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Lonza’s chemical networkDiketene and HCN derivatives, heterocycles and basic chemicals catalog

Diketene and HCN derivatives, heterocycles and basic chemicals catalog

Content

About Lonza 3

Introduction 4

Diketene / ketene derivatives 6

Esters 6Arylides 7Alkylamides 8Pyrazolones 9Dehydroacetic acid 9Lonzamon monomers 10Other diketene derivatives 10

HCN derivatives 12

Heterocycles 14

Basic chemicals 16

Others 17

Alphabetical index 18

3

About LonzaLonza is the global leader in the production and support of active phar-maceutical ingredients both chemically and biotechnologically. Biophar-maceuticals are one of the key growth drivers of the pharmaceutical andbiotechnology industries.

Lonza has strong capabilities in large and small molecules, peptides, amino acids and niche bioproducts which play an important role in the development of novel medicines and healthcare products. In addition, Lonza is a leader in cell-based research, endotoxin detection and cell therapy manufacturing. Furthermore, the company is a leading provider of chemical and biotech ingredients to the nutrition, hygiene, preserva-tion, agro and personal care markets.

From 1897 to the present day combining Swiss tradition with global experience, the company has had an enterprising character, adapting its offerings and services to the needs of customers and to changing technologies. Throughout our history, we have maintained a strong culture of performance, results and dependability that is valued by all of our customers.

Lonza’s cracker in Visp is the back bone of a comprehensive fully back-ward integrated chemical network. Our product portfolio consists of HCN- and diketene derivatives as well as basic chemicals which are key raw materials and intermediates for many sophisticated applications.

4


Diketenes / ketenesDiketene is a colorless liquid produced by dimerization of ketene. It is a highly reactive building block which can be combined with numerous other chemical compounds to make a wide range of products. Because of its high energy content, transport of diketene is forbidden. It is pro-cessed further at the site of manufacture. Lonza is one of the world’s leading suppliers of diketene derivatives manufactured in its production facility in Visp, Switzerland. Our diketene derivatives are used in the pharmaceutical, vitamin, agrochemical and pigment industries. The niche markets are in cosmetics, plasticizers, paints. The acetoacyl group in diketene derivatives has a broad functionality which can be used for the production of further products. Lonza’s most comprehensive diketene product lines are those made with alcohols (aceto-acetic acid and acrylate derivatives), aliphatic amines (alkylamides) and aromatic amines (arylamides). Lonza uses some of these to produce further components (pyrazolones, aminocrotonates, side chains).

The following summary provides an overview of the diketene derivative product groups:

Diketene esters (acetoacetates): “Major” products such as methyl, ethyl, isopropylester of acetoacetic acid are produced in a continuous process and purified by distillation. “Minor” derivatives are produced batchwise in stirred vessel reactors. The products are used mostly in the dye, agrochemical, pharmaceutical and vitamin industries.

Arylamides: A large variety of arylamides are obtained by the reaction of aromatic amines with diketene. Our most important products are AAA, AAOT, AAMX, AAOA, and AAOC; others are made regularly or on special request. These derivatives are used mainly in the production of azo pigments; but also in the dye and agrochemical industries.

Alkylamides: Aliphatic amines react with diketene to result in alkyl-amides. Major products such as monomethyl- or dimethylacetoacet-amides are manufactured as aqueous solutions with continuous pro-cesses; other derivatives and water-free compounds are produced with batch processes. The (alkyl-) acetoacetamides are used principally in the manufacture of insecticides. The derivatives are also deployed in the pigment, pharmaceutical and polymer industries.

DHS / NaDHS: The catalytic dimerization of diketene yields dehydroacetic acid (DHS), which is a solid material. The free acid can be neutralized with sodium hydroxide and is available as the salt NaDHS or its monohy-drate NaDHS-H2O. These products are used above all in the manufacture of PVC stabilizers and as preservatives in the cosmetic industries.

Acrylic acid esters (acetoacetoxy monomers): Acetoacetoxyethyl meth-acrylate (AAEMA), the most important product of this group, is made in a multipurpose batch production plant. It is used as a copolymer for coatings and adhesives in emulsion polymerization (waterborne disper-sions) or solvent polymerization (high solids), and provides improved mechanical and solvent resistance to water or organic solvents. It also promotes adhesion to metallic, mineral and wood surfaces.

