReviewCommittee

Coller,Hilary Chair,AdHOCCommitteetoReviewDissertationYearFellowshipinBiologicalChemistryReviewer,DavidGeffenMetabolismThemeSeedFundsApplicationsMember,MBISeminarCommitteeExecutiveCommitteeMember,DermatologyT32Reviewer,MetabolismThemeAwardsMember,FacultySearchCommittee(MCDB)Member,MCDBPromotionReviewMember,FacultySearchCommittee(Biomathematician)Member,JonssonComprehensiveCancerCenterInternalReviewCommitteeMember,BroadStemCellCenterPredoctoralFellowReviewCommitteeReviewer,IrisCantorWoman'sHealthCenterReviewer,JonssonComprehensiveCancerCenterSeedGrantsReviewer,UCLAInnovationFundGrantApplicationsMember,MBIBoyer/ParvinPostdoctoralFellowAwardCommittee

DeRobertis,Edward Chair,HonorsCommittee(SchoolofMedicine)

Eisenberg,David MBISeminarCommitteeChair,Chem&BiochemistryPostdoctoralResearchAwardsDevelopmentCommittee,Chemistry&BiochemistryDepartmentDistinguishedLectureCommittee(Chem&Biochem)FianniFellowsInterviewCommittee

Ernst,Jason Chair,UCLABioinformaticsSeminarCommitteeMember,UCLABioinformaticsAdmissionsCommitteeMember,UCLABioinformaticsExecutiveCommitteeMember,UCLABioinformaticsWrittenQualifyingExamEvaluationCommitteeReviewer,UCLAStemCellTrainingGrantsReviewer,UCLAInnovationFund

Faull,Kym DepartmentalRepresentative,LegislativeAssemblyoftheUCLAAcademicSenateMember,BoardofGovernors,UCLAFacultyCenterMember,PersonnelSub‐Committee,BoardofGovernors,UCLAFacultyCenterUCLARepresentative,LegislativeAssemblyoftheUCAcademicSenateMember,DepartmentofPsychiatryandBiobehavioralSciencesAppointmentsandAdvancementsCommittee

Fregoso,Oliver Member,LifeSciencesDiversityAdvisoryCommitteeMember,MARCCommittee;Boyer/ParvinPostdoctoralAwardsCommittee

Gelbart,William UCLAGlennT.SeaborgMedalistandSymposiumHonoree

Gonen,Tamir ExecutiveCommittee,DepartmentofPhysiologyUCLA

Guo,Ming Member,SwitzerPrizeSelectionCommitteeChair,AcademicAdvisoryCouncil,SoundBodySoundMindCo‐Chair,WomeninScience&DoctorsofMedicineMember,Advancement&PromotionCommitteeintheDepartmentofNeurologySearchCommittee,FacultyAppointment,Neuroscience

Hallem,Elissa Member,LifeSciencesDiversityAdvisoryCommitteeMember,IMMPAdmissionsCommitteeMember,CommitteeforUCLANeuroscience

Hartenstein,Volker Member,NeuroscienceIDPParentCommitteeMember,MCDBMastersProgramCommittee

25

Hevener,Andrea MEDCAP;Chair,AcademicSenateCommitteeonDevelopmentEndocrinologyChief,SearchCommittee

Hirsch,Ann AdHOCMember,BiosafetyCommittee

Hoffmann,Alexander Member,TaskforceonComputationalBiology,GenomicsandMedicine

Iruela‐Arispe,Luisa Member,UCLASearchCommitteeforAcademicPersonnelVice‐ChancellorMember,UCLAUndergraduateResearchScholarProgramReview

Jacobsen,Steven Director,BroadStemCellResearchCenterSequencingFacilityMCDBPrizeandAwardCommitteeUCLABenGurionCommittee(LeshinFund)PersonnelActionCommittees

Johnson,Tracy UCLACenterfortheStudyofWomenAdvisoryCommitteeUCLAMorenoImplementationCommitteeChair,LifeSciencesDiversityAdvisoryCommitteeCMBTrainingGrantAdvisoryCommittee;Dean,UndergraduateEducationReviewCommitteeUCLAHumanPluripotentStemCellResearchOversight

Kaufman,Daniel DepartmentofMolecular&MedicalPharmacologyMeritReviewCommittee

Koehler,Carla Chair,IACCommitteeCo‐Director,CMBTrainingGrantMember,CBIAdvisoryCommitteeMember,StudentAthleteAdmissionsCommittee

Kohn,Donald Member,JCCCDataSafetyMonitoringCommitteeChair,DataSafetyMonitoringBoardfor"GeneCorrectionofAutologousHematopoieticStemCellsinArtemisDeficientSCIDUCLA‐UCIAlphaStemCellClinicInternalAdvisoryCommittee

Lazazzera,Beth Chair,AcademicSenateUndergraduateCouncilMember,AcademicSenateExecutiveBoard

Lee,Justine Member,UCLAHonors,AwardsandPrizesCommitteeMember,UCLAChildren'sSurgicalGroupCo‐Director,UCLAMulti‐DisciplinaryVascularBirthmarkClinic

Li,Melody Member,UCLAGraduateProgramsinBioscienceAdmissionsCommitteefortheIMMPHomeAreaMember,I3TCommunicationsCommittee

Lipshutz,Gerald Member,CASPP

Loo,Joseph Member,UCLA/DOELaboratoryforGenomicsandProteomicsMember,UCLAMolecularBiologyInstituteMember,Dept.ChemistryandBiochemistryInstrumentationCommitteeMember,Dept.ChemistryandBiochemistryDevelopmentCommitteeMember,AdvisoryCommittee,UCLAMolecularInstrumentationCenterMember,GraduateStudiesCommittee,DepartmentofChemistryandBiochemistryGraduateAdviser,AnalyticalChemistry/MeasurementSciencePh.D.Specialization,DepartmentofChemistryandBiochemistryMember,UCLAAcademicSenateCommitteeonDevelopmentMember,UCLAAcademicSenateGraduateCouncil

McEvoy,Megan Member,FacultySearchCommittee(MIMG)Member,AmgenFacultyReviewCommitteeMember,MBIMembershipReviewCommitteeMentor,RegentsScholarSociety

Morrison,Sherie Member,UCLACollegeCampaignCommittee

Nakano,Austin LegislativeAssembly,CardiovascularThemeResearchCommittee

26

Novitch,Bennett Member,BroadCenterforRegenerativeMedicineandStemCellResearchSteeringCommitteeMember,UCLANeuroscienceInterdepartmentalGraduateProgramMembershipCommitteeMember,UCLAMolecularBiologyInstituteMembershipCommitteeMember,UCLAAnimalProgramforNeuralRepairMember,UCLAClinicalandTranslationalSciencesInstituteScientificReviewCommitteeMember,DavidGeffenSchoolofMedicineatUCLANeurosurgeryChairSearchCommittee

O'Sullivan,Timothy Member,I3TCommunicationsCommitteeMember,IMMPAdmissionsCommittee;Member,I3TSeminarSeriesCommittee

Pellegrini,Matteo Member,CommitteetoEvaluateComputationalBiology(Genomics&MedicineLandscapeUCLA)

Plath,Kathrin Chair,SwitzerPrizeCommitteeMember,DGSOM‐CTSIRecruitmentCommittee

Pyle,April Chair,LifeSciencesExcellenceinResearchAwardsCommitteeMember,UCLAAssistantProfessorMentorshipProgramLifeSciencesMentorshipFacultySearchCommitteeMember,LifeSciencesDiversityAdvisoryCommittee

Quinlan,Margot Co‐Chair,UCLAMBISeminarCommittee

Reddy,Srinvasa Member,CommitteeonTeachingMember,LegislativeAssembly

Reue,Karen MedicalScientistsTrainingProgramAdmissionsCommitteeMBIPost‐doctoralAwardSelectionCommitteeBoyer‐ParvinPostdoctoralAwardCommittee

Sallam,Tamer Member,CardiovascularThemeCommunicationsandDevelopmentCommitteeMember,STARProgramSelectionCommittee

Schweizer,Felix InterimDirector,BrainResearchInstituteChair,GraduateNeuroscienceInterdepartmentalProgram

Spencer,Melissa Member,ESCROCommitteeMember,AdvancementsandPromotionsCommittee(Neurology)NeuromuscularProgramDirectorCo‐Director,CenterforDuchenneMuscularDystrophy

Sun,Ren Co‐Director,UCLAFogartyAITRPprogramonAIDS‐associatedCancersCo‐Director,Co‐InfectionandMalignanciesProgram,UCLAAIDSInstituteDirector,MedicalPharmacologyTrackoftheMolecularandMedicalPharmacologyPharmacologyGraduateTrainingCommitteeUCLAOptimizeCareerServiceProvisionforGraduateandPostdoctoralStudentsCommitteeUCLAPostdoctoralScholarsAdvisoryCommitteeChair,UCLACross‐DisciplinaryTrainingCommitteeSteeringCommitteeofUCLAChinaInitiativesAdvisoryCommitteeofUCLAInternationalInstituteAdvisoryCommitteeofUCLAConfuciusInstituteUCLACTSIEducationCommittee

Teitell,Michael Co‐Director,NIHT32TumorImmunologyTrainingProgramAssociateDirector,UCLA‐CaltechMedicalScientistTrainingProgram(MSTP)SelectionCommittee,MBISeminarSeriesAdmissionsCommittee,IntercollegiateStudent‐AthletesTrainingGrantCommittee,CSUN‐CIRMBridgestoStemCellBiologyNCAAFacultyAthleticsRepresentative;UCLAIntercollegiateStudent‐AthletesAcademicSenateIntercollegiateAthleticsCommittee(IAC)

Tontonoz,Peter UCLARepresentativetotheUCSystem‐wideAcademicSenate

Torres,Jorge Chair,CommitteeonContinuingandCommunityEducationMember,GraduateCouncil/GraduateDivision,MentoringandEvaluationofGraduateAcademicProgressWorkgroupMember,UndergraduateCouncil'sHonors,Awards&PrizesCommitteeMember,DiversityCommitteefortheDivisionofPhysicalSciences

