Putting Botulinum Toxins and Facial Fillers into ... · PDF filePutting Botulinum Toxins and...
Transcript of Putting Botulinum Toxins and Facial Fillers into ... · PDF filePutting Botulinum Toxins and...
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Putting Botulinum Toxins and Facial Fillers into PracticeFacial Fillers into Practice
Sirtaz S. Sibia, D.O., FAOCO, ,Orlando, Florida May 2013
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Approach to the cosmetic patientApproach to the cosmetic patient
Anatomic areas of concern to the patient Give the patient a mirror and have them point out what bothers them Give the patient a mirror and have them point out what bothers them
History of previous treatmentD t ti t’ t Document patient’s anatomy
Educate the patient about treatment optionsBotox Cosmetic, Dysport, Xeomin, Restylane, Perlane, Juvederm, Radiesse, etc.
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Basic Physician Knowledge of Botulinum toxinsBotulinum toxins
Botulinum toxins Indications Administering physicians
• Temporary improvement in the appearance of moderate to severe glabellar lines
• Be well trained• Have knowledge of
muscles controlling facialg• Corrugator and/or
procerus activity• Adults 65 years
muscles controlling facial expression
• Understand the dynamics of agingAdults 65 years g g
• Be qualified to evaluate and determine individual treatment
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Botulinum Toxin Overview
BOTOX® Cosmetic, Xeomin and Dysport are purified natural proteins derived from thepurified, natural proteins derived from the bacterium Clostridium botulinum.
Botulinum toxins works by blocking acetylcholine impulses that trigger hyperactive
l imuscle contractions.
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Botulinum Toxin vs. TheBotulinum Toxin vs. The Aging Face
Glabellar frown linesH i t l f h d li Horizontal forehead lines
Periorbital lines (Crow’s feet) Lateral brow lift
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BOTOX® Cosmetic PackagingBOTOX Cosmetic Packaging
Store vacuum-dried product in refrigerator (2-8°C)in refrigerator (2-8 C).
Administer within 4 hours after reconstituting product.
Store reconstituted product at Store reconstituted product at 2°C to 8°C.
BOTOX® Cosmetic should be clear, colorless and free of particulate matter.
Supplied in a single patient use vial.
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Dysport PackagingDysport Packaging
Store vacuum-dried product in refrigerator (2-8°C)in refrigerator (2-8 C).
Administer within 4 hours after reconstituting product.
Store reconstituted product at Store reconstituted product at 2°C to 8°C.
Dysport should be clear, colorless and free of particulate matter.
Supplied in a single patient use vial.
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Botulinum systemic side effectsBotulinum systemic side effects
Rare Usually not associated with cosmetic indications Usually not associated with cosmetic indications
Generalized weaknessFl lik t Flu-like symptoms
Diffuse skin rash Headache
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Botulinum ContraindicationsBotulinum Contraindications
Pregnancy and breast feedingDi d f th l j ti Disorders of the neuromuscular junction
Myasthenia gravis M thi Myopathies
Aminoglycoside therapy M i i l t i i d th ti l May impair neuromuscular transmission and are a theoretical
contraindication
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Botox/Dysport Preparationy p p
1 cc syringes Insulin syringe with pre-y g p
attached 30 guage needle vs. separate syringe and needle
30 gauge needle 30 gauge needle Digital camera Consent form Consent form Postop instructions
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Anesthesia for InjectionsAnesthesia for Injections
NoneI th l hl id Ice, ethyl chloride
Emla, ELA-Max, BetacaineBetacaine
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Botox/Dysport PreparationBotox/Dysport Preparation
Botulinum toxin needs to be reconstitutedto be reconstituted with sterile, preservative free saline
Refer to Botulinum toxin by units not volume
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Botox: Vial Dilutions
Saline U/ml U/0.1 ml
2.0 ml 50 5.0
2.5 ml 40 4.0
4.0 ml 25 2.5
5.0 ml 20 2.0
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Dysport: Vial Dilutionsy p
Saline U/ml U/0.1 ml
1.5 ml 200 20.0
2.0 ml 150 15.0
2.5 ml 120 12.0
3.0 ml 100 10.0
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Documentation of Botox treatments
Botulinum toxin injection worksheetB f d ft h t h Before and after photographs
Make good notes on how many units injected for each site to help improve results for future Botox/Dysport / Xeomintreatments
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BOTOXR Injection Worksheet
Patient Name: _______________________________ DOB: _________ Date: _________
Treatment Areas: glabella forehead periorbital perioral other
BOTOXR: Lot __________ Expiration ___________ Conc’n ___________
The risks, benefits, and alternatives of Botox injections were discussed with patient.RBotoxR was administered after alcohol skin prep and topical anesthesia placement.
