PROCELL’s Transdermal Cosmeceuticals : pII SKIN™ Oct. 23. 2014.
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Transcript of PROCELL’s Transdermal Cosmeceuticals : pII SKIN™ Oct. 23. 2014.
PROCELL’s Transdermal Cosmeceuticals : pII SKIN™
Oct. 23. 2014
Brand Competitiveness of pII-SKIN™
Innovativeness of ProCell’s platform technology
Collaboration with out-standing Global partners
ProCell’s top notchtechnology
Self supply of cosme-ceutical active ingredients
Production of highly purified materials
Efficacy and safety validated
Product safety is verified by certified clinical test institution 3
2
4
1 Worldwide IP application
and registration
Publication in peer-reviewed top scientific journals
Global Partner : co-development of cosmeceutical active ingredients and PCT application
Collaboration with global cosmetic giants and partnership with domestic - based cosmetic companies
Efficient transdermal delivery of active ingre-dients
Maximizing efficacy through
skin cell activation
Diverse application of ac-tive
ingredients to cosmetics
Top quality and safety-guaranteed active ingredients
Uniqueness and high performance of cosmeceutical active ingredients
Development of unique and high-performance active ingredients
Fusion with innova-tive biotechnology
●
ProCell’s Platform Technology : MITT
Cargo (active ingredients)
▷ Antibodies
▷ Recombinant Proteins
▷ Peptides
▷ siRNA or DNA
▷ Low MW chemicals
▷ Nanoparticles
MTD
Macromolecule Transduction Domain
Basic Technology (MITT)
MITT
Macromolecule Intracellular Transduction Technology
Skin and Skin Cell Permeable MTD
Delivery of MTD-conjugated FITC into artificial skins
Delivery of MTD-conjugated FITC into skin cells
Keratinocyte Melanocyte Fibroblast Cells
3
Skin penetrating MTDs
Functional Pep-tides
siRNAs
Growth Factors
Anti-agingAnti-wrinkle
Whitening
Skin-liftingElasticity
Moisturization
Skin nourishment Natural Materials
Pure to Skin
Premium to Skin
Precious to Skin
pII-SKIN●
pII SKIN™ The novel platform for Cosmetics ●
Paraben free Mineral oil free
ProCell’s Platform Technology - MITT for Transdermal Delivery-
1st ac-tion
MTD efficiently delivers active ingredients into stratum corneum and dermis
2nd action MTD maximizes efficacy of active ingredients by intercellular or intracel-lular delivery
MTD enhances skin permeability of cosmeceutical ingredients
MTD-EGF Effect on Dermal Fibroblast Proliferation
0 0.01 0.1 1 1050.00
100.00
150.00
200.00
Procell MTD-EGFs (ng/mL)
Cell p
rolife
rati
on
(% o
f contr
ol)
0 0.01 0.1 1 1050.00
100.00
150.00
200.00
Procell MTD-EGFs (ng/mL)
Cell p
rolife
rati
on
(% o
f contr
ol)
Human Dermal Fibroblast (NHDF)
Mouse Fibroblast (NIH3T3)
NHDF (Human) NIH3T(Mouse)
control
0.1 ng/mL
1.0 ng/mL
Skin Permeability of MTD-EGF
GF MTD-GF10.00
0.05
0.10
0.15
0.20
0.25
0.30
0.35
6h 24h
pe
rme
ati
on
ra
te
(% o
f d
on
or
pro
tein
co
nc.)
0.3%
0.01%
Skin permeability of MTD-conjugated EGF is 30
times more
than that of EGF after 24 hour treatment on artifi-
cial skin.4
EGF MTD-EGF
MTD-FGF2 Effect on Dermal Fibroblast Proliferation
control
0.8 ng/mL
3.0 ng/mL
Human Dermal Fibroblast (NHDF)
0 0.1 1 10 10050.0
75.0
100.0
125.0
150.0
Procell MTD-FGF2 (ng/mL)
Ce
ll P
rolif
era
tio
n(%
of
co
ntr
ol)
Skin Permeability of MTD-FGF2
4
Skin permeability of MTD-conjugated FGF is 2
times more
than that of FGF after 24 hour treatment on ca-
daver skin.
GF2 MTD-GF20.00
0.10
0.20
0.30
0.40
0.50
0.60
0.1630.186
1h 24h
Pe
rme
ati
on
ra
te
(% o
d d
on
or
pro
tein
co
nc
.)