27

Wang,Yibin DGSOMExecutiveResearchCommittee

Weiss,Shimon UCLAChemistryDepartmentDevelopmentCommitteeUCLAChemistryDepartmentInstrumentationCommitteeUCLACNSIMolecularScreeningSharedResourceAdvisoryBoard

Witte,Owen UCLASPOREinProstateCancerExecutiveCommitteeUCLAClinicalandTranslationalScienceInstituteAdvisoryCommitteeUCLADept.Chairs,MajorCenters&DirectorsCommitteeDGSOMJCCCDirector'sSearchCommitteeGeffenScholarshipSelectionCommittee;Chair,BelzerChairSearch

Xiao,Xinshu(Grace) FacultyMentor,RegentsScholarSocietyatUCLAFacultySearchCommitteeforMathematicalBiology,LifeSciences,UCLAPersonnelCommittee,DepartmentofIntegrativeBiologyandPhysiology,UCLAAdvisoryCommittee,InstituteforQuantitativeandComputationalBiology,UCLAAdvisoryCommittee,BioinformaticsIDP,UCLAAdvisoryCommittee,ComputationalandSystemsBiologyIDP,UCLA

Yang,X.William Member,UCLAMSTPAdmissionsCommitteeMember,FacultyAdvisoryCommitteetotheUCLAAccelerator

Yeaman,Michael Member,ExecutiveCommitteeUCLAI3TProgram

Zack,Jerome Chair,HighContainmentLabOversightCommitteeChair,DualUseResearchCommittee

Zhang,Ye Member,NSIDPAdmissionsCommittee

Zheng,Jie Member,UCLAAcademicSenateCommitteeonFacultyWelfare

MBIFACULTYSERVICEONEXTERNALCOMMITTEES

Adams,John MemberandFormerChair,ExternalAdvisoryPanelfortheMayoClinicNIAPPG"GonadalSteroids

andBone"Member,ExternalAdvisoryCommitteefortheMayoMedicalCenterT32"MusculoskeletalResearchTrainingProgram"Member,DataSafetyMonitoringBoard,NIDDK‐sponsored"VitaminDandType2Diabetes(D2d)"studyCharterMember,Arthritis,MusculoskeletalandSkin(AMS)StudySection,NIAMSNIHMemberandChair,ExternalAdvisoryBoard,JohnsHopkinsOrthopaedicSurgeryNIHT32Member,ExternalAdvisoryBoard,MayoClinicOrthopaedicSurgeryNIHT32Member,ExternalAdvisoryBoard,WashingtonUniversity,MusculoskeletalNIHT32Member,ExternalAdvisoryBoard,WashingtonUniversity,MusculoskeletalNIHP50Chair,ExternalAdvisoryPanelfortheHarbor‐UCLANIDDKT32"TraininginEndocrinologyandMetabolism"Chair,LosAngelesBioMedScientificAdvisoryBoardMember,CIRM‐AlphaStemCellClinicNetworkDirector'sSteeringCommittee

Allard,Patrick NIHSIEEStudySectionNIHIRAPStudySectionCalifornia'sDevelopmentalandReproductiveToxicantIdentificationCommittee

Bitan,Gal EditorialBoardMember,JournalofBiologicalChemistryEditorialBoardMember,ScientificReportsAdHOCMember,NIHSpecialEmphasisPanel/ScientificReviewGroupZRG1MDCN‐E(52),MDCN‐E(56),MDCN‐E(57),MDCN‐P(52)

Black,Douglas Member,NIGMSStudySectionforJuniorMIRAAwards

Bowie,James StockholmUniversitySearchCommitteeBiophysicalSocietyAwardsCommitteeChairofGordonConferenceonMembraneProteinFolding

Braun,Jonathan Chair,ExploratoryStudiesforDelineatingMicrobiome(ZDK1GRB‐6M2)

28

Member,SEP/SRG2017/01ZCA1SRB‐J(J4)RMeetingChair,SAB,MilieuInterieurConsortium‐InstitutPasteur,Paris

Braybrook,Siobhan AcademicEditor,PlantDirectMember,ASPBDigitalFuturesCommittee

Butte,Manish NIHStudySection(NIAIDCMIA)NIHStudySection(NIAID2017/10ZAI1NVM‐I(S1))

Carey,Michael JBCandMCBEditorialBoards,AdHoc,NIHMGBStudySection

Chen,Jau‐Nian Member,CDDNIHStudySectionMember,ZRG1F10ANIHStudySectionMember,CardiovascularDevelopmentAHAStudySection

Chow,Samson Member,AMCBNIHStudySectionClubb,Robert Member,MSFCNIHStudySectionColicelli,John CancerResearchCoordinatingCommitteeColler,Hilary Reviewer,R35MaximizingInvestigators'ResearchAwardforEarlyStageInvestigatorsReviewer,

AustrianScienceFundReviewer,NationalScienceFoundationCareerProgramReviewer,ArthritisResearchUKReviewer,NationalCancerInstituteProvocativeQuestionsReviewer,MedicalResearchCouncilReviewer,JamesandEstherKingBiomedicalResearchProgramPeerReviewReviewer,NationalCancerInstituteP01Reviewer,IsraeliNationalScienceFoundationReviewer,FrenchNationalResearchAgencyReviewer,MarsdenFundReviewer,NCIProvocativeQuestions

DeRobertis,Edward BoardMember,LatinAmericanSocietyofDevelopmentalBiologistsScientificAdvisoryBoard,PewCharitableLatinAmericanFellowsProgramScientificCouncil,AvademicdeCienciasdeAmericaLatina

Eisenberg,David HARCCenterScientificAdvisoryBoardVisitingCommittee,CaltechBeckmanInstituteChair,ScientificAdvisoryBoard(ADRx)

Ernst,Jason TemporaryMember,GCATNIHStudySectionEditorialBoard,GenomeResearchCo‐organizer,ISMB‐RegSysCommunityofSpecialInterestGroupMeetingMember,ProgramCommitteeICML/IJCAIWorkshopinComputationalBiologyMember,ProgramCommitteeRECOMBGeneticsMember,ProgramCommitteeISMBMember,ProgramCommiteeRECOMB/ISCBRegulatoryandSystemsGenomicsConferencewithDREAMChallengesMember,ProgramCommitteeNIPSWorkshopinComputationalBiology

Faull,Kym Member,AdvisoryBoardoftheInternationalJournalofMedicalBiochemistryMember,EditorialBoardoftheSirirajMedicalJournal

Fregoso,Oliver Co‐Organizer,PalmSpringsMeetingonHIV/AIDSGelbart,William Chair,ChemistryGraduateStudiesCommitteeGera,Joseph Member,BenchTestingTherapeutic/IndicationPairingStrategies(UG3/UH3),NCATS,NIHStudy

SectionGoldstein,Andrew Member,2018ProstateCancerFoundationChallengeAwardGonen,Tamir Member,BBMNIHStudySectionGuo,Ming HongKongResearchGrantCouncil(RGC),MonitoringandAssessmentPanelCommitteeMember

AssessorPanelMember,Biology&MedicalSubgroupScientificSelectionCommitteeMember,McKnightNeuroscienceFoundationScientificAdvisoryCommitteeMember,A.P.GianniMedicalFoundationChan‐ZuckerbergInitativeThinkTank,WorkshoponNeurodegeneration

Gwack,Yousang AdHOCMember,CMIBandSpecialEmphasisPanel,NIHStudySectionHallem,Elissa AdHOCPanelist,NIHChemosensorySystemsStudySection

29

Hartenstein,Volker Member,NIHNIMHBrainInitiativeStudyPanelSectionEditor,CellandTissueResearchSectionEditor,DevelopmentalNeurobiologySectionEditor,ArthropodStructureandDevelopment

Hevener,Andrea AmericanDiabetesAssociationScientificSessionsOrganizingCommitteeNIHSpecialEmphasisPanels

Hill,Kent ScientificAdvisoryCounciloftheArnoldandMabelBeckmanFoundationHirsch,Ann Member,ASPBFellowsAwardNominatingCommittee

Reviewer,EuropeanResearchCommissionAssociateEditor,PlantSignaling&BehaviorCommunicatingEditor,MolecularGeneticsandGenomics

Hoffmann,Alexander EditorialBoard,CellResearch,MolecularSystems Biology,MBCSystemsBiologyHouk,Kendall EditorialAdvisoryBoard,JournalofOrganichChemistry,OrganicLetters,

AccountsofChemicalResearchJournalofChemicalTheoryandComputation

Iruela‐Arispe,Luisa AssociateEditor,Atherosclerosis,ThrombosisandVascularBiologyJournalEditorialBoardMember,AngiogenesisJournalEditorialBoardMember,CancerBiologyandTherapyJournalEditorialBoardMember,CellBiologyJournalEditorialBoardMember,Atherosclerosis,ThrombosisandVascularBiologyEditorialBoardMember,CardiovascularPathologyEditorialBoardMember,CancerResearchEditorialBoardMember,JournalofExperimentalMedicineReviewer,ItalianAssociationforCancerResearch(AIRC)Member,NIH/NCI‐BoardofScientificCounselorsforBasicSciencesMember,NHLBIAdvisoryCouncilBoard

Jacobsen,Steven EditorialBoardMember,CurrentBiologyEditorialBoardMember,EpigenomicsEditorialBoardMember,GeneticsandEpigeneticsEditorialBoardMember,EpigeneticsandChromatinEditorialBoardMember,EpigenomesAdvisoryBoardMember,EPICEditorialBoardMember,Non‐GeneticInheritanceNationalAcademyofSciencesSectionLiason

Johnson,Reid NIHSpecialEmphasisReviewPanelJohnson,Tracy NationalCancerInstitute,BoardofScientificCounselorsforBasicResearchKaback,H.Ronald NHLBIBoardofScientificSiteVisitReviewKaufman,Daniel AdHOCReviewer,JuvenileDiabetesResearchFoundation

AdHOCReviewer,GenevaUniversityHospitals&FacultyofMedicineResearchFoundationAdHOCReviewer,NIHRFA‐DK‐003AdHOCReviewer,CysticFibrosisFoundationEditorialBoard,J.Clinical&CellularImmunologyScientificAdvisoryBoard,DiamydMedical

