Preventing and Responding to Influenza in MN LTC … and Responding to Influenza in MN LTC...
Transcript of Preventing and Responding to Influenza in MN LTC … and Responding to Influenza in MN LTC...
Preventing and Responding to Influenza in MN LTC Facilities
Karen Martin, MPH – Influenza SurveillanceMary Ellen Bennett, MPH, RN, CIC – Infection Control
Jennifer Heath, DNP, MPH, RN – Vaccination
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•Activity Update
•Infection Control Measures
•Influenza Vaccination
•Antiviral Medications
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Minnesota Department of Health Weekly Influenza & Respiratory Activity Report for week ending October 28, 2017 | WEEK 43 4
Weekly Influenza & Respiratory Illness Activity Report
A summary of influenza surveillance indicators prepared by the Division of Infectious Disease Epidemiology Prevention & Control
Week Ending January 6, 2018 | WEEK 1All data are preliminary and may change as more information is received
Minnesota Influenza Geographic Spread
No ActivityDuring the week ending January 6, 2018 (Week 1),
surveillance indicators showed widespread geographic spread of influenza.
Since the start of the influenza season, one pediatric influenza-related death
has been reported.
Sporadic
Local
Regional
Widespread
Based on CDC’s Activity Estimates Definitions: http://www.cdc.gov/flu/weekly/overview.htm
Minnesota Influenza Surveillance: http://www.health.state.mn.us/divs/idepc/diseases/flu/stats/Weekly U.S. Influenza Surveillance Report: http://www.cdc.gov/flu/weekly/World Health Organization (WHO) Surveillance: http://www.who.int/influenza/surveillance_monitoring/updates/en/Neighboring states’ influenza information:
Iowa http://www.idph.state.ia.us/IdphArchive/Archive.aspx?channel=FluReportsWisconsin http://www.dhs.wisconsin.gov/communicable/influenza/surveillance.htmNorth Dakota http://www.ndflu.com/default.aspxSouth Dakota http://doh.sd.gov/diseases/infectious/flu/
Minnesota Department of Health Weekly Influenza & Respiratory Activity Report for week ending October 28, 2017 | WEEK 43 5
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Respiratory Disease Outbreak Surveillance (continued)
Long-Term Care (LTC) OutbreaksLTC facilities report to MDH when they suspect an outbreak of influenza in their facility. Laboratory-confirmed outbreaks are reported here.
New LTC outbreaks this week
New LTC outbreaks last week
Total this season (to date)
23 19 55
Confirmed Influenza Outbreaks in LTC by Season
Current week
Minnesota Department of Health Weekly Influenza & Respiratory Activity Report for week ending October 28, 2017 | WEEK 43 6
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Percent of positive molecular tests
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A (not subtyped)
A H3
A (H1N1) pdm09
2014-15 % + by PCR
2015-16 % + by PCR
2016-17 % + by PCR
2017-18 % + by PCR
Laboratory Surveillance The MN Lab System (MLS) Laboratory Influenza Surveillance Program is made up of more than 310 clinic- and hospital-based laboratories, voluntarily submitting testing data weekly. These laboratories perform rapid testing for influenza and Respiratory Syncytial Virus (RSV). Significantly fewer labs perform PCR testing for influenza and three also perform PCR testing for other respiratory viruses. MDH-PHL provides further characterization of submitted influenza isolates to determine the hemagglutinin serotype to indicate vaccine coverage. Tracking the laboratory results assists healthcare providers with patient diagnosis of influenza-like illness and provides an indicator of the progression of the influenza season as well as prevalence of disease in the community.
