PRP Art & science
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Transcript of PRP Art & science
Platelet Rich Plasma
Art & science
Islam Kassem,BDS,MSc,FDS RCS
Consultant oral & maxillofacial Surgeon
Angle Face Left New technology of injection
your own blood to get a
Youthful Look .
.
Why Are Celebrities Injecting Their Faces With Blood?
Platelet?
Anuclear piece of cytoplasm
Include hemostasis,
α-granule,lysosomal granule, dense granules
At least 7 different growth factors that stimulate bone & soft tissue healing
PDGF aa,bb,ab
TGF b1,b2
VEGF
EGF
Days of operation
7 days later
PLT exhausted after 7 days
Macrophage by low oxygen tension, acidity, lactate concentration
Secrete same growth factors
Activated until it is down regulated by the restoration of normal oxygen tension
Day 3rd
17days
Graft is completely permeated by new capillaries
Initial osteoid formation
Osteoclast resorb osteoid and BMP released
New bone formation and maturation
Days 14
Trabecular area Native mandible Autogenous BG
Clinical effects of PRP on soft tissue healing
Split thickness skin graft donor site healing
6 days
Thrombin side : 5% epithelization 95% granulation tissue PRP side ; 95% epithelization 5% granulation tissue
6 months Thrombin side : scarring hypo and hyper-pigmentation area PRP side ;less scarring Much less pigmentation change
Epithelization
1 months
Contraindications
Pre-existing coagulation defect
: thrombocytopenia, hypofibrinogenia…
Hypersensitivity to bovine thrombin
Clinical steps
Clinical application
Ridge preservation