Other diketene derivatives: 4-Chloroacetoacetic acid ester is a highly versatile diketene derivative. It can be used in syntheses of various pharmaceutical intermediates.

Ketene: Lonza has the specific capability to perform a variety of reac-tions with ketene. The production of ethyl 4, 4, 4-trifluoroacetoacetate is one example for such a ketene reaction.

For more information about ketene / diketene chemistry and its various derivatives, please ask for specific brochures and related literature or send mail to [email protected].

5

Hydrocyanic acid (HCN)Hydrogen cyanide is a extremely poisonous colorless or pale-blue liquid that undergoes a wide variety of reactions. Lonza has manufacturing capabilities to offer a solution of hydrogen cyanide in water (hydrocy-anic acid) and producing its derivatives. HCN is used in metallurgical and photographic processes. Furthermore, HCN is a starting material for cyanogen chloride, cyanoacetates, cyanohydrins, sodium cyanide, chelating agents and many more. Cyanogen chloride is a functional building block for other Lonza products like cyanuric chloride and malo-nonitrile. The cyanohydrins, give access to a variety of useful organic compounds including the monomer methyl methacrylate, amino acids via the Strecker synthesis, and the chelating agents EDTA and NTA.

Basic chemicalsBeside ketene and HCN chemicals Lonza’s cracker related product port-folio also offers a selective number of basic chemicals. The chemicals can be used as starting materials and processed further to yield coat-ings, colorants, adhesives, medicines, agrochemicals and more.

Icons

Pharma

Colorants

Agriculture

Polymers

Nutrition

Various

6


Molecular weight CAS RN Minimum assay Minimum stability Melting point ca. Boiling point ca. Density g/cm3 (20°C) EU labeling Packaging Transport information



Methyl acetoacetate (MAA)

C5H8O3

116.12 105-45-3 99.0 % 2 years –28°C 170°C 1.077 Xi irritant drums, bulk not restricted

130.14 141-97-9 99.0 % 2 years –43°C 180°C 1.03 – drums, bulk not restricted

Ethyl acetoacetate (EAA)

C5H10O3

144.17 542-08-5 98.5 % 2 years –27°C 185°C 0.998 Xi irritant drums, bulk not restricted

Isopropyl acetoacetate (IPAA)

C7H12O3

Isobutyl acetoacetate (AAisobutyl)

C8H14O3

158.20 7779-75-1 98.0 % 2 years –20.5°C 205°C 0.974 – drums not restricted

158.20 1694-31-1 98.0 % 2 years –38°C 71°C / 15hPa 0.970 – drums not restricted

t-Butyl acetoacetate (AA-t-butyl)

C8H14O3

Dodecyl acetoacetate (AAdodecyl)

C16H30O3

270.42 52406-22-1 96.0 % 2–3 years – 190°C /20 hPa 0.914 Xi irritant drums not restricted

N-Benzyl-N-methyl-2-aminoethyl-acetoacetate (AABME)

C14H19NO3

249.31 54527-65-0 95.0 % 8 months – 175°C dec. 1.067 – drums not restricted

Benzyl acetoacetate (BAA)

C11H12O3

192.22 5396-89-4 – 2 years 12°C 275°C dec. 1.114 Xi irritant drums not restricted

EstersDiketene / ketenederivatives

7

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Nutrition

Various




192.22 94-02-0 91.0 % 2 years – 93°C / 10 Pa – – drums not restricted

Ethyl benzoylacetate-91 (BESethyl-91)

C11H12O3

4-Nitrobenzyl acetoacetate (30 % in toluene) (PNBAA 30T)

C11H11NO5

237.21 61312-84-3 270-330 g/l 9 months – – – F, Xn; R11-38-48/20-63-65-67 iron drums 56.25 kg, 187.5 kg UN 1993, 3, PG II

2-Methoxyethyl acetoacetate(AAmethoxyethyl)

C7H12O4

160.16 22502-03-0 97.5 % 2 years – 118°C / 26hPa 1.091 T toxic drums not restricted

Acetoacetanilide (AAA)

C10H11NO2

177.20 102-01-2 99.5 % 2 years 83.0°C – – Xn harmful paper bags, big bags not restricted

