Quantum Dots as a Platform for Simultaneous Dual-modality ...Application of Paramagnetic Graphene...
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Application of Paramagnetic Graphene Quantum Dots as a Platform for Simultaneous Dual-modality Bioimaging and Tumor-targeted Drug Delivery Chun-Lin Huang, a Chih-Ching Huang, b Fu-Der Mai, c Chia-Liang Yen, d Shin-Hwa Tzing, a Hsiao-Ting Hsieh, c Yong-Chien Ling, d and Jia-Yaw Chang a* a. Department of Chemical Engineering, National Taiwan University of Science and Technology, 43, Section 4, Keelung Road, Taipei 10607, Taiwan, Republic of China b. Institute of Bioscience and Biotechnology and Center for Marine Bioenvironment and Biotechnology, National Taiwan Ocean UniVersity, Keelung, Taiwan, Republic of China c. Department of Biochemistry, School of Medicine, Taipei Medical University, Taipei, Taiwan, Republic of China d. Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan, Republic of China E-mail: [email protected] Department of Chemical Engineering, National Taiwan University of Science and Technology, 43, Section 4, Keelung Road, Taipei 10607, Taiwan, Republic of China Tel.: +886-2-27303636 Fax: +886-2-27376644 1 Electronic Supplementary Material (ESI) for Journal of Materials Chemistry B. This journal is © The Royal Society of Chemistry 2014
Transcript of Quantum Dots as a Platform for Simultaneous Dual-modality ...Application of Paramagnetic Graphene...
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Application of Paramagnetic Graphene
Quantum Dots as a Platform for Simultaneous
Dual-modality Bioimaging and Tumor-targeted
Drug Delivery
Chun-Lin Huang,a Chih-Ching Huang,b Fu-Der Mai,c Chia-Liang Yen,d Shin-Hwa
Tzing,a Hsiao-Ting Hsieh,c Yong-Chien Ling,d and Jia-Yaw Changa*
a. Department of Chemical Engineering, National Taiwan University of Science
and Technology, 43, Section 4, Keelung Road, Taipei 10607, Taiwan,
Republic of China
b. Institute of Bioscience and Biotechnology and Center for Marine
Bioenvironment and Biotechnology, National Taiwan Ocean UniVersity,
Keelung, Taiwan, Republic of China
c. Department of Biochemistry, School of Medicine, Taipei Medical University,
Taipei, Taiwan, Republic of China
d. Department of Chemistry, National Tsing Hua University, Hsinchu, Taiwan,
Republic of China
E-mail: [email protected]
Department of Chemical Engineering, National Taiwan University of Science and
Technology, 43, Section 4, Keelung Road, Taipei 10607, Taiwan, Republic of China
Tel.: +886-2-27303636
Fax: +886-2-27376644
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Electronic Supplementary Material (ESI) for Journal of Materials Chemistry B.This journal is © The Royal Society of Chemistry 2014
mailto:[email protected]
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400 450 500 550 600 650 700Wavelength (nm)
Inte
nsity
(a.u
.)
160 OC140 OC120 OC80 OC
Figure S1. PL emission spectra of GQD obtained at different reaction temperature
(λex = 350 nm). The insets are digital photographs of the GQD prepared at 160 °C,
140 °C, 120 °C, and 80 °C (from left to right), respectively, under illumination of UV
light (365 nm).
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4.77 [nm]
0.002.00 um 5.00 x 5.00 um
3074355
Figure S2. AFM images of GQDs deposited on a freshly cleaved mica substrate. The
dimensions of the scanned area are 5 × 5 μm2.
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Figure S3. High magnification TEM image of the as-prepared GQDs.
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Figure S4. Optical microscopic images showing the representative morphological
characteristics of zebrafish embryos exposed to different concentrations of (a) GQDs
and (b) folate-GdGQDs at different developmental stages.
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Top
Bottom
a b c
Figure S5. Z-stack confocal imaging obtained from HeLa cell incubated with
nanocarriers. Images were taken from the top to the bottom of the cell with
consecutive Z-axis slices. (a) Green fluorescence originating from nanocarriers; (b)
red emission emitting from DOX; and (c) blue emission emitting from DAPI. Scale
bars represent 20 m.
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