PRINCIPAL POSITIONS HELD...2012 American Association of Immunologists 99th Annual Meeting, AAI,...

1 of 25

Name: Claude J Le Saux , PhD

EDUCATION

2009 - 1989 Universite de

Provence, Marseille,

France

BS MajorBiochemistry and

Microbiology



France

MS MajorCell and Molecular

Biology



France

MENG MajorMicrobiology and

Biotechnology



France

PhD MajorCell and Molecular

Biology

PhD AdvisorDr.

Pascal Sommer

PRINCIPAL POSITIONS HELD

2000 - 2009 University of Hawaii, Honolulu, HI Assistant

Researcher

2009 - 2015 University of Texas Health Science

Center at San Antonio

Assistant Professor

Tenure-Track

Medicine,

Cardiology

2015 - present University of Texas Health Science

Center at San Antonio

Assistant

Professor(10%

FTE)

Medicine,

Pulmonary and

Critical Care

2016 - present UCSF Associate Adjunct

Professor

Medicine

Pulmonary and

Critical Care

OTHER POSITIONS HELD CONCURRENTLY

-

HONORS AND AWARDS

1994 Pre-doctoral Fellowship Award Association pour la Recherche sur le

Cancer

1995 Pre-doctoral Fellowship Award Association pour la Recherche sur le

Cancer

1996 Pre-doctoral Fellowship Award Glaxo Pharmaceutical Products

2 of 25

1996 Award for best promising pre-doctoral

fellow

Association de la Technolopole de

Gerland

2012 Young investigator award 17th colloquium on lung and airways

fibrosis, Modena, Italy

2014 Carol Basbaum Award American Thoracic Society Respiratory

Cell and Molecular Biology

KEYWORDS/AREAS OF INTEREST Pulmonary Fibrosis, Senescence, Aging, Macrophage biology, Cardiac Remodeling

PROFESSIONAL ACTIVITIES

MEMBERSHIPS

2001 - present American Thoracic Society

2009 - 2010 American Heart Association

2016 - present Association for Research in Vision and Ophthalmology

SERVICE TO PROFESSIONAL ORGANIZATIONS

2008 - 2008 Canadian Institutes of Health Research Ad Hoc Reviewer

2008 - 2009 The Netherlands Asthma Foundation Ad Hoc Reviewer

2010 - 2016 Respiratory and Cell Molecular Biology Assembly,

American Thoracic Society

Executive

Committee

Member

2010 - present Respiratory Cell and Molecular Biology Assembly Planning

Committee, American Thoracic Society

Committee

Member

2010 - 2013 National Institute of Health Center for Sciences Reviewer

2011 - 2016 Respiratory Cell and Molecular Biology Assembly Aging

Group, American Thoracic Society

Co-leader

2016 - 2016 Respiratory Cell and Molecular Biology Assembly Aging

Group, American Thoracic Society

Member

2012 - 2016 Respiratory Cell and Molecular Biology Program


Member

2015 - 2015 National institute of Aging, Special Emphasis Panel Reviewer

2016 - 2016 National institute of Heart, Lungs and Blood, Special

Emphasis Panel

Reviewer

2009 - present Chair and co-chair of mini-symposium, symposium, poster

sessions at the American Thoracic Society international

meetings

Co-Chair

3 of 25

2017 - present Member of the Research Advocacy Committee, American

Thoracic Society

Member

2017 - present Respiratory Cell and Molecular Biology Program


Member

SERVICE TO PROFESSIONAL PUBLICATIONS

2004 - Ad hoc reviewers for several journals related to pulmonary and critical care, cell

biology, immunology, and cardiology

2012 - 2014 Editorial Organizing Committee: reparation of the "Molecular Aspects of Aging"

book to establish a milestone in our knowledge in the processes controlling the

aging of the lungs.

INVITED PRESENTATIONS - INTERNATIONAL

2018 Pushing the Limits of Healthspan and Longevity (D3),

Keystone Symposia, Hannover Germany

2018 International Cell Senescence Association International

Conference Montreal, Canada

Speaker

2014 American Thoracic Society (ATS) 2014 International

Conference, A85-Cellular and Molecular Determinants of

the Aging Lung, ATS, San Diego, CA: Sunrise Seminar



the Aging Lung, ATS, San Diego, CA: oral presentation

Speaker



the Aging Lung, ATS, San Diego, CA. Oral presentation

Speaker



the Aging Lung, ATS, San Diego, CA. Post graduate

course

Speaker

2014 Experimental Biology 2014, Cardiovascular Biology,

American Association of Anatomists, San Diego, CA

Co-presenter

2014 INSERM-U651 Hopital Mondor, Faculte' de Medecine,

Creteil, France

Guest Speaker

2014 Ground Rounds, Department of Medicine, Pulmonary

Division, University of Tulane, New Orleans, LA

Guest Speaker

2014 3rd Munich Lung Conference on Lung Aging: Molecular

mechanisms and clinical relevance, Munich October 2013.

Award winning.

