Process design.cancer treatment using nanoparticles. ppt
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Transcript of Process design.cancer treatment using nanoparticles. ppt
PROCESS DESIGN:
USING NANOPARTICLES IN CANCER TREATMENT
HA NOI UNIVERSITY OF SCIENCE AND TECHNOLOGY**** AdVANCEd training PROGRAM ****
Name : Hoàng Văn Ti n ếClass : MSE-K54ID Student : 20092697
CONTENT
• Problem
• Properties and characteristic of nanoparticles
• Use of nanoparticles in cancer treatment
• Applications and promises
• Summary
HOW MANY PEOPLE DIE FROM CANCER IN THE WORLD EACH YEAR ?
• Approximately 7.6 million people die from cancer each year (according to an article titled "ACS Report Focuses on Global Cancer Toll" which was published by the American Cancer Society-2012)
• Viet Nam: -240.000 – 250.000 people are being cancer-150.000 new each year-75.000 dead (2010 )
•
PROBLEM
Estimated cancer prevalence in the United States as of January 1, 2009
Males Females
All invasive cancer sites 12,549,000 5,809,000 6,740,000
Brain and other nervous system 135,000 71,000 65,000
Breast 2,762,000 14,000 2,747,000
Cervix 248,000 0 248,000
Colon & rectum 1,140,000 559,000 581,000
Endometrial cancer and Uterine sarcoma 590,000 0 590,000
What Is NanoBiotechnology?
NanodevicesNanoporesDendrimersNanotubesQuantum dotsNanoshells
Tennis ballA periodWhite blood cell
Water molecule
Nanoparticles Are Small Enough to Enter Cells
Cell
White blood cell
Water molecule
Nanodevices
Nanoparticles
-Most animal cells are 10,000 to 20,000 nanometers in diameter. nanoscale devices (less than 100 nanometers) can enter cells and the organelles inside them to interact with DNA and proteins. Tools developed through nanotechnology may be able to detect disease in a very small amount of cells or tissue. They may also be able to enter and monitor cells within a living body.
Manufacturing Nanodevices
Scattered X-rays
Atoms in crystal
Detector
NanodevicesCrystal White blood cell
CrystalX-ray beam
Nanodevices Can Improve Cancer Detection and Diagnosis
ImagingNanoBiotechnology Physical Exam,Symptoms
Quantum DotsUltraviolet
light off
Whiteblood cell
Watermolecule
NanodevicesQuantum dots
Quantum dots emit light
Ultravioletlight on
Quantumdots
Quantum dotbead
Quantum Dots Can Find Cancer Signatures
Cancer cells
Healthy cells
Quantum dot beads
Quantum dot beads
Healthy cells
Cancer cells
Improving Cancer TreatmentNanotechnology TreatmentTraditional Treatment
Intact noncancerous cells
Noncancerous cells
Toxins Nanodevices
Cancercells
Dead noncancerous cells
Noncancerous cells
Drugs
Deadcancercells
Deadcancercells
ToxinsCancercells
Nanoshells
Nanoshell
Whiteblood cell
Watermolecule
Nanodevices Nanoshells
Gold
Near-infrared light onNear-infrared light off
Nanoshell absorbs heat
− Nanoshells have metallic outer layer and silica core− Selectively attracted to cancer shells either through a
phenomena called enhanced permeation retention or due to some molecules coated on the shells
− The nanoshells are heated with an external energy source killing the cancer cells
Thermal ablation of cancer cells
Nanoshells as Cancer TherapyNanoshells
Dead cancer cells
Nanoshells
Cancer cells
Healthy cells
Intact healthy cells
Near-infrared light
Healthy cells
Cancer cells
- quantum dots to antibodies that guided them to prostate tumor sites in living mice, where they clumped together and were visible using a simple mercury lamp.
APPLICATIONS AND PROMISES
• Cantilevers Can Make Cancer Tests Faster and More Efficient
• Kill the cancer cells without affect to other cells
• Can deliver more of the active ingredient and control more precisely how quickly it is released compared with current leading cancer drugs.
• Cancer treatment by grammar rays(US) : 15.000 – 25.000 USD ((300.000.000 – 500.000.000 vnd)
• Many new drug treatments cost nearly $100,000 a year
• $93,000 for vacxin which can adds four months' survival, on average, for men with incurable prostate tumors.
POTENTIALS
• More cheaper than the traditional methods ( drug ,vacxin , UV ….)
• Low effect to the body (compare with Chemotherapy, Radiation Therapy…)
• Cancer treatment (until now) : tumor's natural recruitment of monocytes, Liver Cancer Treatment, Lung Cancer Treatment, Vaginal Cancer Treatment , Leukemia Treatment Overview….
• Bright futures in uses
CHALENGES
• Nanostructures can be so small that the body may clear them too rapidly for them to be effective in detection or imaging.
• Larger nanoparticles may accumulate in vital organs, creating a toxicity problem.
• Difficult to approximate amount of nanopartiles
• Cytotoxic Effect
REFERENCES
• http://www.sciencedirect.com/science/article/pii/S1470204506707938
• http://triplehelixblog.com/2011/09/nanorobots-novel-technology-for-cancer-therapy/
• http://www.nanotec.or.th/en/?p=3667
• Applications of gold nanoparticles in cancer nanotechnology -Weibo Cai ,Ting Gao,Hao Hong, Jiangtao Sun
• http://cancer.gov/cancertopics/understand
• en.wikipedia.org/wiki/Alternative_cancer_treatmentsingcancer
• Anti-Cancer Drug Loaded Iron–Gold Core–Shell Nanoparticles (Fe@Au) for Magnetic Drug Targeting-Sibnath Kayal and Raju Vijayaraghavan Ramanujan School of Materials Science and Engineering, Nanyang ∗Technological University, 639798, Singapore
Thanks for your attention
QUESTIONS