Kelesidis,Theodoros AdHOCReviewer,NIHNeuroAIDSandotherEnd‐organDiseasesStudySectionAdHOCReviewer,NIHAIDSClinicalStudiesandEpidemiologyStudySectionAdHOCReviewer,NIHAIDSSpecialEmphasisStudySection

Koehler,Carla Member,NOMDNIHStudySectionMember,AHAGrantReviewerPanelScientificandAdvisoryBoardofUnitedMitochondrialDiseaseFoundationScientificAdvisoryBoardofOxalosisandHyperoxaluriaFoundation

Kohn,Donald Member,ExternalAdvisoryBoard,SCID‐NETMember,Immuno‐andGeneTherapyCommitteeMember,2018AnnualMeetingOrganizingCommitteeMember,ReviewPanelfortheDorisDukeCharitableFoundation'sClinicalScientistDevelopmentAwardMember,ClinicalAdvisoryPanel

30

Kurdistani,Siavash AdHOCMember,SpecialEmphasisPanel,NIHAdHOCMember,Fellowship:Genes,Genomes,andGenetics(ZRG1F08)StudySection,NIHAdHOCMember,CancerMolcularPathobiology(CAMP)StudySectionAdHOCMember,GrantReviewPanel,CancerResearch

Lazazzera,Beth Member,NIHTWD‐BStudySection;Member,NSFGeneExpressionPanelLee,Justine AssociateEditor,AnnalsofPlasticSurgery

SectionEditor,CleftPalateCraniofacialJournal(PlasticandReconstructiveSurgerySection)SectionEditor,CleftPalateCraniofacialJournal(CraniofacialSurgerySection)AnnualMeetingProgramandInstructionalCourseCommitteeASPS/PSFResearcherEducationCommitteeASPS/PSFResearchDevelopmentCommitteeASPS/PSFWomenPlasticSurgeonsSteeringCommitteeASPS/PSFCurriculumCommitteeMember,PlasticSurgeryResearchCouncilPSRCMentorshipCommitteeMember

Li,Melody Speaker,WomeninSTEMGloballyPanelDiscussion,AmericanAssociationofUniversityWomenLipshutz,Gerald GDDNIHStudySectionReviewerLoo,Joseph Editor‐in‐Chief,JournaloftheAmericanSocietyforMassSpectrometry

EditorialBoard,MassSpectrometryReviewsEditorialBoard,ClinicalProteomicsEditorialBoard,InternationalJournalofMassSpectrometryMember,USHUPOBoardofDirectorsMember,BoardofDirectors,ConsortiumforTop‐DownProteomicsMember,FoundingExecutiveBoard,LosAngelesMetropolitanMassSpectrometryDiscussionGroupCo‐Organizer,14thUppsalaConferenceonElectronCaptureandTransferDissociation

Lusis,Jake NIHStudySectionsAdHOCReviewer,AmericanHeartAssociationGrantsCommitteeonResearch,AmericanHeartAssociationExternalAdvisoryCommittee,NIHSABReCardiovascularDiseaseInitiativeBurroughs‐WellcomeTrainingPrograminMetabolicDiseasesAdvisoryBoardMember,BoardofScientificCounselors(NIH)BoardofDirectors,KernLipidConferenceReviewEditor,FrontiersinGeneticsofComplexTraitsWellcomeTrustCentreforHumanGenetics,InternationalScientificAdvisoryBoardScientificAdvisoryBoardMeetingSteeringCommittee,PharmacogeneticsResearchNetworkEditorialBoard,Arterisclerosis,ThrombosisandVascularBiologyAssociateEditor,JournalofLipidResearchEditorialBoard,CurrentCardiologyReviewsEditorialBoard,OpenAccessBioinformaticsReviewEditor,FrontiersinGeneticsofComplexTraitsAssociateEditor,JournalofSexDifferencesEditorialBoard,MammalianGenome;EditorialBoard,DiabesityAssociateEditor,SystemsBiologyandMedicine

McEvoy,Megan Member,TWD‐DNIHStudySectionMorrison,Sherie Member,CIINIHStudySection

Nakano,Austin CDDStudySection;PPGStudySectionNovitch,Bennett AdHOCMember,NIHNeurogenesisandCellFateStudySection

AdHOCMember,NIHMolecular,Cellular,andDevelopmentalNeuroscienceIntegratedReviewGroupAdHOCMember,MissouriSpinalCordInjury/DiseaseResearchProgram

Payne,Gregory ResearchGrantsCouncilAreasofExcellenceMonitoringandAssessmentPanel

Plath,Kathrin BoardofReviewingEditors,ScienceChair,PublicationsCommittee,ISSCRMember,InternationalCommittee,ISSCR

31

Pyle,April AdHOC,MDAStudySectionAdHOC,SMEPNIHStudySection

Quinlan,Margot Member,NCSDNIHStudySectionReddy,Srinvasa NIHSpecialEmphasisPanel,VascularHematologyReue,Karen NHLBIInstitutionalTrainingMechanismReviewCommittee

NHLBIR03GrantStudySectionSchweizer,Felix Life‐Trustee,TheGrassFoundationSmale,Steven Member,NIHCMIAStudySection

Member,BlavatnikAwardsforYoungScientistsNationalJurySoragni,Alice BiOverlayAssociateEditor,BiorXivAffiliate

MemberNPISAdvisoryBoardSpencer,Melissa Chair,ScientificAdvisoryBoard,CoalitiontoCureCalpain3

Adhoc,SkeletalMuscle,ExercisePhysiologyStudySectionMember,ScientificAdvisoryCommitteeMuscularDystrophyAssociationMember,ScientificAdvisoryBoard,ParentProjectMuscularDystrophyReviewer,JesseJourneyFoundation;Organizer,FASEBSummerConferenceonCalpainsinHealthandDisease

Sun,Ren BoardofScientificCounselors,NationalCancerInstituteTamanoi,Fuyuhiko SeriesEditor,TheEnzymes,AcademicPress/ElsevierTang,Yi DOEBERReviewPanel,EditorialBoardofMetabolicEngineeringTarling,Elizabeth Member,VCMBandR03SEPNIH/NHLBIStudySections

Member,AHAFellowshipsLipids&ThrombosisPeerReviewCommittee,DeuelConferenceBoardMember,ATVBWomen'sLeadershipCommittee

Teitell,Michael NIH,CancerCenterSupportGrantReviewTeam,NCIOfficeofCancerCentersInternationalScientificCouncil,IsraelCancerResearchFoundationScientificAdvisoryBoard,TheMethodistResearchInstituteChair,MountainPacificSportsFederationAdministrativeCommitteeChair,Pac‐12ConferenceDiversityLeadershipCommitteeChair,Pac‐12ConferenceWomanoftheYearNominatingCommitteeChair,Pac‐12ConferenceNominatingCommitteeChair,Pac‐12ConferenceLegislativeCommittee

Tetradis,Sotirios AdHOCMember,ODCSStudySection,NIHTontonoz,Peter Editor‐In‐Chief,MolecularandCellularBiologyTorres,Jorge AdHOC,NIH‐NIGMSCellBiologyandRegulatorySystemsStudySectionWang,Yibin EditorialBoardMember,JBC,CirculationResearch,JournalofMolecularandCellularCardiology

Member,ScientificAdvisoryBoardofKeystoneSymposiumMember,ScientificAdvisoryBoardofAcademicaSinica

Weiss,Shimon ScientificAdvisoryBoard,MaxPlanckInstituteforMedicalResearch,Heidelberg,GermanyWhitelegge,Julain Member,EBITNIHStudySectionWilliams,David Beckman‐ArgyrosAwardExecutiveCommittee

GrantReviewer,FightforSight,UKFoundationforFightingBlindnessStudySectionGuestEditor,ProceedingsoftheNationalAcademyofSciences

Witte,Owen 2018Louis‐JeantetFoundationReviewCommitteePresident'sCancerPanelChildren'sResearchInstitute,UTSouthwesternMedicalCenter,ExternalAdvisoryBoardAndersonMoonShotsReviewCommitteeAACRNominatingCommitteeNationalAcademyofSciencesTemp.NominatingGroup,ClassIVCancerCellEditorialBoardProstateEditorialBoardProceedingsoftheNationalAcademyofSciencesUSAEditorialBoard

Wong,David CharteredMember,CancerBiomarkerStudySection,NIHCenterofScientificReviewXiao,Xinshu(Grace) NIHNCI2018/08Immuno‐OncologyTranslationNetworkStudySection,ZCA1SRB‐C(A1)R

AdHOC,NIHCSRSpecialEmphasisPanelAdHOC,IsraelScienceFoundation;Member,NIHBiodataManagementandAnalysisStudySection

32

Yang,X.William CharteredMember,NIHCellularandMolecularBiologyofNeurodegenerationStudySectionScientificAdvisoryBoardMember,HereditaryDiseaseFoundationEditorialBoardMember,MolecularNeurodegenerationEditorialMember,JournalofHuntington'sDisease

Yeaman,Michael NIHStudySectionService:NIHZRG1EditorialBoardService:PLoSPathogensJournalReviewerService:InfectionandImmunity,JournalofInfectiousDiseases,AntimicrobialAgents&Chemotherapy,NewEnglandJournalofMedicine,Nature,JournalofLeukocyteBiology,Nature[Immunology],EukaryoticCell,JournalofBacteriology,Nature[Microbiology],PNAS

Zheng,Jie ScientificReviewer,Technology/TherapeuticDevelopmentAwardApplicationReviewCommitteeVisionResearchProgramMember,ProfessionalDevelopmentandEducationCommittee,AssociationforResearchinVisionandOphthalmologyEditorialBoard,CellCommunication&Signaling

Zhou,Hong AdHOC,NSFandNIHReviewCommittee

PATENTSISSUED2017‐2018

Member PatentName PatentNumber

Inventors

Clubb,Robert Methodsandcompositionstoincreasetherateoflitigationreactionscatalyzedbyasortaste

15164 R.Clubb,B.Amer

Eisenberg,David Structure‐basedPeptideInhibitorsofP53AggregationasaNewApproachtoCancerTherapeutics

9,873,718 A.Soragni,L.Jiang

Gelbart,William InVitroReconstitutedPlantVirusCapsidsforDeliveringRNAGenestoMammalianCells

183635 W.Gelbart,etal.

Kaufman,Daniel GabaAntagonistsintheTreatmentofDisordersAssociatedwithMetabolicSyndromeandGabaCombinationsinTreatmentorProphylaxisofTypeIDiabetes

9,820,955 D.Kaufman,J.Tian

Morrison,Sherie CD138‐Targetedinterferondemonstratedpotentapoptoticandanti‐tumoractivities.