Patient tolerated procedure well and there were no complications.
Return appointment: ___________________
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Key Muscles of the Upper Face
Corrugator FrontalisCorrugatorSupercilii
Frontalis
Procerus OrbicularisOculi
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Discussing BOTOX® Cosmetic, Xeomin or Dysport with yourXeomin or Dysport with your
Patients
BOTOX® Cosmetic/ Dysport/ Xeomin is a natural purified BOTOX Cosmetic/ Dysport/ Xeomin is a natural, purified protein that relaxes wrinkle-causing muscles, creating a smoothed and improved appearance.
® BOTOX® Cosmetic/ Dysport/ Xeomin is administered via a few tiny injections of purified protein into the muscle to block nerve impulses that trigger wrinkle-causing muscle contractions.
BOTOX® Cosmetic/ Dysport/ Xeomin is a simple and quick, minimally invasive treatment that delivers dramatic results with no downtimeno downtime.
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Discussing BOTOX® Cosmetic, Xeomin, d D t ith P ti tand Dyport with your Patients
Don’t
“fixed” “frozen” “paralyzed” “deaden”fixed , frozen , paralyzed , deaden ,
“needles”
Do
“ th” “ l ” “ f h” “ti“smooth”, “relax”, “refresh”, “tiny injection”, “soften”
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Botulinum Toxin Marketingg
Internal marketing Botox/Dysport/Xeomin brochures Botox/Dysport/Xeomin brochures Treat office staff with left over Botox/Dysport
External marketingg Traditional advertising Spas, salons, gyms, health clubs
Pricing “Botox Days”
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Glabellar Frown LinesGlabellar Frown Lines
Rhytids (wrinkles) between the browsbetween the brows
Produced by corrugator g procerus orbicularis oculi depressor supercilli
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Before and After: GlabellaBefore and After: Glabella
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Glabellar line treatmentGlabellar line treatment
5 injection sites:5 injection sites: • 1 in procerus• 2 in each corrugator2 in each corrugator
Total dose: • Botox/Xeomin: 20 U
(4U/injection site)• Dysport: 50 U
(10 U/injection site)
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Decrease in Glabellar Lines after ®Treatment with BOTOX® Cosmetic
Baseline Day 30
Unretouched clinical trial photos taken while frowning before BOTOX® Cosmetic and after BOTOX® Cosmetic. Individual
ltresults may vary.