Acetoacetanilide, flakes (AAA,flakes)

C10H11NO2

177.20 102-01-2 95.0 % 9 months 62.0°C – – Xn harmful big bags not restricted

Acetoacet-o-toluidide (AAOT)

C11H13NO2


205.26 97-36-9 99.5 % 2 years 89°C – – Xn harmful paper bags, big bags not restricted

Acetoacet-m-xylidide (AAMX)

C12H15NO2

Arylides

8





Acetoacet-4-chloro-2,5-dimethoxy-anilide (ASIRG)

C12H14ClNO4

271.70 4433-79-8 98.0 % 2 years 104°C – – Xn harmful paper bags not restricted

241.68 52793-11-0 99.0 % 2 years 92°C – – – paper bags not restricted

Acetoacet-5-chloro-2-methoxy-anilide (AAMOC)

C11H12ClNO3

Potassium N-(acetoacetyl) sulfanilate (AAsulfanil-K)

C10H10KNO5S

295.36 70321-85-6 96.0 % 2 years >300°C – – – paper bags, big bags not restricted

Alkylamides

129.16 2044-64-6 80.0 % 6 months – 106°C 1.060 – drums, bulk not restricted

N,N-Dimethylacetoacetamide(DMAA-80)

C6H11NO2

N-Methylacetoacetamide (MMAA)

C5H9NO2


N,N-Diethylacetoacetamide (DEAA)

C8H15NO2


Acetoacet-o-anisidide (AAOA)

C11H13NO3


Acetoacet-o-chloroanilide (AAOC)

C10H10ClNO2

211.65 93-70-9 99.5 % 2 years 103.5°C – – Xn harmful paper bags not restricted

Diketene / ketenederivatives

9

Pharma

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Agriculture

Polymers

Nutrition

Various




Acetoacetamide (AAmid)

C4H7NO2

101.11 5977-14-0 98.5 % 18 months 52°C – – – paper bags not restricted

Dehydroacetic acid

190.134418-26-2

99.0 %2 years

–––

Xn harmfuldrums

not restricted

C8H7O4Na

Dehydroacetic acid, sodium salt

(NaDHS)

208.1564039-28-7

98.0 %2 years

109°C––

Xn harmfuldrums

not restricted

C8H9O5Na

Dehydroacetic acid, sodium salt monohydrate (NaDHS-H2O)

168.15520-45-6

99.0 %2 years

109°C––

Xn harmfulpaper bags

not restricted

Dehydroacetic acid (DHS)

C8H8O4

Pyrazolones

98.11108-26-9

99.0 %2 years

217°C–––

drums not restricted

3-Methyl-5-pyrazolone (MP)

C4H6N2O

96.1367-51-699.0 %

3 years107°C218°C

––

drumsnot restricted

3,5-Dimethylpyrazole (DMP)

C5H8N2

10





Other diketene / ketenederivatives

114.062892-51-5

98.5 %2 years

293°C –

1.82–

drumsnot restricted

Squaric acid (QS)

C4H2O4

170.175231-87-8

98.0 %12 months

4–8°C (solidification)95°C / 0.1 hPa

1.15T toxic; R21-25-36/37/38-42-43

iron drumsUN 2810, 6.1, PG III

Diethyl squarate (QS, diethyl)

C8H10O4

380.4591-96-3

98.0 %2 years

206°C–––

bag-in-box, drumsnot restricted

Diacetoacet-o-tolidide (DiAA-o-tolidid)

C22H24N2O4

276.2924731-73-5

98.5 %2 years

171°C–––

paper bagsnot restricted

Diacetoacet-1,4-phenylenediamide (DiAAphen)

C14H16N2O4

304.3824304-50-5

98.0 %2 years

232°C–––


Diacetoacet-2,5-dimethyl-1,4-phenylenediamide (DiAA DM)

C16H20N2O4

Lonzamon monomers

214.2121282-97-3

95.0 %1 year–60°C

100°C / 1hPa1.122

Xi irritantdrums

not restricted

C10H14O5

2-(Acetoacetoxy) ethylmetha crylate (AAEMA)

386.422208-25-9

92.0 %2 years

–30°C300°C

––

drumsnot restricted

C18H26O9

Propane-1.1.1-triyltrimethyl tris (acetoacetate) (AATMP)