9,803,021 S.Morrison

Nakano,Austin Metabolicinterventionsforpreventionofcongenitalheartdisease

A.Nakano,H.Nakano

Pyle,April Methodsforgeneratingandenrichingskeletalmuscleprogenitorcells

62/443,499 Hicks,A.Pyle

Soragni,Alice Structure‐basedPeptideInhibitorsofP53AggregationasaNewApproachtoCancerTherapeutics

9,873,718 D.Eisenberg,A.Soragni,L.Jiang

Spencer,Melissa CRISPR/CAS9MediatedGenome;DrugsThatIncreaseMuscleMass;NanoparticleDeliveryCRISPR;PolyrtaxaneNanoparticles;StemCellDelivery

Spencer,Melissa

Tang,Yi WeedControl 62/474,528 S.Jacobsen,Y.Tang,Y.Yan,Y.LiuTeitell,Michael UseofLiveCellInterferometrytoDetermine

ChangesinMassofMammalianCells9,810,683 J.Gimzewski,J.Reed,M.Teitell

Weiss,Shimon Electronicdisplaysusingopticallypumpedluminescentsemiconductornanocrystals;Semiconductornanocrystalprobesforbiologicalapplicationsandprocessformakingandusingsuchprobes

9,063,363;9,182,621;9,671,536;9,530,928

S.Weiss,Schlamp,M.C.,Alivisatos,A.P.;S.Weiss,M.Bruchez,Jr.,P.Alivisatos

Yang,X.William ACell‐BasedSeedingAssayforHuntingtonAggregation

62/571,433 X.W.Yang

Yeaman,Michael Peptidesandmethodsforinducingcelldeath 9,562,083 M.Yeaman,N.Y.Yount,E.P.BrassAnti‐infectivehydroxy‐phenylbenzoatesandmethodsofuse

9,585,897 M.Yeaman,A.S.Bayer

33

Zack,Jerome Engineeringanti‐viralTcellimmunitythroughstemcellsandchimericantigenreceptors

9951118 S. Kitchen,J.Zack,O.O.Yang,I.Chen,M.Kamata

VISITINGFACULTY&SCHOLARS

Host Visitor HomeInstitution DatesatUCLA

Bitan,Gal

HudaAlalami CornellUniversity 6/19/17to9/8/2017

ZizihengLi UniversityofTokyo 12/1/17topresent

Black,Douglas

HidehitoKuroyanagi,PhD TokyoMedicalandDentalUniversity

9/17to6/18

ManuelAres,Ph.D. UniversityofCalifornia,SantaCruz

1/18to2/18

MelissaJurica,Ph.D. UniversityofCalifornia,SantaCruz

2/18to3/18

Chen,Irvin LanWang,Ph.D. PekingUnionMedicalCollege 7/1/17topresent

Clarke,Catherine LuciaFernandezdelRio,Ph.D. UniversityofCordoba 10/1/2017to6/30/2018

DeRobertis,Edward

LaurenAlbrecht,Ph.D. NorthwesternUniversity 7/15topresent

GabrieleColozza,Ph.D. UniversityofSiena 6/2012topresent

YiDing,Ph.D. TsinguaUniversity 1/2014topresent

YukiMoriyama,Ph.D. ShizuokaUniversity 6/2013to8/2018

NydiaTejeda,Ph.D. NationalAutonomousUniversityofMexico

9/1/2016topresent

Faull,Kym HaiqiangWu,Ph.D. ShenzhenUniversity 12/17to8/18

Gunsalus,Robert

AnzouMa,Ph.D. ChineseAcademyofSciences 10/1/16to10/17

UsmanAhmad,M.S. GCUniversity(Pakistan) 5/1/17to2/1/18

Houk,Kendall

EricBlock,Ph.D. AlbanyUniversity 1/1/18to6/30/18

Xiao‐SongXue,Ph.D. NankaiUniversity 10/1/17to6/30/18

YileiZhao,Ph.D. ShanghaiJiao‐TongUniversity

7/1/18to6/30/19

Jacobsen,Steven MariaNohales,Ph.D. UniversityofSouthernCalifornia

7/1/17to4/30/18

Johnson,Reid KiyotoKamagata,Ph.D. TohokuUniversity 8/1/17to3/31/18

Johnson,Tracy

ManuelAres,Ph.D. UniversityofCalifornia,SantaCruz

1/2018to3/2018

MaratPavliukov,Ph.D. UniversityofAlabamaatBirmingham

3/2018to5/2018

Kelesidis,Theodoros AnthanasiosKossyvakis,Ph.D. InstitutPasteurInternationalNetwork‐HellenicPasteurInstitute

07/01/17to06/30/18

Lin,Chentao XuWang,Ph.D. FujainAgricultureUniversity 12/1/17to1/31/18

Loo,Joseph XinhuaGuo,Ph.D. JilinUniversity 3/2018topresent

Nakano,Austin AyakoShigenta,MD,Ph.D. ChibaUniversity 1/1/2017to12/31/2017

Pellegrini,Matteo DavideVarnevali,Ph.D. UniversityofParma

Reddy,Srinvasa XinyingYang,Ph.D. ChineseAcademyofSciences 06/2016to09/2017

Reue,Karen YunlanLi,Ph.D. ShanxiMedicalUniversity 9/1/2017to8/31/2018

Rodriguez,Jose GustavoHelguera,Ph.D. CONICET 11/30/2017to02/01/2018

34

Yang,X.William ChristianNeri,Ph.D. InstituteofBiologyParis‐Seine

07/2017to08/2017

Yeaman,Michael

LianaChan,Ph.D. UniversityofCalifornia,Berkeley

2014topresent

WpulieNarawatne,M.D. Pediatrics,Harbor‐UCLA 2016topresent

Zhou,Hong KaituoWang,Ph.D. UniversityofCopenhagen 8/1/2016to1/31/2018

XueYang,Ph.D. NankaiUniversity 12/15/2016to12/14/2017

35

InstituteforQuantitative&ComputationalBiosciences(QCBio)AlexanderHoffmann,Director

QCBio is housed on the 5th floor of Boyer Hall and encompasses a range of quantitative and computationalbiosciences research, research training and educational program. QCBio Laboratories develop cutting edgequantitativeandcomputationaltools,rangingfromstatisticalanalysisandmodelingapproachestophysics‐basedalgorithms and mechanistic modeling. QCBio functions as the sponsor to the QCBio Collaboratory and theInterdepartmental Graduate Program inBioinformatics to provide research training, and provides coordinationamongotherquantitativeandcomputationalbiosciencesgraduateprograms.QCBioFacultyalsodirectandsupportthe Interdepartmental Undergraduate Programs in Computational & Systems Biology (the CaSB major) and inBioinformatics(aminor),aswellasthefreshmanmathematicsforLifeSciencespre‐majors.QCBioorganizestheBruins‐in‐Genomics(B.I.G.)SummerUndergraduateResearchProgram.QCBiosponsorstheBioinformaticsSeminarseries,aweeklyResearchLunch,ScientificWorkshopsandConferences,SymposiaandanAnnualRetreat.TheseactivitiesaresupportedbyBoyerHallstaff.

MoreinformationontheQCBiocanbefoundat:http://qcb.ucla.edu.

TheQCBioCollaboratory

MatteoPellegrini,CollaboratoryDirector

The mission of the QCBio Collaboratory is to provide computational research support to projects initiated byexperimentalists.Thismissionispursuedatthreelevels:(i)collaborativesupportorconsultingwork;(ii)workshopsto convey commonly used bioinformatics skills for the analysis of Next Gen Sequencing data; (iii) maintainingsoftwareplatforms(e.g.Galaxy)thatenablemultipletypesofanalysesofnextgenerationsequencingdata.TheseactivitiesaresupportedbytheQCBioCollaboratorypostdoctoralfellows,whoareselectedfromabroadapplicantpoolforrenewableannualappointments.QCBCollaboratoryworkshopsalsoformthebasisforgraduatecoursesavailabletoMBI‐IDPandothergraduatestudents.

MoreinformationonTheCollaboratorycanbefoundat:http://qcb.ucla.edu/collaboratory.

UCLA‐DOEInstitute

SabeehaMerchant,Director

The UCLA‐DOE Institute is a team of research laboratories working on fundamental research and technologydevelopmentsinbroadDOEmissionareasrangingfrommicrobes,tobiofuelsandgreenchemistry,tothedesignofnewbiomaterials.BoyerHallhousesfourofthesixUCLA‐DOECoreTechnologyCenters:

•BioinformaticsandComputationalCoreTechnologyCenter‐ToddYeates,Director/DuilioCascio,ManagerProvidescomputerhardwareandsoftwareinstallationandmaintenanceforawiderangeofofficeandscientificapplications;maintainsWWWserviceforsoftwareanddatabasedissemination.•MacromolecularCrystallizationCoreTechnologyCenter‐JamesBowie,Director/MichaelCollazo,ManagerTheMacromolecularCrystallizationCoreprovidesstate‐of‐the‐art,high‐throughput,andcrystallizationservicestoallinstitutions.•ProteinExpressionTechnologyCenter(PETC)‐JamesBowie,Director/MarkArbing,ManagerThePETCprovidessupportinallaspectsofproteinexpressionfromcloningthroughexpressionoptimizationandproteinpurification.•X‐rayCrystallographyCoreTechnologyCenter‐ToddYeates,Director/DuilioCascio,ManagerTheX‐rayCrystallographyCoreprovidesstate‐of‐the‐artresources,enablingthedetailed3‐Danalysisofbiologicalmacromoleculesthatplayessentialrolesinhumanhealth.

