Pyruvate Oxidation and Krebs Cycle - Weebly
Transcript of Pyruvate Oxidation and Krebs Cycle - Weebly
recall that glycolysis involved one splitting glucose producing 2 molecules of each: NADH, H2O, ATP and pyruvate
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Stage 2: Pyruvate Oxidation
occurs in matrix of mitochondria
when O2 is present, the 2 pyruvate molecules made in glycolysis get transported through transport proteins in to enter the matrix
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Overall equation for pyruvate oxidation:
2 pyruvate + 2NAD+ + 2 CoA → 2 AcetylCoA + 2NADH + 2H+ + 2CO2
* CoA stands for Coenzyme A
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3 changes happen in one step:Cytoplasm
Matrix of Mitochondria
Pyruvate
CO2 1) Remove CO2
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3 changes happen in one step:Cytoplasm
Matrix of Mitochondria
Pyruvate
CO2NAD+
NADH
1) Remove CO2
2) 2C complex gets oxidized to become acetate
Saturday, October 14, 17
3 changes happen in one step:Cytoplasm
Matrix of Mitochondria
Pyruvate
Acteyl CoA
CO2NAD+
NADH
Coenzyme A
1) Remove CO2
2) 2C complex gets oxidized to become acetate
3) Coenzyme A attaches to acetate via S, forms acetylCoA
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Final Products of Pyruvate Oxidation:
2 NADH (saved for ETC)
2 AcetylCoA
can either be stored as fat or it well enter Krebs to create ATP
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Overall equation for Krebs Cycle:
oxaloacetate + acetylCoA + ADP + P + 3 NAD+ + FAD → CoenzymeA + ATP + 3NADH + FADH2 + 3H+ + oxaloacetate + CO2
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Citrate (6C)
aconitate (6C)
isocitrate (6C)
a-ketoglutarate (5C)
H2O
H2O
CO2 NADNADH
Saturday, October 14, 17
Citrate (6C)
aconitate (6C)
isocitrate (6C)
a-ketoglutarate (5C)
succinyl CoA (4C)
H2O
H2O
CO2 NADNADH
NADNADH
CO2CoA
Saturday, October 14, 17
Citrate (6C)
aconitate (6C)
isocitrate (6C)
a-ketoglutarate (5C)
succinyl CoA (4C)
succinate (4C)
H2O
H2O
CO2 NADNADH
NADNADH
CO2CoA CoA
Saturday, October 14, 17
Citrate (6C)
aconitate (6C)
isocitrate (6C)
a-ketoglutarate (5C)
succinyl CoA (4C)
succinate (4C)
H2O
H2O
CO2 NADNADH
NADNADH
CO2CoA CoA
GDP
GTP
Saturday, October 14, 17
Citrate (6C)
aconitate (6C)
isocitrate (6C)
a-ketoglutarate (5C)
succinyl CoA (4C)
succinate (4C)
H2O
H2O
CO2 NADNADH
NADNADH
CO2CoA CoA
GDP
GTPADP
ATPSaturday, October 14, 17
Citrate (6C)
aconitate (6C)
isocitrate (6C)
a-ketoglutarate (5C)
succinyl CoA (4C)
succinate (4C)
fumarate (4C)
H2O
H2O
CO2 NADNADH
NADNADH
CO2CoA CoA
GDP
GTPADP
ATP
FADFADH2
Saturday, October 14, 17
Citrate (6C)
aconitate (6C)
isocitrate (6C)
a-ketoglutarate (5C)
succinyl CoA (4C)
succinate (4C)
fumarate (4C)
malate (4C)
H2O
H2O
CO2 NADNADH
NADNADH
CO2CoA CoA
GDP
GTPADP
ATP
FADFADH2
H2O
Saturday, October 14, 17
Citrate (6C)
aconitate (6C)
isocitrate (6C)
a-ketoglutarate (5C)
succinyl CoA (4C)
succinate (4C)
fumarate (4C)
malate (4C)
oxaloacetate (4C)
H2O
H2O
CO2 NADNADH
NADNADH
CO2CoA CoA
GDP
GTPADP
ATP
FADFADH2
NAD
NADH
H2O
Saturday, October 14, 17
Citrate (6C)
aconitate (6C)
isocitrate (6C)
a-ketoglutarate (5C)
succinyl CoA (4C)
succinate (4C)
fumarate (4C)
malate (4C)
oxaloacetate (4C)
H2O
H2O
CO2 NADNADH
NADNADH
CO2CoA CoA
GDP
GTPADP
ATP
FADFADH2
NAD
NADH
H2O
Saturday, October 14, 17
Citrate (6C)
aconitate (6C)
isocitrate (6C)
a-ketoglutarate (5C)
succinyl CoA (4C)
succinate (4C)
fumarate (4C)
malate (4C)
oxaloacetate (4C)
Acetyl CoA (2C) CoA *Recycled to pyruvate oxidation
H2O
H2O
CO2 NADNADH
NADNADH
CO2CoA CoA
GDP
GTPADP
ATP
FADFADH2
NAD
NADH
H2O
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CooksApproved
InKitchens
ServeSavory
FoodMoreOften
CitrateAconitateIsocitrate
KetoglutarateSuccinyl CoA
SuccinateFumarateMalate
Oxaloacetate
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