Program Plan for the Pharmaceutical Research Center

University of Colorado at Denver and Health Sciences Center Program Plan for the Pharmaceutical Research Center

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PROGRAM PLAN FOR THE

PHARMACEUTICAL RESEARCH CENTER I. Preface and Summary 1. Executive Summary A new Pharmacy Research Center facility housing the research and office functions of the University of Colorado School of Pharmacy (UCSP) at the University of Colorado at Denver and Health Sciences Center (UCDHSC) Fitzsimons campus will allow the research function of the UCSP to expand and provide for the relocation of all UCSP programs to be relocated to the new Health Sciences Center campus. The mission of the School of Pharmacy is to provide programs of excellence in teaching, research, and community/professional service for Colorado and the nation. The ability to serve the State of Colorado pursuant to this mission has been greatly enhanced by the opportunity to be a part of the 21st century academic health center being built on the Fitzsimons Campus. At the core of the UCDHSC Institutional Master Plan, approved by the University of Colorado Board of Regents in October 1998, is the relocation of all programs of the five Health Sciences Center schools (Dentistry, Graduate, Medicine, Nursing, and Pharmacy) to new state-of-the-art facilities. Along with education buildings currently under construction at the Fitzsimons campus, the Pharmaceutical Research Center program plan fulfills this goal for the School of Pharmacy. The University of Colorado’s School of Pharmacy is the only pharmacy school in Colorado. The school’s current degree programs include the entry-level PharmD, an on-line non-traditional PharmD, a PhD in toxicology, and a PhD in pharmaceutical sciences. It has a long history and strong record of commitment to diversity. The school is organized into two academic departments: the Department of Clinical Pharmacy and the Department of Pharmaceutical Sciences. The School of Pharmacy is characterized by a vigorous research environment within the Department of Pharmaceutical Sciences. Nationally, the school is in the top tier of research pharmacy schools and is widely


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recognized for its excellence in pharmaceutical biotechnology, cancer experimental therapeutics, cardiovascular therapeutics, AIDS/HIV clinical trials, molecular toxicology, and biomolecular structure. It is consistently in the top ten pharmacy schools for NIH funding. The UCDHSC proposes to design and construct this facility to the north of Building 500 and facing the Library Commons. The 4 story structure will include 105,215 gross square feet (gsf) and 68,510 assignable square feet (asf). The major program elements and their assignable square footages are listed below: ♦ Research Laboratories – 37,800 asf ♦ Research Lab Support – 3,630 asf ♦ Offices – 16,900 asf ♦ Conference Rooms – 4,725 asf ♦ Clinical Trials Suite – 1,240 asf ♦ Other Support Areas – 4,215 asf

Research laboratories will be designed with flexibility similar to the laboratory concepts found in Research Complexes I and II. These state of the art facilities include an open laboratory plan supported by specifically designed procedure rooms, work rooms, and equipment storage areas nearby. One of these specialty areas will include an NMR unit. Research offices will be proximate to the laboratories. A clinical trials suite will be an attractive and comfortable space for research subjects to occupy. The facility will also house a Dean’s suite overseeing the administration of the School of Pharmacy. Meeting rooms of various sizes will be located on each floor, and each room will be well equipped technologically for data presentations. The School of Pharmacy is seeking additional capital funding and would like to add either a shelled floor at an upper level or as a basement. Should additional funding become available, the program plan may be amended to include additional costs and shelled square feet. The project cost is $42,032,512. This is a cash project and includes a substantial donor contribution. The project schedule anticipates design work from July 2007 to June 2008, construction from July 2008 to May 2010, and occupancy in July 2010. The purpose of this facility program plan is to seek appropriate approvals of the University of Colorado Board of Regents and the Colorado Commission on Higher Education (CCHE) to:


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Permit the University of Colorado at Denver & Health Sciences Center to proceed with the planning, design, and construction of a 105,215 gross square foot facility at the Fitzsimons site to house the research program of the School of Pharmacy at a project cost of $42,032,512.

2. Process The Institutional Master Plan that details the development of the University of Colorado Health Sciences Center at Fitzsimons describes the need for research and office space that includes those of the School of Pharmacy. The School of Pharmacy’s education requirements are addressed in the education facilities currently under construction at the Fitzsimons campus. During the planning for the relocation of the entire Health Sciences Center campus from its 9th Avenue site to the new Fitzsimons campus in Aurora, different iterations sited the School of Pharmacy’s research and faculty office functions alternatively in a future Research Complex III, the currently under construction Research Complex II and Academic Office West, and in a separate facility. The recent obtainment of a significant philanthropic gift enables the UCDHSC to plan and construct a separate facility to house the research requirements of the School of Pharmacy as well as its faculty and administrative offices. A program plan for the research and administration facility was drafted in the fall of 2006, primarily by a faculty and administrative oversight committee comprised the Executive Committee of the School of Pharmacy, program directors, and staff who include the dean, associate and assistant deans, department chairs, program directors, and the IT manager. The steps taken in developing this plan included: Discussing the future strategic direction for the School of Pharmacy, and the

appropriate facilities needed at Fitzsimons; Identifying enrollment goals and growth; Agreeing on goals and assumptions for the facility and the facility’s major functions

of providing pharmaceutical research along with housing the Pharmacy faculty and school administrative resources;

Identifying specific types of spaces to meet program needs including particular features deemed important to the future facility design;

Reviewing budget and schedule; and Identifying the appropriate location for the facility.

As a result of the activities of the committee, this program plan was developed and approved and subsequently forwarded for review and approval by the Board of Regents of the University of Colorado and by the Colorado Commission on Higher Education.


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II. Program Information Pharmaceutical Research Center 1. Program Description The University of Colorado’s School of Pharmacy is the only pharmacy school in Colorado. The school’s current degree programs include the entry-level PharmD, an on-line non-traditional PharmD, a PhD in toxicology, and a PhD in pharmaceutical sciences. It has a long history and strong record of commitment to diversity. The school is organized into two academic departments: the Department of Clinical Pharmacy and the Department of Pharmaceutical Sciences. The two departments characterize the broad mission of the school. The educational mission is carried out on two planes: professional practice and basic research. Department of Clinical Pharmacy faculty members provide direct patient care to assist patients and prescribers with methods to optimize drug-therapy and minimize the potential for drug-related problems. These faculty serve as role models and preceptors for PharmD students who are enrolled in their clinical clerkships as well as providing part of the regular curriculum. Department of Pharmaceutical Sciences faculty members are responsible for the vigorous research environment and provide the balance of the regular curriculum. Nationally, the school is in the top tier of research pharmacy schools and is widely recognized for its excellence in pharmaceutical biotechnology, cancer experimental therapeutics, cardiovascular therapeutics, AIDS/HIV clinical trials, molecular toxicology, and biomolecular structure. The School of Pharmacy is consistently in the top ten pharmacy schools for NIH funding and within the Health Sciences Center community of schools, the School of Pharmacy ranks second, behind only the School of Medicine, in NIH funding. The entry-level PharmD degree prepares graduates for pharmacy practice in Colorado as well as throughout the nation to ensure the safe, effective, and economical use of medicines in prevention and treatment of human diseases. In addition to the entry-level PharmD degree, the School of Pharmacy offers a part time post-baccalaureate Doctor of Pharmacy Degree program via a non-traditional pathway (Non-Traditional PharmD degree program, NTPD). The program is offered online via the internet to be readily accessible to pharmacists throughout the state and flexible enough to meet the diverse time and practice needs of working pharmacists.


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The University of Colorado School of Pharmacy has two graduate degree programs outside the professional curriculum. The PhD programs are in Pharmaceutical Sciences, Molecular Toxicology, and Environmental Health Sciences (Toxicology). An MS degree program in Pharmaceutical Biotechnology is being developed. The Toxicology graduate degree program has grown since it was first approved in 1992. The interdisciplinary program has attracted a strong core of faculty with excellent peer-reviewed funding. The pharmaceutical sciences graduate degree program is focused principally on the area of Pharmaceutical Biotechnology. Concentration on formulation, drug delivery, and bioanalytical chemistry, especially for biotechnology products, has allowed the curriculum to focus on core competencies in a carefully controlled manner. This resulted in the award of an NIH training grant in Pharmaceutical Biotechnology. The school’s diversity program has received two large grants – one federal, one private – that enhanced its nationally acclaimed diversity program. The need to sustain the diversity effort lies ahead, and the search for support continues. The curriculum provides students with a wealth of knowledge, skills, and abilities to become leaders in providing pharmaceutical care. The school looks forward to its recent graduates becoming superb preceptors for its future students. New research programs and entrepreneurial activities will bolster research support throughout the school. The school’s clinical faculty members are expanding and pioneering new pharmaceutical care services to better serve patients and to provide improved learning opportunities for students. The University of Colorado School of Pharmacy has had an astounding period of growth and prosperity since its move to the Health Sciences Center. By all measures, the school is now exceptionally well established in its educational, research, and service programs. The challenge the school faces now is to build on its achieved excellence and to take the accomplishments of the past and leverage them into even greater accomplishments during the next decade. 2. History, Role and Mission, Unique Programs History: The UCDHSC School of Pharmacy was originally established in April 1911 on the Boulder Campus. In 1986, the School of Pharmacy was administratively transferred to the university’s Health Sciences Center campus in Denver, and the first classes were held in Denver in August of 1992 following the completion of the school’s current building.


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Role and Mission: The school's mission statement is an integral component of the strategic plan and addresses four principal missions for the school: a curriculum focused on pharmaceutical care; scholarly activities of the faculty; public and professional service by the faculty; and diversity within the student body, faculty, and staff. This mission is aligned with the university's mission and reads as follows:

MISSION STATEMENT The University of Colorado School of Pharmacy

(Adopted November 8, 1999; revised January 8, 2002)

The University of Colorado School of Pharmacy is a comprehensive institution of higher education committed to excellence in teaching, research and public/professional service in areas unique to the practice of pharmacy and to the pharmaceutical sciences. The school's professional educational programs have as their principal purpose the training of pharmacy practitioners who are compassionate, ethical and caring; scientifically knowledgeable and technically competent; skilled at communication and teamwork; motivated to pursue lifelong learning; and dedicated to fulfilling the public trust by assuring the safe, effective and efficient use of prescription and non-prescription drug products. The school's faculty endorses the concept that pharmaceutical care, defined as "the responsible provision of drug therapy for the purpose of achieving definite outcomes that improve a patient's quality of life" constitutes the essence of the pharmacy profession and as such must provide the foundation for every aspect of the school's professional curriculum. Faculty members are committed to teaching excellence and to continuous monitoring of the professional curriculum to assure its faithfulness and relevance to the tenets of pharmaceutical care. Pursuant to this commitment, faculty members welcome the scrutiny provided by student and peer evaluations and by outcomes measurements that assess overall teaching quality and lead the way to improvements in the school's instructional programs. The faculty also is dedicated to the discovery and dissemination of new knowledge. Encouraging faculty members to engage in creative activities that have a positive impact on the well-being of society, providing these faculty members with the resources necessary to develop into accomplished scholars and supporting graduate, post-graduate and post-professional research training programs are major priorities of the School of Pharmacy. The faculty of the School of Pharmacy recognizes the value of diversity in enriching the school's cultural, learning and scholarly environment and is dedicated to promoting diversity within itself and among the school's students and staff. To achieve this goal, the school makes every effort to recruit and retain individuals from diverse educational, cultural, ethnic and socioeconomic backgrounds. The faculty also recognizes its responsibility to advance the profession of pharmacy through public advocacy, provision of opportunities for life-long learning and participation in the affairs of local, national and international pharmacy organizations.