0.5%
0.25%
FGF2 MTD-FGF2
MTD-FGF2 Effect on Dermal Fibroblast Proliferation
control 1 ng/mL 3.0 ng/mL
Human Dermal Fibroblast (NHDF)
0 0.1 1 10 10050.0
75.0
100.0
125.0
150.0
Procell MTD-FGF2 (ng/mL)
Ce
ll P
rolif
era
tio
n(%
of
co
ntr
ol)
Cell proliferation was stimulated in human
dermal fibroblast after 72 hrs treatment of
MTD-FGFs.
Cell migration by MTD-FGF2
control 5 ng/mL
MTD-FGF2 treatment greatly enhanced the
migration of HUVEC cell compared to control.
control MTD-FGF250
75
100
125
150
Nu
mb
er
of
Mig
rati
ng
Ce
lls/F
ield
s(%
of
co
ntr
ol)
MTD-VEGF Effect on HUVEC Cell Proliferation and Migration
control 5 ng/mL 25 ng/mL
Increased cell proliferation of HUVEC cells was
observed after 72 hrs treatment of MTD-VEGF.
Cell migration by MTD-VEGFcontrol 25 ng/mL
MTD-VEGF treatment greatly enhanced the
migration of HUVEC cell compared to control.
HUVEC cell
control 3 ng 6 ng 12 ng 25 ng80
100
120
140
160
Pcocell MTD-VEGF (ng/mL)
Cell P
rolife
rati
on
(% o
f co
ntr
ol)
0 3 6 12 25
control MTD-VEGF50
75
100
125
150
175
Nu
mb
er o
f M
igra
tin
g
Cel
ls/F
ield
s(%
of
con
tro
l)
Skin Permeability & Collagen synthesis
Efficacy of acetylpentapeptide-MTD
Acetyl pentapeptide (AP)
IntoSkinCell-AP®0
5
10
15
20
0.5
14.2
Hu
man
Cad
aver
Ski
n F
lux
rat
e (%
)
MTD-AP
Cadaver skin permeability of acetylpentapeptide-MTD
In vitro collagen synthesis efficacy of acetylpentapeptide-MTD
control AP MTD-AP90.0
95.0
100.0
105.0
110.0
115.0
120.0
Collag
en
syn
thesis
(%
of
con
trol)
Conc. : 10 ppmCell-line : NHDF
pII SKIN™ Solutions
Products functions Characteristics
Regenerative Anti-wrinkle
CreamAnti-wrinkle
Advanced skin permeability of growth factors and peptides effective for skin elasticity : MEGF. MFGF, MVEGF, P2Skin-AP, P2Skin-AH
Exceptional efficacy of anti-wrinkle and skin elastic-ity, compared to any other brand’s products
Bright Whitening Serum
Whitening
New concept whitening ingredient by the collabora-tion with Institut Curie
IP co-application and registration in International Cosmetic Ingredient Dictionary(ICID)
New concept whitening serum strengthened with anti-wrinkle and skin elasticity
Multi-factors Double Action
High-perfor-mance
- skin regenera-tion - anti-aging - anti-wrinkle - whitening
Development of high-performance ampule contain-ing highly purified and concentrated ingredients
Outstanding efficacy of anti-wrinkle and elasticity via customized ampule application
Strengthened skin regeneration and elasticity with the simultaneous use of anti-wrinkle cream
5
Skin penetrating MTDs
Functional Peptides
Functional proteins Hormones
Growth Factors
Skin penetration Intracellular delivery
Anti-aging/wrinkle Hair regrowth
Anti-oxidation Slimming
Anti-wrinkle Whitening
Moisturization Skin nourishment
Natural Materials
The main ingredients of pII-SKIN™ so-lutions
●
ProCell patented MTDs M085, M1067, M2173A etc.
EGF, FGF-2, KFG, VEGF, IGF-1, SCF, PDGD etc.
SOD, Irisin, FGF21 etc.
Acetyl & Amidated Di, Tri, Penta-peptides
Plant extracts Natural origin proteins
PROCELL Anti-wrinkle Cream
Application
MainIngredients
Characteristics
Anti-wrinkle, skin cell regeneration, and anti-aging
• MTD-applied skin permeable human growth factors
- MTD-EGF, MTD-FGF, MTD-VEGF, and other growth factors
• MTD-applied skin permeable cell regenerative peptides
- MTD-conjugated peptides
• Nonapeptide-29 Pentapeptide-4 and Nonapeptide-29 Hexapeptide-8: ProCell’s patented peptides highly effective for collagen synthe-sis and skin lifting.