36

MoreinformationontheDOEanditsCorescanbefoundat:www.doe‐mbi.ucla.edu

FermentationCoreFacilityJamesBowie,Director/MarkArbing,Manager

The Fermentation Core Facility is housed on the 1st floor of Boyer Hall. It consists of three Bio Engineeringfermenterswhichallowthelarge‐scalegrowthofbacteriaoryeastusingcontrolledregulationofcellgrowth,andalsohastheabilitytointroduceadditionalnutrientsand/orsupplementaloxygenthatallowmicrobialgrowthtohighcelldensities.

MoreinformationontheFermentationCorecanbefoundat:www.mbi.ucla.edu/fermentation‐core‐facility

37

MOLECULARBIOLOGYINTERDEPARTMENTALPH.DPROGRAM(MBIDP)AshleyTerHorstandStephanieCuellar(SAO)

Sincetheprogram’s initiation in1966‐67,a totalof457individualshaveearnedtheirPh.D.degree inMolecularBiology.Duringthe2017‐18academicyear,therewere130studentsintheMBIDP,including36admissions,and11completingtheirdegreerequirements.The2017‐2018facultymentors intheMolecularBiologyIDPhaveprimaryappointments inthedepartmentsof:Anesthesiology;BiologicalChemistry;Cardiology;Chemical&BiomolecularEngineering;Chemistry&Biochemistry;Dentistry‐Oral Biology; Digestive Diseases; Human Genetics; Microbiology, Immunology & Molecular Genetics;Molecular & Medical Pharmacology; Molecular, Cell & Developmental Biology; Molecular, Cell & IntegrativePhysiology;Neurobiology;Neurology;Pathology&LaboratoryMedicine;PediatricGenetics;Pediatrics;Psychiatry&BehavioralScience;RadiationOncology;SurgeryandUrology.HomeAreaspromotein‐deptheducationalprogramswhilemaintainingflexibilityforstudentstoexplorebeyondasingle home area and faculty to contribute to multiple home areas according to their research interests. TheMolecularBiologyIDPconsistsoffourhomeareas:Cell&DevelopmentalBiology(CDB);Biochemistry,Biophysics,&StructureBiology(BBSB);GeneRegulation,EpigenomicsandTranscriptomics(GREAT);andImmunity,Microbes,&MolecularPathogenesis(IMMP).EachhomeareahasadirectorthatactsastheGraduateAdviserforthatarea’sstudents.

MBIDPSTUDENTS2017‐18

StudentName Mentor 2017‐2018Support

ADELAJA,ADEWUNMI(MSTP) Hoffmann,Alexander VascularBiologyTrainingGrant/GraduateStudentResearcher

AFASIZHEVA,ANNA(MSTP) Plath,Kathrin GraduateStudentResearcherALVAREZ,SANDY Butler,Samantha TeachingAssistantship/CellularandMolecularBiology

(CMB)TrainingGrant/GraduateStudentResearcherARAGON,RAQUEL Iruela‐Arispe,Luisa TeachingAssistantship/HHMIGilliamGraduate

FellowshipAROS,CODY(MSTP) Gomperts,Brigitte UCLAEli&EdytheBroadStemCellResearchCenter

TrainingGrantRecipient/GraduateStudentResearcherBACK,SUNGMIN(PETER) Bradley,Peter TeachingAssistantship/CellularandMolecularBiology

(CMB)TrainingGrant/GraduateStudentResearcherBOWLER,JEANNETTE Eisenberg,David GraduateStudentResearcher

BROWN,TAYLOR Hallem,Elissa CotaRobles/HHMIGilliamGraduateFellowship

CAMPOS,OSCAR KurdistaniSiavash GraduateStudentResearcher

CASTELLON,JOSE Backus,Keriann TeachingAssistantship/NationalScienceFoundationGraduateResearchFellowshipProgram

CHAI,MIN Huang,Jing GraduateStudentResearcher

CHANG,PATRICK Crooks,Gay Whitcome/GraduateStudentResearcher

CHAU,ANTHONY Plath,Kathrin Whitcome/GraduateStudentResearcher

CHEN,YI‐PEI Johnson,Patricia GraduateStudentResearcher

CHENG,QUEN(STAR) Hoffmann,Alexander DeptofMedicine/GraduateStudentResearcher

CHI,FANGTAO Banerjee,Utpal TeachingAssistantship/BroadStemCellResearchCenterTrainingGrant

CHIEN,PEGGIE Pyle,April GPB/TeachingAssistantship/GraduateStudentResearcher

CHITIASHVILI,TSOTNE Plath,Kathrin/Clark,Amander

NRST/BoehringerIngelheimPhDFellowship/GraduateStudentResearcher

CHOI,CHARLESPAUL Bradley,Peter GraduateStudentResearcher

CORVALAN,ADRIANA Coller,Hilary GraduateStudentResearcher

38

CROWELL,PRESTON Goldstein,Andrew TeachingAssistantship/CellularandMolecularBiology(CMB)TrainingGrant/GraduateStudentResearcher

DALY,ALLISON Smale,Stephen GPB/TeachingAssistantship/GraduateStudentResearcher

DAMODAREN,NIVEDITA Plath,Kathrin/Black,Douglas

NRST/GPB/Teaching Assistantship/GraduateStudentResearcher

DEMARCO,STEPHANIE Hill,Kent DissertationYearFellowship/GraduateStudentResearcher

DENG,WILLIAM(WEIXIAN) Plath,Kathrin/Wohlschlegel,James

NRST/GPB/TeachingAssistantship/GraduateStudentResearcher

DIALAFITZGERALD(MSTP) Johnson,Patricia GraduateStudentResearcher

DIMAPASOC,MELANIE Zack,Jerome TeachingAssistantship/CellularandMolecularBiology(CMB)TrainingGrant/GraduateStudentResearcher

DO,TRAN(MSTP) Modlin,Robert DermatologyScientistTrainingGrant/GraduateStudentResearcher

EDWARDS,SAMANTHA Johnson,Tracy Whitcome/GraduateStudentResearcher

ELAHI,LUBAYNA Kornblum,Harley GPB/TeachingAssistantship/GraduateStudentResearcher

EMAMI,MICHAEL Spencer,Melissa TeachingAssistantship/NationalScienceFoundationGraduateResearchFellowshipProgram/CellularandMolecularBiology(CMB)TrainingGrant

EVANS,DECLAN Houk,Ken TeachingAssistantship/Chemistry‐BiologyInterface(CBI)TrainingGrant/GraduateStudentResearcher

FAN,XIAORUI Wohlschlegel,James Whitcome/GraduateStudentResearcher

FENG,AN‐CHIEH(ANGELA) Smale,Stephen NRST/GPB/TeachingAssistantship/GraduateStudentResearcher

FERRER,DAVID Bradley,Peter CotaRobles/GraduateStudentResearcher

FLORES,AIMEEALYSSA Lowry,William GraduateStudentResearcher

GANG,SPENCER Hallem,Elissa GraduateStudentResearcher

GIBBS,DEVIN Pyle,April/Crosbie‐Watson,Rachelle

GPB/TeachingAssistantship/GraduateStudentResearcher

GLADYS,DEVIN (1styearrotations) NRST/TeachingAssistantship/GatesMillenniumScholar

GOLDEN,LISA Voskuhl,Rhonda Whitcome/GraduateStudentResearcher

GOMEZ,ADAM Jones,Leanne NationalScienceFoundationGraduateResearchFellowshipProgram/GraduateStudentResearcher

GRAY,DAVID Kohn,Donald Whitcome/GraduateStudentResearcher

HANCOCK,GRACE Clark,Amander UCLAEli&EdytheBroadStemCellResearchCenterTrainingGrantRecipient/GraduateStudentResearcher

HERNANDEZ,GLORIA Iruela‐Arispe,Luisa TeachingAssistantship/VascularBiologyTrainingGrant/GraduateStudentResearcher

HILDRETH,ANDREW O’Sullivan,Tim GPB/TeachingAssistantship/GraduateStudentResearcher

HO,CHI‐MIN Egea,Pascal/Zhou,Hong

TeachingAssistantship/MicrobialPathogenesisTrainingGrant/GraduateStudentResearcher

HODGE,RACHEL Jones,Leanne TeachingAssistantship/CellularandMolecularBiology(CMB)TrainingGrant/GraduateStudentResearcher

HSU,EMILY Berk,Arnold VirologyandGeneTherapyTrainingGrant/GraduateStudentResearcher

HU,XUCHEN(MSTP) Young,Stephen VascularBiologyTrainingGrant/GraduateStudentResearcher

ICHINO,LUCIA Jacobsen,Steven NRST/GPB/TeachingAssistantship/GraduateStudentResearcher

JONES,ERIC Kosuri,Sriram GraduateStudentResearcher

39

KIM,ELLIOT RobertModlin GraduateStudentResearcher

KO,ARTHUR Pajukanta,Paivi GraduateStudentResearcher

KORSAKOVA,ELENA Lowry,William TeachingAssistantship/BroadStemCellResearchCenterTrainingGrant

KRONENBERG,MICHAEL Carey,Michael TeachingAssistantship/CellularandMolecularBiology(CMB)TrainingGrant/GraduateStudentResearcher

KRYZA,JORDAN Jones,Leanne TeachingAssistantship/CellularandMolecularBiology(CMB)TrainingGrant/GraduateStudentResearcher

LANIADO,JOSHUA Yeates,Todd GraduateStudentResearcher

LEE,DEREK (1styearrotations) GPB/TeachingAssistantship/GraduateStudentResearcher

LEE,HANEUL(SKOTT) Coller,Hilary DissertationYearFellowship/GraduateStudentResearcher

LEE,JOSHZIXI Wang,Yibin GraduateStudentResearcher

LEUNG,CALVIN Johnson,Tracy DissertationYearFellowship/GraduateStudentResearcher

LEWIS,SOPHIA Jones,Leanne GraduateStudentResearcher

LI,YAN Guo,Feng NRST/GPB/TeachingAssistantship/GraduateStudentResearcher

LI,YANRUIDE(CHARLIE) Yang,Lili NRST/GPB/TeachingAssistantship/GraduateStudentResearcher