11




Pharma

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Agriculture

Polymers

Nutrition

Various

164.59638-07-3

97.0 %1 year–8.5°C220°C1.212

T toxic, N environmentdrums

UN-No.: 2922, 8, PG II

Ethyl 4-chloroacetoacetate (CAAEt)

C6H9ClO3

324.7741131-65-1

97.0 %5 years

192°C–––


Diacetoacet-2-chloro-5-methyl-1,4-phenylenediamide (DiAA MC)

C15H17ClN2O4

345.1842487-09-2

97.0 %5 years

197°C–––


Diacetoacet-2,5-dichloro-1,4- pheny lene diamide (DiAA DC)

C14H14Cl2N2O4

115.1314205-39-1

98.0 %–

81°C112°C / 55hPa

–Xi irritant

drumsnot restricted

Methyl 3-aminocrotonate (ACMe)

C5H9NO2

256.3014205-47-1

96.0 %2 years

146°C–––

bag-in-boxnot restricted

1,4-Butyleneglycolbis (3-amino crotonate) (BGAC)

C12H20N2O4

142.165394-63-8

93.0 %3 months

12°C66°C / 3mbar

1.094F flammable

drumsUN-No.: 1993, 3, PG II

Diketene-acetone adduct (DAA)

C7H10O3

288.3713560-49-1

96.0 %2 years

88°C––

N environmentfibre container

UN-No.: 3077, 9, PG III

Thiodiglycolbis(3-aminocrotonate) (TGAC)

C12H20N2O4S

2,5-Dimethyl-2,4-dihydro-pyrazol-3-on (DMPO)

C5H8N2O

112.13 2749-59-9 >98.0 % – 117–118°C 105–115°C / 8 hPa 1.14 Xi irritant – not restricted

12

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Various





HCNderivatives

184.41 108-77-0 99.5 % 6 months 145.0–147.0°C 193°C / 1013 hPa – – bags in box not restricted

Cyanuric chloride A (CC A)

C3Cl3N3

184.41 108-77-0 99.5 % 6 months 145.0–147.0°C 193°C / 1013 hPa – – big bags not restricted

Cyanuric chloride AS (CC AS)

C3Cl3N3

Adenine

C5H5N5

135.13 73-24-5 98.0–102.0 % 2 years 360°C – – – drums not restricted

144.1742558-54-3

98.0 %12 months

–75°C192°C

1.01 –

drum or iso-containernot restricted

Methyl 4-methyl-3-oxopentanoate (OPMe, 4-methyl)

C7H12O3

116.12 34846-90-7, 5788-17-0 (linear structure) ≥98.0 % 2 years 2–3°C 95°C / 100 hPa 1.07 – – not restricted

(E)-Methyl 3-methoxyacrylate(E-MMA)

C5H8O3

Methyl 3,3-dimethoxypropanoate(PRSMe,DM)

C6H12O4

148.16 7424-91-1 98.0 % 12 months <–65°C 77°C / 26 mbar 1.06 – – not restricted

184.12372-31-6

98.0 %6 months

–39°C131°C

1.2586Xn harmful

drumsnot restricted

Ethyl 4,4,4-trifluoroacetoacetate(ETFAA)

C6H7F3O3


13




2-Methoxyethyl cyanoacetate (CNES methoxyet)

C6H9NO3

143.14 10258-54-5

≥99.0 % 2 years – 257°C / 1000 hPa – – iron drums 200 kg, container not restricted

Butyl cyanoacetate (CNESbutyl)

C7H11NO2

141.17 5459-58-5 99.0 % 2 years – 109.0°C / 13.0 hPa 0.998–1.002 – drums 200 kg not restricted

Allyl cyanoacetate (CNESallyl)

C6H7NO2

125.13 13361-32-5 99.0 % 2 years –40°C 89–90°C / 5 hPa – T toxic; R25 drums 200 kg UN 3276, 6.1, PG III

Chlorosulfonyl isocyanate (CSI)

CClNO3S

141.53 1189-71-5 99.0–100.3 % 12 months – 1060°C 1.626 C corrosive; R14-20/21/22-34 drums UN 3264, 8, PG I