PROCELL Regenerative Anti-wrinkle Cream contains ProCell’s platform technology-applied human growth fac-tors such asEGF, FGF, and VEGF designed for efficient transdermal delivery and high-performance peptides for anti-wrin-kle, and efficient delivery of these active ingredients into skin fibroblast cells helps skin regeneration and lifting.
Anti-wrinkle cream developed using innovative human growth factors including EGF, FGF, VEGF effective for anti-wrinkle and cell regeneration
ProCell Regenerative Anti-wrinkle Cream
ProCell Regenerative Anti-wrinkle Cream
- Boosting the proliferation of dermal fibroblast cells – anti-wrinkle effect
- Enhanced skin elasticity through increasedcollagen synthesis- Reduction in transepidermal water loss(TEWL)
* Skin irritation and cytotoxicity test completed
• EGF(Epidermal Growth Factor): interacts with skin cell receptorsand boosts proliferation of dermal fibroblast cells, and has function of skin regeneration, anti-aging, and anti-wrinkle
• FGF(Fibroblast Growth Factors) and VEGF(Vascular Endothelial Growth Factor) induce proliferation and differentiation of dermal fibroblast cells, and endotherial cells in blood vessel.Both factors enhance the synthesis of collagen and elastin, fi-
nallyelevating skin elasticity.
6
PROCELL Skin Regenerative Ampule
Application
MainIngredients
Characteris-tics
• Anti-wrinkle, collagen synthesis, and improved skin
elasticity• Whitening and moisturization
• Ampule
- Concentration of growth factors, based on their optimized
combination ratio, and exceptional skin elasticity and
regeneration
- Anti-wrinkle and lifting effects on sagging skins
- Whitening via anti-oxidants and whitening ingredients
• Regenerative Anti-wrinkle Cream
- Improved skin elasticity and regeneration, after application
of Ampule on deeply lined and sagging skins
- Skin protection by reduction of Transepidermal Water Loss
- Improved skin elasticity through collagen synthesis
• MTD-applied skin permeable human growth factors
- MTD-EGF, MTD-FGF2, MTD-VEGF
• MTD-applied skin permeable cell regenerative peptides
- MTD-Acetylpentapeptide, MTD-Acetylhexapeptide
• Niacinamide, Adenosine, Tranexamic acid
pII SKIN Multi-factors Double Action contains highly purified and concentrated skin-perme-ablehuman growth factors effective for anti-aging andanti-wrinkle. Also, pII SKIN Multi-factors Dou-ble Action helps skin regeneration via prompt and efficient delivery of human growth fac-tors into skin
pII SKIN Multi-factors Double Action
pII SKIN Multi-factors Double Action
- Boosting skin elasticity and regeneration- Anti-wrinkle and lifting effects on sagging skins- Whitening via anti-oxidants and whitening ingredients
* Skin irritation and cytotoxicity test completed
pII SKIN Multi-factors Double Action System is developed by the aid of ProCell’s innovative platform technology designedfor efficient transdermal delivery of bioactive ingredients, and pII SKIN’s unique and optimized combination ratio of skinpermeable growth factors helps effective skin regeneration and lifting.
PROCELL Whitening Serum
Application
MainIngredients
Characteristics
Whitening, Anti-oxidant, and moisturizing
• Co-development material with Institut Curie, France
- MTD-Kif13A
• Inhibitory effect of melanin translocation
• Melanogenesis inhibition
• Reduction in melanin pigmentation through the
deoxidation and removal of produced melanin
• Boosting collagen synthesis
• Strengthened moisturizing effect
• Skin anti-aging effect using Omega ingredient rich in
vegetable oil and lycopene
Main ingredient of PROCELL WHITENING SERUM Was developed by the application of ProCell’sInnovative platform technology to Curie’s newConcept whitening ingredient.
ProCell Bright Whitening SerumProCell Whitening Cream Serum Fresh
Whitening serum was developed by the application of ProCell’s innovation platform technology to Institut Curie’s new concept whitening ingredient. Its main functions are inhibition of melanin translocation and melanogenesis, and consequent reduction in melanin pigmentation
PROCELL whitening Serum
- Inhibitory effect of melanin translocation
- Melanogenesis inhibition
- Reduction in melanin pigmentationthrough the deoxidation and inhibi-
tionof melanin synthesis- Boosting collagen synthesis
Skin irritation and cytotoxicity test com-pleted
Vol.: 30 mL
• MTD-applied skin permeable human growth factors
- MTD-EGF, MTD-FGF, MTD-VEGF
8
Thank you for your atten-tion !