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Unique Programs: The University of Colorado’s School of Pharmacy is the only pharmacy school in Colorado. The NTPD program is unique and the 1st such program in the US to be offered via the internet. It is administered through the Office of Postgraduate Professional Education. The office is staffed by the Assistant Dean for Post Professional Education, three faculty coordinators, and several classified staff and hourly employees. Another unique program within the School of Pharmacy is the Center for Pharmaceutical Biotechnology which is a cooperative effort between the School of Pharmacy and the College of Engineering in Boulder. The Center combines a traditional graduate school curriculum with industry internship opportunities. In addition, it provides interdisciplinary distance learning between campuses and for employees of biotech firms. Faculty in the field of medicinal chemistry can use the move to Fitzsimons to design adequate research space for drug development studies. The space would include a room to house a nuclear magnetic resonance spectrometer (NMR). This instrument is used to prove the structure of small organic molecules such as those found in drugs and natural products. 3. Program Needs and Trends Enrollment increases at the entry level professional program and at the graduate level are a national trend to meet the shortage of pharmacists and academicians. Likewise, the offering of satellite programs is on the increase to make established programs more accessible within states while avoiding the costs of establishing entirely new colleges and universities. Increasing the number of students will require an increase in the number of faculty members and will require additional staff support.

School of Pharmacy Enrollment Projections (May 2006) 2005-06 2006-07 2007-08 2008-09 2009-10 2010-11 2011-12 2012-13

PharmD 512 514 517 549 573 603 630 629

Toxicology PhD

22 24 25 25 25 26 28 30

Pharm Sci PhD

21 24 25 25 26 27 28 30

TOTAL SOP 555 562 567 599 624 656 686 689

Online PharmD

355 3375 362 322 277 232 187 187

TOTAL SOP 910 937 929 921 901 888 873 876


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In addition to graduate students, the school employs or trains a number of post-doctoral fellows, highly trained technicians, and undergraduate researchers. Research Fellows generally spend two years in a research-intensive program following graduation from a PharmD or PhD program. The constraints of the current PharmD educational component of the School of Pharmacy will be eased substantially with the opening of new educational facilities currently under construction at the Fitzsimons campus. The 2008-09 data show the beginning of an increasing trend in PharmD student enrollment subsequent to the new larger facilities coming on line. In addition to the enrolled students, the School of Pharmacy includes a faculty consisting of 55 faculty, 10 instructors, 68 fellows and professional research assistants, 108 part time faculty, and 25 administrators. 4. Relation to Academic or Institutional Strategic Plans The mission of the School of Pharmacy is supported by a primary relationship with the Health Sciences Center's major teaching hospital, the University of Colorado Hospital (UCH). A UCH Resource Council serves in an advisory capacity to the chancellor, the hospital president, and the Board of Directors. The Dean of the School of Pharmacy is a member of the Resource Council. The dean also is a member of the hospital's Strategic Planning Committee. In addition, the dean and the Chair of the Department of Clinical Pharmacy serve as members of the hospital's Medical Board.

Clinical pharmacists in the employ of the hospital's Pharmacy Department are eligible for clinical faculty status in the school's Department of Clinical Pharmacy, and many of these individuals participate in the latter department's academic programs. Nearly all of the clinical pharmacy faculty members in the school possess hospital privileges and contribute to the hospital's patient care programs.

In addition to its primary relationship with UCH, the School of Pharmacy also has formal, secondary relationships through affiliation agreements with several other health care institutions in the Denver metropolitan area, viz., Kaiser Permanente, the Department of Veteran Affairs Medical Center, the Colorado Mental Health Institute at Fort Logan, Centura/Saint Anthony's Hospital, and the University of Colorado School of Medicine's Departments of Family Medicine and Neurology. Many of the clinical pharmacists employed by these affiliated institutions have clinical faculty appointments in the school's Department of Clinical Pharmacy and serve as preceptors for students in the school's experiential education program. Some School of Pharmacy faculty members hold joint appointments with the School of Medicine’s departments. The central administration of the Health Sciences Center provides a multitude of important support services to the School of Pharmacy. There is centralized support for


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alumni relations and development, library services, facilities management and planning, grants and contracts, budget and finance, diversity training and planning, educational services, information technology/telecommunications, government relations, public relations, student financial aid, legal services, ombudsman services, institutional review board services, animal care services, etc. Individuals within the various offices and units of campus central administration work closely with the school's administrators, faculty, staff and students to assure smooth, reliable and efficient delivery of the multitude of services necessary for effective management of the school's academic and research programs. Information Technology Strategic Plan The University of Colorado Health Sciences Center Information Technology Council developed a campus-wide Strategic Plan for information technology with goals and objectives in 1998. The School of Pharmacy has implemented numerous technologies consistent with the plan, including development of on-line courses, a simulation program with highly advanced instructional AV technology in student learning labs, and wireless network access for student laptop computers in instructional areas. An IT staff consisting of three FTEs is available to assist students, faculty, and staff with their computing needs. The technology investments of the school support the informatics related topics now integrated into the PharmD curriculum, including computer skills assessment at matriculation, formal and informal instructional methods in the P1-P3 years, and competency assessments throughout the program to ensure that graduates are prepared to practice pharmacy in the highly computerized environment of the 21st century. 5. Relation to Other Programs or Agencies Relationships with external constituencies are strong. The assistant dean for student and professional affairs is the school's official liaison with the Colorado State Board of Pharmacy. The School of Pharmacy has developed affiliation agreements with chain drugstore enterprises in the state in an initiative to broaden the availability of pharmacist-run disease state management programs throughout the Denver community. The sites where these programs are under development also offer excellent clerkship rotation opportunities.

The school also has established partnerships to promote the development of pharmacy practice and high quality clerkship training sites in rural Colorado. Numerous grants support pharmacist-run anticoagulation clinics, diabetes education clinics and ambulatory lipid clinics. Further initiatives to develop additional contemporary pharmacy programs and model clerkship sites in rural Colorado are funded and currently being implemented.


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6. Existing Programmatic/Operational Deficiencies There are challenges ahead. Budget shortfalls in the state required the school to maintain its successes by identifying alternative sources of funding for its current academic programs. Also, the school must increase enrollments in response to the pharmacist shortage. This will place still additional strains on the school's fiscal and human resources. The Pharmaceutical Research Center will increase both research space and faculty office space of the School of Pharmacy to allow faculty growth along with student enrollment and to satisfy its mission – to provide programs of excellence in education, research, and service. Specific program deficiencies are highlighted below: • The number and size of research laboratories is inadequate restricting needed growth

in faculty and researchers. • A clinical trials suite is necessary to conduct certain research projects where the

research subjects need to be closely monitored. The current site is being used to house the NTPD administrative program.

7. Program Alternatives The only programmatic alternative to a separate pharmaceutical research center facility would be to curtail anticipated growth in student enrollment, faculty complement, and research grant opportunities by either remaining in the current facility on the 9th Avenue campus or by moving to the Fitzsimons campus and housing research activities in a portion of the Research Complex II and faculty offices in a portion of Academic Office West. Programmatically, constraining opportunities for growth on the School of Pharmacy is unacceptable for the obvious reason that there is a need to educate more pharmacists in Colorado. The US population has exceeded 300 million residents as of the time of this writing, requiring more pharmacists and other health care professionals to meet the needs of the growing population. The school will not be able to implement a 20 percent increase in student enrollment in its PharmD degree program because space will not be available to accommodate the additional faculty and staff members this increase will command. In addition, the school would be fragmented with either faculty offices and research separated from the campus where teaching will occur or the faculty of the two departments would be separated from one another and from the school’s central administration.


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Research opportunities need to be able to expand to develop new treatments, cures, and prevention alternatives in the growing health care field. Without this proposed facility, research growth for the School of Pharmacy would be limited either in existing space in the existing building or by setting up an intensely competitive situation for space in Research Complex II with the School of Medicine (the major tenant in the research facilities at Fitzsimons). Moreover, the potential economic benefits that could accrue by placing one of America’s premier pharmaceutical sciences faculties in a distinct, high-profile building juxtaposed to the emerging Colorado Bioscience Park at Fitzsimons would not be realized if the School of Pharmacy were integrated into existing buildings.


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III. Facilities Needs 1. Total Space Requirements The program requirements of the Pharmaceutical Research Center in its proposed new facility translate into 105,215 gross square feet. The major program elements and their assignable and gross square footages are listed below:

Program Areas Pharmacy Research Center

Program Area GSF ASFResearch Laboratories 58,154 37,800Research Laboratory Support

5,585 3,630

Administrative Office – Laboratory Proximity

7,969 5,180

Administrative Office 18,031 11,720Conference Rooms 7,269 4,725Other Support 4,238 2,875Building Support 2,062 1,340Clinical Trials Suite 1,908 1,240Total 105,215 68,510 The current facility for the School of Pharmacy contains 99,804 gross square feet. Included within this amount is 12,395 gsf of education space, leaving 87,409 gsf used for research and office space. The new facility, at 105,215 gsf, represents a 21% increase in gsf over the current facility excluding education space. This increase in square footage is primarily attributable to a 30% increase in research laboratories plus associated support areas. The proposed new facility will support the current faculty of 55 and its projected growth to 73. A. General Planning Assumptions Planning assumptions used to determine the functional and space requirements for the proposed Pharmaceutical Research Center include the following:

The Pharmaceutical Research Center will be located at the Fitzsimons campus and will be consistent with the Institutional Master Plan. The Pharmaceutical Research Center will be located at the edge of the research zone and proximate to the campus education facilities and the developing biotech park.


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The Pharmaceutical Research Center will contain research laboratories, sufficient faculty office space to accommodate a larger faculty appropriate to the quantity of lab space designed, a dean’s and other administrative offices for the School of Pharmacy, conference and meeting areas, and a clinical trials suite.

Restrooms, janitor’s closets, telecommunications closets, and trash rooms are not

included in the space program, but are included in the assignable to gross square footage conversion factor. These rooms will to be included in the design process.

Parking for research subjects will be convenient.

The design of the facility will encourage interaction among the faculty and between

researchers, administrators, and students.

The design and construction of the building may include future expansion through a shelled basement or additional shelled upper floor should additional funding be obtained during the design period. At a minimum, the structure will be able to support at least one additional floor.

The facility will be outfitted with the state-of-the-art technologies to accommodate

advanced research projects.

