Optimum release of actives for

a long-lasting moisturizing effect

PTsmSubmicrometric

Technology

Platform

Aqueous

Phase

Technology

(APT)

WATER: The source of life

WATER SUPPORTS LIFE ON EARTH

Probably one of the MOST NECESSARY of all our needs.

It is the most needed compound.

Between 60% to 70% of the whole human body is water,

brain is composed of 70% water, our lungs, 80%

Most of BIOLOGICAL processes are carried out

in the presence of water.

Optimum release of actives for a long-lasting moisturizing effect

EARTH is a WATERY place+ 70% of the Earth́ s surface is water covered

Optimum release of actives for a long-lasting moisturizing effect

Our body Our skin Our skin cells

70%

+85%water

30%Stratum corneum SC

70-80%epidermis-dermis

Water is VITAL tothe mechanics of

our human body

Our anatomy and

physiology

DEPENDS ON water.

Helps to regulate

our temperature Under normal conditions,

well-moistened skin,

maximizes its PROTECTIVE role.

Gives the skin its SOFT, SMOOTH

and FLEXIBLE TEXTURE.

In skin, it comes from the atmosphere,

underlying layers of the skin

and sweat.

Water is ESSENTIAL

to normal HOMEOSTATICregulation.

WATER: The most necessary of our needs

TRANSEPIDERMAL WATER LOSS

HYDRATION LEVELS

Optimum release of actives for a long-lasting moisturizing effect

TEWL is the water loss through the intact SCWater is lost through diffusion or evaporationAny malfunction of the skin barrier dramatically INCREASES TEWL andhas a great impact on normal homeostasis.

Humidity Temperature

WA

TER

DIF

USSIO

N G

RA

DIE

NT

WATERCORNEOCYTE LIPIDS

TEWL

BARRIER FUNCTION

Stratum corneum cells, corneocytes, protect against desiccation and environmental challenge by regulatingwater flux and retention. The barrier isnot perfect and water is lost

Hydration levels fluctuates throughout

the day and age. The older the skin is, the lower the hydration level is. Maintaining sufficient hydration levels can alleviate symtomps associated to age.

WATER: Water loss and hydration

Optimum release of actives for a long-lasting moisturizing effect

1. OCCLUSIVES

They coat the stratum corneum (SC) and prevent TEWL

Exhibit emollient properties

Ingredients: paraffin, squalane, silicone derivatives,

oils, lanolin, lecithin, beeswax, stearyl stearate…

2. HUMECTANTS

Hygroscopic, water soluble substances

Attract water to the external environment

Trap water from the underlying layers of skin

Ingredients: hyaluronic acid, sorbitol, glycerin, minerals, sugars…

WA

TER

DIF

USSIO

N G

RA

DIE

NT

BLOCKS WATERDIFFUSION AND EVAPORATION

TRAPS WATER FROMUNDERLYING LAYERS

HOW TO AVOID WATER LOSS?Occlusive and humectant systems

MARINE strategy for an INTENSIVE,

LONG-LASTING and

EFFECTIVE HYDRATION of the skin.

PTsmSubmicrometric

Technology

Platform

Optimum release of actives for a long-lasting moisturizing effect

Active ingredientsLaminaria extract (mineral, sugars)

Sorbitol

Vegetal GlycerinDiatom-like structures

Silica

MOLECULAR FILMSubmicrodispersion

Floating monolayers in water

Incoporates encapsulated

actives in between

Ingredient: LECITHIN

1

2

DELIVERY SYSTEM

DELIVERY SYSTEM

st

nd

BRINGS A FILMOGEN EFFECT TO SKIN

RELEASES ACTIVES

IN A SUSTAINED REALEASE PROFILE

APT: Aqueous phase technology

BLOCKS WATERDIFFUSION AND EVAPORATION

Optimum release of actives for a long-lasting moisturizing effect

OCCLUSIVES

HUMECTANTS

MOLECULAR FILMCoat the stratum corneum

and prevent TEWL

Releases encapsulated

actives trapped

into its layers

WA

TER

DIF

USSIO

N G

RA

DIE

NT

ENCAPSULATED ACTIVES

IN DIATOM-LIKE structuresEncapsulated actives eventually absorps

water from the environment

and from underlying layers of the skin.

