PureWoman™

*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

PMS PROTOCOL*05

About PureWoman™Treating the whole patient is a pillar of functional and integrative medicine. What makes women unique is not solely a matter of anatomy and hormones. It is the complex interplay of hormones, their receptors, and dietary, lifestyle and environmental factors that converge on every organ system in a woman’s body. PureWoman™ recognizes these complex relationships and the science behind them, empowering practitioners with nutritional supplements and education to bring a new level of health and wellness to female patients at all stages of life. Developed in collaboration with integrative gynecologist Felice L. Gersh, M.D., the PureWoman™ platform allows practitioners to address critical issues in women’s health, including cardiovascular, metabolic, musculoskeletal, emotional, breast, neurocognitive and reproductive health with practical knowledge, protocols and products.*

The PMS Protocol* is Designed to:Support normal PMS symptoms in healthy women*

Help decrease fatigue, breast tenderness and food cravings*

Moderate cramps and bloating associated with the menstrual cycle*

Provide support for behavior and mood symptoms associated with the luteal phase*

Overview Premenstrual syndrome (PMS) affects 75-80% of premenopausal women to varying degrees. It encompasses a wide range of symptoms that occur exclusively within the 10 to 14 days prior to menses. Symptoms are usually mild and include mood swings, food cravings, abdominal bloating, fatigue and irritability. While the etiology of PMS remains unclear, evidence suggests that fluctuating ovarian hormone levels, changes in serotonergic and GABA-mediated neurotransmission, and prostaglandin production play important roles in its frequency and intensity.1

Factors that are strongly linked to PMS include poor diet, a sedentary lifestyle and micronutrient deficiencies.2 Many women find that small changes in diet and lifestyle, if followed consistently, attenuate PMS symptoms. Evidence from numerous clinical studies supports the efficacy of certain vitamins, minerals, botanicals and essential fatty acids in mitigating or managing PMS.3 This protocol outlines nutritional and lifestyle modalities supported by both published studies and clinical experience.*

Felice L. Gersh, M.D.†† is an award-winning, innovative

physician and one of a small

number of board-certified

OB/GYN graduates from the

prestigious Fellowship in

Integrative Medicine at the

University of Arizona School

of Medicine. Dr. Gersh speaks

nationally on a wide spectrum

of health topics of great

importance to women across

all ages with a special expertise

in women’s hormones and the

impact of environmental toxins,

medications, nutrition and aging.

She is a graduate of Princeton

University and the University of

Southern California School of

Medicine.

††Dr. Felice. L. Gersh has been retained as a medical consultant in advising Pure Encapsulations. She is compensated for this service.

Dietary & Lifestyle RecommendationsNutrition:

• Eat a diet rich in essential fatty acids. Decrease consumption of animal fats while increasing omega-3 intake through cold-water fish, such as sardines, herring and wild salmon. Two tablespoons per day of ground flaxseeds provide fiber and lignans to support hormonal balance.

• Limit salt intake to moderate bloating and fluid retention.

• Consume whole foods high in fiber, phytonutrients and complex carbohydrates, such as fruits, vegetables and whole grains. Avoid sugar, sweetened beverages and packaged foods.

• Limit caffeine and alcohol, particularly during the luteal phase (the two weeks prior to menses).

• Consume fermented foods such as tempeh, unsweetened yogurt and miso soup.

Exercise:• Engage in aerobic exercise at least 30 minutes per day, three to five days per week during menstrual cycle.4

Stress:• Manage stress. Consider breathing exercises, yoga, meditation, and calming teas such as chamomile and holy basil.

Sleep:• Take five minutes for a simple three-step breathing exercise prior to bedtime: Breathe in slowly through the nose for four

seconds, hold for seven seconds and exhale through the mouth for eight seconds.

• Drink a cup of holy basil tea, which may also support relaxation and sleep onset.

• Take two capsules of Best-Rest Formula as needed 30 to 60 minutes prior to bedtime for additional sleep support.*

Duration The foundation products are intended for continuous, long-term use. The targeted support products may be taken either continuously or during the luteal phase of the cycle. This protocol may require several months to take effect.*

Assessment A symptom diary is helpful for identifying dietary and lifestyle patterns associated with symptoms and for monitoring progress. It also helps to identify symptoms that may not be PMS-related (e.g. those that also occur earlier in the cycle).