98.11 109-77-3 83.5–86.5 % 2.5 months

19.5°C – 1.011 (35°C) T,N; R10-23/24/25-39/23/24/25-50/53 drums, rail tank wagon UN 2929, 6.1 (3), PG ll

Malononitrile (85 % in methanol) (MDN)

C3H2N2 ; CH4O

66.06 109-77-3 99.0 % 18 months – 218–219°C 1.0494 (35°C) T toxic, N environment; R23/24/25-50/53 drums UN 2647, 6.1, PG ll

Malononitrile (MDN)

C3H2N2

3-Aminocrotononitrile (Diacetonitril)

C4H6N2

82.11 1118-61-2 96.0 % 8 months 40–67°C – 0.9520 (77°C) – drums not restricted

1,1,3,3-Tetramethylguanidine (TMG)

C5H13N3

115.18 80-70-6 99.0 % 1 year – 162°C / 1013 hPa 0.92 – drums, bulk not restricted

Sodium dicyanamide (Na-dicyanamide)

C2N3Na

89.03 1934-75-4 ≥97.0 % 2 years >260°C – – – drums, BB packaging on request not restricted

14





155.16 36315-01-2 98.0–101.0 % 2 years 96–98°C – – – drums not restricted

2-Amino-4,6-dimethoxypyrimidine(ADMP)

C6H9N3O2

Heterocycles

174.59 13223-25-1 98.0–100.3 % 2 years 102–104°C – – – drums not restricted

2-Chloro-4,6-dimethoxypyrimidine

(DMP, 2-Chlor)

C6H7ClN2O2

2-(5-Ethyl-2-pyridyl)ethanol (PRD-2-etol, 5-Et)

C9H13NO

151.21 5223-06-3

95.0 % 2 years 45°C 147–149°C 1.042 – iron drum 200 kg not restricted

6-Hydroxynicotinic acid (NS,6-Hydroxy)

C6H5NO3

139.11 5006-66-6

97.5–100.3 % 2–3 years 314 –316°C – – – drums not restricted

5-Ethyl-2-methylpyridine (MEP)

C8H11N

121.18 104-90-5 – 1 year –70.9°C 178.3°C 0.918–0.921

– iron drum 180 kg not restricted

Sodium nicotinate (NS-Na)

C6H4NNaO2

145.09 54-86-4 99.0–100.3 % 3 years 410°C – – – drums not restricted

Akolidine 10 (Pyridine, alkyl derivatives)

– 68391-11-7 – – –

– 0.978–0.990 – iron drum, bulk not restricted


– 68391-11-7 – – – – 1.018–1.034 – iron drum, bulk not restricted


– 68391-11-7 – – – – 1.024–1.038 – iron drum, bulk not restricted

All akolidines contain the following components:

15

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Agriculture

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Nutrition

Various




Niacin min. 99.5 % (NS fg)

C6H5NO2

123.11 59-67-6 99.5–100.3 % 3 years 234.0–237.0°C – – – paper bags, big bags not restricted

Meta™ metaldehyde (META tc)

C8H16O4

176.21 108-62-3

98.0–99.8 % 3 years (10°C) 246°C – – – bag-in-box 25 kg not restricted

Niacinamide USP (NSA USP)

C6H6N2O

122.13 98-92-0

99.0–101.0 % 3 years 128.0–131.0°C – – – bag-in-box 20 kg not restricted

2-Picoline (Picoline,2)

C6H7N

93.13 109-06-8 99.0 % 2 years –66.8°C 125–130°C – – iron drum 180 kg, bulk not restricted

Paraldehyde (PARA)

C6H12O3

132.16 123-63-7

99.5 % 60 days – – 0.993–0.997 kg/l (20°C) – iron drum 200 kg, bulk not restricted

93.13 108-89-4 >98.0 % – 3.6°C 145.4°C 0.954 T toxic; R10, R20/22, R24, R36/37/38 – not restricted

4-Picoline (Picoline,4)

C5H7N

Pyrimidine (<0.5 % water)(Pyrimidine W<0.5)

C4H4N2

80.09 289-95-2 98.5–100.0 % 2 years 20–22°C 122–24°C 1.016 – drums not restricted

4,6-Dimethoxy-2-[(phenoxy- carbonyl)amino]pyrimidine(ADMP-carbamat)

