Program Goals
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Transcript of Program Goals
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Program Goals
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Introduction
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Program Outline
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Patient-reported End-of-life Cancer Symptoms
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Loss of Appetite Affects Survival
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Effect of Weight Loss on Survival
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Body Composition Changes in Cancer
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Consequences of Cachexia
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Definition and Classification of Cancer Cachexia
An International Consensus
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Ubiquitin-Proteasome System
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Cachexia is Not Starvation
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Program Outline
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Parenteral Nutrition
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Meta-analysisTPN for Cancer Patients Receiving Chemotherapy
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Effect on SurvivalOral Feeding for Malnourished Cancer Patients
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Approach to the Patient With Cachexia
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Megestrol Acetate Dosing
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Megestrol Acetate vs Placebo Effect on Appetite
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Megestrol AcetateLimitations
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Despite Improvements in Appetite, Quality of Life Is Not Always
Improved
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Program Outline
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New Avenues of Investigation for Treatment of Cancer-related
Cachexia
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Antimyostatin Agents
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Antimyostatin Therapy Improvements in Body Weight and Survival
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Example of Natural Myostatin Deficiency
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Example of Natural Myostatin Deficiency (cont)
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JAK Inhibition Associated With Weight Gain in Myelofibrosis
Patients
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Ruxolitinib for Treatment of Metastatic Pancreatic Cancer
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Ghrelin Analogues Anamorelin for Treatment of Cancer Cachexia
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Treatment With Anamorelin Improves Patient-reported
Symptoms
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Summary
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Abbreviations
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References
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References (cont)
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References (cont)
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References (cont)
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References (cont)