% molecular tests positive this week
% molecular tests positive last week
23.7% 26.6%
Specimens Positive for Influenza by Molecular Testing*, by Week
* Beginning in 2016-17, laboratories report results for rapid molecular influenza tests in addition to RT-PCR results
Current week
Minnesota Department of Health Weekly Influenza & Respiratory Activity Report for week ending October 28, 2017 | WEEK 43 7
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2013-14
2014-15
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2017-18
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MMWR Week
B (no genotype)
B (Yamagata)
B (Victoria)
A (not subtyped)
A H3
A H1 (unspecified)
A (H1N1)pdm09
A (H1N2v)
A (H3N2v)
A&B
Unknown
Hospitalized Influenza SurveillanceHospitalized influenza cases are based on disease reports of laboratory-positive influenza (via DFA, IFA, viral culture, EIA, rapid test, paired serological tests or RT-PCR) and specimens from hospitalized patients with acute respiratory illness submitted to MDH-PHL by hospitals and laboratories. Due to the need to confirm reports and reporting delays, consider current week data preliminary.
Hospitalized Influenza Cases by Type Minnesota (FluSurv-NET*)
Hospitalized Influenza Cases by Season, Minnesota (FluSurv-NET*)
*Influenza Surveillance Network
Season Total hospitalizations (historic)
2012-2013 3,0682013-2014 1,5402014-2015 4,1382015-2016 1,5412016-2017 3,7382017-2018 1,765 (to date)
Hospitalizations this week
Hospitalizations last week
Total hospitalizations(to date)
503 598 1,765
Current week Current week
Minnesota Department of Health Weekly Influenza & Respiratory Activity Report for week ending October 28, 2017 | WEEK 43 8
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Hospitalizations per 100,000 Persons
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Age Group (years)
# of hospitalizations
Incidence (cases) per100,000 Persons
26.4
39.8
11.723.3 25.8 24.6 18.8 18.3
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Number of Influenza Hospitalizations and Incidence by Region, Minnesota
October 1, 2017 – January 6, 2018
Number of Influenza Hospitalizations and Incidence by Age, Minnesota
October 1, 2017 – January 6, 2018
Median age (years) at time of admission
74.0
Region Hospitalizations this week
Total (to date)
Central 63 (13%) 198 (11%)Metro 336 (67%) 1,208 (68%)Northeast 5 (1%) 38 (2%)Northwest 13 (3%) 37 (2%)South Central 25 (5%) 75 (4%)Southeast 28 (6%) 124 (7%)Southwest 17 (3%) 41 (2%)West Central 16 (3%) 44 (3%)
Hospitalized Influenza Surveillance (continued)
Hospitalizations per 100,000 Persons
Identifying and Reporting Influenza Outbreaks
• Identifying an Outbreak
• Outbreak definition: at least two residents with onset of influenza-like illnesses within 72 hours of each other AND at least one resident has laboratory-confirmed influenza.
• Reporting an Outbreak to MDH
• Submit a Long-Term Care Facility Influenza and RSV Report Form, 2017–18 (www.health.state.mn.us/divs/idepc/diseases/flu/ltc/ltcreport.pdf) to MDH by email or fax when an influenza outbreak is identified in your LTC facility. Please call 651-201-5924 if you have questions regarding reporting or influenza outbreak control measures.
