Protein Metabolism

Protein Metabolism

Nitrogen Pool

Transamination

Transamination

Transamination

Oxidative Deamination

Oxidative Deamination

Oxidative Deamination

Urea Cycle

PKU - Phenylketonurea

Other errors of metabolism • B. Goitrous Cretinism D. Tyrosinosis

• C. Albinism E. Alkaptonuria

Heme Catabolism • Heme to Bilirubin in liver to gall bladder to small intestine

• Converted to urobilinogen reabsorbed to blood, liver,

kidney

Bilirubin • Heme to bilirubin to bilirubin diglucuronide (soluble)

Jaundice Lab Test • LAB TEST

• Normal Biliary Hepatic Hemolytic

Obstruction Diseases Diseases

• Bilirubin Neg. Pos. Pos. Neg.

• Urobilinogen Pos. Neg. Pos. or low Pos. high

Summary of Metabolism

Diagnostic Serum Enzymes

Alcohol Metabolism Effects