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Potential complications of glabellarp gtreatments
BruisingB Pt i Brow Ptosis
Diplopia Eyelid Ptosis Treat with Naphcon A or Iopidine, the alpha agonistic activity
ti l t M ll ’ l hi h lift th lid d t f thstimulates Mueller’s muscle which lifts the lid and compensates for the loss of the levator
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Why use Botulinum in glabella vs. fillersy g
Occlusion of cutaneous vessels (Zyplast)Bli d (C ll f t t i i l ) Blindness (Collagen, fat, triamcinolone)
Cerebrovascular occlusion (fat)
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Forehead LinesForehead Lines
Rhytids (wrinkles) across the forehead
Produced by frontalis muscle
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Before and After:Forehead
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Forehead line treatment
Botox/Xeomin: 2 U/ site
Dyport: 5U/ site to prevent eyelid ptosis,
injections should be at least 1 cm above the supraorbital rim pand away from the area above the lateral eyebrow
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Potential complications of foreheadptreatments
BruisingB Pt i Brow Ptosis
Eyelid Ptosis
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Periorbital Lines (Crow’s Feet)Periorbital Lines (Crow s Feet)
Rhytids (wrinkles) di i f hradiating from the
lateral canthus, especially when aespecially when a person smiles
Produced by Produced by orbicularis oculi
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Before and After: periorbital linesp
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Periorbital line treatmentPeriorbital line treatment
Botox/Xeomin: 3 U per site3 U per site
Dysport: 8 U per site Inject 1 cm away from orbital Inject 1 cm away from orbital
rim To prevent bruising in this area
use intradermal or subcutaneoususe intradermal or subcutaneous injections
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Potential complications of periorbitalp ptreatments
DiplopiaK titi Keratitis
Ectropion Epiphora Weakness of zygomaticus muscleWeakness of zygomaticus muscle
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Lateral Brow Lift
Performed mainly for female patientsfemale patients
Treat the lateral brow depressors so the brow pelevators work unopposed
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Before and After:lateral brow lift
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Lateral Brow Lift Treatment
4 units Botox/Xeomin 3 units Botox/Xeomin 3 units Botox/Xeomin 2 units Botox/Xeomin treat just like you do the treat just like you do the
glabellar lines add an additional 2 units into
the orbicularis oculi 1-2 cmthe orbicularis oculi 1 2 cm lateral to the orbital rim and at the tip of the eyebrow
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Postop Instructionsp
Do not lie down for the next 4 hoursD t l f th t 4 h Do not lean over for the next 4 hours
Do not touch or massage the treated areas in any fashion for at least 4 hours
Immediately after the injections, frown and y jsmile repeatedly for the next 15 to 30 minutes
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Fillers: Temporary, Semipermanent, and Permanent
Temporary Fillers1. Less durable and enduring2. Biodegradable
Semipermanent fillers1. Slowly biodegradable2. Liquid Silicone: Silikon 10002. Biodegradable
3. Bovine Collagen: Zyderm and Zyplast
4. Human dollagen: Cosmoderm and Cosmoplast
2. Liquid Silicone: Silikon 10003. Polylactic acid: Sculptra4. Calcium Hydroxylapatite:
Radiesse5. Fat fillersp
5. Hyaluronic acid: Restylane, Perlane, Captique, Hylaform, Juvederm Ultra
6. Fat fillers
5. Fat fillers
Permanent fillers:1. Nonbiodegradable2. Polymethylmethacrylate:
Artefill, Artecoll3. Fat fillers
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Collagen Implants:Z d d Z l tZyderm and Zyplast
FDA approved in 1981 and 1985, respectively
Bovine collagen implant Pros: safe, reliable, user-friendly, contains
lidocaine Cons: allergic reaction, redness, swelling,
skin test is required, and a second skin test is recommendedtest is recommended
Recommended use: fine to deep wrinkles, frown lines, smile lines, crow’s feet, lip border acne and other scarsborder, acne and other scars
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Collagen Replacement:Cosmoderm and Cosmoplast
FDA approved in 2003 Pros: immediate rsults with no down time Cons: short-lived correction Recommended use for Cosmoderm:
superficial papillary dermis for correction of wrinkles and acne scars
Recommended use for Cosmoplast: mid to Recommended use for Cosmoplast: mid to deep dermis for correction of wrinkles and acne scars
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Synthetic Calcium: R diRadiesse
FDA approved in 2006 Volume composition made up of 70% p p
carboxymethylcellulose and 30% calcium hydroxylapatitePros: no allergy testing long shelf life Pros: no allergy testing, long shelf life, longevity once injected
Cons: nodules common, especially in lips, , p y p ,mistakes no easily forgiven
Recommended use: nasolabial folds, d d l idepressed scars, oral commissures
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Synthetic Poly-L-Lactic Synthetic Poly L Lactic Acid: Sculptra
FDA approved in 2004 Synthetic poly-L-lactic acidy p y Pros: long-lasting, long safety record as an