LIM,HANYOUNG Black,Douglas GraduateStudentResearcher

LIN,TASHA(STAR) Chen,Yvonne STAR,DivisionofHematology‐Oncology,T32HematologyTrainingGrant,T32ImmunologyTrainingGrant

LIN,YING Zipursky,Larry Whitcome/GraduateStudentResearcher

LIU,HUACHUN Lin,Chentao Whitcome/GraduateStudentResearcher

LIU,WANLU Jacobsen,Steve GraduateStudentResearcher

LO,HUNG‐HAO Smale,Stephen GraduateStudentResearcher

LOPEZ,ANDREW Fregoso,Oliver MicrobialPathogenesisTrainingGrant/GraduateStudentResearcher

LOWE,MATTHEW Clark,Amander TeachingAssistantship/CellularandMolecularBiology(CMB)TrainingGrant/GraduateStudentResearcher

MA,FEIYANG Pellegrini,Matteo NRST/GPB/TeachingAssistantship/GraduateStudentResearcher

MASIUK,KATELYN(MSTP) Kohn,Donald GraduateStudentResearcher

MILLER,JARRETT Plath,Kathrin GraduateStudentResearcher

MILLER,JUSTIN Yeates,Todd NIHUCLABiotechnologyTrainingGrant/GraduateStudentResearcher

MILLER,MATTHEW

Butte,Manish GPB/TeachingAssistantship/GraduateStudentResearcher

MIRANDA,MATILDE

Lowry,William NationalScienceFoundationGraduateResearchFellowshipProgram/GraduateStudentResearcher

MOLGORA,BRENDAMARIA Johnson,Patricia CotaRobles/GraduateStudentResearcherMURRAY,KEVIN(MSTP)

Eisenberg,David Chemistry‐BiologyInterface(CBI)TrainingGrant/GraduateStudentResearcher

NAVARRO,HECTOR

Goldstein,Andrew GPB/TeachingAssistantship/GraduateStudentResearcher

NESTERENKO,PAVLO Witte,Owen GPB/TeachingAssistantship/GraduateStudentResearcher

NEVES,LAURENTAYLOR Johnson,Tracy GraduateStudentResearcher

NITZAHN,MATTHEW Lipshutz,Gerald GraduateStudentResearcher

40

OCHOA,JESSICA

Yeates,Todd TeachingAssistantship/HHMIGilliamGraduateFellowship

OKONKWO,SHAWNTEL

Johnson,Tracy NationalScienceFoundationGraduateResearchFellowshipProgram/GraduateStudentResearcher

ONG,JESSICA(MSTP) Reue,Karen GraduateStudentResearcher

PATEL,AANAND(MSTP) Quinlan,Margot GraduateStudentResearcher

PERRONE,IAN Fregoso,Oliver GraduateStudentResearcher

POHL,KATHERINE

Yang,Xianjie GPB/TeachingAssistantship/GraduateStudentResearcher

PRONOVOST,GEOFFREY Hsiao,Elaine MolecularPathogenesisTrainingGrant/GraduateStudentResearcher

QIAN,KEVIN(MSTP)

Tontonoz,Peter GeffenScholarship

READ,GRAHAM (1styearrotations) GPB/TeachingAssistantship/GraduateStudentResearcher

RIGGAN,LUKE

O’Sullivan,Tim GPB/TeachingAssistantship/GraduateStudentResearcher

SAHAKYAN,ANNA Plath,Kathrin GraduateStudentResearcher

SALISBURY,DAVIDALEX

Sallam,Tamer/Tontonoz,Peter

TeachingAssistantship/VascularBiologyTrainingGrant/GraduateStudentResearcher

SANCHEZ,LUIS Quinlan,Margot TeachingAssistant/GraduateStudentResearcher

SANDHU,JASPREETSINGH(MSTP) Tontonoz,Peter GraduateStudentResearcher

SANDOVAL,CARINA

Fregoso,Oliver GPB/TeachingAssistantship/GraduateStudentResearcher

SERCEL,ALEXANDER

Teitell,Michael UCLATumorImmunologyTrainingGrant/GraduateStudentResearcher

SHIA,DAVID(MSTP) Gomperts,Brigitte GraduateStudentResearcher

SHIMADA,ERIKOCHRISTINE Teitell,Michael MichaelTeitellLaboratory

SHU,CYNTHIA

Crosbie‐Watson,Rachelle

MuscleCellBiology,Pathogenesis,andTherapeuticsGrant/EurekaScholarship

SUN,VICTORIA(MSTP) Crooks,Gay GraduateStudentResearcher

TAN,YINGXUANSHAWN Plath,Kathrin GraduateStudentResearcher

TAO,YANG

Martin,Kelsey DissertationYearFellowship/GraduatestudentResearcher

TESSEMA,KALEAB(MSTP) Kornblum,Harley GraduateStudentResearcher

THIND,AMARA

Bradley,Peter GPB/TeachingAssistantship/GraduateStudentResearcher

THURLOW,LAUREN

Johnson,Tracy TeachingAssistantship/NationalScienceFoundationGraduateResearchFellowshipProgram/CellularandMolecularBiology(CMB)TrainingGrant

TISNADO,JERRELLRAY

Gelbart,William NationalScienceFoundationGraduateResearchFellowship/GraduateStudentResearcher

URTECHO,GUILLAUME Kosuri,Sriram CotaRobles/GraduateStudentResearcher

VALLIERE,MEAGHAN Bowie,James TeachingAssistantship/GraduateStudentResearcherVANLOON,AARON Sagasti,Alvaro GraduateStudentResearcherVAN,CHRISTINA Waschek,James GraduateStudentResearcherVAVILINA,ANASTASIA Mikkola,Hanna TeachingAssistantship/VascularBiologyTraining

Grant/GraduateStudentResearcherVUONG,CELINEKIM Black,Douglas DouglasBlackLaboratory

WANG,LULAN Cheng,Genhong GraduateStudentResearcherWATERS,LYNNEARAE Teitell,Michael GraduateStudentResearcherWEISS,DAVID(MSTP) Modlin,Robert GraduateStudentResearcherYANG,EMILY

Li,Melody GPB/TeachingAssistantship/GraduateStudentResearcher

41

YOUNG,BRIANDANIEL(MSTP) Wohlschlegel,James JamesWohlschlegelLaboratoryYOUNG,COURTNEY Spencer,Melissa MelissaSpencerLaboratoryYU,JIAJI

Yang,Lili NRST/TeachingAssistantship/BroadStemCellResearchCenterTrainingGrant/GraduateStudentResearcher

ZEMKE,NATHANROBERT Berk,Arnold GraduateStudentResearcherZENG,SAMUEL(MSTP) Yang,Lili GraduateStudentResearcherZHAN,LINGYU Sul,JaeHoon NRST/GPB/TeachingAssistantship/GraduateStudent

ResearcherZHANG,JIAYAN

Zhou,Hong NRST/GPB/TeachingAssistantship/GraduateStudentResearcher

ZHANG,TIANHAO Sun,Ren GraduateStudentResearcherZHANG,YURUN Chute,John GraduateStudentResearcher

STUDENTSWHOADVANCED‐TO‐CANDIDACY2017‐2018

StudentName Mentor

Adelaja,Adewunmi(MSTP) Hoffmann,Alexander

Aros,Cody Gomperts,Brigitte

Brown,Taylor Hallem,Elissa

Chang,Patrick Crooks,Gay

Chau,Anthony Plath,Kathrin

Cheng,Quen Hoffmann,Alexander

Diala,FitzGerald Johnson,Patricia

Fan,Xiaorui Wohlschlegel,James

Hancock,Grace Clark, Amander

Hsu,Emily Berk,Arnold

Hu,Xuchen(MSTP) Young,Stephen

Lim,HanYoung Black,Douglas

Lin,Ying Zipursky,Larry

Lopez,Andrew Fregoso,Oliver

Nitzahn,Matthew Lipshutz,Gerald

Ochoa,Jessica Yeates,Todd

Ong,Jessica Reue,Karen

Patel,Aanand(MSTP) Quinlan,Margot

Sercel,Alexander Teitell,Michael

Weiss,David Modlin,Robert

Zhang,Jiayan Zhou,Hong

Zhang,Tianhao Sun,Ren

STUDENTSAWARDEDPH.Ds2017‐2018

StudentName Mentor DissertationTitle

Aschemeyer,SharrayaLynn Ganz,Tomas Themechanismofactionandregulationofhepcidin.

Campos,Oscar Kurdistani,Siavash Theeukaryoticnucleosomeregulatescopperhomeostasisviacopperandreduction.

Flores,Aimee Lowry,Bill InvestingtheRoleofMetabolisminTissueHomeostasis andTumorInitiationbyHairFollicleStemCells.

42

Li,Yanjing Wu,Lily TargetingCXCR2+Neuroendocrine‐likeCellsfortheTreatmentofCastration‐resistantProstateCancer.

Liu,Wanlu Jacobsen,Steve MechanismsofDNAmethylationcontrolandepigenomeengineering.

Neves,LaurenTaylor Johnson,Tracy HistonevariantH2A.Zcoordinatestheprocessesoftranscriptionandpre‐mRNAsplicing.

Sahakyan,Anna Plath,Kathrin MechanismsofX‐chromosomeRegulationDuringMammalianDevelopment.

Shimada,ErikoChristine Teitell,Michael ManyFacetsofPNPase‐ UncoveringtheRoleofPNPaseintheMitochondria.

Vuong,CelineKim Black,Douglas RegulationofNeuronalExcitabilitybytheRNA‐BindingProteinRbfox1.

Young,Brian Wohlschlegel,James IdentificationofamultisubunitE3ubiquitinligaserequiredforheterotrimericG‐proteinbeta‐subunitubiquitinationandcAMPsignaling.

Young,Courtney Spencer,Melissa DevelopmentofaTherapeuticCRISPR/Cas9PlatformforDuchenneMuscularDystrophy.

