Profile research DescriPtion - SERBserb.gov.in/pdfs/ramanujan2014/Rajeev-S-Menon.pdfMenon, R. S.:...

RAMANUJAN FELLOWS 140 Edited by G. Molander & P. Knochel, Elsevier (Amsterdam), (in press). 3. “Reactions Involving a Carbonyl Compound as Electrophilic Component with an Isonitrile as One Component: Modifications of the Ugi Reaction” Menon, R. S.: Nair, V., in Science of Synthesis Reference Library, Editor, T. J. J. Muller, Thieme Chemistry (Stuttgart) (In press). Rajeev S. Menon Ramanujan Fellow, Chemistry CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, Andhra Pradesh, India [email protected] PROFILE Rajeev Menon obtained his M.Sc. in Chemistry (2000) from the University of Calicut. He was awarded Ph.D. in organic chemistry in 2005 by the University of Kerala for the work carried out under the supervision of Dr. Vijay Nair, CSIR-NIIST, Trivandrum in the area of isocyanide based mulcomponent reacons. He was an Alexander von Humboldt post-doctoral fellow in the research group of Professor Henning Hopf, Technical University, Braunschweig, Germany during 2006-2007. In 2008, he was awarded an Australian Research Council Discovery Grant and post-doctoral fellowship to work in the research group of Professor Marn Banwell, Australian Naonal University, Canberra. In 2011, he joined the Medicinal Chemistry and Pharmacology Division of CSIR-Indian Instute of Chemical Technology, Hyderabad as a Ramanujan Fellow. RESEARCH DESCRIPTION Our research group at the CSIR-IICT is focused on the synthesis of natural products and natural product like molecules (NPLM) for exploring biologically relevant chemical space. Such synthetic efforts are undertaken as the first stage in the design and development of pharmaceutical agents with improved activity and fewer side effects. Practical synthetic approaches that are tailored specifically to deliver a number of analogues of anticancer natural products are being undertaken for understanding the structure activity relationship (SAR) and deciphering the minimum structural requirements for the anticancer activity. The natural products and analogues that are under investigation include rhazinilam, colchicines, noscapin and the vinca alkaloids that display antitumor activity by binding to the cellular protein tubulin. Investigations directed at developing the appropriate synthetic methodology are also carried out whenever required for the construction of the synthetic targets. In this context, emphasis is on the development of novel catalytic, stereoselective and green processes that are scalable for the production of large quantities of the synthetic targets. COMPLETE LIST OF PUBLICATIONS AS A RAMANUJAN FELLOW 1. “1,2-Benzoquinones in Diels-Alder reactions, dipolar cycloadditions, nucleophilic additions, multicomponent reactions and more” Nair, V.; Menon, R. S.; Biju, A. T.; Abhilash, K. G. 2012, Chemical Society Reviews ,volume 41, page 1050 (DOI: 10.1039/C1CS15186J). 2. “Intramolecular 1,3-dipolar cycloadditions of alkenes, alkynes and allenes” Menon, R. S.: Nair, V in Comprehensive Organic Synthesis, 2nd edition,

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Transcript of Profile research DescriPtion - SERBserb.gov.in/pdfs/ramanujan2014/Rajeev-S-Menon.pdfMenon, R. S.:...

RAMANUJAN FELLOWS140

Edited by G. Molander & P. Knochel, Elsevier (Amsterdam), (in press).

3. “Reactions Involving a Carbonyl Compound as Electrophilic Component with an Isonitrile as One Component: Modifications of the Ugi Reaction” Menon, R. S.: Nair, V., in Science of Synthesis Reference Library, Editor, T. J. J. Muller, Thieme Chemistry (Stuttgart) (In press).

Rajeev S. MenonRamanujan Fellow, Chemistry CSIR-Indian Institute of Chemical Technology, Hyderabad 500 007, Andhra Pradesh, [email protected]

ProfileRajeev Menon obtained his M.Sc. in Chemistry (2000) from the University of Calicut. He was awarded Ph.D. in organic chemistry in 2005 by the University of Kerala for the work carried out under the supervision of Dr. Vijay Nair, CSIR-NIIST, Trivandrum in the area of isocyanide based multicomponent reactions. He was an Alexander von Humboldt post-doctoral fellow in the research group of Professor Henning Hopf, Technical University, Braunschweig, Germany during 2006-2007. In 2008, he was awarded an Australian Research Council Discovery Grant and post-doctoral fellowship to work in the research group of Professor Martin Banwell, Australian National University, Canberra. In 2011, he joined the Medicinal Chemistry and Pharmacology Division of CSIR-Indian Institute of Chemical Technology, Hyderabad as a Ramanujan Fellow.

research DescriPtion Our research group at the CSIR-IICT is focused on the synthesis of natural products and natural product like molecules (NPLM) for exploring biologically relevant chemical space. Such synthetic efforts are undertaken as the first stage in the design and development of pharmaceutical agents with improved activity and fewer side effects. Practical synthetic approaches that are tailored specifically to deliver a number of analogues of anticancer natural products are being undertaken for understanding the structure activity relationship (SAR) and deciphering the minimum structural requirements for the anticancer activity. The natural products and analogues that are under investigation include rhazinilam, colchicines, noscapin and the vinca alkaloids that display antitumor activity by binding to the cellular protein tubulin. Investigations directed at developing the appropriate synthetic methodology are also carried out whenever required for the construction of the synthetic targets. In this context, emphasis is on the development of novel catalytic, stereoselective and green processes that are scalable for the production of large quantities of the synthetic targets.

comPlete list of Publications as a ramanujan fellow 1. “1,2-Benzoquinones in Diels-Alder reactions,

dipolar cycloadditions, nucleophilic additions, multicomponent reactions and more” Nair, V.; Menon, R. S.; Biju, A. T.; Abhilash, K. G. 2012, Chemical Society Reviews ,volume 41, page 1050 (DOI: 10.1039/C1CS15186J).

2. “Intramolecular 1,3-dipolar cycloadditions of alkenes, alkynes and allenes” Menon, R. S.: Nair, V in Comprehensive Organic Synthesis, 2nd edition,

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Profile research DescriPtion - SERBserb.gov.in/pdfs/ramanujan2014/Rajeev-S-Menon.pdfMenon, R. S.:...

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Transcript of Profile research DescriPtion - SERBserb.gov.in/pdfs/ramanujan2014/Rajeev-S-Menon.pdfMenon, R. S.:...