Senior author

4 of 25

2013 American Thoracic Society 2013 International Meeting,

C108. THE BEST FROM IN VIVO MODELS OF

PULMONARY FIBROSIS,, ATS, Philadelphia, PA

Senior author

2012 17th International Colloquium on Lung and Airways

Fibrosis, Center for Rare Lung Diseases, University of

Modena & Reggio Emilia, Modena, Italy

Invited speaker

2012 INSERM-U651 Hopital Mondor, Faculte' de Medecine,

Creteil, France

Guest Speaker


Conference, A61- Antifibrotics and Therapeutic Targets in

Expermiental Lung Fibrosis, ATS, San Francisco, CA

Senior Author

2012 Translation of Basic Research to Human Disease and

novel Therapeutics, ATS International Conference, San

Francisco, CA

Invited speaker

2012 Department of Life Sciences, University of Modena and

Reggio Emilia, Modena, Italy

Guest speaker

2011 Anatomy and Cell Biology Department Seminar Series,

School of Medicine, McGill University, Montreal, Canada

Guest Speaker

2010 American Thoracic Society International Conference 2010,

A-19 Preclinical Testing in Mouse Models of Pulmonary

Fibrosis, ATS, New Orleans, LA

Senior author

2009 Telomere Biology and DNA Repair, Poster Abstract,

Keystone Symposia on Molecular and Cellular Biology,

Ashmore, Australia

Senior author

2009 American Thoracic Society 2012 International Meeting,

C107. Prevalence and Regulation of Epithelial

Mesenchymal Transition, ATS, San Francisco, CA

Senior author

2008 American Heart Association, New Orleans, Louisiana Invited Speaker

INVITED PRESENTATIONS - NATIONAL

2019 National Institutes of Health DNA Damage, Telomeres,

and Senescence in Lung Aging and Disease Workshop

Speaker

2019 Scleroderma Workshop, Scleroderma Foundation, San

Francisco, CA

Speaker

2016 Fibrosis 2016 Keystone Conference on Fibrosis: From

Basic Mechanisms to Targeted Therapies

Oral Presenter

2016 Center for Comparative Respiratory Biology and Medicine,

UC Davis seminar

Guest Speaker

2015 San Antonio Nathan Shock Center of Excellence in the

Basic Biology of Aging, San Antonio, TX

Guest Speaker

5 of 25

2014 Seminar. Buck Institute of Aging, Novato, CA. Guest Speaker

2014 Seminar Series, Lovelace Respiratory Research Institute,

Albuquerque, NM

Guest Speaker

2013 Research Seminar Series, Dept. of Regenerative

Medicine and Cell Biology, Medical University of South

Carolina, Charleston, SC

Guest Speaker

2013 Seminar Series, Baylor School of Medicine Guest Speaker

2012 American Academy of Pediatrics Symposium, Perinatal

Section, AAP, Marco Island, FL

Co-author on oral

presentation

2012 Special Seminar, Dept. of Human Genetics, University of

Pittsburgh-Graduate School of Public Health, Pittsburg,

PA

Guest Speaker

2012 Aspen Conference, Aspen, CO Co-author on oral

presentation

2012 American Association of Immunologists 99th Annual

Meeting, AAI, Boston, MA

Co-author on oral

presentation

2012 Fibrosis Across Organ Systems Symposium, American

Thoracic Society Special Emphasis Panel, Denver, CO

Guest Speaker

2012 American Heart Associate Scientific Session,

Inflammation and Adhesion Molecules, American Heart

Association, Orlando, FL

Guest Speaker

2012 Gordon Research Annual Conference, Lung

Development, Injury & Repair, Salve Regina University,

Newport, RI

Senior Author

2011 ATS 2011 International Conference, Respiratory Cell &

Molecular Biology, Denver, CO Sunrise Seminar

Speaker

2011 Keystone Symposia, Lung Development and Repair (B5),

Keystone, Santa Fe, NM

Senior Author

2010 Experimental Biology 2010, Poster Session Title:

Cardiovascular Cell Biology and Disease, Experimental

Biology, Anaheim, CA

Senior Author

2010 Grand Rounds, Pulmonary, Allergy & Critical Care

Medicine, University of Alabama, Birmingham, AL

Guest Speaker

2010 Keystone Symposia, Extracellular Matrix and

Cardiovascular Remodeling (B2), Tahoe City, CA

Senior Author

INVITED PRESENTATIONS - REGIONAL AND OTHER INVITED PRESENTATIONS

2016 12th Bay Area Aging Meeting Invited Speaker

2016 Internal Research Seminar series at the Buck Institute Speaker

6 of 25

2016 Theravance Biopharma Invited Speaker

2016 Touro University Biological and Pharmaceutical Sciences-

College of Pharmacy

Invited Speaker

2015 Research Seminar series, Medicine, UTHSCSA, San

Antonio, TX

Speaker

2014 Pulmonary Conference Presentations, The Division of

Pulmonary Diseases and Critical Care Medicine,

UTHSCSA, San Antonio, TX

Guest Speaker

2013 Research Seminar series, Medicine, UTHSCSA, San

Antonio, TX

Guest Speaker

2013 Women Faculty Association, UTHSCSA, San Antonio, TX Guest Speaker

2012 San Antonio Nathan Shock Center of Excellence in the

Basic Biology of Aging, San Antonio, TX

Guest Speaker

2012 Cardiothoracic Surgery Research Meeting, UTHSCSA, San

Antonio, TX Ground Rounds

Guest Speaker

2012 3rd Annual Frontiers of Translational Science, San Antonio,

TX

Senior Author

2012 Keystone Symposia, Cardiovascular Development and

Regeneration, Taos, NM

Senior Author

2010 National Conference of State Legislatures, Legislators in

the Lab, UTHSCSA, San Antonio, TX

Speaker

2010 Cellular and Structural Biology Seminar Series, Cellular and

Structural Biology, The University of Texas Health Science

Center, San Antonio, TX

Speaker

2010 Research Seminar, Department of Pediatrics, The

University of Texas Health Science Center, San Antonio,

TX

Speaker

2010 Grand Rounds, Division of Cardiothoracic Surgery, The

University of Texas Health Science Center, San Antonio,

TX

Speaker

2010 Pediatrics Research Seminar, Pediatric Department,


Speaker

2009 Medicine Research Seminar, Department of Medicine, UT

Health Science Center, San Antonio, TX

Speaker

CONTINUING EDUCATION AND PROFESSIONAL DEVELOPMENT ACTIVITIES

2016 Participant at the Keystone symposia on Fibrosis: From Basic Mechanisms to

Targeted Therapies

7 of 25

2016 Participant Association for Research in vision and ophtalmology international

meeting

2016 Participant at American Thoracic Society Meeting

2015 Participant American Thoracic Society Meeting

2014 Participant American Thoracic Society Meeting

2014 Cardiac Catheterization Lecture Series, "Myectomy for nonobstructive HCM"

2014 Center for Excellence in Women's Health, "Chronic Disease Begins in the

Womb" presented by Kent L. Thornburg, Ph.D., Professor of Medicine, Knight

Cardiovascular Institute Director, Center for Developmental Health, Bob and

Charleen Moore Institute for Nutrition and Wellness Oregon Health and Science

University.

2014 Barshop Seminar Series, "Death, Disease and Aging in Drosophila" presented

by David Walker, Ph.D., Associate Professor, Departments of Integrative

Biology and Physiology, University of California, Los Angeles, CA

2014 Barshop Institute Seminar, "Cellular and Molecular Basis for the Heart Disease

of Aging" presented by Mark Entman, M.D. Professor, Department of Medicine,

Pathology, and Immunology Chief, Cardiovascular Sciences Section Baylor

College of Medicine, Houston, TX.

2104 Barshop Institute Seminar, "Marmoset Monkeys as an Integrating Model of

Development, Obesity and Aging" presented by Suzette Tardif, Ph.D.,

Professor, Barshop/Cellular and Structural Biology, UTHSCSA, San Antonio,

TX

2014 Cellular & Structural Biology Seminar, "Hedgehog and androgen receptor

signaling pathways in prostate cancer" presented by LuZhe Sun, Ph.D.,

Department of Cellular and Structural Biology, UTHSCSA, San Antonio, TX.

2014 Barshop Institute Seminar, "Aging - A Perspective from Proteostasis and the

Health of the Proteome" presented by Richard Morimoto, Ph.D., Bill and Gayle

Cook Professor of Biology, Director, Rice Institute for Biomedical Research,

Department of Molecular Biosciences, Weinberg College of Arts and Sciences

Northwestern University, Evanston, IL

2014 Grant Seeker's program, external review process prior to submission of NIH

R01 entitled "Preventing adverse cardiac remodeling by targeting caveolin-1"

submitted 02.2014

2013 Participant at the American Thoracic Society meeting

2013 Grant Seeker's program, internal review process prior to submission of NIH R01

entitled "Preventing adverse cardiac remodeling by targeting caveolin-1"

submitted 02.2014.

2013 Barshop Institute Seminar, "Redox-Regulation of Monocyte Migration and

Macrophage Recruitment" presented by Reto Asmis, Ph.D., Professor of

Clinical Laboratory Sciences and Biochemistry, UTHSCSA, San Antonio, TX.

8 of 25

2013 Barshop Institute Seminar, "Pneumococcal Pneumonia in the Elderly: How

Chronic Inflammation Opens the Door for The Old Man's Friend" presented by

Carlos Orihuela, Ph.D., Associate Professor of Microbiology and Immunology,

UTHSCSA, San Antonio, TX.

