Prevention of early-onset GBS disease

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Prevention of early-onset GBS disease

Transcript of Prevention of early-onset GBS disease

  • Prevention of early-onset GBS disease CDC, 2010. Prof. Aboubakr Elnashar Benha university, Egypt Aboubar Elnashar
  • Incidence Asymptomatic carriage of GBS: Common. 10-30% of all pregnant women Organism Streptococcus agalactiae: Gram-positive Colonize the lower GIT & Spread to the genitourinary tract Aboubar Elnashar
  • Found in pairs or chains 6 groups: A, B, C, D, F, and G by antibodies that recognize surface antigens (Streptococcus fluorescent antibody stain (digitally colorized). The most important: A, B and D. 3 types of hemolysis after growth of streptococci on blood agar. Alpha: partial hemolysis Beta: complete clearing Gamma: no lysis. Group A and group B are beta hemolytic Aboubar Elnashar
  • Aboubar Elnashar
  • Complications 1.PTL 2.Premature ROM 3.Chorioamnionitis 4.Puerperal sepsis 5.Postpartum osteomylitis & mastitis. 6.Fetal & neonatal infections Aboubar Elnashar
  • Neonatal sepsis USA: GBS is the leading cause of neonatal bacterial sepsis UK: GBS is the most frequent cause of neonatal severe early onset infection (0.5/1000 births). There is controversy about its prevention Aboubar Elnashar
  • Early onset disease (