The utilities and infrastructure will be based upon the campus wide utilities and infrastructure requirements and guidelines of the Master Plan.

Research laboratories will be designed in an open concept to facilitate interaction

between researchers and to optimize space utilization management along with changes in grant funding.

Conference rooms will be designed for maximum flexibility and with the latest

technology appropriate for both research seminars and administrative sessions.

The aesthetic appearance of the complex will comply with UCDHSC Design Guidelines.

The building design process will consider life cycle energy costs.

Interdepartmental Adjacencies/Access The interdepartmental functional relationships are illustrated in the following narrative:

The Offices of Student Affairs and the Experiential Programs offices should be on the first floor and at the end of the building closest to the education facilities as they are


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high student traffic areas. As adjacent spaces, they can share a waiting area and a file storage area and may be adjacent to or be connected with the NTPD program offices.

The clinical trials suite should be near a public entry for easy access by research

subjects.

Research laboratories should be on the upper floors with increased security.

Research labs should be easily serviced by nearby lab alcoves, linear equipment corridor storage, procedure rooms, work rooms, and the service elevator.

Faculty research offices should be near the labs.

Animal holding areas should be accessible from research labs without the research

subjects passing through public areas. This can be accomplished through adjacencies or service passages and elevators. Animal holding areas should be accessible from the receiving area without passage through public areas.

Each floor should have one or more meeting rooms.

Facility Layout/Design Considerations: • The research lab zoning concept of Research Complexes I and II are held as a model

for appropriate flow and efficiency of laboratory design.

Areas likely to be accessed by the public should be zoned to the first floor or easily accessible from the lobby and elevator at the north end of the building.

B. Planning Assumptions Relative to Specific Selected Program Areas Research Labs The research laboratories in the School of Pharmacy are to be designed on an open lab concept with similar flexible lab modules sited sequentially to one another allowing for flexibility in space assignment. The laboratories will be well-equipped with a broad array of general research equipment. Animal Holding The campus’ Animal Resource Center provides for all long term animal care needs of the school’s research faculty. The School does not utilize animals for teaching purposes. A short term animal holding area will be provided with restricted assess to the research labs.


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Research Support Areas Large pieces of equipment (including noisy and heat producing equipment) and specialized facilities including ultracentrifuges, scintillation counters, and spectrophotometers will be located in the linear equipment corridor, alcoves, and special procedure rooms. Special use spaces will be available for conducting clinical trials, production of photos and slides, and short term animal holding. Clinical Trials Suite A clinical trials suite will be developed to accommodate research subjects involved in research studies where their observation or monitoring is critical to the study methodology and results. The suite will be comfortable and ambient for the research subjects. Offices Each faculty member will have a private office adequate for some dry research activities and for student counseling. Other office suites include the Dean’s office suite and the Office for Student Services and departmental administration. Meeting Rooms There will be a variety of meeting rooms sizes to accommodate varying uses. Size will range from a 14 seat conference rooms to a large seminar room able to accommodate 75 attendees and an even larger board room with flexibility to accommodate a variety of functions. Receiving The receiving area will accommodate outside delivery trucks and provide appropriate specialized storage facilities for compressed gases and flammable materials along with a segregated and secure area for contaminated waste. C. Planning Assumptions by Systems Structure The structure will be designed to accommodate at least one additional floor for future expansion. This additional floor is dependent on obtaining additional funding. Should funding become available, the additional floor may be considered as a shelled upper floor or a shelled basement.


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Operational Support System Assumptions The facility contains various functions, all of which support health sciences education. Specific functions within the building have operational requirements outlined in the following narrative. Access and Security

There will be different levels of access to portions of the Pharmacy Research Center:

− Open access: Waiting areas, meeting areas, student areas. − Controlled access: Research laboratories, faculty offices, clinical trials. − Secured: Storage areas, NMR room.

A controlled key/card system will be provided at all building entry points and storage areas.

The Pharmacy Research Center will be open 7 days a week on a 24-hour-a-day basis

to faculty members through controlled key/card access. The main entrance will be open during daily business hours for students and research study subjects.

Alarm systems will be installed to protect areas from unauthorized users and for the

safekeeping of expensive equipment. Environmental Control Systems Laboratories, procedure rooms, and alcoves with hoods will be equipped with

appropriate ventilation systems. Equipment processing areas must be equipped with appropriate autoclaves and

adequate ventilation. Central computing areas have specialized environmental control needs to maintain

system integrity. Information Technology

The entire Pharmaceutical Research Center will have wireless internet access.

This facility will have access to a centralized computer network/fiber optics system.

All offices must be equipped with wiring for computer and telephone usage.


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All meeting spaces will be equipped to utilize a variety of educational technologies. These “smart” learning areas will be capable of using audio/video and computer graphics.

Electrical Systems and Lighting

Electrical system will have excess capacity to accommodate a significant increase in lab growth and automation.

Task lighting in the labs will be an area of design concern.

Emergency power will be provided for selected areas.

Mechanical Systems

The building’s mechanical systems (vacuum) must meet optimum research operation efficiency and building standards.

Water • Deionized water will be available throughout the research laboratories. Service/Trash/Materials Management

A loading dock must be constructed adjacent to the rear of the building with adequate entrance to the first floor and a special materials elevator with controlled access service to the various areas of the building.

The loading dock must be sufficiently sized for the delivery of supplies and

equipment and the removal of waste.

Trash and hazardous waste will be held in a designated trash room and removed by environmental services personnel or health and safety personnel.

A segregated waste management system is needed for the disposal of hazardous

waste.

An elevator will be required for vertical movement of materials. Any movement of animals between floors will be by a service elevator whose access can be restricted at the time of transfer.

Optimal Adjacencies The diagram below depicts optimal adjacencies for departments/functions located in the proposed Pharmaceutical Research Center.


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Research laboratories are the core of the Pharmaceutical Research Center. Adjacent to them are laboratory support areas including procedure rooms and linear equipment storage. Ideally adjacent are research faculty offices as well as the animal holding facility. The animal holding facility needs to be accessed from the receiving area without passage through public corridors or elevators. Experiential Programs and Student Services should be adjacent to each other. A public lobby should be proximate to the clinical trials suite and to the Seminar Room and Board Room and can function as a pre and post function area. Meeting rooms and break rooms need to be distributed throughout the facility.

Optimal Program Adjacencies

Pharmaceutical Research Center


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2. Unique or Special Features Unique to this facility are: An NMR Facility: A nuclear magnetic resonance spectrometer (NMR) facility will be needed to support the work of medicinal chemists working in drug development. The NMR consists of three major components requiring specific consideration in construction: the super conducting magnet and probe to measure the sample; the console containing all the electronics to transmit and receive radio frequency pulses to the probe; and the computer from which the operator runs the experiments and processes the data. The facility must be constructed to accommodate the magnetic field, a substantial amount of cryogenic helium and nitrogen, and to have tight control (+/- 1-2 degrees F) of temperature. The NMR itself weighs over 3,000 pounds suggesting a ground level or basement installation. Clinical Trials Suite: A clinical trials suite will handle drug studies which involve patient monitoring for 12-24 hours. It will include patient exam rooms, lavatory facilities, a room for storage and preparation of convenience foods, and a solarium or living space for reading, TV, or other entertainment of the patients. Also, it will include desk areas for two staff members and a small lab for preparation of samples collected during the study. Animal Holding Facility: An animal holding facility for short term (up to 24 hours) containment of laboratory animals will be required to accommodate research animal protocols which must be conducted outside of the campus vivarium. At least two species may have to be separated in rooms with adequate caging, temperature, humidity, and light control, and easily sanitized surfaces.

3. Health, Life Safety, and Code Issues The current 15 year old School of Pharmacy building at UCDHSC’s 9th Avenue campus has physical facility deficiencies as identified in its facility audit. Most noteworthy of these are projects for Roof Replacement ($125,000) and Window Repair (including some masonry repair) ($40,000). Furthermore, the UCHSC Facility Audit Program assessed the building’s major components to have the following deficiency ratings and costs:


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Assessment Rating and Deficiency Cost


Building Component System Deficiency Rating Estimated Cost of Deficiency

Building Structure 63% $1,935,885HVAC Systems 89% $604,950Electrical Systems 82% $423,600Plumbing Systems 98% $25,500Code Compliance and Safety 98% $12,750Total $3,002,685

The total estimated system deficiency costs are $3,002,685. The Facility Audit Program Building Inspection Report for this current facility can be found in the Appendix. Future plans of the UCDHSC are to sell this structure along with the rest of the 9th Avenue campus. The Facility Audit Report is included in the Appendix. 4. Site Requirements Site The new Pharmaceutical Research Center will be constructed on the Fitzsimons Campus on a site at the east edge of the research zone. It is proposed to face the commons area opposite the Library in the approximate center of the campus (including the bioscience research park). In this location, it is convenient to the educational facilities located primarily in Education Facility 1B and Education Facility II where the pharmacy skills labs and pharmacy classrooms will be located, to the library, to the clinical zone, to the research zone, and to parking. The Pharmaceutical Research Center’s proposed location not only accommodates the building footprint, but also allows for minor expansions of the facility to be accommodated in the future. A more substantial expansion would be accomplished vertically. A parking structure will be located immediately west of the site. The proposed site is relatively flat causing minimal grading issues and allowing for easy accessibility by pedestrians and service vehicles. Utilities An extensive evaluation regarding the development of utilities and infrastructure on the Fitzsimons campus has been completed. The evaluation is detailed in the Health Sciences Center Physical Master Plan Update(s). This Center will be served by the


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existing utility and infrastructure systems as well as be supported by the proposed infrastructure developments planned for the site. A summary of on-site infrastructure and utilities serving the Fitzsimons campus site is provided below:

Potable Water The City of Aurora is the current water supplier for Fitzsimons. Static water pressure at the city water connection is 100 p.s.i. A 12” water line runs between the parking structure currently under construction to the west of the proposed project and the proposed Pharmaceutical Research Center itself. Sanitary Sewer Effluent generated on the Fitzsimons site is conveyed to a City of Aurora sanitary sewer interceptor to the north of the Fitzsimons development. This interceptor line feeds into the Metro Wastewater Reclamation District Treatment Plant. Existing lines vary in size from 4” to 18.” An 18” sanitary sewer line, sized to accommodate the proposed project, will run along the west side of the proposed project between it and the parking structure currently under construction. Stormwater Sewer On-site storm drainage is collected in an underground system and is to be discharged into Toll Gate Creek and Sand Creek. The Master Plan calls for a 36” stormwater sewer line to run from the current retention pond to the north of Research Complex I to Montview Boulevard and on to a city line at 21st Avenue. Natural Gas Natural gas is available at the center of the Fitzsimons development but can be extended to serve any campus facility at minimal cost. Currently, natural gas feeds Research Complex I from 17th Place. Electrical The existing system includes both above and below grade lines in combination with pad-mounted transformers. The system is fed from the UCDHSC switch located just south of the Central Utility Plant (CUP). Electric power runs under 19th Avenue on the south side. Telecommunications The communication system will be extended through a duct bank from the Building 500 telecommunications and switch room to the parking structure currently under construction to the immediate west of the proposed project. Steam and Chilled Water Steam and chilled water are available from the CUP at minimal cost. Steam and chilled water lines run along 19th Avenue and are accessible from vault #5 located


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at the west end of the Ignacio parking lot which is adjacent to 19th Avenue to the south of the proposed project.