2013 Barshop Institute of Aging Grant Seekers, internal review process prior to

submission of NIH R01 entitled "Telomerase and telomere regulation in

pathobiology of pulmonary fibrosis" submitted 02.2014

2013 Barshop Institute Seminar, "A genomic approach to analysis of the effects of

rapamycin on aging and cancer" presented by Carolina Livi, Ph.D., Assistant

Professor Research, Department of Molecular Medicine, UTHSCSA, San

Antonio, TX

2013 Stem Cell Conference, Conference held at the University of Vermont,

Burlington, VT. I attended this conference to learn the latest knowledge on

therapeutic approaches for pulmonary fibrosis treatment.

2013 Microbiology Seminar Series, "IL-13 modulation of Th17 immune responses"

presented by Ray Stokes Peebles, Jr., MD, Ph.D., Division of Allergy,

Pulmonary & Critical Care Medicine, Vanderbilt University Medical Center,

Nashville, TN.

2013 Cellular and Structural Biology Seminar, "Integrin-mediated inflammasome

activation. Novel insights into epithelial cell derived inflammation" presented by

Peter H. Dube, Ph.D., Department of Microbiology, UTHSCSA, San Antonio,

TX.

2013 Barshop Institute Seminar, "Aging and the Inflammatory Responses After

Injury" presented by Elizabeth J. Kovacs, Ph.D., Professor, Vice Chair for

Research, Departments of Surgery and Cell Biology, Neurobiology, and

Anatomy, Loyola University, Chicago, IL.


2012 Participant at the Keystone Symposia Fibrosis: Translation of Basic Research

to Human Disease and Novel Therapeutics

2012 Cellular and Structural Biology Seminar, "LY2157299, A First-in-Class TGF-

beta Type I Receptor Inhibitor" presented by Jonathan Yingling, Ph.D., Eli Lilly

and Company, Indianapolis, IN.

2012 Barshop Institute Seminar, "Aging and Cancer: Rival Demons?" presented by

Judith Campisi, Ph.D., Professor, Buck Institute for Research on Aging, Novato,

CA.

2012 Cellular and Structural Biology Seminar, "Telomere and Age-Related Disease"

presented by Mary Armanios, M.D., Associate Professor of Oncology, John

Hopkins School of Medicine,Baltimore, MD.


9 of 25

2011 Cellular and Structural Biology Seminar, "The Plasticity of Aging" presented by

Anne Brunet, Ph.D., Assistant Professor, Department of Genetics, Stanford

University, Stanford, CA.

2011 Barshop Institute Seminar, "Cardiac Remodeling from the Extracellular Matrix"

presented by Merry Lindsey, Ph.D., Associate Professor and Director of the

Cardiovascular Proteomics Center, Department of Medicine and the Barshop

Institute, UTHSCSA, San Antonio, TX

2011 Cellular and Structural Biology Seminar, "miRNAs and Cardiovascular Disease"

presented by Carlos Fernandez-Hernando, Ph.D., Department of Medicine &

Cell Biology, New York University, New York, NY.

2011 Description Mouse Genetics 2011 Conference, The Genetics Society of

America Conference, Washington, DC. Learned how to make a transgenic

mouse model

2011 Barshop Institute Seminar, "Modeling Aging and Cancer in Mice with Telomere

Dysfunction" presented by Sandy Chang, M.D., Ph.D., Associate Professor,

Department of Laboratory Medicine Yale University School of Medicine,New

Haven, CT. Madison, CT

2011 Cellular and Structural Biology Seminar, "Gene expression profiling to study the

mechanisms of calorie restriction and rapamycin in mice" presentated by

Carolina Livi, Ph.D., Assistant Professor, Department of Molecular Medicine,


2011 Cellular and Structural Biology Seminar, "TGF-beta Signaling in Colon Cancer

Metastasis" presented by Jing Wang, Ph.D.,Eppley Cancer Institute, University

of Nebraska Medical Center, Omaha, NE.

2011 Cellular and Structural Biology Seminar, "Mitochondrial ROS: a key to

intermediate cardiac aging and hypertrophy" presented Peter S. Rabinovitch,

M.D., Ph.D.,Department of Pathology, University of Washington, Seattle, WA.

GOVERNMENT AND OTHER PROFESSIONAL SERVICE

2008 - 2008 2008- 2008 Canadian Institutes of Health Research Role Ad Hoc Reviewer

2008 - 2009 The Netherlands Asthma Foundation Ad Hoc Reviewer

2010 - 2013 National Institute of Health Center for Sciences Reviewer

2010 - American Heart Association Reviewer

2015 - 2015 National institute of Aging, Special Emphasis Panel Reviewer

2016 - 2016 National institute of Heart, Lungs and Blood, Special

Emphasis Panel

Reviewer

2017 - present National Institutes of Health, Center for Scientific Review,

Small Business Respiratory Study Section

Reviewer

10 of 25

UNIVERSITY AND PUBLIC SERVICE

SCHOOL OF MEDICINE

-

SCHOOL OF DENTISTRY

-

SCHOOL OF NURSING

-

SCHOOL OF PHARMACY

-

SERVICE AT OTHER UNIVERSITIES

2014 - 2015 Co-chair for the organization of the Barshop Institute

Seminar Series

UTHSCSA

2014 - 2014 Judge for Basic & Clinical Research Quality Improvement &

Patient Safety Day

UTHSCSA

2012 - 2015 nterviewer for candidate applying for faculty position in the

Dept of Physiology

UTHSCSA

2011 - 2015 Interviewer for candidate applying for faculty position in the

Dept of Medicine/Pulmonary

UTHSCSA

2012 - 2012 Judge for Honors College Undergraduate Research

Symposium

UTSA

2012 - 2016 Member of the Institutional Review Board UTHSCSA

2011 - 2015 Interviewer for candidate applying for faculty position in the

Dept of Medicine/Cardiology

UTHSCSA

2011 - 2015 Cardiovascular Fellowship Interviewees UTHSCSA

2010 - 2012 Reviewer of applications for Medical Student Summer

Research Program

UTHSCSA

2011 - 2016 Member of the Medical Student Research Review

Committee

UTHSCSA

2010 - 2015 Interviewer for Graduate student candidates UTHSCSA

2010 - 2011 Board Member of the Visual Arts -Connective Tissue

Magazine

UTHSCSA

2010 - 2010 Judge for the Dental Science Symposium UTHSCSA

2009 - 2012 Judge for Medical Student Research Day UTHSCSA

11 of 25

1998 - 2009 Judge for the Biomedical Research Symposium University of

Hawaii

COMMUNITY AND PUBLIC SERVICE

2014 - 2015 Comal County Translational project The mission of the

Translational Advisory Board is to serve as a

representative body which aims to improve community

health through the facilitation of community-based

participatory research and educational outreach activities.

This project is a joint project with UTHSCSA IIMS-

community engagement and the South Central Area

Health Education Center. My contribution as a member of

the Comal County Translational Advisory Board, is to

bring my expertise in lung and cardiac diseases and

experience as an Institutional Review Board (IRB)

member will help in setting the agenda for research and

outreach activities.