EXTRAMURALFELLOWSHIPS&AWARDS

RuthL.KirschsteinNationalResearchServiceAwards

Demarco,Stephanie Emami,Michael Gang,Spencer Molgora,Brenda Loon,AaronVan

NationalScienceFoundationGraduateResearchFellowships

Aragon,Raquel Castellon,Jose Emami,Michael Gomez,Adam Hernandez,Gloria Miranda,Matilde Okonkwo,Shawntel Thurlow,Lauren Tisnado,Jerrell

GRADUATEDIVISIONAWARDSEugeneV.Cota‐RoblesFellowships

Ochoa,Jessica Urtecho,Guillaume

GraduateDivisionDissertationYearFellowshipAwards

Tao,Yang Waters,Lynnea Young,Courtney Demarco,Stephanie

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Lee,HaNeul(Skott) Leung,Calvin

MBIDPGRADUATESTUDENTSEMINARS

ModeledaftertheMBIInterdisciplinaryFacultySeminars, thesetalksarepresentedbyourgraduatestudents intheirthirdandfifthyearwithintheprogram.Facultyarenotpresentforthetalks,whichprovidesourstudentswithanopportunitytopresenttheirresearchinarelaxed,collegialatmosphereoverlunch,andallowsforconstructivediscussionandcritique.Somestudentsusethisforumaspracticefortheiroralqualifyingexamand/ordissertationdefense.Theseminarserieshasproventobeagreatsuccessduetotheformatandtheenthusiasmofourgraduatestudents.Theseminarpresentationsduringthe2017‐2018AcademicYearwere:Date 1stSpeaker 2nd Speaker

Wednesday,October4th

AimeeFlores“InvestigatingtheRoleofMetabolisminTissueHomeostasisandTumorInitiationbyHairFollicleStemCells”

AdewunmiAdelaja“Context‐specificRegulationofNFκBSignalinginPrimaryMacrophages”

Wednesday,October18th

CalvinLeung“AhistonemodificationregulatesRNAsplicingbyunexpectedmechanisms”

DavidWeiss“TheRoleofTh17CellsinHostDefense”

Wednesday,November1st

LulanWang“Studyingtheevolutionofemergingvirusesusinggenomewideanalysis”

AanandPatel“FHODfamilyforminsnucleateactinforcellmotilityandcontractility”

Wednesday,November15th

TaylorBrown"Decipheringtheinteractionsbetweenskin‐penetratingparasiticnematodesandbacteria"

WanluLiu“MechanismsofDNAmethylationcontrolandepigenomeengineering”

Wednesday,November29th

JessicaOng“Diet1andintestinalhomeostasis”

Wednesday,December13th

FitzGeraldDiala“IdentificationandcharacterizationoftheproteintargetsofmetronidazoleinTrichomonasvaginalis”

Tian‐HaoZhang“EffectsofMutationsonReplicativeFitnessandMHC‐IBindingAffinityAreAmongtheDeterminantsUnderlyingCytotoxic‐T‐LymphocyteEscapeofHIV‐1GagEpitopes”

Wednesday,January10th

ChristinaVan“RoleofPACAP/PAC1inprotectingneuronsandmodulatinginflammationinamodelofmultiplesclerosisandopticneuritis”

MattNitzahn“GeneandCellTherapyApproachesfortheUreaCycleDisorderCPS1Deficiency”

Wednesday,January24th

YingLin“Thedevelopmentofsynapticspecificityindrosophilavisualsystem”

Yi‐PeiChen“ATrichomonasvaginaliscadherin‐likeproteinmediatesadherencetoandkillingofhostcells”

Wednesday,February7th

StephanieDeMarco“RegulationofsocialmotilityintheprotozoanparasiteTrypanosomabrucei”

CharlesChoi“AphotocrosslinkableunnaturalaminoacidsystemtostudytheToxoplasmagondiiinnermembranecomplex”

Wednesday,February21st

CourtneyYoung“DevelopmentofaCRISPR/Cas9geneeditingplatformforDuchennemusculardystrophy”

PatrickChang“Engineeringstemcell‐derivedTcellsforimmunotherapy”

Wednesday,March7th

JessicaOchoa“ExploitingMicrocompartmentShellProteinstoExploreMechanismsofSubcellularOrganizationandtoCreateNovelMaterials”

EmilyHsu“TranscriptionalactivationofearlyviralgenesbyadenoviruslargeE1Aviainteractionswithp300”

44

Wednesday,March21st

HanYoungLim“ChromatinRetentionofPre‐mRNAasaMechanismformRNAQualityControl”

XiaoruiFan“Molecularmechanismofiron‐sulfurproteinmaturationmediatedbycytosolicFe/Sclusterassemblypathway”

Wednesday,April4th

EricJones“AScalable,MultiplexedAssayforDecodingReceptor‐LigandInteractions”

YangTao“Howdoesagingalterhippocampalchromatinaccessibilityandgeneexpressionpattern”

Wednesday,April18th

SkottLee“DefiningthemechanisticbasisfortheeffectofRECKalternativepolyadenylationoncellmigrationandinvasion”

CodyAros“Wnt/Beta‐cateninsignalingregulatesairwaybasalstemcellhomeostasis”

Wednesday,May2nd

AndrewLopez“HowdoesHIVactivatetheDNAdamageresponse?”

QuenCheng“ConditioningwithTypeIorIIinterferonaltershumanmacrophageresponsesinagene‐andstimulus‐specificmanner”

Wednesday,May16th

AdrianaCorvalan“UnderstandingtheroleofH4K20me3andSuv4‐20h2incellularquiescence”

AnthonyChau“InvestigatingtheRoleoftheCRepeatinXistFunction”

Wednesday,May30th

AlexSercel“Usingmitochondrialtransferandtissueengineeringtomodelandengineertherapiesformitochondrialdisordersofthecentralnervoussystem”

GraceHancock“Transcriptionfactorsfornaïvepluripotencyinprimordialgermcelldevelopment”

CONFERENCEPARTICIPATION

Adelaja,Adewunmi

MD‐PhDNationalStudentConference;Keystone,CO.July2017. SouthernCaliforniaBiomedicalSciencesGraduateSymposium;LosAngeles,CA.October2017. APSAWestRegionalMeeting;Irvine,CA.December2017. AAP/ASCI/APSAJointConference;Chicago,IL.April2018. SystemsBiologyofHumanDisease;LosAngeles,CA.June2018. ImmunologyLA;LosAngeles,CA.June2018.

Aros,Cody

GordonResearchConferenceonWntSignaling;Stowe,VT.August6‐11,2017. UCLAEli&EdytheBroadStemCellResearchSymposium;UCLA.February2,2018.

Bowler,Jeannette

FASEBScienceResearchConference;SteamboatSprings,CO.June11‐16,2017.Brown,Taylor

WWAMImeeting,Caltech.Chai,Min

KeystoneSymposiaMitochondrialBiology&SelectiveAutophagy;Kyoto,Japan.April22‐26,2018.Chang,Patrick

LaJollaImmunology;SanDiego,CA.October17‐19,2017. BroadStemCellCenterSymposium;UCLA.February5,2018. DavidBaltimoreSymposium;Caltech,Pasadena,CA.March23,2018. EngineeringImmunity;LakeArrowhead,CA.May7‐8,2018. I3TRetreat;UCLA,LosAngeles,CA.June12,2018. UCLABiomedical/LifeScienceInnovationDay;UCLA,LosAngeles,CA.June13,2018.

45

Chen,Yi‐Pei

MolecularParasitologyMeeting;WoodsHole,MA.September2017. AmericanSocietyforTropicalMedicineHygiene;Baltimore,MD.November2017. SouthernCaliforniaEukaryoticPathogenSymposium;Riverside,CA.December2017. MicrobialPathogenesisTrainingGrantTraineeSeminars;LosAngeles,CA.May2018.

Cheng,Quen

KeystoneConferenceonMyeloidCells;Breckenridge,CO.April2018.Chi,Fangtao

ColdSpringsHarborAsia‐Cancer&Metabolism;Suzhou,China.March2018.Crowell,Preston

KeystoneTumorMetabolismConference;SnowbirdSkiResort,UT.January21‐25,2018.Demarco,Stephanie

SouthernCaliforniaEukaryoticPathogensSymposium;UCRiverside,CA.December6,2017.Deng,William(Weixian)

AmericanSocietyofMassSpectrometryAnnualConference;SanDiego,CA;June2‐5,2018.Diala,FitzGerald(MSTP)

AmericanPhysicianScientistsAssociationWestRegionalConference;Irvine,CA.December2,2017. 2018StudentNationalMedicalAssociation(SNMA)AnnualMedicalEducationConference(AMEC);San

Francisco,CA.March29‐April1,2018. 2018AmericanSocietyforMicrobiology(ASM)MicrobeConference;Atlanta,GA.June7‐10,2018.

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AmericanAcademyofDermatologistAnnualMeeting;SanDiego,CA.February16‐20,2018. InternationalInvestigativeDermatologyConference;Orlando,FL.May16‐19,2018.

Edwards,Samantha

RNASocietyMeeting;Berkeley,CA.May29‐June3,2018.Emami,Michael

AnnualBiomedicalConferenceforMinorityStudents(ABRMCS);Phoenix,AZ.November1‐4,2017. AmericanSocietyofGeneandCellTherapy;May16‐19,2018. NewDirectionsofBiologyandDiseaseinSkeletalMuscleConference;NewOrleans,LA.June25,2018.

Fan,Xiaorui

AmericanSocietyforMassSpectrometryAnnualConference;SanDiego,CA.Feng,An‐Chieh(Angela)

AAIImmunologyAdvancedTrainingCourse2018;Boston,MA.July22‐27,2018.Gang,Spencer

FASEBMolecularPathogenesis:MechanismsofInfectiousDisease;Snowmass,CO.July9‐14,2017.Golden,Lisa

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Gray,David AnnualMeetingoftheAmericanSocietyforGeneandCellTherapy;Chicago,IL. GenomeEngineering:TheCRISPR‐CasRevolution;ColdSpringsHarborLaboratory,LongIsland,NY.