Landscape Development There are many large, mature trees in the existing landscape at the Fitzsimons site. The landscape is closely tied with Fitzsimons’ historic heritage. The site was originally developed as a nursery prior to the establishment of the Fitzsimons Army Medical Center in the early 1900’s. Consequently, some of the existing mature trees may be traced to the 1920’s, when more than 200 trees were transplanted from the Pike National Forest to the Fitzsimons site as a part of the development of the Fitzsimons property as a treatment center for tuberculosis. Many trees will be protected under the landscape plan which covers the entire campus. The proposed Pharmaceutical Research Center will be sited on the Library Commons which will contain landscape upgrades as a part of the Library construction project. Two large mature trees and a stone war memorial have been preserved; these landscape elements are located to the immediate south of the Red Cross Building and will be features of the site. 5. Equipment Requirements Equipment required for the Pharmacy Research Center includes research equipment for the wet laboratories as well as the dry research areas. Research areas also include 2 cold rooms, an NMR, and a nitrogen generator whose respective costs will exceed $50,000. Office and meeting room furniture includes chairs, desks, tables, and computers. The clinical trials suite will include medical examination equipment as well as lounge furniture. 6. Acquisition of Real Property The University of Colorado at Denver and Health Science Center campus is a 217 acre property located in Aurora, Colorado (known as the Fitzsimons campus). It is bounded by Colfax Avenue, Peoria Street, Montview Boulevard, and the Fitzsimons Parkway. The UCDHSC campus is part of a larger campus including the adjacent Fitzsimons Biotech Research Park. The subject of numerous conveyances from the Department of the Army, ownership of the UCDHSC campus has been transferred to the University of Colorado. The site of the proposed Pharmaceutical Research Center is among the conveyed parcels now owned by the University of Colorado at the Fitzsimons campus.


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IV. Project Description 1. Facility Improvements and Scope of Work To fulfill the vision for the Fitzsimons campus, to accomplish the School of Pharmacy’s programmatic missions, and to provide facilities in which to conduct cutting edge pharmaceutical research, the Pharmaceutical Research Center will contain on-campus wet research laboratories and all of their necessary technologic and administrative support areas. The research and other areas in the facility described here include: Research Laboratories Research Laboratory Support Areas Offices Clinical Trials Suite Building Support Areas

The space program for the Pharmaceutical Research Center addresses these highlighted needs for each programmed space in the square footage table found below:

Square Footage by Program Element


GSF ASF Total Total Subtotal Subtotal GSF ASF # ASF Research Laboratories 58,154 37,800 Wet Laboratories 38,769 600 42 25,200 Alcoves 12,923 100 84 8,400 Linear Equipment Corridor Allocation 6,462 110 42 4,200 Research Laboratory Support 5,585 3,630 Dark Room 246 80 2 160

Tissue Culture 2,538 275 6 1,650 Animal Holding Facility 923 600 1 600 Lab Utility 492 160 2 320 NMR 615 400 1 400 Mass Spectrometer Room 308 200 1 200 Cold Room 308 100 2 200 Nitrogen Generation Room 154 100 1 100 Office – Laboratory Proximity 7,969 5,180 Research Faculty 5,908 120 32 3,840


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GSF ASF Total Total Subtotal Subtotal GSF ASF # ASF Research Faculty (no teaching) 1,846 120 10 1,200 Department Chair 215 140 1 140 Office 18,031 11,720 Faculty 6,092 120 33 3,960 Associate Dean 215 140 1 140 Assistant Dean 431 140 2 280 Program Director 431 140 2 280 Department Chair 215 140 1 140 Dean 369 240 1 240 Administrative Staff Dean: Administrator 923 120 5 600 Dean: Clerical 92 60 1 60

Dean: Executive Assistant 369 120 2 240 Chair; Administrative Assistant 369 120 2 240 Chair: Clerical 462 60 5 300 Experiential Programs: Administrator 185 120 1 120 Experiential Programs: Clerical 185 60 2 120

Post Professional Education: Administrative Assistant 369 120 2 240

Post Professional Education: Part-time Faculty 554 120 3 360

Associate Dean: Administrative Assistant 185 60 2 120

Fellows & Residents 831 60 9 540 Graduate Students 615 40 10 400 Office of Student Services Offices - Administrative Staff 738 120 4 480 Offices - Clerical 92 60 1 60 IT Offices 554 120 3 360 IT Workroom 308 200 1 200 Copy Room 738 120 4 480 Break Room 738 120 4 480 Storage: Office Supply 308 40 5 200 Waiting Dean Suite 185 120 1 120

Experiential Programs & Student Services 277 180 1 180

Department Chair 369 120 2 240 File Storage Dean Suite 185 120 1 120 Experiential Programs 92 60 1 60 Department Chair 185 60 2 120 Office of Student Services 185 120 1 120 Post Graduate Professional 185 1 120


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GSF ASF Total Total Subtotal Subtotal GSF ASF # ASF

Education 120

Conference Rooms 7,269 4,725 Dean’s Conference Room 615 400 1 400 Board Room (Skaff) 2,308 1,500 1 1,500 Catering Kitchen 231 150 1 150

Storage: Furniture 231 150 1 150 Seminar Room (75) 1,731 1,125 1 1,125 Conference Room A (24) 923 600 1 600 Conference Room B (14) 1,231 400 2 800 Other Support Areas 4,238 3,875 Lobby A 2,000 1,300 1 1,300 Lobby B 1,038 675 1 675 Interaction 1,077 50 14 700 Vending 308 200 1 200 Building Support Areas 2,062 1,340 Receiving Loading Dock 308 200 1 200 Flammables 231 150 1 150 Contaminated Waste 231 150 1 150 Office 185 120 1 120 Storage 615 400 1 400 Mail Room 123 80 1 80 Mechanical: Vacuum Room 185 120 1 120 Mechanical: Water Distillation 185 120 1 120 Clinical Trials Suite 1,908 1,240 Exam Room 369 120 2 240 Solarium 585 380 1 380 Wet Lab 308 200 1 200 Office 185 60 2 120 File Storage 92 60 1 60 Kitchenette 123 80 1 80 Toilet & Shower 246 80 2 160 TOTAL 105,215 68,510

Additional data further describing the requirements of each room and program space can be found in the Appendix. Code and Standard Requirements Applicable Codes and Standards The UCDHSC has the overall jurisdiction for the project and will provide final interpretation on code issues. The campus requires that construction projects conform to the following codes and regulations. Unless otherwise indicated, the latest edition of listed codes and regulations will be used.


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The codes, regulations, and guidance documents that govern this project include: Code and Standards Requirements

Applicable Codes and Standards The UCDHSC has the overall jurisdiction for the project and will provide final interpretation on code issues. The campus requires that construction projects conform to the following codes and regulations per state requirement of the Department of State Buildings. Unless otherwise indicated, the latest edition of listed codes and regulations will be used. The following approved building codes and standards have been adopted by State Buildings Programs (SBP) as the minimum requirements to be applied to all state-owned buildings and physical facilities including capital construction and controlled maintenance construction projects. The 2003 edition of the International Building Code (IBC) (as adopted by the Colorado State Buildings and Real Estate Programs as follows: Chapters 2-35 and Appendices C and I) The 2003 edition of the International Mechanical Code (IMC) (as adopted by the Colorado State Buildings and Real Estate Programs as follows: Chapters 2-15 and Appendix A) The 2003 edition of the International Energy Conservation Code (IECC) (as adopted by the Colorado State Buildings and Real Estate Programs) The 2005 edition of the National Electrical Code (NEC) (National Fire Protection Association Standard 70) (as adopted by the Colorado State Electrical Board) The 2003 edition of the International Plumbing Code (IPC) (as adopted by the Colorado Examining Board of Plumbers as follows: Chapter 1 Section 101.2,102, Chapters 2-13 and Appendices B, D, E, F and G) The 2003 edition of the International Fuel Gas Code (IFGC) (as adopted by the Colorado Examining Board of Plumbers as follows: Chapter 1 Section 101,102, Chapters 2-8 and Appendices A, B, C and D) The National Fire Protection Association Standards (NFPA) (as adopted by the Department of Public Safety/Division of Fire Safety as follows with editions shown in parentheses: NFPA-1 (2000), 11 (1998), 11A (1999), 12 (2000), 12A (1997), 13 (1999), 13D (1999), 13R (1999), 14 (2000), 15 (1996), 16


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(1999), 17 (1998), 17A (1998), 20 (1999), 22 (1998), 24 (1995), 25 (2002), 72 (1999), 231D (1998), 409 (1995), 423 (1999), 705 (1997) and 2001 (2000)) The 2001 edition of the ASME Boiler and Pressure Vessel Code (as adopted by the Department of Labor and Employment/Boiler Inspection Section as follows: sections I, IV, VIII-Divisions 1 and 2, X and B31.1) The 2001 edition of the National Boiler Inspection Code (NBIC) (as adopted by the Department of Labor and Employment/Boiler Inspection Section) The 2002 edition of the Controls and Safety Devices for Automatically Fired Boilers CSD-1 (as adopted by the Department of Labor and Employment/Boiler Inspection Section) The 2001 edition of the Boiler and Combustion Systems Hazards Code, NFPA 85 (as adopted by the Department of Labor and Employment/Boiler Inspection Section) The current edition of the Rules and Regulations Governing the Sanitation of Food Service Establishments (as adopted by the Department of Public Health and Environment/Colorado State Board of Health) The 1998 edition of ICC/ANSI A117.1, Accessible and Usable Buildings and Facilities (as adopted by the Colorado General Assembly as follows: CRS 9-5-101, as amended, for accessible housing) University of Colorado at Denver and Health Sciences Center Requirements: The Manual of Guidelines and Standards for Construction Projects - website location: (www.uchsc.edu/projects/ and click on Construction, then click on Campus Standards. Colorado Rules and Regulations pertaining to Radiation Control, 6 CCR 1007 Part 1-20. The latest edition of the Life Safety Code (NFPA 101) (use most restrictive interpretation where it conflicts with the IBC). AIHA American Standard for Laboratory Ventilation ANSI/AIHA Z9.5-1992. Last edition of "Guide for Care and Use of Laboratory Animals." UCHSC Campus Standard Biosafety Level (BL3) Construction Standards.

http://www.uchsc.edu/projects/and


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The National Fire Protection Standards, 45, 72 latest addition. Note: Additional codes, standards and appendices may be adopted by the state agencies and institutions in addition to the minimum codes and standards herein adopted by State Buildings Programs. 1. The 2003 edition of the IBC became effective on July 1 of 2004. Consult the state electrical and plumbing boards and the state boiler inspector and the Division of Fire Safety for adoption of current editions and amendments to their codes. 2. Projects should be designed and plans and specifications should be reviewed based upon the approved codes at the time of A/E contract execution. If an agency prefers to design to a different code such as a newer edition of a code that State Buildings Programs has not yet adopted, the agency must contact SBP for approval and then amend the A/E contract with a revised Exhibit D, Approved State Building Codes. Please note that the state plumbing and electrical boards enforce the editions of their codes that are in effect at the time of permitting not design. 3. The state’s code review agents, or the State Buildings Programs approved agency building official, shall review all documents for compliance with the codes stipulated herein. Note: The Department of Public Health and Environment, Division of Consumer Protection will review drawings for food service related projects. 4. This policy does not prohibit the application of various life safety codes as established by each agency for specific building types and funding requirements. NFPA 101 and other standards notwithstanding, approved codes will supersede where their minimum requirements are the most restrictive in specific situations. If a conflict arises, contact State Buildings Programs for resolution. 5. It is anticipated that compliance with the federal Americans with Disabilities Act Accessibility Guidelines for Buildings and Facilities (ADAAG) and Colorado Revised Statutes Section 9-5-101 will be met by compliance with the 2003 International Building Code and ICC/ANSI A117.1. However, each project may have unique aspects that may require individual attention to these legislated mandates. 6. The 2003 edition of the International Building Code (IBC) is to be applied to factory-built nonresidential structures as established by the Division of Housing within the Department of Local Affairs.