Board Member

2014 - 2014 2014 Community Health Summit Facilitator

2012 - 2013 American Heart Association -Doctor‘s Day Faculty

Representative

2011 - 2011 Women's Faculty Association-Science Fair judge

2009 - 2011 National Doctors‘ Day Volunteer Guest Speaker in

several High

Schools

2009 - 2010 American Heart Association Board of Director‘s Meeting Guest Speaker

2009 - 2009 Women's Faculty Association Science Fair Judge

2007 - 2009 Hawaii Lung Association- Asthma camp Volunteer

TEACHING AND MENTORING

TEACHING SUMMARY I intend to mentor students and fellow in the lab. If a formal teaching opportunity arises, I will certainly be glad to contribute.

FORMAL TEACHING

Not

UCSF

Academic Yr Course No. & Title Teaching Contribution School Class

Size

X 2019 - Bio2805 Genetics Lab

course

Lecturer 60

2018 - QB3 2019 Tissue

Repair Pathology

Course

Organization and lecture 20

12 of 25

Not

UCSF


Size

X 2011 - 2015 INTD5000

Fundamentals of

Biomedical Sciences

(IMGP)

lectures 20

X 2014 - 2015 Analysis of the

senescent Cell

Post graduate seminar 60

X 2014 - 2015 Aging Lungs: From

Physiologic

Conditions to

Pathologies

Sunrise SeminarLecture 20

X 2014 - 2015 Age and age-related

diseases in the lungs:

convergence and

divergence

Lecture for the pulmonary

and critical care fellow

15

X 2010 - 2011 Respiratory Care

Lecture Series

Lecture entitled "Aging

lungs: How and what are the

consequences?"was

presented to the respiratory

therapist students.

45

X 2010 - 2011 Does Telomerase

Activity Only

Lengthen Telomere?

Implications in IPF

Sunrise SeminarLecture 20

X 2010 - 2015 Journal Club for the

cardiology fellow

Director of the Journal

Research Club organizing

schedules, lectures and

other related activities as

needed

15

X 2008 - 2009 Physiology 442 and

442L)

Lectures 40

X 2008 - 2009 Course 622-

Regulation of

Transcription/mRNA

Processing

Lectures 15

X 2006 - 2007 Anatomy &

Physiology Laboratory

in pre-nursing

Curriculum

Lectures 30

13 of 25

Not

UCSF


Size

X 2006 - 2007 Introduction to Biology

for non-biology Major

Lectures 30

X 2004 - 2009 Ethics and Science:

Data ownership and

Data Management

lectures 10-20

PREDOCTORAL STUDENTS SUPERVISED OR MENTORED

Dates Name Program or

School

Mentor Type Role Current

Position

2013 - 2013 Alejandro Juul St Mary's Hall

School High

School

Summer

internship

Mentor College

student

2013 - 2013 Allison Price UTHSCSA 2nd Year

Medical Student

who took an

elective course

to perform

research

Mentor Resident

2013 - 2013 Greggory

Melish

UTHSCSA 2nd Year

Medical Student

who took an

elective course

to perform

research

Mentor Resident

2013 - 2015 Summer 2013:

Brian Ku, UT

South Western

School of

Medicine,

Dallas, TX

Summer 2014;

Craig Cook,

UTHSCSA,

San Antonio,

TX

UTHSCSA Medical Student

Training in Aging

Research

(MSTAR) Mentor

My role is to mentor

students who have

been selected to

participate in the

MSTAR program

Medical

students

2012 - 2012 Daniel Herlihy UTHSCSA 2nd Year

Medical Student

who took an

elective course

to perform

research

Mentor Resident

14 of 25


School


Position

2011 - 2013 Laura Solis UTSA Honor thesis

student

Research mentor Graduate

student

2010 - 2011 Monica

Benavides

UTHSCSA 3rd Year Medical

Student who took

an elective

course to

perform research

Mentor MD

2010 - 2010 Abby

Richmond

UTHSCSA 1st Year Medical

Student who took

an elective

course to

perform research

Mentor MD in

practice

2010 - 2011 Luke Mein Health

Careers High

School

UTHSCSA

Internship Mentor College

student

2010 - 2012 Yosef

Ansarizadeh

Keystone

High School

Internship Mentor College

student

2010 - 2011 Diana Anzueto UTSA Honor thesis

student

Co-Research mentor Research

Assistant

2010 - 2013 Cindy Martinez UTHSCSA BS student Mentor Medical

Laboratory

Technician

2010 - 2012 Justin Moreno UTSA Master

Thesis

Co-Mentor Graduate

student

2009 - 2011 Ariel Vinas University of

Hawaii

Medical Student Mentor

2004 - 2009 Kelsa Teeters PhD

ThesisUniver

sity of Hawaii

Mentor Postdoctoral

fellow

2002 - 2003 Christye Naole Master

ThesisUniver

sity of Hawaii

Rotation Mentor Assistant

Professor

Chaminade

University

Hawaii

2007 - 2009 Rachel Rueili University of

Hawaii

BS student Research Mentor Research

Assistant

15 of 25


School


Position

2016 - 2016 Laura

Delacourte

UniversiteUni

versité Pierre

et Marie

Curie (Paris)

Research/Schola

rly Mentor

Research mentor Graduate

Student

2019 - 2019 Richard Ruan UC Berkeley Project Mentor Supervisor Undergraduat

e Student

POSTDOCTORAL FELLOWS AND RESIDENTS MENTORED

Dates Name Fellow Mentor Role Faculty Role Current

Position

2011 - 2013 Ali Jafari Mehr Cardiology Research Mentor Faculty at

UTHSCSA in

Cardiology

div.

2011 - 2013 Julie Hisey Pediatrics Co research

Mentor

2011 - 2013 Pooja

Shivshankar

Research

postdoctoral

Mentor Assistant

Professor,

Texas Tech

University

Health

Science at

Lubbock ·

Department

of Medicine

2011 - 2012 Diego Maseli Pulmonary

and Critical

Care

Research mentor Faculty

UTHSCSA

pulmonary

and critical

care div.

2010 - 2013 Hector Payan Pulmonary

and Critical

Care

Research mentor Private

practice

2010 - 2012 Harshita

Bhatnagar

Research

postdoctoral

Mentor

2009 - 2010 Yelena

Rosenberg

Cardiology Research Mentor Private

practice

2008 - 2009 Christopher

Brampton

Research

postdoctoral

Mentor Junior

Scientist

Biorad

16 of 25

Dates Name Fellow Mentor Role Faculty Role Current

Position

2016 - 2016 Branca Pereira Fellow Project Mentor MD

2016 - 2017 Christopher

Wiley

Research

postdoctoral

Project Mentor Postdoctoral

Fellow

RESEARCH AND CREATIVE ACTIVITIES

RESEARCH AND CREATIVE ACTIVITIES SUMMARY My research activities will focus on understanding the role of senescent cells in aging and fibrotic lungs.

RESEARCH AWARDS - CURRENT

1. U01 HL134766 co-investigator 14 % effort Chapman, HA (PI)

NIH/NHLBI 09/21/2016 05/31/2023

Epithelial stem/progenitor cells as repair agents in

diffuse alveolar damage

The overall objective of this application is to develop human lung epithelial stem/progenitor

cells, either endogenous or derived from iPS cells, as an adjunctive therapy to promote

recovery from severe lung injury, i.e diffuse alveolar damage. The application involves a

multi-disciplinary investigative team and uses influenza infection in both mice and macaques

as pre-clinical models to assess efficacy of cell-based therapy in lung repair.

Perform mouse pre-clinical models and determine whether senescent mesenchymal cells

contribute to the severity of the lung injury.