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Sign Up for Weekly Influenza Updates
• http://www.health.state.mn.us/divs/idepc/diseases/flu/stats/index.html
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Infection Prevention
• Influenza characteristics• Surveillance• Isolation • Prevention• Tools for management • References
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Influenza Characteristics
Influenza in Elderly Persons
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Disease Presentation• Influenza-like illness (ILI) in elderly persons may be atypical• New onset of cough, sore throat, nasal congestion or rhinorrhea, or a
temperature 100° F or greater; however, fever may be absent• Atypical complaints: anorexia, mental status changes, and unexplained
fever may be the presenting symptoms
Disease Presentation in General Population• Fever or feeling feverish/chills, cough, sore throat, runny or stuffy
nose, muscle or body aches, headaches, fatigue (tiredness)
Influenza in Elderly Persons
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Complications: • Worsening respiratory status: (residents with COPD or CHF) • Primary viral pneumonia and bacterial suprainfection (leading to
tracheobronchitis or pneumonia)
Transmission• Large respiratory droplets (particles >5 µ in diameter) expelled from
resp. tract• Close contact (< 3 feet) usually is required for transmission• Direct contact with respiratory droplets or secretions• Touching the nose or mouth
Influenza in Elderly Persons
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Incubation• 1 to 4 days, usually 2 days
Contagiousness (or Infectious Period)• 24 hours prior to onset of illness to at least 5 days after onset of
symptoms• Immunocompromised shed virus for 7 days or more after onset of
symptoms
Duration• 1-2 weeks with severe symptoms in the first few days
Surveillance
Surveillance for Influenza & ILI in LTC Facilities
• Residents are monitored for illness on a routine basis • Clusters of illness or infection can be detected by this
type of monitoring • A log of illnesses and infection is kept by nursing staff• Influenza and influenza like illness can be kept on the
routine tracking forms or the facility can use a special influenza tracking form from MDH
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Tracking Tool
Infection and Antibiotic Use Tracking tool (Appendix L)http://www.health.state.mn.us/divs/idepc/dtopics/antibioticresistance/asp/ltc/
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Line List
Influenza-like Illness (ILI) Line List: Do not submit to MDHhttp://www.health.state.mn.us/divs/idepc/diseases/flu/ltc/index.html 20
Isolation for Influenza and Influenza Like Illness (ILI)
CMS LTC Interpretive Guidance –Transmission Based Precautions
The diagnosis of many infections is based on clinical signs and symptoms, but often requires laboratory confirmation. However, since laboratory tests (especially those that depend on culture techniques) may require two or more days to complete, transmission-based precautions may need to be implemented …….. a resident with influenza and signs of infection should wear a facemask (e.g., surgical or procedure facemask) when leaving his/her room for medically-necessary care (i.e., droplet precautions for the duration of the illness). State Operations Manual, Appendix PP – Guidance to Surveyors 11-22-2017 see pages 673-714 for Infection Control https://www.cms.gov/Regulations-and-Guidance/Guidance/Manuals/downloads/som107ap_pp_guidelines_ltcf.pdf
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Standard and Droplet Precautions
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• Standard precautions: use for all patients• Droplet precautions: use with standard precautions for residents with
known or suspected influenza or influenza-like illness• Precautions should be in place for the duration of the symptoms of illness
o Best to have a private room if available – can cohort ill persons o Signageo Procedure mask: correct don/doff procedureo Care of patient care equipment – clean all equipment going in and out
with a EPA registered disinfectanto Hand hygiene
https://www.cdc.gov/infectioncontrol/guidelines/isolation/index.html
CMS LTC Interpretive Guidance –Transmission Based Precautions
• Clearly identify the type of precautions and the appropriate PPE to be used;
• Place signage in a conspicuous place outside the resident’s room such as the door or on the wall next to the doorway identifying the CDC category of transmission-based precautions (e.g. contact, droplet, or airborne), instructions for use of PPE, and/or instructions to see the nurse before entering. Ensure that signage also complies with residents’ rights to confidentiality and privacy;
• Make PPE readily available near the entrance to the resident’s room; • Don appropriate PPE upon entry into the environment (e.g., room or
cubicle) of resident on transmission-based precautions;
State Operations Manual, Appendix PP – Guidance to Surveyors 11-22-2017 see pages 673-714 for Infection Control https://www.cms.gov/Regulations-and-Guidance/Guidance/Manuals/downloads/som107ap_pp_guidelines_ltcf.pdf
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Enforce Correct Mask Use
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• Hand hygiene before and after touching (masks are contaminated)
• Follow instructions for donning and removal by type of mask (i.e., ear loops, ties)
• Do not wear around the neck, on an ear, on top of the head, or re-use between residents
• Provide easy access to masks, alcohol hand sanitizer, and waste receptacles
http://www.apic.org/Resource_/TinyMceFileManager/consumers_professionals/APIC_DosDontsofMasks_hiq.pdf
How to put on a face mask1. Clean your hands with soap and water or hand sanitizer before touching the mask.2. Remove a mask from the box and make sure there are no obvious tears or holes in either side of the mask. 3. Determine which side of the mask is the top. The side of the mask that has a stiff bendable edge is the top and is meant
to mold to the shape of your nose.4. Determine which side of the mask is the front. The colored side of the mask is usually the front and should face away
from you, while the white side touches your face.5. Follow the instructions below for the type of mask you are using.