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2. Project Sketches The Pharmaceutical Research Center will be a both a programmatic and an esthetic addition to the Library Commons. Located adjacent to the Library and the Red Cross Building, it will be a significant anchor to the west side of the commons. The site plan below suggests the potential attractiveness of the Library Commons with this research and administrative facility, the Library, the Red Cross Building, and Building 500 at its edges.

Proposed Site Pharmaceutical Research Center

Library Commons Area North of Building 500

The diagrams below depict the conceptual stacking of program elements by floor and some targeted adjacencies in the proposed facility. The research laboratories and their support areas which will have the least visitor traffic are anticipated to be on the upper floors. The animal care facility will be adjacent to one of the research areas and will have restricted passage from the receiving area and to the other research labs by a restricted access elevator. HVAC equipment is envisioned to be mounted on the roof. First floor


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program elements include offices for student services and experiential programs likely located on the end of the building closest to the education zone, conference facilities that are sometimes accessed by individuals outside the university community, and vending, lobby and receiving areas. Administration can be located in various areas, but at this early level of facility planning are envisioned to be largely on the first floor with the dean’s portion and some departmental administration on the upper floors. A clinical trials suite which will be accessed by research study subjects will be located adjacent to a public stair and elevator. Meeting rooms are distributed throughout the floors but are stacked at the north end to facilitate possible public access from an elevator and lobby at the north end.


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Proposed Stacking DiagramPharmaceutical Research Center

3rd Floor 4th Floor

Dean'sConference Dean Conference

Administration

Administration

Research ResearchLaboratories Laboratories

Research ResearchOffices Offices

Core Core

Animal Holding

1st Floor 2nd Floor

Lobby Board ConferenceRoom

ClinicalTrials

Faculty Offices SeminarResearchLaboratories

Conference

VendResearch

Lobby OfficesCore Core

ExprProg

MechReceiving & StudentStorage NMR Services

3. Project Cost Estimate(s) Construction The capital construction budget for the construction of Pharmaceutical Research Center is $42,032,512. The sources of these cost estimates include professional estimating resources applied to gross square footage projections as well as recent experiences with actual construction costs of the University of Colorado at Denver and Health Sciences Center with projects under construction or recently constructed on the Fitzsimons campus. This facility includes a considerable amount of research space in its program. Utility, plumbing, and HVAC costs associated with research space will cause this facility to be more costly than a typical education or office facility on a higher education campus. The estimated project costs are detailed in the following table.

Capital Construction Budget Pharmaceutical Research Center

A. Land Acquisition:

Land Purchase Cost $0

B. Professional Services:

Architectural/Engineering/Basic Services $3,150,639

Code Review/Inspection $71,500

Commissioning Services $200,000

Site Surveys, Investigative Reports $124,519

Other Professional Services $236,797

Total Professional Services $3,783,455

C. Construction:

Infrastructure:

(a) Service/Utilities $723,353

(b) Site Improvements $1,446,706

New Construction (105,215 GSF) $28,968,366

Other: 0

(a) Site Demolition $67,968

(b) Site Soil Abatement $300,000

Total Construction Costs $31,506,393

D. Equipment and Furnishings:

Equipment (Fixed Equipment Incl in Construction) $0

Furnishings $1,841,263

Communications $946,935

Total Equipment & Furnishings Costs $2,788,198

E. Miscellaneous:

Relocation $438,512

TAP Fees (City of Aurora) $936,870

Security $210,430

Misc $267,028

Total Miscellaneous Costs $1,852,840

F. Project Contingency

Project Contingency 5% $2,101,626

Total Contingency $2,101,626

Total Budget Request $42,032,512

Source of Funds

CFE $42,032,512

Equipment The equipment and furniture needs for the Pharmacy Research Center are projected at $2,104,300 and $1,841,263, respectively. Included in these categories are laboratory equipment and office furnishings. The laboratories will be designed for maximum flexibility with most laboratory benches being portable and adjustable in height for sitting or standing. Only a few items are anticipated to cost in excess of $50,000. These items include 2 preassembled cold rooms, an NMR, and a nitrogen generator. The clinical trials suite will be equipped with lounge furniture in the solarium and with medical office equipment and furnishings in the exam rooms. Office furniture includes desks, chairs, file cabinets, and office computers. Conference rooms will be equipped with a data projector, computer, DVD player, electronic white board, and projector screen and will be equipped for distance learning capabilities. Cost Effects of Project Delay Construction costs are escalating at significant rates. Rider Hunt Levett & Bailey publish actual and projected construction cost escalation rates. They recently published a construction cost index for the next 6 to 12 months projecting a 10% annualized rate of escalation. They also published Denver area escalation percentage increases of 2.03 and 1.97 for the first two quarters, respectively, of 2006 which would annualize to about an 8% escalation rate. A delay in commencing this project will likely result in annual increased costs of this magnitude. Operating Costs First year annual facility operating costs for the Pharmaceutical Research Center with a July 2010 occupancy are projected at $1,268,893 including $639,707 in utility costs and $629,186 in other operating and maintenance costs. Second year total operating costs are projected at $1,332,338 with utility costs of $671,692 and other operating costs of $660,645.


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4. Life Cycle Cost Analysis Life Cycle Cost analysis tables for this project are found in the Appendix. In a 30 year study, they indicate that the current project expenditure of $42,032,512 plus the present value of future operating costs and capital replacements of $37,463,824 compare favorably to a future facility value of $136,605,664. Due to the commitment to develop Fitzsimons as the replacement campus of the 9th Avenue campus by the University of Colorado at Denver and Health Sciences Center, comparative life cycle cost analyses for alternative off campus sites not owned by the University of Colorado were not considered. During the design process for this project, UCDHSC will be evaluating different systems including HVAC options and will be evaluating their purchase and installation costs along with their projected operating costs. Furthermore, the design team intends to achieve a level of LEED certification. The UCDHSC policy on Commitment to Sustainability is included in the Appendix. 5. Financial Analysis The Pharmaceutical Research Center is a 100% cash funded project. The following table displays the funding timing and distribution for capital development costs over the period of design and construction for the project:

Projected Funding Sources for Capital Development Pharmaceutical Research Center

University of Colorado at Denver and Health Sciences Center Project Funding 07-08 08-09 09-10 10-11 Total Cash Funds $3,816,621 $9,695,166 $27,319,516 $1,201,209 $42,032,512 Total $3,816,621 $9,695,166 $27,319,516 $1,201,209 $42,032,512


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6. Project Schedule Relation to Other Projects and Programs The Pharmaceutical Research Center project is related to a number of other UCDHSC projects currently under construction at the Fitzsimons campus. These include the education facilities of ED 1B, ED II, and the Library as well as the vivarium in Research Complex I. All UCDHSC classes will be held at the Fitzsimons campus beginning in January 2008. To the extent that faculty in the School of Pharmacy collaborate with other researchers in other UCDHSC schools, the sooner they can all be relocated to the same campus, the sooner mutual functioning will be restored. Urgency The Pharmaceutical Research Center is fortunate to have a capital donation that enables the design and construction of this facility to proceed expeditiously. Relocating all UCDHSC facilities to the Fitzsimons campus as soon as possible is a matter of urgency both for the integrated functioning of all parts of the School of Pharmacy as well as the Health Sciences Center as a whole. In particular regard for the School of Pharmacy, all students will be on the Fitzsimons campus as of January 2008. The period between January 2008 and the occupancy of this project will be a considerable inconvenience and disruption for faculty and students traveling between the campuses and should not be prolonged unnecessarily. Schedule The information below reflects the project implementation schedule for the design and construction of the Pharmaceutical Research Center at the Fitzsimons Campus.

Activity Expected Completion Date Program Plan Completion November 2006 Regent Approval December 2006 CCHE, OSPB, CDC, JBC Approvals February 2007 to April 2007 Architect and Contractor Selections April-June 2007 Design Completion June 2008 Construction Completion May 2010 Occupancy July 2010


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V. Relation to Master Plan/Other Projects The Master Plan for the future of the University of Colorado Health Sciences Center was developed during an 18-month period in 1997 and 1998. The research vision within the plan was developed by a campus-wide faculty research committee and was designed to accommodate then current research needs necessary to relocate the Health Sciences Center to the Fitzsimons campus and with projections to meet the needs of future research growth. The 1998 Master Plan referenced research facilities as Research Complex I, Research Complex II, and Research Complex III. The research facility needs of the School of Pharmacy were quantified within the projections for Research Complex III. Interim planning has focused on the need to meet these research needs in facilities being constructed earlier. The identification of a philanthropic donor enables the Health Sciences Center to proceed to develop a portion of the programmed research space which was proposed in the Master Plan in a manner to meet the School of Pharmacy’s needs and the wishes of the donor. The programmatic uses of the Pharmaceutical Research Center relate to education facilities in the Master Plan. The education of pharmacy students will occur in Education Facility II and Education Facility 1B. The library needs of the School of Pharmacy will be met by the Library under construction on the Fitzsimons campus. Many research needs involving live animals will be met by the vivarium housed within Research Complex I. This program plan also relates to the program plan, pending CCHE approval, for remediation following the vacating of the 9th Avenue campus which including the vacating of the current School of Pharmacy facility.