implant/suture material Cons: approved for HIV lipodystrophy only;
granulomas have been reported Recommended use: filler for HIV Recommended use: filler for HIV
lipodystrophy-related atrophy; and mild volume loss
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Polydimethylsiloxane: Silik 1000Silikon 1000
FDA approved in 1997 Purified polydimethylsiloxanep y y Pros: low biological toxicity potential,
inert material Cons: approved for retinal tamponade
during vitreoretinal surgery only, requires multiple treatmentsp
Recommended use to treat facial lipoatrophy in patients with HIV
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PMMA/Bovine Collagen:A t ll d A t FillArtecoll and ArteFill
FDA approved in 2006(Artefill) Made up of 20% precision-filtered
polymethylmethacrylate microspheres and 80% purified bovine collagen
Pros: long-lasting, must be injected g g, jcorrectly
Cons: skin testing required, contraindicated with allergies, thin skin contraindicated with allergies, thin skin surgical excisions required for removal, multiple treatments required
Recommended use: nasolabial folds Recommended use: nasolabial folds
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Hyaluronic Acid: CaptiqueHyaluronic Acid: Captique
FDA approved in 2004 Bacterial fermentation-derived hyaluronic y
acid Pros: safe, reliable, user-friendly,
predictable results no allergy testingpredictable results, no allergy testing Cons: rare allergic reactions, post-
injection swelling, painj g, p Recommended use: moderate to severe
facial wrinkles
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Hyaluronic Acid: R t lRestylane
FDA approved in 2003 Bacterial-cultured stabilized hyaluronic y
acid Pros: safe, reliable, user-friendly,
predictable results no allergy testingpredictable results, no allergy testing Cons: rare allergic reactions and particles
may lead to uneven distributiony Recommended use: superficial defects,
lips, lines, contouring for moderate to i klsevere wrinkles
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Hyaluronic Acid: PerlaneHyaluronic Acid: Perlane
FDA approved in 2007 High-viscosity bacterial-cultured g y
hyaluronic acid Pros: excellent for deeper folds requiring a
thicker filler fills deep folds with less thicker filler, fills deep folds with less material than Restylane
Cons: rare allergic reactionsg Recommended use: shaping facial
contours, defining cheeks, eliminating d f ld d l i lideep folds and enlarging lips
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Hyaluronic Acid: Juvederm Ult d Ult lUltra and Ultra plus
FDA approved in 2006 Bacterial-cultured stabilized hyaluronic y
acid Smooth-consistency gel Pros: safe, reliable, user-friendly, no
allergy testing Cons: temporary injection-site redness Cons: temporary injection-site redness
and tenderness Recommended use: lips, lines, contouring
moderate wrikles
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Importance of HA fluid retentionfluid retention
Hyaluronic acid is a naturally occurring polysaccharide(sugar)occurring polysaccharide(sugar)
The most important characteristics of hyaluronic characteristics of hyaluronic acid relevant to its performance as a dermal filler is its fluid as a dermal filler is its fluid retention, i.e., water binding capabilitiescapabilities
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Possible side effects and Possible side effects and complications with fillers
Early1. Bruising
Late Allergic reactiong
2. Swelling3. Pain4 Herpes
g Asymmetry Scarring Nodules4. Herpes
5. Overcorrection6. Undercorrection
Nodules Granulomas Elevations
7. Necrosis8. Hematoma
Migration Lumping
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Before and After Fillers
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Before and After Filler
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Filler for tear troughsFiller for tear troughs
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Before and After Fillers in LipsBefore and After Fillers in Lips
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Before and After Fillers in LipsBefore and After Fillers in Lips
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Before and After Fillers in LipsBefore and After Fillers in Lips
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Removal of Fillers from LipsRemoval of Fillers from Lips
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Removal of Fillers from LipsRemoval of Fillers from Lips
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Removal of Fillers from LipsRemoval of Fillers from Lips
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Latisse for hypotrichosisLatisse for hypotrichosis
Latisse is FDA approved to grow eyelashes, making them longer, making them longer, thicker and darker.
Applied at night to the upper eyelid margins at the base of the lashes.
Patients with a history of abnormal intraocular pressure need to be pressure need to be supervised by their ophthalmologist.
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Latisse: Side EffectsLatisse: Side Effects
May cause darkening of the eyelid skin.
May cause increased May cause increased brown pigmentation of the iris.
May cause itching y gsensation or redness of the eyes.
May cause dry eyes.