PRESENTED BY :-MALVIKA BANSAL

1. PROTEIN STRUCTURE2. NCBI3. DATABASES4. BLAST5. ExPASy6. SWISS-PROT7. PIR8. PDB

1. PROTEIN STRUCTURE2.NCBI

1.PROTEIN STRUCTURE2. NCBI

1. PROTEIN STRUCTURE2. NCBI3. DATABASES

Protein Database is a collection of sequences from several sources, including translations from annotated coding regions in Gen Bank, Ref Seq as well as records from SWISS-PROT, PIR & PDB.

1. PROTEIN STRUCTURE2. NCBI3. DATABASES4. BLAST5. EXPASY6. SWISS-PROT7. PIR8. PDB

Finds regions of local similarity between sequences.

Compares nucleotide or protein sequences to sequence databases.

Calculates statistical significance from matches.

Can be used to infer functional and evolutionary relationships between sequences.

It can also help in identifying members of the gene family.

1. PROTEIN STRUCTURE2. NCBI3. DATABASES4. BLAST5. ExPASy6. SWISS-PROT7. PIR8. PDB

ExExpert pert PProtein rotein AAnalysis nalysis SySystemstemExPASy is a bioinformatics ExPASy is a bioinformatics resource portal operated by resource portal operated by the Swiss Institute of the Swiss Institute of Bioinformatics (SIB).Bioinformatics (SIB).The portal is aimed for both The portal is aimed for both expert users and for people expert users and for people that are not familiar with a that are not familiar with a specific domain in life specific domain in life sciencessciences..

It provides access to It provides access to scientific databases and scientific databases and software tools (i.e., software tools (i.e., resourcesresources) in different ) in different areas of life sciences areas of life sciences including proteomics, including proteomics, genomics, phylogeny, genomics, phylogeny, systems biology, systems biology, population genetics, population genetics, transcriptomics etctranscriptomics etc.

ExExpert pert PProtein rotein AAnalysis nalysis SySystemstem

1. PROTEIN STRUCTURE2. NCBI3. DATABASES4. BLAST5. EXPASY6. PUB-MED7. SWISS-PROT8. PIR9. PDB10. PDB

•SWISS-PROT also called UniProt is;SWISS-PROT also called UniProt is; a comprehensive, high-quality and a comprehensive, high-quality and freely accessible database of protein freely accessible database of protein sequence and functional sequence and functional information.information.

•Many entries are derived from Many entries are derived from genome sequencing projects. genome sequencing projects.

• Contains a large amount of information Contains a large amount of information about the biological function of proteins about the biological function of proteins derived from the research literature.derived from the research literature.

• The mission of UniProt is to provide the The mission of UniProt is to provide the scientific community with a comprehensive, scientific community with a comprehensive, high-quality and freely accessible resource high-quality and freely accessible resource of protein sequence and functional of protein sequence and functional informationinformation..

SWISS-PROTSWISS-PROT

1. PROTEIN STRUCTURE2. NCBI3. DATABASES4. BLAST5. EXPASY6. PUB-MED7. SWISS-PROT8. PIR9. PDB10. PDB

PIR was established in 1984 by the National PIR was established in 1984 by the National Biomedical Research Foundation (NBRF) as a Biomedical Research Foundation (NBRF) as a resource to assist researchers in the resource to assist researchers in the identification and interpretation of protein identification and interpretation of protein sequence information.sequence information.

PIR has provided many protein databases PIR has provided many protein databases and analysis tools freely accessible to the and analysis tools freely accessible to the scientific community, including the Protein scientific community, including the Protein Sequence Database (PSD).Sequence Database (PSD).

1. PROTEIN STRUCTURE2. NCBI3. DATABASES4. SWISS-PROT5. PUB-MED6. EXPASY7. BLAST8. PIR9. PDB

Protein Data Bank (PDB) is a repository for the 3-Protein Data Bank (PDB) is a repository for the 3-D structural data of large biological molecules, such D structural data of large biological molecules, such as proteins and nucleic acids.as proteins and nucleic acids.

PDB is overseen by an organization called the PDB is overseen by an organization called the Worldwide Protein Data Bank, wwPDB.Worldwide Protein Data Bank, wwPDB.

PDB is a key resource in areas of structural PDB is a key resource in areas of structural biology, such as structural genomics.biology, such as structural genomics.