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VI. Facilities Alternatives The Facilities Alternatives listed below were considered but were rejected as unacceptable because they would not allow the School of Pharmacy or the UCDHSC to accomplish its objective of providing sufficient space for its programs, providing appropriate space and location for its programs, and allowing for the timely vacating of the UCDHSC 9th Avenue campus. Alternatives to the construction of a new Pharmacy Research Center as proposed in this program plan include (1) Retaining the School of Pharmacy’s current building at the 9th Avenue campus, (2) Leasing an off-campus facility near Fitzsimons, (3) Occupying space in buildings currently under construction at Fitzsimons, and (4) Constructing a new facility on a different site within the Fitzsimons campus. None of these alternatives allow the Pharmaceutical Research Center to meet its needs and objectives effectively. Retain the School of Pharmacy’s Research Function at the 9th Avenue Campus This alternative is unacceptable as it would fragment the Health Sciences Center campus, necessitate inefficiencies, impair collaboration, constrict the growth of space for research labs, and require unnecessary lease payments after the building is sold. Lease an off-campus facility near Fitzsimons While this alternative may provide sufficient space to meet the needs of the program in a larger facility if an appropriate facility were identified and available for lease, an off campus location would make the Center’s programs inaccessible to many of its constituents and create unnecessary ongoing leasing payments when the University of Colorado already owns an appropriate site at Fitzsimons. Occupy Research Space in Research Complex II and Faculty Offices in Academic Office West This would be a temporary occupancy at best. Two relocation moves for one school in a short time period would be an unacceptable disruption to a research program. The construction of a separate Pharmaceutical Research Center allows for the School of Pharmacy to have a physical identity, locates all school faculty in the same facility, and allows for growth of other school’s research programs in the buildings under construction for completion in 2008. Construct a new facility on a different site within the Fitzsimons campus Alternate sites were considered for this project. The other sites were deemed less favorable due to higher infrastructure costs, delayed schedule considerations, distance to important amenities such as parking, and concerns over the permanency of location due to adjacent programs which may have significant future expansion requirements.


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Appendices Map

Site Plan Pharmaceutical Research Center

Health Sciences Center – Fitzsimons Campus University of Colorado


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Other Approvals This Project Request is in conformance with the most recently approved facility Master Plan for the University of Colorado Health Sciences Center entitled Institutional Master Plan – University of Colorado Health Sciences Center and the University of Colorado Hospital Authority and approved in October 1988 by the Board of Regents of the University of Colorado. Subsequent Institutional Master Plan Updates of 1999, 2000, and 2001, respectively, were approved by the Board of Regents of the University of Colorado and submitted to CCHE.

This specific program plan is being submitted to the Board of Regents and is anticipated to be approved on December 2, 2006. Room Utilization Addendum The principal program elements in the Pharmaceutical Research Center for which utilization concerns are relevant are conference and seminar rooms. Some of their usage will be for graduate students. The projected educational usage for the Seminar Room and Conference Room A are 85% and 50%, respectively. Other administrative uses will fill most weekday working times. Research activities are currently at capacity at the 9th Avenue campus and will grow to 100 % capacity of the proposed facility in the next 10 years. Offices for researchers associated with those laboratories and for faculty associated with research growth and with student enrollment growth also will be 100 % utilized. Life Cycle Owning and Operating Cost Analysis The following tables constitute the Life Cycle Owning and Operating Analysis over a 30 year period. The tables are discussed briefly in the program plan above.


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LIFE CYCLE COST ANALYSIS Project: UCDHSC Pharmaceutical Research Center Study Period: 30 years Discount Rate: 6% Study Method: Present Value at One Dollar Construction: $ 28,934,125 Project Cost & Fees: $ 42,032,512 Addl Optg & Maint Costs $ 629,186 first year Addl Energy/Utilities: $ 639,707 first year Inflation Factor: 5%

Salvage Value

Escalator: 4% compounded annually

Year

Initial Investment

Including Soft Costs

Major Repair &

Replacement Operating & Maintenance

Energy/ Utilities Salvage Value Total

Discount Rate

Present Value

1 $ 42,032,512 $ 629,186 $ 639,707 $ 1,268,893 0.9434 $ 1,197,074 2 $ 660,645 $ 671,692 $ 1,332,338 0.8900 $ 1,185,781 3 $ 693,678 $ 705,277 $ 1,398,955 0.8396 $ 1,174,562 4 $ 728,361 $ 740,541 $ 1,468,902 0.7921 $ 1,163,517 5 $ 764,780 $ 777,568 $ 1,542,347 0.7473 $ 1,152,596 6 $ 803,018 $ 816,446 $ 1,619,465 0.7050 $ 1,141,723 7 $ 843,169 $ 857,269 $ 1,700,438 0.6651 $ 1,130,961 8 $ 885,328 $ 900,132 $ 1,785,460 0.6274 $ 1,120,198 9 $ 929,594 $ 945,139 $ 1,874,733 0.5919 $ 1,109,654

10 $ 976,074 $ 992,396 $ 1,968,470 0.5584 $ 1,099,193 11 $ 1,024,878 $ 1,042,015 $ 2,066,893 0.5268 $ 1,088,839 12 $ 1,076,122 $ 1,094,116 $ 2,170,238 0.4970 $ 1,078,608 13 $ 1,129,928 $ 1,148,822 $ 2,278,750 0.4688 $ 1,068,278 14 $ 1,186,424 $ 1,206,263 $ 2,392,687 0.4423 $ 1,058,285 15 $ 4,331,091 $ 1,245,745 $ 1,266,576 $ 6,843,412 0.4173 $ 2,855,756 16 $ 1,308,033 $ 1,329,905 $ 2,637,937 0.3936 $ 1,038,292 17 $ 1,373,434 $ 1,396,400 $ 2,769,834 0.3714 $ 1,028,716 18 $ 1,442,106 $ 1,466,220 $ 2,908,326 0.3503 $ 1,018,787 19 $ 1,514,211 $ 1,539,531 $ 3,053,742 0.3305 $ 1,009,262 20 $ 307,049 $ 1,589,922 $ 1,616,508 $ 3,513,478 0.3118 $ 1,095,503 21 $ 1,669,418 $ 1,697,333 $ 3,366,751 0.2942 $ 990,498 22 $ 1,752,889 $ 1,782,200 $ 3,535,088 0.2775 $ 980,987 23 $ 1,840,533 $ 1,871,310 $ 3,711,843 0.2618 $ 971,760 24 $ 1,932,560 $ 1,964,875 $ 3,897,435 0.2470 $ 962,666 25 $ 11,756,514 $ 2,029,188 $ 2,063,119 $ 15,848,821 0.2330 $ 3,692,775 26 $ 2,130,647 $ 2,166,275 $ 4,296,922 0.2198 $ 944,463 27 $ 2,237,179 $ 2,274,589 $ 4,511,768 0.2074 $ 935,741 28 $ 2,349,038 $ 2,388,318 $ 4,737,357 0.1956 $ 926,627 29 $ 2,466,490 $ 2,507,734 $ 4,974,224 0.1846 $ 918,242 30 $ 8,128,463 $ 2,589,815 $ 2,633,121 $(136,605,664) $ 13,351,399 0.1741 $ 2,324,479

Total Present Value for Owning and Operating Costs over the Study Period $37,463,824


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MAJOR REPAIR AND REPLACEMENT COSTS Project: UCDHSC Pharmaceutical Research Center Date: 13-Oct-06

Inflation

Factor: 5%

Construction

Cost: $ 28,934,125 Study Period: 30 years

Facility Subsystem Likely Life Range Useful Life

Chosen

% Replaced @ Useful

Life Chosen

% of Pjct. Costs

Current Constr. Cost

Provision for

Renewal w/o

Inflation

FV Factor 5%,

Useful Life

Replace. Cost w/ Inflatn, Useful Life Chsn, & % Replaced

Foundation/structure n/a n/a 25% $ 7,233,531 Roofing 25 15-40 15 100% 3% $ 868,024 $ 57,868 2.079 $ 1,804,621 Exterior Closure n/a 50 up 30 20% 19% $ 5,497,484 $183,249 4.322 $ 4,752,025 Interior Construction 50 25 up 30 10% 12% $ 3,472,095 $115,737 4.322 $ 1,500,639 Interior Finishes 10 5-15 15 60% 7% $ 2,025,389 $ 135,026 2.079 $ 2,526,470 Elevators 40 25 up 30 50% 3% $ 868,024 $ 28,934 4.322 $ 1,875,799 Plumbing 30 20-80 40 50% 4% $ 1,157,365 $ 28,934 7.04 $ 4,073,925 HVAC 25 15-75 25 50% 15% $ 4,340,119 $173,605 3.386 $ 7,347,821 Electrical 35 20-75 25 50% 9% $ 2,604,071 $ 104,163 3.386 $ 4,408,693 Fire Protection 50 20-100 40 30% 1% $ 289,341 $ 7,234 7.04 $ 611,089 Special Equip/Misc 30 10-50 20 20% 2% $ 578,683 $ 28,934 2.653 $ 307,049 TOTALS 100% $ 28,934,125 $863,684


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OPERATING COST ANALYSIS Pharmaceutical Research Center University of Colorado at Denver and Health Sciences Center Operating Costs in $/GSF

Cost/GSF/Year GSF

Annual Operating

Costs

Categorized Annual

Operating Costs

Utilities $ 6.08 105,215 $ 639,707 $ 639,707 Operating & Maintenance Building Maintenance and Repairs $ 1.85 105,215 $ 194,648 Environmental Services $ 1.19 105,215 $ 125,206 Grounds Maintenance $ 0.23 105,215 $ 24,199 Environmental Health and Safety $ 0.62 105,215 $ 65,233 Police/Security $ 1.42 105,215 $ 149,405 Insurance $ 0.67 105,215 $ 70,494 Subtotal $ 629,186 Total $ 1,268,893


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Library Space Any additional space requirements in the Library which may arise as a result of this project can be accommodated in the new Library at Fitzsimons. Independent Third Party Review The third party review of this program plan, conducted by Anderson Mason Dale Architects of Denver, Colorado, is attached on the following pages.


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Student Demographics Additional student demographic data for the UCDHSC School of Pharmacy is found in the tables below. Enrollment data by degree program can be found in the earlier Program Description section of this program plan. Residency Data Class Admissions

2003 2004 2005 2006

Resident 99 102 110 93 Non Resident

31 28 21 38

Ethnicity Class of 2010

White Asian/Pacific African American

Hispanic Native American

62% 24% 9% 4% 1% Gender

Male Female 39 92

Incoming Class GPA

Cumulative Mathematics Chemistry Biology 3.51 3.41 3.35 3.40


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Facilities Audit Program

Building Summary Inspection Report

Building Name:

Building No: Campus/Location Occupancy Type:

Gross Space (sq ft): Number of Levels

Year Built: Year Remodeled:

Date Inspected:

School of Pharmacy 104 9th Ave & Colo Blvd Office/Lab 99,804 4 1991

Building Estimated Current Replacement Value (C.R.V.): $15,000,000 The replacement cost is obtain using a combination of standard per square foot estimating data for the particular building occupancy type, recent renovations, site considerations, with minor adjustments for year built. Critical Needs (only the top five priorities are list here – see project list for more detail) Brief identification of top-priority major-maintenance needs that should be pursued within the next 5 years. Potential Controlled Maintenance Projects: • Roof Replacement $ 125,000 • Window Repair (including some brick work) $ 40,000 Summary: Assessment Rating & Deficiency Cost

Building Component System Deficiency

Rating

Building Component Multiplier

Component Value

(C.R.V.)