2. 1R01 HL142265 co-investigator 35 % effort Chapman, HA (PI)

NHI/NHLBI 02/01/2019 01/31/2024

LOXL-2 dependent blockade of TGF Beta1

signaling and lung fibrosis

This proposal aims to translate the recent discovery of a lysyl-oxidase-like-2 (LOXL2)-

dependent pathway for fibroblast-specific inhibition of TGFb1 signaling into a clinical

therapeutic to attenuate pulmonary fibrosis. The specific aims are intended to further define

the LOXL2-dependent inhibition pathway and execute a proof of principle pilot study in

patients scheduled for lung biopsies to determine if combined LOXL2 and TGFb1 inhibition

can be achieved in vivo.

Development of biomarkers that will use in the clinical trial

RESEARCH AWARDS - SUBMITTED

1. Grant Number PI 35 % effort Jourdan Le

Saux, C (PI)

Scleroderma Research Foundation Start Date Start Date

Dynamic expression of senescence-associated

eicosanoids contributes to fibrotic phenotypes in

scleroderma

$ 199,735

direct/yr 1

$ 199,735 total

17 of 25

The major goals of this project are identify the dynamic change in senescence-induced

eicosanoid production in SSc and normal human skin and lung fibroblasts and its relevance

to fibrosis in the skin and the lungs.

I will be directly responsible for overseeing every phase of this project, will develop methods

as necessary to address the project aims, and analyze the data. She will also be responsible

for the dissemination of the results in the scientific community (journal articles, seminars, or

posters).

RESEARCH AWARDS - PAST

1. G12RR-03601 Co-investigator Your Effort %50 %

effort

PI NameTam, E (PI)

Granting Agency NIH-NCRR Start Date 09.2001 Start Date 09.2001

Grant TitleResearch Centers in minority

institutions program

$ Yr 1 Direct Costs

direct/yr 1

$ Total Direct

Costs$650,000 total

Grant Description NIH Research Center for Minorities Institution-Activity 3 pilot Project

Your contribution to the grant to study the Molecular Pathogensis of Airway Remodeling in

Asthma. Our project aimed to determine what are the genetic variations that could explain

the high prevalence of asthma among Asian and Pacific Islanders. We hypothesized that the

variants should be found in genes encoding inflammatory factors and consequently

enhanced airway remodeling.

2. NIH-NCRR 20 RR-1 Junior investigator Your Effort %50 %

effort

PI NameSmith, Dean

(PI)

NIH-NCRR Start Date04/2005 Start Date04/2005

Grant Title Hawaii State Biomedical

Research Infrastructure Network

$ Yr 1 Direct Costs

direct/yr 1

$ Total Direct Costs

total

Grant Description The goal of this grant was to increase the biomedical research capacity of

Hawaii.

Your contribution to the grant Junior investigator in charge of a project on pulmonary

fibrosis.

3. PF-7291 PI Your Effort % 10 %

effort

PI NameLe Saux, C

(PI)

Granting Agency Pfizer Inc. Start Date09/2014 Start Date09/2014

Grant Title Test of Janus Kinase inhibitor in

mouse lung bleomycin model

$ Yr 1 Direct

Costs$80,000

direct/yr 1


total

Grant Description contract to test the anti-fibrotic properties of a Janus Kinase inhibitor

compound in mouse lung bleomycin model.

Your contribution to the grant: conduct the studies and prepare report

4. Grant Number PI Your Effort %10 %

effort

PI NameLe Saux,C

(PI)

Granting Agency Janey Briscoe

Distinguished Chair

Start Date09/2013 Start Date09/2013

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Grant TitlePreventive Effect of Tacrolimus on

Restenosis after Coronary Stenting

$ Yr 1 Direct

Costs$10,000

direct/yr 1


total

Grant Description This award provided the funding necessary for the supplies to test the

hypothesis that inhaled tacrolimus could limit restenosis after coronary stenting.

Your contribution to the grant conduct the studies and prepare report

5. 10GRNT4020024 PI 10 % effort Le Saux, C (PI)

American Heart Association 07/2010 03/2013

Caveolin-1 prevents the development and

progression of cardiac remodeling.

$ 70,000 direct/yr 1 $ 140,000 total

The goal of this study is to determine how caveolin-1 regulates remodeling of the left

ventricle (LV) following myocardial infarction (MI), focusing on macrophage activation

mechanisms.

Conduct the studies and prepare report

6. 42588 PI 10 % effort Le Saux, C (PI)

HCF Fund-Leahi Fund to Treat and Prevent

Pulmonary Diseases

01/2010 01/2012

Caveolin-1 is a key mediator for the

development and progression of lung fibrosis

$ Yr 1 Direct Costs

$60,000 direct/yr 1


$120,000 total

Grant Description The aim of this grant was to determine the role of caveolin-1 in the

regulation of TGF-beta signaling pathway, the main pathway that promotes pulmonary

fibrosis.



Hawaii Community Foundation 09/2008 09/20010

Caveolin-1 in the regulation of TGF-beta

signaling in myocardial remodeling

$ 50,000 direct/yr 1 $ 100,000 total

Grant Description The aim of this grant was to determine the role of caveolin-1 in the

regulation of TGF-beta signaling pathway

Conduct Research


Hawaii Community Foundation

Involvement of IL-4 in airway remodeling:

activation of the lung fibroblasts

The aim of this proposal was to identify the cell and molecular mechanism that was

triggered by IL-4 in airway fibroblasts


9. Grant Number NIH R21-

12167181

PI 40% % effort Le Saux, C (PI)

Granting Agency NIH 06/01/2016 05/31/2018

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Grant TitleCharacterization of the Various

Senescent Cells in the Aging Lungs

$ Yr 1 Direct Costs

direct/yr 1


total

Grant Description This work proposes to determine whether senescence cells contribute to

the age-associated structural changes. We will determine whether the presence of

senescence cells is necessary to provoke the age-associated structural changes.

Furthermore, we will characterize the secretome of three main cell types (endothelial and

alveolar epithelial cells, and fibroblasts) and determine their relative contribution to the

structural changes.

Your contribution to the grant is to be directly responsible for overseeing every phase of this

project, develop methods as necessary to address the project aims, and analyze the data. I

will also be responsible for the dissemination of the results in the scientific community

(journal articles, seminars, or posters).

10. Grant Number AHA

15GRNT25710065

PI 10% % effort Le Saux, C (PI)

Granting Agency American Heart Association 07/2015 Start Date 07/2015

Grant TitleCellular senescence due to

invasive pneumococcal disease leads to

cardiac interstitial fibrosis

$ Yr 1 Direct Costs

$63,500 direct/yr 1

$ Total Direct

Costs$127,000 total

Grant Description This project explores how S. pneumoniae induced cellular senescence in

cardiomyocytes resulting in the release of senescence-associated secreted proteins that

recruit immune cells and elicit a profibrotic response and permanent cardiac alterations that

negatively impact cardiac function.

Your contribution to the grant is to directly be responsible for overseeing every phase of this

project and to develop methods as necessary to address the project aims. I will have final

authority on all aspects of the project.