Endocrine

• LH and FSH• Prolactin• DHEA(S), pregnenolone, estradiol and testosterone• TSH, free T3, reverse T3, free T4, anti-TPO, and

thyroglobulin antibodies

Assessment

• NutraEval® (Genova Diagnostics)

• MTHFR genotype – if positive for C677T, consider additional L-methylfolate (Folate 1000)*

Other Tests to Consider

• Gut microbial profile (Genova G.I. Effects®)

• hsCRP, oxidized LDL, MPO, and lipid profile – if necessary, consider adding O.N.E.™ Omega, EndoLOX, ResCu-SR™ and/or CholestePure Plus for cardiometabolic support*

Secure online ordering and information at www.PureEncapsulations.com

*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

The Protocol‡

Product Breakfast Lunch Dinner

ProSoothe II 2 capsules

2 capsules

Best-Rest Formula

2 capsules

E.P.O (evening

primrose oil)

2 capsules

Ashwagandha 1 capsule

Magnesium (glycinate)

1 capsule

2 capsules

Women’s Pure Pack

1 packFO

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Targeting the Whole Woman at

Every Stage of Life*

**The above are recommendations to be used for foundational support.‡The above are general recommendations. Please follow the recommended dosing of your healthcare professional.

Pure Encapsulations® Supplements

Where multiple supplements are suggested, please note that the patient may not require all of them.*

**The above are recommendations to be used for foundational support.

Product Name Ingredients Function How it works

ProSoothe II

4 capsules provide:• Chaste tree (Vitex agnus-castus) extract

(fruit) 400 mg• Relora® (Magnolia officinalis and

Phellodendron amurense extracts) (bark) 540 mg

• Rhodiola rosea extract (root) 100 mg• Vitamin B6 100 mg• Calcium (from di-calcium malate) 200 mg• Magnesium (from di-magnesium malate)

200 mg • Vitamin D3 800 IU• Vitamin E 400 IU

• Positive mood*• Relief from cramps, food

cravings, nervous tension, fatigue, breast tenderness and bloating associated with the menstrual cycle2, 6-35*

Promotes serotonergic, opioid and GABA neurotransmission. Maintains healthy prolactin levels. Promotes uterine smooth muscle relaxation, luteinizing hormone release and progesterone production. Supports the hypothalamic-pituitary-adrenal (HPA) axis to maintain healthy cortisol levels*

Best-Rest Formula

• Valerian (Valeriana officinalis) extract (root) 400 mg

• Vitamin B6 5 mg.• Melatonin 1 mg• GABA 300 mg• L-theanine 50 mg• Lemon balm (Melissa officinalis) extract

(leaf) 150 mg• Hops (Humulus lupulus I.) extract (aerial

parts) 150 mg• Passion flower (Passiflora incarnate

I.) extract (aerial parts) (contains 3.5% vitexin) 100 mg

• Chamomile (Matricaria recutita) extract (flower) 100 mg

• Relaxation, sleep onset and sleep quality*

Supports alpha wave production and inhibitory neurotransmission in the brain*

E.P.O. (evening

primrose oil)

• Cold-pressed evening primrose oil (9% gamma-linolenic acid) 500 mg

• Prostaglandin balance* Fosters the production of prostaglandin E1 (PGE1)5*

Ashwagandha• Ashwagandha (Withania somnifera)

extract (2.5% withanolides) 500 mg• Relaxation and healthy stress

responses36* Supports the HPA axis and maintains healthy cortisol levels35-40*

Magnesium (glycinate)

• Magnesium (glycinate) 120 mg • Positive mood*• Breast comfort* • Supports emotional well-being

and maintains fluid balance associated with the luteal phase6-9, 13, 16*

Encourages serotonin production and GABA-mediated neurotransmission. Synergizes with vitamin B6

9*

Women’s Pure Pack

• Women’s Nutrients (multivitamin featuring HMRlignan™)

• EPA/DHA essentials (300/200 mg) 1,000 mg

• Calcium (citrate) 500 mg• CoQ10 60 mg• Vitamin D

3 1,500 IU

• Açai 600 mg

• Daily wellness*• Positive mood*• Metabolic and reproductive

health 2-20,41-46*

Maintains healthy prostaglandin balance5 and prolactin secretion.46 Promotes healthy estrogen metabolism. Supports mitochondrial function and serotonin neurotransmission30*FO

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*These statements have not been evaluated by the Food & Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

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PWPMSP216

This information is intended for use by healthcare practitioners, is for informational purposes only, and does not establish a doctor-patient relationship. Please be sure to consult your physician before taking this or any other product. Consult your physician for any health problems.

References

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