Principle of Endocrine & Metabolic Diseases
-
Upload
henriette-angel -
Category
Documents
-
view
41 -
download
1
description
Transcript of Principle of Endocrine & Metabolic Diseases
Contents
1. Endocrine system and Hormones
2. Diagnosis of Endocrine Diseases
3. Treatment of Endocrine Diseases
4. Progress
1. Endocrine system & Hormones
(1) Endocrine system & function
(2) Hormone & function
(3) Regulation of hormone
(4) Mechanism of hormone action
Hypothalamus Pituitary
CRH ACTH
TRH TSH
GnRH(LRH) FSH, LH
GHRH, GHRIH GH
PIF, PRIF PRL
ADH ADH
Endocrine System & Hormones
Hormones
Organ
Organ Hormone
Parathyroid PTH
Thyroid TH(T3,T4) , Cacitonine
Pancreas Insulin, Glucagon, SS
Adrenal gland Glucocorticoid, Aldosterone, Testosterone
Catecholamine
Ovary Estrogen, Progesterone
Testis Testosterone
Endocrine System & Hormones
Cells Hormone
APUD cells Peptide or
Catecholemine
Adipocytes Leptin
Endothelium cells Peptides
Endocrine Cells & Hormones
Hormone
Classification
① Peptides or Proteins: GH
② Amine: Catecholamines
③ Amino Acid Analogs: TH
④ Steroids: Cortisol, VitD
Hormone
Secretion Rhythms① Pulsatile or cyclic secretion: likes a wave
Insulin, PRL, TSH change from min. to hr. FSH, LH, E, and P change in wks T4 change in season
② Circadian variability ACTH and cortisol : 8am/4pm/midnight
③ Sleep-associated rhythms GH, Prolectin
Hormone
Regulation
① Endocrine and Nervous system
② Endocrine and Endocrine
③ Endocrine and Immune system
④ Endocrine and Metabolism
Hypothalamus-pituitary-target glands Feedback Regulation
Nerve impulse & Cytokines
Advanced never center
Hypothalamus
Pituitary
Target Glands
One hormone, Multiple actions
One function, Multiple hormones
Interaction of Hormones
Self-review
Hormone
Other regulation system
Mechanism of action
Hormone receptors
2. Diagnosis of Endocrine Diseases
(1) Symptoms--- Fantastico
(2) Signs--- Inspection
(3) Lab Tests--- Function
(4) Causes or Localization
Symptoms & signs Diseases
Weight gain Hypothalamic syn. Cushing syn.
Hypothyroidism, Insulinoma
Weight loss Adrenal insufficiency, Hyperthyroidsm,
DM, Hypopituitarism, Pheochromocytoma
Short stature Idiopathic GH deficiency (Dwarfism),
Turner’s syn.
Tall stature Pituitary giganism, Sexual precocity
Symptoms & Signs
Symptoms & signs Diseases
Polyuria Diabetes insipidus, Diabetes mellitus,
Hypercalcemia, Hypokalemia
Hyperpigmentation Addison’s syn. Nelson’s syn.
Hypopigmentation Panhypopituitarism
Acne Androgen excess, PCOS, Cushing syn.
Striae Cushing syn.
Symptoms & Signs
Symptoms & signs Diseases
Decreased body hair Hypothyroidism, Hypopituitarism
Hirsutism Androgen excess states, Cushing syn.
Amenorrhea Adrenal insufficiency, Cushing syn. Hyperprolactinemic states, PCOS, Hypopituitarism, Ovarian failure
Galactorrhea Hyperprolactinemic states, Prolactinomas, Hypothyroidism
Symptoms & Signs
Symptoms & signs Diseases
Proptosis Graves’ disease, Obital tumor
Hypokalemia Primary aldosteronism,
Paralysis Renin-secreting tumors Cushing syn.
Acanthosis nigricans Obesity, PCOS, Acromegaly,
Severe insulin resistance, Cushing syn.
Bone pain Osteoporosis, Hypercalcemia, Hyperparathyroidism
Symptoms & Signs
The level of hormone: TH, GH, Insulin
The effect of hormones: BG, Ca
Basal condition or to some provocative stimulus
Blood or urine samples
Laboratory Tests
Basal levels: FT3, FT4, TT3, TT4
Hormone’s rhythm: ACTH-Cortisol
Provocative (functional) tests
Stimulation test: on hypofunction disease
eg. TRH, ACTH, OGIRT
Suppression test:on hyperfunction disease.
eg. dexmethasone suppression test
on Cushing syndrome.
Laboratory Tests
Localization & Cause Diagnosis
Localization
Imaging studies: MRI , CT, ECT, B ultrasound
Cause diagnosis
Immunoassay: IAA, ICA, GAD, TPOAb, TgAb
Genetic analysis: DNA analysis
Biopsy procedures: Fine-needle biopsy
3. Treatment of Endocrine Diseases
(1) To causes
(2) To Excess of hormone
(3) To Deficiency of hormone
(4) To resistance to hormone
Cause of Endocrine Hyperfunction
① Tumor: ACTH-producing tumor
② Hyperplasia: Adrenal hyperplasia
③ Autoimmune stimulation: GD
④ Ectopic endocrine syndrome
⑤ Drugs
Cause of Endocrine Hypofunction
① Destruction of the gland
Autoimmune disease Schmidt’s syn.(hypothyridism, Addison) Neoplasms, infection or hemorrhage.
② Extraglandular disorders
③ Congenital defects in hormone biosynthesis
④ Receptor Deficiency
⑤ Drugs
Defects in Sensitivity to Hormone
① Type 2 diabetes mellitus
② Pseudohypoparathyroidism
③ Some hypothyroidism
④ Nephrogenic diabetes insipidus
⑤ Rickets (vitamin D insensitivity)
Treatment to Hyperfunction
① Remove tumors
② Pharmacology block hormone production
③ Control sequelae of hyperfunction
④ Immunotherapy
⑤ Radiothyrapy
Treatment to Hypofunction
① Replacement with hormone in a physiologic
manner: insulin
① Replacement with hormone mimics: Vitamin D
② Replacement with cations: Ca, P
③ Immunotherapy
④ Transplantation
Hypothalamus Pituitary Target Diseases
CRH ↑ ACTH↑ CS↓ Addison’s Disease
↑ ↑ ↑ Cushing’s Disease
↓ ↓ ↑ Adrenal hyperfunction
TSH ↓ TH↑ Hyperthyroidism
↑ ↓ Hypothyroidism
Changes of Hormone