11. Grant ISSEXEN0012 PI 25% % effort Le Saux, C (PI)

Granting Agency AstraZeneca 6/2016 6/2017

Grant TitleGradient of inflammation in

Adipocytes near Coronary Vessel Wall

Associated with Atherosclerotic Plaque

$ Yr 1 Direct Costs

direct/yr 1


$390,848.00 total

Grant Description This project is designed to determine the possible role of the perivascular

fat in atherogenesis in particular the activation of macrophage and inflammatory markers.

Your contribution to the grant is to directly be responsible for overseeing every phase of this

project and to have final authority on all aspects of the project.

12. 7501313/7504366 co-OI 0 % effort Tien (PI)

UCSF-Academic Senate Shared Instrument

Awards

02/01/2017 07/31/2018

Integrated Lung Physiology Platform for

Murine Models

$ 35000 direct/yr 1

To provide an integrated lung physiology platform to improve the quality and reproducibility

of our studies in various lung pathology models.

Provide support to investigators who would like to use the Flexivent (Scireq) equipment

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PEER REVIEWED PUBLICATIONS

1. Baulard A, Jourdan C, Mercenier A, Locht C. Rapid mycobacterial plasmid analysis by electroduction between Mycobacterium spp. and Escherichia coli. Nucleic Acids Research. 1992; 20(15):4105. PMID: 1508702

2. Jourdan Le Saux C, Gleyzal C, Garnier JM, Peraldi M, Sommer P, Grimaud JA. Lysyl oxidase cDNA of myofibroblast from mouse fibrotic liver. Biochemical and Biophysical Research Communications. 1994; 199(2):587-92. PMID: 7510957

3. Jourdan Le Saux C, Gleyzal C, Raccurt M, Sommer P. Functional analysis of the lysyl oxidase promoter in myofibroblast-like clones of 3T6 fibroblast. Journal of Cellular Biochemistry. 1997; 64(2):328-41. PMID: 9027591

4. Jourdan Le Saux C, Le Saux O, Donlon T, Boyd CD, Csiszar K. The human lysyl oxidase-related gene (LOXL2) maps between markers D8S280 and D8S278 on chromosome 8p21.2-p21.3. Genomics. 1998; 51(2):305-7. PMID: 9722957

5. Jourdan Le Saux C, Tronecker H, Bogic L, Bryant-Greenwood GD, Boyd CD, Csiszar K. The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in reproductive tissues. The Journal of Biological Chemistry. 1999; 274(18):12939-44. PMID:10212285

6. Reynaud C, Gleyzal C, Jourdan Le Saux C, Sommer P. Comparative functional study of the lysyl oxidase promoter in fibroblasts, Ras-transformed fibroblasts, myofibroblasts and smooth muscle cells. Cellular and Molecular Biology. 1999; 45(8):1237-47. PMID: 10643973

7. Jourdan Le Saux C, Le Saux O, Gleyzal C, Sommer P, Csiszar K. The mouse lysyl oxidase-like 2 gene (mLOXL2) maps to chromosome 14 and is highly expressed in skin, lung and thymus. Matrix Biology. 2000; 19(2):179-83. PMID: 10842102

8. Hein S, Yamamoto SY, Okazaki K, Jourdan Le Saux C, Csiszar K, Bryant-Greenwood GD. Lysyl oxidases: expression in the fetal membranes and placenta. Placenta. 2001; 22(1):49-57. PMID: 11162352

9. Jourdan Le Saux C, Tomsche A, Ujfalusi A, Jia L, Csiszar K. Central nervous system, uterus, heart, and leukocyte expression of the LOXL3 gene, encoding a novel lysyl oxidase-like protein. Genomics. 2001; 74(2):211-8. PMID: 11386757

10. Lozanoff S, Johnston J, Ma W, Jourdan Le Saux C. Immunohistochemical localization of Pax2 and associated proteins in the developing kidney of mice with renal hypoplasia. The journal of Histochemistry and Cytochemistry. 2001; 49(9):1081-97. PMID: 11511678

11. Chan DS, Callahan CW, Beckham S, Kishaba G, Yamamoto K, Malone FJ, Boychuk R, Tam E, Jourdan Le Saux C, Underwood G, Vogt TM, Takafuji E. Report of the first annual Hawaii Asthma Research Consortium. Hawaii Medical Journal. 2002; 61(9):194-8. PMID: 12422384

12. Jourdan Le Saux C, Bollt O, Orozco C, Concepcion J, Yamaga K, Yamamoto F, Haymer D, Tam EK. A base substitution in the interleukin-10 (IL-10) promoter between Sp1 and ets-1 binding sites is not associated with variation of IL-10 levels. Cellular and Molecular Biology. 2003; 49(7):1109-15. PMID: 14682393

13. Tam EK, Jourdan LeSaux C, Stauder S, Bollt O, Reber B, Yamamoto F, Haymer D. Polymorphisms in the interleukin-4 receptor alpha chain: association with traits of allergy

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and asthma in an admixed population in Hawaii. Cellular and Molecular Biology. 2003; 49(8):1345-9. PMID: 14984008

14. Hayashi K, Cao T, Passmore H, Jourdan Le Saux C, Fogelgren B, Khan S, Hornstra I, Kim Y, Hayashi M, Csiszar K. Progressive hair loss and myocardial degeneration in rough coat mice: reduced lysyl oxidase-like (LOXL) in the skin and heart. The Journal of Investigative Dermatology. 2004; 123(5):864-71. PMID: 15482472

15. Harrigan RC, Easa D, Jourdan Le Saux C, Millar L, Kagihara LE, Shomaker TS, Greer MH, Beck JD, Offenbacher S. Oral health disparities and periodontal disease in Asian and Pacific Island populations. Ethnicity & Disease. 2005; 15(4 Suppl 5):S5-39-46 PMID: 16315381

16. Hoffmann PR, Jourdan Le Saux C, Hoffmann FW, Chang PS, Bollt O, He Q, Tam EK, Berry MJ. A role for dietary selenium and selenoproteins in allergic airway inflammation. Journal of Immunology. 2007; 179(5):3258-67. PMID: 17709542

17. Hoffmann PR, Gurary A, Hoffmann FW, Jourdan Le Saux C, Teeters K, Hashimoto AC, Tam EK, Berry MJ. A new approach for analyzing cellular infiltration during allergic airway inflammation. Journal of Immunological Methods. 2007; 328(1-2):21-33. PMID: 17825315

18. Jourdan Le Saux C, Teeters K, Miyasato SK, Hoffmann PR, Bollt O, Douet V, Shohet RV, Broide DH, Tam EK. Down-regulation of caveolin-1, an inhibitor of transforming growth factor-beta signaling, in acute allergen-induced airway remodeling. The Journal of Biological Chemistry. 2008; 283(9):5760-8. PMID: 18056268

19. Le Saux O, Teeters K, Miyasato S, Choi J, Nakamatsu G, Richardson JA, Starcher B, Davis EC, Tam EK, Jourdan Le Saux C. The role of caveolin-1 in pulmonary matrix remodeling and mechanical properties. American Journal of Physiology. Lung Cellular and Molecular Physiology. 2008; 295(6):L1007-17. PMID: 18849439

20. Jourdan Le Saux C, Zhang J, Lindsey ML. Extracellular matrix roles during cardiac repair. Life sciences. 2010; 87(13-14):391-400. PMID: 20670633