Estimated Cost of

Deficiency

Building Structure 63% 0.35 5,250,000 1,935,885 HVAC Systems 89% 0.37 5,550,000 604,950 Electrical Systems 82% 0.16 2,400,000 423,600 Plumbing Systems 98% 0.08 1,200,000 25,500 Code Compliance & Safety 98% 0.04 600,000 127,50 100%=Perfect Total: $ 3,002,685 Facilities Condition Index (1-(Deficiency/C.R.V.))X100=F.C.I.

F.C.I. = 1 - Cost of Deficiency $ 3,002,685 = 80.0% C.R.V. $ 15,000,000

Percent Change from Previous = x%

University of Colorado Health Sciences Center Program Plan for the Pharmaceutical Research Center

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Program Plan Assumptions by Room


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Room/Area Name: Research Laboratory Total Identical Rooms: 42 Room Size: 600 asf Primary Function: Pharmaceutical wet research including dry instrument areas Location Adjacencies: Adjacent to other research areas and proximate to lab

support areas, and research offices. Adjacent to: Adjacent to other research laboratory areas and some core

support areas such as alcoves for hoods and equipment corridors.

Close to: Lab support areas including dark room, tissue culture

rooms, lab utility rooms, isotope lab, and lab equipment storage. The animal holding facility needs to be accessible. Offices need to be nearby.

Special Requirements: Open wet lab area with as much flexibility through

moveable equipment as possible. Relocatable columns for power and gases. Replicated design of lab bench modules. Alcoves for special equipment.

Built-in Equipment: Counter with sink, drying rack, exhausted hoods,

emergency showers, eye wash stations and controlled substance cabinets.

Movable Equipment: Adjustable height portable wet lab benches, undercounter

storage cabinets with removable top layer to accommodate adjustable benches, adjustable stools and chairs moveable dry research benches, storage pedestals, chairs, computers, supply storage shelving.

Other Design Considerations: Color corrected lighting at 100 foot candles for ambient

lighting and appropriate task lighting at benches. Emergency power connections, gas cylinder racks, over counter shelving, flammable and acid storage


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Room/Area Name: Alcove Total Identical Rooms: 84 Room Size: 100 asf Primary Function: Area for specialty equipment, hoods, etc. Location Adjacencies: 2 alcoves per laboratory module Adjacent to: Each lab Close to: Special Requirements: Ventilation system connections, emergency power Built-in Equipment: Some with hoods Movable Equipment: Benches Other Design Considerations: Emergency power connections, ice machines, DI water

service


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Room/Area Name: Linear Equipment Corridor Total Identical Rooms: 1 per research floor Room Size: 100 asf per laboratory plus circulation Primary Function: Storage of equipment, such as refrigerators, that generates

heat and noise in a location convenient to the laboratories and external to them

Location Adjacencies: Adjacent to wet laboratories Adjacent to: Close to: Special Requirements: Adequate heat exhaust for operating equipment Built-in Equipment: Movable Equipment: Freezers, refrigerators Other Design Considerations: Emergency power connections, ice machines, DI water

service


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Room/Area Name: NMR Total Identical Rooms: 1 Room Size: 400 asf Primary Function: House NMR and controller computer Location Adjacencies: Distance from metallic materials both horizontally and

vertically is critical (12’ ceiling height), also from RF sources and floor vibrations

Adjacent to: Close to: Special Requirements: Floor to support nearly 4,000 lbs. exacting temperature

control, magnetic field isolation, controlled access, cryogenic helium and nitrogen supply and usage precautions

Built-in Equipment: Movable Equipment: NMR and computer controller, sample preparation benches Other Design Considerations:


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Room/Area Name: Dark Room Total Identical Rooms: 2 Room Size: 80 asf Primary Function: Film processing Location Adjacencies: Near research labs, probably 2nd and 4th floors Adjacent to: Close to: Special Requirements: Revolving door for light exclusion, water supply

and drain, possibly a floor drain Built-in Equipment: Movable Equipment: Film developer Other Design Considerations:


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Room/Area Name: Tissue Culture Total Identical Rooms: 6 Room Size: 275 asf Primary Function: Location Adjacencies: Research labs, probably two per floor Adjacent to: Close to: Special Requirements: Air supply and return locations not to interfere with

biosafety cabinets, emergency power Built-in Equipment: Counters Movable Equipment: Biosafety cabinets, incubators, gas cylinder racks Other Design Considerations:


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Room/Area Name: Animal Holding Facility Total Identical Rooms: 1 Room Size: 600 asf Primary Function: Location Adjacencies: On research floor, probably 3rd, near service

elevator for transport of animals away from public spaces

Adjacent to: Close to: Special Requirements: Built-in Equipment: Movable Equipment: Racks, carts, cages Other Design Considerations: Humidification, easily cleanable wall and floor

surfaces, floor drain


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Room/Area Name: Lab Utility Total Identical Rooms: 2 Room Size: 160 asf Primary Function: Location Adjacencies: On research floors, probably 2 and 4 Adjacent to: Close to: Special Requirements: Built-in Equipment: Autoclave, sink, glasswash Movable Equipment: Tables for equipment Other Design Considerations:


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Room/Area Name: Mass Spectrometer Room Total Identical Rooms: 1 Room Size: 200 asf Primary Function: House mass spectrometer units in one secure and

easily managed location Location Adjacencies: Wet laboratories Adjacent to: Close to: Special Requirements: Built-in Equipment: Counters Movable Equipment: Mass spectrometers Other Design Considerations:


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Room/Area Name: Cold Room Total Identical Rooms: 2 Room Size: 100 asf Primary Function: Location Adjacencies: Adjacent to: Close to: Special Requirements: Built-in Equipment: Cold Room unit Movable Equipment: Other Design Considerations:


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Room/Area Name: Nitrogen Generation Room Total Identical Rooms: 1 Room Size: 100 asf Primary Function: Location Adjacencies: Adjacent to: Close to: Special Requirements: Built-in Equipment: Movable Equipment: Compressor Other Design Considerations:


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Room/Area Name: Office A Total Identical Rooms: 98 Room Size: 120 asf Primary Function: Administrative Office for faculty, directors,

administrators, IT staff Location Adjacencies: Various – by labs, administrative suites, department

administration. Student/public access Adjacent to: Close to: Special Requirements: Built-in Equipment: Movable Equipment: Desk, files, bookcase, desk chair, 2 guest chairs,

computer table Other Design Considerations: Well sound proofed to maintain conversations

within office. Personal storage space


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Room/Area Name: Office B Total Identical Rooms: 7 Room Size: 140 asf Primary Function: Location Adjacencies: Adjacent to: Close to: Special Requirements: Built-in Equipment: Movable Equipment: Desk, files, bookcase, desk chair, 2 guest chairs,

computer, small conference table with 2 chairs. Other Design Considerations: Sound proofed, personal storage


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Room/Area Name: Dean’s Office Total Identical Rooms: 1 Room Size: 240 asf Primary Function: Location Adjacencies: Adjacent to: Close to: Special Requirements: Built-in Equipment: Movable Equipment: Desk, files, bookcase, desk chair, 2 guest chairs,

computer, conference table with 6 chairs. Other Design Considerations: Sound proofed, personal storage


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Room/Area Name: Office C Total Identical Rooms: 13 Room Size: 60 asf Primary Function: Open office modules for administrative assistants Location Adjacencies: Adjacent to: Close to: Special Requirements: Built-in Equipment: Movable Equipment: Desk, computer table, chair, printer stand,

bookshelf, files, personal storage Other Design Considerations:


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Room/Area Name: Fellows and Residents Office Total Identical Rooms: 9 Room Size: 60 asf each Primary Function: Open office module Location Adjacencies: Adjacent to: Close to: Special Requirements: Built-in Equipment: Desk, computer table, files Movable Equipment: Chair Other Design Considerations: Common or shared equipment such as printers,

guest seating, full walls, lockable door to meet HIPAA requirements for patient data


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Room/Area Name: IT Workroom Total Identical Rooms: 1 Room Size: 200 asf Primary Function: Work space for computer repairs and assistance

with faculty presentations Location Adjacencies: Adjacent to: Close to: Faculty Special Requirements: Built-in Equipment: Work benches at both standing and sitting heights Movable Equipment: Storage shelving and cabinets, stools and chairs Other Design Considerations: Power strips at work benches. Good task lighting.


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Room/Area Name: Copy Room Total Identical Rooms: 4 Room Size: 120 asf Primary Function: Location Adjacencies: One per floor in or near administrative suites Adjacent to: Close to: Special Requirements: Built-in Equipment: Cupboards for paper/supply storage Movable Equipment: Copier, facsimile machine, work table or counter

top, recycle bins Other Design Considerations:


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Room/Area Name: Break Room Total Identical Rooms: 4 Room Size: 120 asf Primary Function: Location Adjacencies: Adjacent to: Close to: Administrative suites or conference spaces Special Requirements: Built-in Equipment: Double sinks with disposal, dishwasher, cupboards Movable Equipment: Tables, chairs, refrigerators, microwave ovens,

toaster ovens


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Room/Area Name: Office Supply Storage Total Identical Rooms: 5 Room Size: 40 asf Primary Function: Location Adjacencies: Within administrative suites Adjacent to: Close to: Special Requirements: Built-in Equipment: Cupboards, some tall enough for easels, flipcharts,

posters and stands, counter top at work height Movable Equipment: Other Design Considerations:


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Room/Area Name: Waiting Areas Total Identical Rooms: 1 Room Size: 180 asf Primary Function: Seated waiting areas for Student

Services/Experiential Training Program offices Location Adjacencies: Adjacent to: Close to: Special Requirements: Built-in Equipment: Movable Equipment: Chairs, low table, information rack Other Design Considerations: Circulation space for student “lines”, not too close

to reception desk for confidential conversations


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Room/Area Name: Waiting Areas Total Identical Rooms: 3 Room Size: 120 asf Primary Function: Seated waiting areas for the Dean, Department

Chairs (2) Location Adjacencies: Adjacent to: Close to: Special Requirements: Built-in Equipment: Movable Equipment: Chairs, low table, information rack Other Design Considerations:


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Room/Area Name: File Storage Total Identical Rooms: 6 Room Size: 120 asf Primary Function: Location Adjacencies: Within administrative suites (Deans, Dept. Chairs,

Student Services/Experiential programs, NTPD) Adjacent to: Close to: Special Requirements: Built-in Equipment: Movable Equipment: File cabinets, shelving for box storage or notebooks,

some tall racks for posters, composite photos, work table or counter

Other Design Considerations:


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Room/Area Name: Dean’s Conference Room Total Identical Rooms: 1 Room Size: 400 asf Primary Function: Location Adjacencies: Adjacent to: Close to: Special Requirements: Sink and counter Built-in Equipment: White Board, automatic screen, data projection Movable Equipment: Tables and chairs (14) Other Design Considerations:


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Room/Area Name: Board Room Total Identical Rooms: 1 Room Size: 1,500 asf Primary Function: Location Adjacencies: Near public stair/elevator for guest access Adjacent to: Close to: Special Requirements: Built-in Equipment: Automatic screen, white board, data projection Movable Equipment: Couches, chairs, tables, display cabinets Other Design Considerations: Sound/acoustics, variable lighting controls, coat

room


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Room/Area Name: Board Room Catering Kitchen Total Identical Rooms: 1 Room Size: 150 asf Primary Function: Location Adjacencies: Adjacent to: Close to: Special Requirements: Electrical power sufficient for catering equipment Built-in Equipment: Cupboards and counter top Movable Equipment: Refrigerator, dishwasher, microwave and toaster

ovens Other Design Considerations: Direct access to board room and corridor, double

sinks with disposal and adequate water supply


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Room/Area Name: Board Room Furniture Storage Total Identical Rooms: 1 Room Size: 150 asf Primary Function: Location Adjacencies: Adjacent to: Close to: Special Requirements: Built-in Equipment: Movable Equipment: Other Design Considerations: Lights, locks, possibly 2 doors: one to board room

and one to corridor


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Room/Area Name: Seminar Room Total Identical Rooms: 1 Room Size: 1,125 asf Primary Function: Conference room with seating for 75 Location Adjacencies: At lobby for pre/post functions Adjacent to: Close to: Special Requirements: Built-in Equipment: Sink, counter, staggered seating, automatic screen,

white board, data projection Movable Equipment: Podium w/ sound Other Design Considerations: No windows, wireless hub/access


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Room/Area Name: Conference Room A Total Identical Rooms: 1 Room Size: 600 asf Primary Function: Location Adjacencies: Adjacent to: Close to: Special Requirements: Built-in Equipment: Sink and counter Movable Equipment: Table, chairs (24), automatic screen, whiteboard Other Design Considerations: Wireless access


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Room/Area Name: Conference Room B Total Identical Rooms: 2 Room Size: 400 asf Primary Function: Location Adjacencies: Adjacent to: Close to: Special Requirements: Built-in Equipment: Automatic screen, whiteboard, sink, counter Movable Equipment: Table and chairs (14) Other Design Considerations: Wireless access


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Room/Area Name: Lobby A Total Identical Rooms: 1 Room Size: 1,300 asf Primary Function: May also function as pre and post function space for

adjacent Seminar Room on special occasions Location Adjacencies: Street access Adjacent to: Seminar Room Close to: Elevators and staircase Special Requirements: Built-in Equipment: Movable Equipment: Benches Other Design Considerations: Donor/Art wall, sun angle for afternoon/evening

receptions, display spaces, lighting variable controls


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Room/Area Name: Lobby B Total Identical Rooms: 1 Room Size: 725 asf Primary Function: Location Adjacencies: SE end of building for student access Adjacent to: Close to: Student Services, Experiential Training Special Requirements: Built-in Equipment: Movable Equipment: Benches Other Design Considerations: Display space


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Room/Area Name: Interaction Space Total Identical Rooms: 14 Room Size: 50 asf Primary Function: Intrafaculty communication Location Adjacencies: Research offices Adjacent to: Close to: Special Requirements: Built-in Equipment: Movable Equipment: Lounge chairs or upholstered benches Other Design Considerations: Sound consideration for conversations


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Room/Area Name: Vending Total Identical Rooms: 1 Room Size: 200 asf Primary Function: Location Adjacencies: Adjacent to: Close to: Special Requirements: Built-in Equipment: Movable Equipment: Vending machines Other Design Considerations: Power for vending machines and possible increase

in number of vending machines.


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Room/Area Name: Loading Dock Total Identical Rooms: 1 Room Size: 200 asf Primary Function: Location Adjacencies: Freight elevator to labs and roof; access to animal

holding facility without public passage Adjacent to: Close to: Special Requirements: Built-in Equipment: Movable Equipment: Other Design Considerations: Dock or lift to accommodate different delivery

trucks


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Room/Area Name: Flammable Storage Total Identical Rooms: 1 Room Size: 150 asf Primary Function: Location Adjacencies: Adjacent to: Close to: Special Requirements: Built-in Equipment: Movable Equipment: Other Design Considerations: Vented cabinets for solvents?


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Room/Area Name: Contaminated waste Total Identical Rooms: 1 Room Size: 150 asf Primary Function: Location Adjacencies: Adjacent to: Close to: Special Requirements: Built-in Equipment: Movable Equipment: Other Design Considerations: H&S specifications, ventilation


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Room/Area Name: Office Total Identical Rooms: 1 Room Size: 120 asf Primary Function: Location Adjacencies: Adjacent to: Close to: Within receiving area Special Requirements: Built-in Equipment: Movable Equipment: Desk, computer table, chair, guest chair,

bookcase/shelves, files Other Design Considerations:


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Room/Area Name: Receiving Storage Total Identical Rooms: 1 Room Size: 400 asf Primary Function: Location Adjacencies: Adjacent to: Close to: Special Requirements: Built-in Equipment: Movable Equipment: Shelves, cart storage space Other Design Considerations:


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Room/Area Name: Mail Room Total Identical Rooms: 1 Total Identical Rooms: 80 asf Primary Function: Location Adjacencies: Adjacent to: Close to: Special Requirements: Space to add individual mail slots, counter top for

sorting mail, collection place, recycle bins, scales Built-in Equipment: Mail bins and individual mail slots Movable Equipment: Other Design Considerations: Access, security


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Room/Area Name: Exam Room – Clinical Trials Total Identical Rooms: 2 Room Size: 120 asf Primary Function: Location Adjacencies: Adjacent to: Close to: Special Requirements: Built-in Equipment: Cupboard for clothes, supplies, sink, counter Movable Equipment: Exam table, lights, stool, computer Other Design Considerations:


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Room/Area Name: Solarium Total Identical Rooms: 1 Room Size: 380 asf Primary Function: Location Adjacencies: Adjacent to: Close to: Special Requirements: Built-in Equipment: TV, DVD player, sink, cupboards & counter Movable Equipment: Lounge sofas and chairs; table and chairs Other Design Considerations: Natural lighting. Carpet


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Room/Area Name: Wet Lab Total Identical Rooms: 1 Room Size: 200 asf Primary Function: Location Adjacencies: Adjacent to: Close to: Special Requirements: Built-in Equipment: Benches & sink. Movable Equipment: Other Design Considerations:


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Room/Area Name: Office Total Identical Rooms: 2 Room Size: 60 asf Primary Function: Location Adjacencies: Adjacent to: Close to: Special Requirements: Built-in Equipment: Movable Equipment: Desk, computer table, chair, files, bookcase, guest

chair, computer Other Design Considerations:


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Room/Area Name: File Storage Total Identical Rooms: 1 Room Size: 60 asf Primary Function: Location Adjacencies: Adjacent to: Close to: Special Requirements: Built-in Equipment: Movable Equipment: File cabinets, shelves for boxed storage Other Design Considerations:


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Room/Area Name: Kitchenette Total Identical Rooms: 1 Room Size: 80 asf Primary Function: Location Adjacencies: Adjacent to: Close to: Special Requirements: Built-in Equipment: Sink, cabinet, countertop, disposal, dishwasher Movable Equipment: Refrigerator, microwave oven Other Design Considerations:


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University of Colorado-

Commitment to Sustainability April 13, 2006

Sustainable Development is "development that meets the needs of the present without compromising the ability of future generations to meet their own needs." Sustainable development implies economic growth together with the protection of environmental quality, each reinforcing the other. The essence of this form of development is a stable relationship between human activities and the natural world, which does not diminish the prospects for future generations to enjoy a quality of life at least as good as our own. The University is a leader in environmental issues, committed to protecting the environment and natural resources. All University campuses shall proactively manage capital construction projects to minimize adverse impacts to the environment, while responsibly managing University resources. Continuing a role of leadership in environmental sciences and sustainability, the University shall provide fiscally sound, environmentally responsible development and stewardship of its campuses. The University is committed to:

• Complying with sound environmental practices, including the commitment to meet or exceed applicable legal and other regulatory requirements.

• Outreaching to local, state, and federal agencies for the purpose of promoting sustainable development and operations in areas that enhance the University’s ability to contribute through research and/or teaching.

• Properly managing wastes and pollution. • Managing capital construction processes, materials and natural resources while

considering the environmental impacts associated with decisions and actions. • Revising campus development standards and policies to support the ability to

achieve, the equivalent of a United States Green Building Council Leadership in Energy and Environmental Design™ (LEED) certification level for new construction.

• Monitoring the newly established development standards and policies for existing buildings to determine an appropriate course of action with an understanding that the redesigned campus development standards and policies for new construction will automatically enhance many design features for renovation activities.

• Granting sustainability greater stature when considering the competing priorities of cost, quality and schedule.


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Each University of Colorado campus will revise its campus development standards and policies with the intent to achieve an equivalent of a LEEDTM certification level for new construction with the following considerations:

• Inherent opportunities and constraints of the site, space and orientations within existing campus built environments

• Special emphasis on unique Colorado geographical and environmental sensitivities.

• Building life-cycle analysis. Life-cycle costs will be considered when evaluating the potential benefits of environmentally responsible solutions. In addition to first costs associated with building design and construction, all costs, including lifetime operation, maintenance, and salary costs should be considered when making decisions.

• “Energy Star” appliances and equipment shall be chosen for building and labs when it does not result in a significant increase in costs.

For the purpose of consistency, each campus shall incorporate the following LEEDTM prerequisites in their respective new campus development standards and policies:

• Erosion & Sedimentation Control • Fundamental Building Systems Commissioning • Minimum Energy Performance • Chlorofluorocarbon (CFC) Reduction in HVAC&R Equipment • Storage & Collection of Recyclables • Minimum Indoor Air Quality Performance • Environmental Tobacco Smoke (ETS) Control

Campuses shall have the flexibility to selectively choose how to revise the balance of their campus development standards and policies. Campuses may choose from a variety of sustainable development criteria pertaining to site, energy, water, materials and indoor air quality to meet the requirement for the campus development standards and policies to achieve an equivalent of a LEEDTM certification level. Each campus shall engage a LEEDTM accredited professional to validate that its revised campus development standards and policies support the ability to meet or exceed the equivalent of a LEEDTM certification level. Each campus will identify LEEDTM accredited professionals responsible for monitoring and documenting the equivalent LEEDTM rating for new construction, major renovations, and existing building upgrades, operations and maintenance.


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Prepared by: Paul Tabolt and Moe Trabizi, John Allison, Kathy McNally, Noel Copeland, Mike Barden and Jim Nelson – Brian Burnett and Dave Schnabel


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Program Plan for the Pharmaceutical Research Center

Documents

Transcript of Program Plan for the Pharmaceutical Research Center