Principles of Structure Dr. Helen Berman September 11, 2002.

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Principles of Structure Dr. Helen Berman September 11, 2002

Transcript of Principles of Structure Dr. Helen Berman September 11, 2002.

Page 1: Principles of Structure Dr. Helen Berman September 11, 2002.

Principles of Structure

Dr. Helen Berman

September 11, 2002

Page 2: Principles of Structure Dr. Helen Berman September 11, 2002.

CONFIGURATION

To go from to a bond is broken

REPRESENTATION

•Ball and stick•Haworth•Fischer

Voet, Donald and Judith G. Biochemistry.John Wiley & Sons, 1990, p. 249.

Page 3: Principles of Structure Dr. Helen Berman September 11, 2002.

Fischer Projections

Voet, Donald and Judith G. Biochemistry.John Wiley & Sons, 1990, p. 68.

Page 4: Principles of Structure Dr. Helen Berman September 11, 2002.

Haworth Projection

Voet, Donald and Judith G. Biochemistry.John Wiley & Sons, 1990, p. 248.

Page 5: Principles of Structure Dr. Helen Berman September 11, 2002.

Stereoisomers

n chiral centers yield 2n stereoisomers

Voet, Donald and Judith G. Biochemistry.John Wiley & Sons, 1990, p. 69.

Page 6: Principles of Structure Dr. Helen Berman September 11, 2002.

Amino Acids

“corn crib”

Voet, Donald and Judith G. Biochemistry.John Wiley & Sons, 1990, p. 68.

Page 7: Principles of Structure Dr. Helen Berman September 11, 2002.

D sugars

Voet, Donald and Judith G. Biochemistry.John Wiley & Sons, 1990, p. 248.

Page 8: Principles of Structure Dr. Helen Berman September 11, 2002.

Torsion Angles

Dihedral Angles

Saenger, Wolfram. Principles of Nucleic Acid Structure.Springer-Verlag New York Inc., 1984, p. 15.

Page 9: Principles of Structure Dr. Helen Berman September 11, 2002.

Klyne Prelog

Other nomenclatures

Saenger, Wolfram. Principles of Nucleic Acid Structure.Springer-Verlag New York Inc., 1984, p. 16.

Page 10: Principles of Structure Dr. Helen Berman September 11, 2002.

Newman Projection

Creighton, Thomas. Proteins: Structures and Molecular Principles.W. H. Freeman and Company, 1984, p. 160.

Page 11: Principles of Structure Dr. Helen Berman September 11, 2002.

Cyclohexanes

Pyranose sugars

Voet, Donald and Judith G. Biochemistry.John Wiley & Sons, 1990, pp. 249-250.

Page 12: Principles of Structure Dr. Helen Berman September 11, 2002.

Water Structure

Voet, Donald and Judith G. Biochemistry.John Wiley & Sons, 1990, p. 30.

Page 13: Principles of Structure Dr. Helen Berman September 11, 2002.

Water hydrogen bonding

Voet, Donald and Judith G. Biochemistry.John Wiley & Sons, 1990, p. 30.

Page 14: Principles of Structure Dr. Helen Berman September 11, 2002.

Ice structure

Voet, Donald and Judith G. Biochemistry.John Wiley & Sons, 1990, p. 31.

Page 15: Principles of Structure Dr. Helen Berman September 11, 2002.

Hydration of ions

Voet, Donald and Judith G. Biochemistry.John Wiley & Sons, 1990, p. 32.

Page 16: Principles of Structure Dr. Helen Berman September 11, 2002.

Hydration of polar groups

Voet, Donald and Judith G. Biochemistry.John Wiley & Sons, 1990, p. 33.

Page 17: Principles of Structure Dr. Helen Berman September 11, 2002.

Clathrate hydrates

Voet, Donald and Judith G. Biochemistry.John Wiley & Sons, 1990, p. 179.

Page 18: Principles of Structure Dr. Helen Berman September 11, 2002.

Clathrate hydrates

Voet, Donald and Judith G. Biochemistry.John Wiley & Sons, 1990, p. 179.