21. Miyasato S, Loeffler J, Shohet R, Zhang J, Lindsey M, Jourdan Le Saux C. Caveolin-1 modulates TGF-β1 signaling in cardiac remodeling. Matrix Biology. 2011; 30(5-6):318-29. PMID: 21641995

22. Shivshankar P, Boyd A, Jourdan Le Saux C, I-Tien Yeh, Orihuela C. Cellular senescence increases expression of bacterial ligands in the lungs and is positively correlated with increased susceptibility to pneumococcal pneumonia. Aging Cell. 2011; 10(5):798-806. PMID:21615674

23. Shivshankar P, Brampton C, Miyasato S, Kasper M, Thannickal VJ, Jourdan Le Saux C. Caveolin-1 deficiency protects from pulmonary fibrosis by modulating epithelial cell senescence in mice. American Journal of Respiratory Cell and Molecular Biology. 2012; 47(1):28-36. PMID: 22362388

24. Ramirez TA, Jourdan Le Saux C, Joy A, Zhang J, Dai Q, Mifflin S, Lindsey ML. Chronic and intermittent hypoxia differentially regulate left ventricular inflammatory and extracellular matrix responses. Hypertension Research. 2012; 35(8):811-8. PMID: 22495609

25. Jourdan Le Saux C, Davy P, Brampton C, Ahuja S S, Fauce S, Shivshankar P, Nyugen H, Ramaseshan M, Tressler R, Pirot Z, Harley CB, Allsopp R. A novel telomerase activator suppresses lung damage in a murine model ofidiopathic pulmonary fibrosis. PloS one. 2013; 8(3):e58423. PMID: 23516479

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26. Gabehart, KE, Royce, S, Maselli Caceres D, Miyasato, S, Davis, E, Tang, M, Jourdan Le Saux C. Airway hyperresponsiveness is associated with airway remodeling but not inflammation in aging Cav1-/- mice. Respiratory Research. 2013; 14:110. PMID: 24138138

27. Medina JL, Coalson JJ, Brooks EG, Jourdan Le Saux C, Winter WT, Chaparro A, Principe MFR, Solis L, Kannan TR, Baseman JB, Dube PH. Mycoplasma pneumoniae CARDS toxin exacerbates ovalbumin-induced asthma-like inflammation in BALB/c mice. PloS one. 2014; 9(7):e102613. PMID: 25058417

28. Hung JY, Horn D, Woodruff K, Prihoda T, Jourdan Le Saux C, Peters J, Tio F, Abboud-Werner SL. Colony-stimulating factor 1 potentiates lung cancer bone metastasis. Laboratory Investigation. 2014; 94(4):371-81. PMID: 24468794

29. Royce, S and Jourdan Le Saux C. Role of caveolin-1 in asthma and chronic inflammatory respiratory diseases. Expert Review of Respiratory Medicine. 2014; 8(3):339-47. PMID: 24742020

30. Brown AO, Mann B, Gao G, Hankins JS, Humann J, Giardina J, Faverio P, Restrepo MI, Halade GV, Mortensen EM, Lindsey ML, Hanes M, Happel KI, Nelson S, Bagby GJ, Lorent JA, Cardinal P, Granados R, Esteban A, Jourdan Le Saux C, Tuomanen EI, Orihuela CJ. Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function. PLoS pathogens. 2014; 10(9):e1004383. PMID: 25232870

31. Shivshankar P, Payan H, Calhoun C, William R, Jahgidair J, Levine S, Peters J, Jourdan Le Saux C. Inhaled Tacrolimus Modulates Fibrosis Development without Promoting Inflammation in Bleomycin-Injured Mouse Lungs. Journal of Drug Delivery Science and Technology. 2014 September.

32. Shivshankar P, Halade GV, Calhoun C, Escobar GP, Mehr AJ, Jimenez F, Martinez C, Bhatnagar H, Mjaatvedt CH, Lindsey ML, Jourdan Le Saux C. Caveolin-1 deletion exacerbates cardiac interstitial fibrosis by promoting M2 macrophage activation in mice after myocardial infarction. Journal of Molecular and Cellular Cardiology. 2014; 76:84-93. PMID: 25128086

33. Sanders YY, Cui Z, Jourdan Le Saux C, Horowitz JC, Rangarajan S, Kurundkar A, Antony VB, Thannickal JV. SMAD-independent down-regulation of caveolin-1 by TGF-β: effects on proliferation and survival of myofibroblasts. PloS one. 2015; 10(2):e0116995. PMID: 25658089

34. Calhoun C, Shivshankar P, Sloane LB, Orihuela CJ, White E, Richardson A, Jourdan Le Saux C. Senescent Cells Contribute to the Physiological Remodeling of Aged Lungs. The Journals of Gerontology. Series A, Biological sciences and medical sciences. 2015; PMID: 25568097

35. Sanon VP, Sawaki D, Mjaatvedt CH, Jourdan Le Saux C. Myocardial tissue caveolae. Comprehensive Physiology. 2015; 5(2):871-86. PMID: 25880516

36. Pinkerton KE, Harbaugh M, Han MK, Jourdan Le Saux C, Van Winkle LS, Martin Ii WJ, Kosgei RJ, Carter EJ, Sitkin N, Smiley-Jewell SM, George M. Women and Lung Disease: Gender Differences and Global Health Disparities. American Journal of Respiratory and Critical Care Medicine. 2015; PMID: 25945507

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37. Halaney DL, Zahedivash A, Phipps JE, Wang T, Dwelle J, Jourdan Saux C, Asmis R, Milner TE, Feldman MD. Differences in forward angular light scattering distributions between M1 and M2 macrophages. J Biomed Opt. 2015 PMID: 26538329.

38. Wan F, Letavernier E, Jourdan Le Saux C, Houssaini A, Abid S, Czibik G, Sawaki D, Marcos E, Dubois-Rande JL, Baud L, Adnot S, Derumeaux G, Gellen B. Calpastatin overexpression impairs postinfarct scar healing in mice by compromising reparative immune cell recruitment and activation Am J Physiol Heart Circ Physiol. 2015. PMID: 26453333

39. Wei Y, Kim TJ, Peng DH, Duan D, Gibbons DL, Yamauchi M, Jackson JR, Le Saux CJ, Calhoun C, Peters J, Derynck R, Backes BJ, Chapman HA. Fibroblast-specific inhibition of TGF-β1 signaling attenuates lung and tumor fibrosis. J Clin Invest. 2017;127(10):3675-3688. doi: 10.1172/JCI94624. Epub 2017 Sep 5. PMID:/> 28872461

40. Jourdan Le Saux C, Chapman HA. Idiopathic Pulmonary Fibrosis: Cell Death and Inflammation Revisited. American Journal of Respiratory Cell and Molecular Biology. 2018; 59(2): 137 doi.org/10.1165/rcmb.2018-0083ED

41. Pereira BI, Devine OP, Vukmanovic-Stejic M, Chambers ES, Subramanian P, Patel N, Virasami A, Sebire NJ, Kinsler V, Valdovinos A, Jourdan Le Saux C, Passos JP, Antoniou A, Rustin MHA, Campisi J, Akbar AN. Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition. Nature Communications. 2019; 10:2387. 10.1038/s41467-019-10335-5