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FromStemCellstoHumanDevelopment;Surrey,UK.September23‐26,2018.Ho,Chi‐Min

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ofHost‐ParasiteInteractionsGRC;Newport,RI.June10‐15,2018.Hsu,Emily

DNATumorVirusMeeting;Birmingham,UK.July17‐22,2017.Hu,Xuchen(MSTP)

DeuelConferenceonLipids;March2018.Jones,Eric

GPCRWorkshop;Kona,HI.December5‐9,2017. ProteinSocietyAnnualMeeting;Boston,MA.July9‐12,2018

Kronenberg,Michael

MechanismsofEukaryoticTranscription2017;ColdSpring,NY.August29‐September2,2017.Lee,HaNeul(Skott)

MBIDPRetreat;Ventura,CA.April2018. ASCBConference;Philadelphia,PA.December2017.

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ColdSpringHarborAsia:StemCellCrossroads;Suzhou,China.May7‐10.Leung,Calvin

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HHMISciencemeeting;ChevyChase,Maryland.March2018.Lo,Hung‐Hao

I3TRetreat;LosAngeles,CA.June12,2018.Lopez,Andrew

AmericanSocietyforVirology(ASV);CollegePark,Maryland.July14‐18,2018.Lowe,Matthew

StemCellSymposium;UCLA.February2,2018. MWRI;Pittsburgh,PA.April3‐4,2018.

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AmericanSocietyofHematology;SanDiego,CA.December2017 EmergingCellularTherapies:TCellsandBeyond;Keystone,CO.February2018.

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AmericanSocietyofGeneandCellTherapy;WashingtonDC.May2018.Molgora,Brenda

SouthernCaliforniaEukaryoticPathogenSymposium;Riverside,CA.December6,2017 AmericanSocietyforMicrobiology(ASM)MicrobeConference;Atlanta,GA.June7‐11,2018.

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RosettaCon;Seattle,WA.July2017.Nitzahn,Matthew

AmericanSocietyofGeneandCellTherapy21stAnnualConference;May15‐19,2018.Patel,Aanand(MSTP)

GordonResearchSeminar&ConferenceonMotile&ContractileSystems;NewLondon,NH.July29‐August4,2017.

BiophysicalSocietyAnnualMeeting;SanFrancisco,CA.February17‐21,2018. AmericanSocietyforCellBiologyAnnualMeeting;Philadelphia,PA.December2‐6,2017.

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KeystoneSymposiaonNoncodingRNAs:Form,Function,Physiology;Keystone,CO.February25‐March1,2018.

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CellSymposiaMultifacetedMitochondria;ParadisePoint,SanDiego,CA.June4‐6,2018.Shu,Cynthia

NewDirectionsinBiologyandDiseaseofSkeletalMuscleConference;NewOrleans,LA.June25‐28,2018.Tan,YinXuan(Shawn)

14thAnnualStemCellConference(UCLA)Thurlow,Lauren

2017SACNASNationalConference;SaltLakeCity,UT.October18‐21,2017. UCLAMolecular,CellandDevelopmentalBiologyResearchConference;LakeArrowhead,CA.December1‐

3,2017. 23rdAnnualMeetingoftheRNASociety;Berkeley,CA.May29‐June3,2018.

Urtecho,Guillaume

MarineBiologicalLaboratoryAdvancedResearchCourse‐MicrobialDiversity;WoodsHole,MA.July7‐August23.

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BASFResearchForumattheendofAugustVanLoon,Aaron

GRC:MotileandContractileSystems;Colby‐SawyerCollege,NewLondon,NH.July30‐August4,2017. InternationalZebrafishConference;UniversityofWisconsin,Madison,WI.June20‐24,2018.

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MovingTargetsSymposium;USC,LosAngeles,CA.August17,2017. 13thInternationalSymposiumonPACAP,VIP,andRelatedPeptides;HongKong,China.December5,2017. CURE:DigestiveDiseasesResearchCenterAnnualMeeting;UCLA,LosAngeles,CA.March23,2018.

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InauguralI3TScientificRetreat;UCLA,LosAngeles,CA.June12,2018.Wang,Lulan

ImmunologyLA;SkirballCenter.June15,2018.Waters,Lynnea

LaJollaImmunologyConference;LaJolla,CA.October2017.Young,Courtney

AmericanSocietyforGeneandCellTherapy(ASGCT)AnnualMeeting;Chicago,IL.May16‐19,2018. WorldMuscleSociety;St.Malo,France.Oct3‐7,2017. PPMDConnectConference;Chicago,IL.June29‐July1,2017.

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ImmunologyLA;LosAngeles,CA. 14thAnnualStemCellSymposium;UCLA.

Zemke,Nathan

DNATumorVirusMeeting;UniversityofBirmingham,UK.July17‐22,2017.Zhan,Lingyu

SymposiumofFrontiersandCareersincryoEM;CNSI,UCLA.April27‐28,2018. SouthernCaliforniaSocietyforMicroscopyandMicroanalysis(SCSMMspringmeeting);MichelsonCenter

forConvergentBioscienceatUSC.April13,2018.Zhang,Tianhao

PalmSpringHIV/AIDSannualsymposium;PalmSprings,CA.March2018.

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WHITCOMEPRE‐DOCTORALTRAININGPROGRAM

TheWhitcomePre‐doctoralTrainingProgramsupportsstudentswithaMB‐IDPmentorintheir3rd,4thor5thyearofgraduateschool.Traineesareeligibleforoneyearofsupportwithpossibilityforcompetitiverenewal.Therearenocitizenshiprestrictionsforthisprogram;internationalstudentsarewelcometoapply.Theprogramiscompetitiveandmeritbased.Congratulationstothefollowinggraduatestudents,whowereselectedfortheWhitcomeTrainingProgramthisyear:Name GraduateProgram MentorNatalieChen Molecular,Cellular&IntegrativePhysiology StephenYoungCharlesChoi MBIDP(Immunity,MicrobesandMolecularPathogenesis) PeterBradleyHaNeulLee MBIDP(CellandDevelopmentalBiology) HilaryCollerHanYoungLim MBIDP(Biochemistry,Biophysics,andStructuralBiology) DouglasBlackCalvinLeung MBIDP(Biochemistry,Biophysics,andStructuralBiology) TracyJohnsonWanluLiu MBIDP(CellandDevelopmentalBiology) SteveJacobsenJerryLo MBIDP(Immunity,MicrobesandMolecularPathogenesis) StephenSmale

54

KatelynMasiuk(MSTP) MBIDP(Immunity,MicrobesandMolecularPathogenesis) DonaldKohnThangNguyen Bioengineering MichaelTeitellJessicaOng(MSTP) MBIDP(CellandDevelopmentalBiology) KarenReueJaspreetSandhu(MSTP) MBIDP(GeneRegulation,EpigenomicsandTranscriptomics) PeterTontonozHannahSunshine Molecular,Cellular&IntegrativePhysiology LuisaIruela‐Arispe

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CortnieS.Vogelsberg,FernandoJ.Uribe‐Romo,AndrewS.Lipton,SongYang,K.N.Houk,StuartBrown,and

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MichaelM.Gilbert,MatthewD.DeMars,SongYang,JessicaM.Grandner,ShouleiWang,HengbinWang,

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DavidE.Hill,KatherineL.Bay,Yun‐FangYang,R.ErikPlata,RyosukeTakise,K.N.Houk,Jin‐QuanYi,and

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KuiZhang,LingchaoCai.ZhongyouYang,K.N.Houk,andOhyunKwon:"Bridged[2.2.1]BicyclicPhosphine

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BrianJ.Levandowski,DinushkaHerath,NathanM.Gallup,andK.N.Houk:"Originofpi‐FacialStereoselectivityinThiophene1‐OxideCycloadditions,"J.Org.Chem.,83,2611‐2616.2018.

ZhongyueYang,XiaofeiDong,YanminYu,PeiyuanYu,YingziLi,CooperJamieson,andK.N.Houk:

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JianxinGuan,ChuanchengJia,YanweiLi,ZitongLiu,JinyingWang,ZhongyueYang,ChunhuiGu,DingkaiSu,

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ZhongyueYangandK.N.Houk:"TheDynamicsofChemicalReactions:AtomisticVisualizationsofOrganic

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BrianJ.Levandowski,TrevorA.Hamlin,RogerC.Helgeson,F.MatthiasBickelhaupt,andK.N.Houk:"OriginsoftheEndoandExoSelectivitiesinCyclopropenone,Iminocyclopropene,andTriafulveneDiels‐AlderCycloadditions,"J.Org.Chem.,83,3164‐3170.2018.

ShumingChenandK.N.Houk:"OriginsofStereoselectivityinMannichReactionsCatalyzedbyChiral

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SeanA.Newminster,ShashaLi,MarcGarcia‐Borras,JacobN.Sanders,SongYang,AndrewN.Lowell,FenganYu,JanetL.Smith,RobertM.Williams,K.N.Houk,andDavidH.Sherman:"StructuralBasisoftheCopeRearrangementandCyclizationinHapalindoleBiogenesis,"NatureChem.Biol.,14,345‐351.2018.

JackT.Ly,StevenA.Lopez,JaniceB.Lin,JaeJoonKim,HyunbokLee,EdmundK.Burnett,LeiZhang,Alan

Aspuru‐Guzik,K.N.Houk,andAlejandroL.Briseno:"OxidationofRubrene,andImplicationsforDevideStability,"J.Mat.Chem.C,6,3757‐3761.2018.

MorganM.Walker,ShumingChen,BrandonQ.Mercado,K.N.Houk,andJonathanA.Ellman:"Formationof

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SherminS.Goh,PierAlexandreChampagne,SureshbabuGuduguntla,TakashiKikuchi,MakotoFujita,K.N.

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ShumingChen,YuZheng,TianjiaoCui,EricMeggers,andK.N.Houk:"Arylketonepi‐ConjugationControls

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XiaomingWang,YingziLi,TobiasKnecht,ConstantinDaniliuc,K.N.Houk,andFrankGlorius:

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RaspudinSaleem‐Batcha,FrederickStull,JacobN.Sanders,BradleyS.Moore,BruceA.Palfrey,K.N.Houk,

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HuiminTao,FangLiu,RuxinZeng,ZhuzhouShao,LufengZou,YangCao,JenniferM.Murphy,K.N.Houk,

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KatherineL.Bay,Yun‐FangYang,andK.N.Houk:"MultipleRolesofSilverSaltsinPalladium‐CatalyzedC‐H

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