C13H13N3O4

275.26 89392-03-0 97.0–101.0 % 2 years 120–122°C > 250°C – – drums not restricted

16





Nitrosylsulfuric acid 40 % (SS,Nitrosyl 40)

HNO5S

127.08 7782-78-7 39.5–40.5 % 2 years –12 – –3°C 333°C 1.893 – rail tanker not restricted

Acetic anhydride (ESanhydrid)

C4H6O3

102.09 108-24-7 99.5 % 2 years –73°C – 1.0820 – drums 200 kg, rail tanker not restricted

Nitric acid 65 %

HNO3

63.01 7697-37-2 65.0–65.5 % – –33°C 121°C / 1013 hPa – – rail tanker not restricted

Ammonia aqueous (Ammonia 24)

approx. 24.5–24.9 % chemically pure

NH3

17.03 1336-21-6 24.5–24.9 % 2 years – – 0.9150–0.9110 g/ml (15°C) – drums, road and rail tanker not restricted

44.05 75-07-0 99.5 % 1 year –123.5°C 21°C 0.784–0.786 kg/l (15°C) – drums, bulk not restricted

Acetaldehyde (AcAl)

C2H4O

Acetic acid (glacial) (ES 99)

C2H4O2

60.05 64-19-7 99.5–100.0 % 2 years 15.8–16.3°C 113–115°C / 933 hPa 1.050 g/ml (20°C) – drum 200 kg, bulk not restricted

Ammonia techn. (Ammonia tc)

NH3

17.03 7664-41-7 99.8 % 2 years – 33.4°C / 1013 hPa 0.609 – rail tanker not restricted

Malonic acid (MA)

C3H4O4

104.06 141-82-2 99 % 1 year 134°C (Mettler) – – Xi irritant; R36 bags not restricted

Basicchemicals

17

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Agriculture

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Nutrition

Various



Others4,4-Dimethoxy-butan-2-one (DMB)

C6H12O3

132.16 5436-21-5 >92.0 % 2 years –83 – –81°C 169–71°C 0.9977 – drums, bulk not restricted

2,6-Diisopropylaniline (DIPA)

C12H19N

177.29 24544-04-5 92.0 % 1 year

–45°C 257°C / 1013 mbar 0.940 R52/53 iron drum 180 kg, bulk not restricted

2,6-Diethyl-4-methylaniline (DEMA)

C11H17N

163.26 24544-08-9 >98.0 % 1 year

–12°C – –7°C – 0.945 Xn harmful; R21/22 steel drums, bulk not restricted

Valeronitrile (VN)

C5H9N

83.13 110-59-8 99.5 % 2 years – 139–141°C / 1013 hPa 0.7990 – drums, bulk not restricted

18


Alphabetical index

Page Product Abbreviation

A

16 Acetaldehyde AcAl 16 Acetic acid (glacial) ES 99 16 Acetic anhydride ESanhydrid 9 Acetoacetamide AAamid 7 Acetoacetanilide AAA 8 Acetoacet-4-chloro-2,5-dimethoxyanilide ASIRG 8 Acetoacet-5-chloro-2-methoxyanilide AAMOC 7 Acetoacet-m-xylidide AAMX 8 Acetoacet-o-anisidide AAOA 8 Acetoacet-o-chloroanilide AAOC 7 Acetoacet-o-toluidide AAOT 10 2-(Acetoacetoxy)ethyl methacrylate AAEMA 12 Adenine Adenine 14 Akolidine 10 Akolidine 10 14 Akolidine 11 Akolidine 11 14 Akolidine 12 Akolidine 12 13 Allyl cyanoacetate CNESallyl 14 2-Amino-4,6-dimethoxypyrimidine ADMP 13 3-Aminocrotononitrile Diacetonitril 16 Ammonia aqueous approx. 24.5–24.9 % chemically pure Ammonia 24 10 Ammonia techn. Ammonia tc

B 6 Benzyl acetoacetate BAA 6 N-Benzyl-N-methyl-2-aminoethylacetoacetate AABME 13 Butyl cyanoacetate CNESbutyl 6 t-Butyl cyanoacetate AA-t-butyl 11 1,4-Butyleneglycolbis(3-aminocrotonate) BGAC