Face Mask with Ear loops: Hold the mask by the ear loops. Place a loop around each ear.Face Mask with Ties: Bring the mask to your nose level and place the ties over the crown of your head and secure with a bow.Face Mask with Bands: Hold the mask in your hand with the nosepiece or top of the mask at fingertips, allowing the headbands to hang freely below hands. Bring the mask to your nose level and pull the top strap over your head so that it rests over the crown of your head. Pull the bottom strap over your head so that it rests at the nape of your neck.
6. Mold or pinch the stiff edge to the shape of your nose. 7. If using a face mask with ties: Then take the bottom ties, one in each hand, and secure with a bow at the nape of your
neck.8. Pull the bottom of the mask over your mouth and chin. 26
Prevention
Employee Illness
• Offer vaccination to all employees throughout the season • Vaccinate new employees who start during the season • Staff should know the symptoms of influenza so they can
recognize it in themselves and the residents• Enforce staff not working when they are sick• Staff should know that they can be infectious 1 day before
they exhibit classic symptoms of influenza• Encourage staff to notify managers if they do develop an
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Visitors Entering the Facility• Post signs at entry to restrict ill
visitors• Publish visitor restriction notices to
the local community• Limit visitor movement in facility• Alcohol hand rubs at entry with
signage• Cover your cough signs• Encourage visitors to get a flu shot
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Visiting the Ill Resident
• Limit visiting to persons necessary for the resident’s well-being and care
• Hand hygiene before entering, after leaving the resident’s room
• Instruct visitors how to wear and dispose of PPE as per facility policy
• Instruct visitors to not visit other residents before removing PPE (if worn) and perform hand hygiene
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Visiting Restrictions
• Stronger measures can be implemented at the digression of the facility during an influenza outbreak
• For instance• Alerting visitors about the outbreak• Restricting visiting for children• Screening all visitors for illness before
visiting
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Tools
Tip Sheet
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• Before an Outbreak Occurs• Identifying an Outbreak• Reporting an Outbreak to MDH• Testing• Monitor• Control• Additional Control Measures to Consider• Treatment• Chemoprophylaxis
www.cdc.gov/flu/pdf/professionals/interim-guidance-outbreak-management.pdf
Signs – Droplet Precautions
Washington State Isolation Signs – scroll down to SIGNS. Can download or purchase actual sign for $1.10http://www.wsha.org/quality-safety/projects/standardization/ 34
Example of a transmission based precaution isolation sign
Do not put resident’s name on the sign
Note: MDH does not endorse any particular sign
References
• MDH www.mdhflu.com
• CDC www.cdc.gov/flu/
• Minnesota Immunization Information Connection (MIIC) http://www.health.state.mn.us/miic
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Intramuscular Route
• Nearly all flu vaccine formulations
• Exception is intradermal vaccine
• Needle length is important!
• 1” or 1 ½” for many, but not all, adults
• Isolate the muscle
• 90 degrees
Storage and Handling of Flu Vaccine
• Maintenance of temperature is critical to the vaccine’s viability and effectiveness
• Loss of inventory, thousands of dollars even with a modest amount of vaccine
• Colder is not better• Especially vulnerable to freezing temperatures
• CDC’s guidance recently changed, ideal temperature is 40F or 4.4C
• Temperature monitoring • Several options for monitoring
• Temps recorded by a human twice per day
• Utilize MDH’s resources linked in the Fall Flu Guide.
Storage and Handling of Flu Vaccine
• Appropriate storage units• CDC recommends “stand-alone” or pharmacy grade units
• Combination units are less capable of maintaining consistent temperatures in both compartments
• Temperature monitoring • Several options for monitoring: data logger, electronic temperature monitoring or
thermometer
• All systems should be calibrated with certificate
• Temps recorded by a human twice per day
• Utilize MDH’s resources linked in the Fall Flu Guide.