42. Ying Wei, M.D., Julia Jackson, B.S., Genevieve Montas, B.S., Darren Leong, B.S., Jeffrey A. Golden, M.D., Binh N. Trinh, M.D., Ph.D., Elena Foster, M.S., Justin M. Oldham, M.D., Angela L. Linderholm, Ph.D., Paul J. Wolters, M.D., Xiaopeng Li, M.D., Julia Klesney-Tait, M.D., Ph.D., Prerna Kotak, M.S., Martin Decaris, Ph.D., Scott Turner, Ph.D., Jin Woo Song, M.D., Ph.D., Claude Jourdan Le Saux, Ph.D., Kirk Jones, M.D., and Harold A. Chapman, M.D. Reversal of TGFb1-driven Profibrotic State in Pulmonary Fibrosis Patients. Submitted

43. Christopher D. Wiley, Alexis N. Brumwell, Sonnet S. Davis, Julia R. Jackson, Alexis Valdovinos, Cheresa Calhoun, Fatouma Alimirah, Carlos A. Castellanos, Richard Rui, Ying Wei, Harold A. Chapman, Arvind Ramanathan, Judith Campisi, and Claude Jourdan Le Saux. Secretion of Leukotrienes by Senescent Lung Fibroblasts promotes Pulmonary Fibrosis. J Clin Invest In-sight. In Revision

44. Fan H, Rosson G, Wolf M, Sadtler K, Elisseeff J, Pardoll D, Houssean F, Wu X, Narain E, Chung L, Lebid A, Mageau A, Jourdan Le Saux C, Tam A, Vanderzee I, Čiháková D, Maestas D, Zhang X, Andorko, J.Interleukin-17 and senescence regulate the foreign body. Science Translational Medicine. In Revision

BOOKS AND CHAPTERS

1. Shivshankar P, Jourdan Le Saux C. Molecular Aspects of Aging. Rojas M, Meiners S, Jourdan Le Saux C, editors. Hoboken, New Jersey: John Wiley et sons Inc.; 2014. Chapter 5, The cellular senescence program; p.8.

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2. Keyt H, Levine S, Jourdan Le Saux C. The Aging Lung: Mechanism and Clinical Sequeia. Lee P, Bucala R, editors. Washington DC: World Scientific Press; 2015. Chap 7, Environmental and Genetic Factors - Race Ethnicity and Gender

3. Molecular aspects of aging. Rojas M, Meiners S, Jourdan Le Saux C, editors. Hoboken, New Jersey: John Wiley et sons Inc.; 2014. 207p.

SIGNIFICANT PUBLICATIONS

1. I am interested in the mechanisms by which aging and injury trigger cellular senescence in

the lungs leading to the remodeling of the pulmonary tissue. I have built over the course of

the last 20 years my expertise on remodeling/fibrosis and in the last 5 years on cellular

senescence. This publication is one of the first ones to demonstrate not only the presence

of senescent cells in aged lungs but their causal role of the age-associated remodeling

features of the lungs

Calhoun C, Shivshankar P, Saker M, Sloane LB, Livi CB, Sharp ZD, Orihuela CJ, Adnot S,

White ES, Richardson A, Jourdan Le Saux C. Senescent Cells Contribute to the

Physiological Remodeling of Aged Lungs. J Gerontol A Biol Sci Med Sci. 2015 Jan

7;PubMed PMID: 25568097.

Senior Author

2. My initial work focused on the characterization of the transcriptional regulation of lysyl

oxidase and collagen type I in the liver fibrosis. At that time only 2 members were

characterized in the family of lysyl oxidase and lysyl oxidase-like family. By RNA screening

and computer analysis, we identified additional unknown members. I spent my postdoctoral

fellowship cloning and characterizing these additional members of the lysyl oxidase family in

mouse and human (Lysyl oxidase-2, -3 and -4). Because of the identification and

characterization of these additional proteins, a better understanding of the substrate

specificity could be achieved and these proteins are now used as therapeutic targets in

various fibrotic disorders

Jourdan-Le Saux C, Tronecker H, Bogic L, Bryant-Greenwood GD, Boyd CD, Csiszar K.

The LOXL2 gene encodes a new lysyl oxidase-like protein and is expressed at high levels in

reproductive tissues. J Biol Chem. 1999 Apr 30;274(18):12939-44. PubMed PMID:

10212285.

First author

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3. I initiated a project on gene variations implicated in the immune response in asthma and the

frequencies of these alleles in Asian and Pacific Islanders to determine how they differ from

those described in Caucasian, Hispanic, or African-American populations. My research

project evolved on airway remodeling in asthma to combine my new expertise in

inflammation and previous one on fibrosis. Our work demonstrated the regulation of

caveolin-1 by interleukin-4 and subsequent activation of TGF-beta signaling in airway

remodeling identifying a link between the inflammation and the remodeling processes

characteristic of asthma. Our studies were among the first ones to demonstrate a role for

caveolin-1 in pulmonary diseases./> a. Le Saux CJ, Teeters K, Miyasato SK, Hoffmann PR,

Bollt O, Douet V, Shohet RV, Broide DH, Tam EK. Down-regulation of caveolin-1, an

inhibitor of transforming growth factor-beta signaling, in acute allergen-induced airway

remodeling. J Biol Chem. 2008 Feb 29;283(9):5760-8. PubMed PMID: 18056268.

b. Shivshankar P, Brampton C, Miyasato S, Kasper M, Thannickal VJ, Le Saux CJ.

Caveolin-1 deficiency protects from pulmonary fibrosis by modulating epithelial cell

senescence in mice. Am J Respir Cell Mol Biol. 2012 Jul;47(1):28-36. PubMed PMID:

22362388; PubMed Central PMCID: PMC3402795.

Senior Author

4. We broaden our discovery on caveolin-1 regulating TGF-beta signaling in the airways to its

role in pulmonary fibrosis. We demonstrated that caveolin-1 prevents fibrosis by regulating

cellular senescence and therefore modulating cellular senescence could potential become a

therapeutic target. The importance of cellular senescence was at the time not thought to be

relevant for pulmonary fibrosis. We further studied cellular senescence and discovered that

it was an important process not only in repair of the lungs in the context of inflammation but

in aging as well./> a. Shivshankar P, Boyd AR, Le Saux CJ, Yeh IT, Orihuela CJ. Cellular

senescence increases expression of bacterial ligands in the lungs and is positively

correlated with increased susceptibility to pneumococcal pneumonia. Aging Cell. 2011

Oct;10(5):798-806. PubMed PMID: 21615674; PubMed Central PMCID: PMC3173515.

b. Shivshankar P, Brampton C, Miyasato S, Kasper M, Thannickal VJ, Le Saux CJ.

Caveolin-1 deficiency protects from pulmonary fibrosis by modulating epithelial cell

senescence in mice. Am J Respir Cell Mol Biol. 2012 Jul;47(1):28-36. PubMed PMID:

22362388; PubMed Central PMCID: PMC3402795.

c. Le Saux CJ, Davy P, Brampton C, Ahuja SS, Fauce S, Shivshankar P, Nguyen H,

Ramaseshan M, Tressler R, Pirot Z, Harley CB, Allsopp R. A novel telomerase activator

suppresses lung damage in a murine model of idiopathic pulmonary fibrosis. PLoS One.

2013;8(3):e58423. PubMed PMID: 23516479; PubMed Central PMCID: PMC3597721.

Senior Author

PRINCIPAL POSITIONS HELD...2012 American Association of Immunologists 99th Annual Meeting, AAI,...

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