So AQUASHUTTLE combines…

BLOCKS WATERDIFFUSION AND EVAPORATION

Optimum release of actives for a long-lasting moisturizing effect

WA

TER

DIF

USSIO

N G

RA

DIE

NT

HYDRATING EFFICIENTLY: HOW AQUASHUTTLE WORKS?

IMMEDIATE/INTENSIVE

MOISTURIZING EFFECT

LONG LASTING

MOISTURIZING EFFECT+BLOCKS WATERDIFFUSION AND EVAPORATION

MOLECULAR FILM

A superficial action of IMMEDIATE hydration exerts a FILMOGENIC HUMECTANT EFFECTto provide the skin with a homogenousappearance and to reduce TEWL.

The encapsulation system starts being degraded and released actives penetrate through the SC.Capsules are hydrolyzed and releasehighly hygroscopic actives (humectants)inside the skin. Other actives can also be encapsulated. They retain moisture and increase the water content (hydration level) of the skin.

OVER TIMEOVER TIME

LONG-LASTING activityMore than 24h

MARINE strategy

for an INTENSIVE,

LONG-LASTING

and EFFECTIVE HYDRATION

of the skin.

PTsmSubmicrometric

Technology

Platform

ACTIVES (laminaria extract)

FILMOGENIC EFFECT (lecithin)

ACTIVES release over time

EFFICACY TEST

Efficacy test: in-vivoOptimum release of actives for a long-lasting moisturizing effect

5%

MOISTURIZATION TEST 8 and 24 hours

15 volunteersGel formulation

Data taken at 1, 8 and 24 hDevice: corneometer CM825

vs PLACEBOInactive formulation

designed to resemble

a drug or treatment

and given in the same way.

Efficacy test: in-vivoOptimum release of actives for a long-lasting moisturizing effectMOISTURIZATION TEST

8 and 24 hours15 volunteers

Gel formulationData taken at 1, 8 and 24 h

Device: corneometer CM825

24 hours 1 to 8 hours

18%

53%

21%

-2%

AquaShuttle

Placebo

Efficacy test: in-vivoOptimum release of actives for a long-lasting moisturizing effect

vs HYALURONIC ACID

MOISTURIZATION TEST 15 volunteers

Gel formulationData taken at 1, 2 and 4 h

Device: corneometer CM825

0.3% 0.5%

Hyaluronic acid is highly effective humectant.

It can hold HUNDREDS OF TIMES its weight in water.

4%

Efficacy test: in-vivoOptimum release of actives for a long-lasting moisturizing effectMOISTURIZATION TEST

15 volunteersGel formulation

Data taken at 1, 2 and 4 hDevice: corneometer CM825

1 hour 2 hours 4 hours

81%

63%

51% 50%

40%

30%

41%

21%

9%

AquaShuttle

Hyaluronic acid 0.5%

Hyaluronic acid 0.3%

Efficacy test: in-vivoOptimum release of actives for a long-lasting moisturizing effect

MOISTURIZATION TEST 15 volunteers

Gel formulationData taken at 1, 4, 8 and 12 h

Device: corneometer CM825

8%

vs HYALURONIC ACID

0.8% 1%

Hyaluronic acid is highly effective humectant.

It can hold HUNDREDS OF TIMES its weight in water.

Efficacy test: in-vivoOptimum release of actives for a long-lasting moisturizing effectMOISTURIZATION TEST

15 volunteersGel formulation

Data taken at 1, 4 , 8 and 12 hDevice: corneometer CM825

1 hour 4 hours 8 hours 12 hours

AquaShuttle

Hyaluronic acid 1.0%

Hyaluronic acid 0.8%

92%

81%

71%73%

51%

38%

52%

35%

26%

40%

28%

21%

+22%

+48%

LONG LASTING MOISTURIZING EFFECTAquaShuttle avoids TEWL and traps water thanks

To its combination of occlusive and humectant system,

While HA can only absorp water.

AquaShuttle can eventually keep a higher water content in the skin

NATURAL TECHNOLOGY

IMMEDIATE AND LONG-LASTING

MOISTURIZING EFFECT

BETTER THAN HYALURONIC ACID (*)

IN CLINICAL TEST

(*) in tested concentrations

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15-21 Baldiri i Reixac

08028 BARCELONA

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