C 14 2-Chloro-4,6-dimethoxypyrimidine DMP, 2-Chlor 13 Chlorosulfonyl isocyanate CSI 12 Cyanuric chloride A CC A 12 Cyanuric chloride AS CC AS


D

9 Dehydroacetic acid DHS 9 Dehydroacetic acid sodium salt monohydrate NaDHS-H2O 9 Dehydroacetic acid sodium salt NaDHS 11 Diacetoacet-2-chloro-5-methyl-1,4-phenylenediamide DiAA MC 11 Diacetoacet-2,5-dichloro-1,4-phenylenediamide DiAA DC 10 Diacetoacet-2,5-dimethyl-1,4-phenylenediamide DiAA DM 10 Diacetoacet-1,4-phenylenediamide DiAAphen 10 Diacetoacet-o-tolidide DiAA-o-tolidid 8 N,N-Diethylacetoacetamide DEAA 10 Diethyl squarate QS, diethyl 16 2,6-Diethyl-4-methylaniline DEMA 11 Diketene-acetone adduct DAA 16 2,6-Diisopropylaniline DIPA 16 4,4-Dimethoxy-butan-2-one DMB 15 4,6-Dimethoxy-2-[(phenoxy-carbonyl)amino]pyrimidine (ADMP-carbamat) 8 N,N-Dimethylacetoacetamide DMAA 11 2,5-Dimethyl-2,4-dihydro-pyrazol-3-on DMPO 9 3,5-Dimethylpyrazole DMP 6 Dodecyl acetoacetate AAdodecyl

E 6 Ethyl acetoacetate EAA 7 Ethyl benzoylacetate BESethyl 11 Ethyl 4-chloroacetoacetate CAAEt 14 5-Ethyl-2-methylpyridine MEP 14 2-(5-Ethyl-2-pyridyl)ethanol PRD-2-etol, 5-Et 12 Ethyl 4,4,4-trifluoroacetoacetate ETFAA

H 14 6-Hydroxynicotinic acid NS,6-Hydroxy

I 6 Isobutyl acetoacetate AAisobutyl 6 Isopropyl acetoacetate IPAA

M 16 Malonic acid MA 13 Malononitrile (85 % in methanol) MDN 13 Malononitrile MDN 15 Meta™ metaldehyde META tc 7 2-Methoxyethyl acetoacetate AAmethoxyethyl 13 2-Methoxyethyl cyanoacetate CNES methoxyet 9 3-Methyl-5-pyrazolone MP 12 Methyl 3,3-dimethoxypropanoate PRSMe,DM 11 Methyl 3-aminocrotonate ACMe 12 (E)-Methyl 3-methoxyacrylate E-MMA 12 Methyl 4-methyl-3-oxopentanoate OPMe, 4-methyl 8 N-Methylacetoacetamide MMAA 6 Methyl acetoacetate MAA


N

15 Niacin min. 99.5 % NS fg 15 Niacinamide USP NSA USP 16 Nitric acid 65 % 7 4-Nitrobenzyl acetoacetate (30 % in toluene) PNBAA 30T 16 Nitrosylsulfuric acid 40 % SS,Nitrosyl 40

P 15 Paraldehyde PARA 15 2-Picoline Picoine,2 15 4-Picoline Picoline,4 8 Potassium N-(acetoacetyl)sulfanilate AAsulfanil-K 10 Propane-1,1,1-triyltrimethyl tris(acetoacetate) AATMP 15 Pyrimidine (<0.5 % water) Pyrimidine W<0.5

S 13 Sodium dicyanamide Na-dicyanamide 14 Sodium nicotinate NS-Na 10 Squaric acid QS

T 13 1,1,3,3-Tetramethylguanidine TMG 11 Thiodiglycolbis(3-aminocrotonate) TGAC

V 16 Valeronitrile VN

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The information contained herein is believed to be correct and corresponds to the latest state of scientific and technical knowledge. However, no warranty is made, either expressed or implied, regarding its accuracy or the results to be obtained from the use of such information. Some products may not be available in all markets or for every type of application. Any user must make his own determination and satisfy himself that the products supplied by Lonza Group Ltd and the informa-tion and recommendations given by Lonza Group Ltd are (i) suitable for intended process or purpose, (ii) in compliance with environmental, health and safety regulations, and (iii) will not infringe any third party’s intellectual property rights.

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