Essential Resource
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Vaccination of Residents
• Continue to vaccinate• Vaccine protects against 3 or 4 strains
• Second doses not recommended
• Standard, high-dose, or adjuvanted– no preference
• Be mindful of proper administration techniques• Frail patients may require “bunching” or a shorter needle length for IM administration
• Obese patents may require a longer needle length
• Use the Minnesota Immunization Information Connection (MIIC)• http://www.health.state.mn.us/miic
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Vaccination of HCP
• Continue to vaccinate
• New employees, former decliners
• If you cannot provide vaccine refer employees to other sources: pharmacy, clinic, community vaccinator
• Un and underinsured adult vaccine program: http://www.health.state.mn.us/divs/idepc/immunize/adultvax/clinicsearch.html
• Consider your educational resources
• Tailor to a lay audience
• Seek out translations (or interpreters)– even if proficient in English
• Use the Minnesota Immunization Information Connection (MIIC)
• http://www.health.state.mn.us/miic
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Finding the Flu and Vaccine Materials
www.mdhflu.com
Influenza For Health Professionals
Antiviral Medications for the 2017-2018 Season
• Antiviral medications reduce illness and severe outcomes of influenza based on evidence from randomized controlled trials, meta-analyses of randomized controlled trials, and observational studies. https://www.cdc.gov/flu/professionals/antivirals/index.htm
• Three FDA-approved influenza antiviral drugs recommended by CDC this season to treat influenza:
• oseltamivir (available as a generic version or under the trade name Tamiflu®),
• zanamivir (trade name Relenza®), and
• peramivir (trade name Rapivab®).
• Oseltamivir (Tamiflu®) is the most common antiviral used in LTC facilities.
• Circulating strains are sensitive to oseltamivir at this time.1/12/2018 46
Antiviral Shortage?
• Manufacturers report being able to meet expected demand of season
• No supply shortage, but temporary spot shortages have been reported in parts of the country
• CDC recommends
• Call pharmacy in advance
• Call multiple pharmacies if needed
• Remember to ask for generic and brand-name oseltamivir
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CDC Antiviral Recommendations for LTC and Assisted Living
• Can be difficult logistically and financially
• Antiviral recommendations for LTC and assisted living are consistent with previous years
• Severe season underscores need for treatment/prophylaxis
• Priority groups specified if unable to implement for entire facility immediately
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Treatment with Antiviral Medications
• Treat residents with confirmed or suspected influenza with antivirals immediately.
• Treatment should not wait for laboratory confirmation of flu.
• Antiviral treatment works best when started within the first 2 days of symptoms, but can be beneficial after that period.
• Dosing: oseltamivir (Tamiflu®) antiviral treatment is typically 75 mg twice daily for 5 days.
• Longer treatment courses for patients who remain severely ill after 5 days of treatment can be considered.
• Always consult the resident’s physician for dosing guidance.
• Patients with renal impairment may require lower doses.
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Chemoprophylaxis with Antiviral Medications
• All eligible well residents in the entire LTC facility (not just currently affected wards) should promptly receive antiviral chemoprophylaxis as soon as an influenza outbreak is determined.
• Priority should be given to residents living in the same unit or floor as an ill resident. However, all non-ill residents are recommended to receive antiviral chemoprophylaxis to control influenza outbreaks.
• Dosing: In the LTC facility setting, oseltamivir (Tamiflu®) antiviral chemoprophylaxis is typically 75 mg once daily for a minimum of 2 weeks, continuing for 7 days after the last known case was identified.
• Always consult the resident’s physician for dosing guidance.
• Patients with renal impairment may require lower doses.
• Consider offering prophylaxis to staff in the facility. Alternatively, have staff contact their primary care provider to discuss prophylaxis.
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Resources
• CDC
• https://www.cdc.gov/flu/professionals/antivirals/index.htm
• MDH
• http://www.health.state.mn.us/divs/idepc/diseases/flu/ltc/index.html
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Questions?
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