Prevalence Estimates For Three Types of Motor Speech ...€¦ · of Motor Speech Disorders. Motor...
Transcript of Prevalence Estimates For Three Types of Motor Speech ...€¦ · of Motor Speech Disorders. Motor...
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Prevalence EstimatesFor Three Types of Motor Speech Disorders
In Complex Neurodevelopmental Disorders (CND)
Lawrence D. Shriberga
Edythe A. Strandb
Heather L. Mabiea
aWaisman CenterUniversity of Wisconsin-Madison
bDepartment of Neurology Mayo Clinic-Rochester
Eighteenth Biennial Conference on Motor SpeechMotor Speech Disorders & Speech Motor Control
Newport Beach, CA, March 6, 2016
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Marios Fourakis Christie Tilkens
Sheryl Hall Emily White
Heather Karlsson David Wilson
Jane McSweeny Erin Wilson
Alison Scheer-Cohen
Collaborators
Leonard Abedutto
Adriane Baylis
Raphael Bernier
Richard Boada
Steve Camarata
Thomas Campbell
Simon Fisher
Jordan Green
Jeffrey Gruen
Kathy Jakielski
This research is supported by the National Institute on Deafness and Other Communication Disorders [DC00496]and a core grant to the Waisman Center from the National Institute of Child Health and Development [HD03352]. L. Shriberg, E. Strand, and H. Mabie have no financial or non-financial relationships to disclose.
Barbara Lewis
Christopher Moore
Katharine Odell
Bruce Pennington
Nancy Potter
Erin Redle
Heather Rusiewicz
Shelley Smith
Jennifer Vannest
Yvonne Wren
Waisman Center Phonology ProjectUniversity of Wisconsin-Madison
http://www.waisman.wisc.edu/phonology/
Acknowledgments
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Statement of Purpose
Advances in the neurogenetics, treatment, and prevention of pediatric speech sound disorders require a nosology that cross-classifies a speaker’s descriptive linguistic and motor speech status.
Extensions to the finalized version of the Speech Disorders Classification System (SDCS) address this need.
We summarize constructs, measures and prevalence estimates for three types of pediatric motor speech disorders in complex neurodevelopmental contexts.
Purpose Participants Findings ConclusionsSDCS
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III. Clinical Typology(Behavioral Phenotype)
Speech Delay(SD)
Speech Delay-Developmental Psychosocial Involvement
(SD-DPI)
Speech Delay-Otitis Media
With Effusion(SD-OME)
Motor Speech Disorder-Apraxia
Of Speech(MSD-AOS)
Speech Delay-
Genetic(SD-GEN)
Speech Errors(SE)
Motor Speech Disorder(MSD)
Speech Errors -/s/
(SE-/s/)
Motor Speech Disorder-
Not Otherwise Specified
(MSD-NOS)
Speech Errors -/r/
(SE-/r/)
Motor Speech Disorder-Dysarthria
(MSD-DYS)
IV. Diagnostic Markers(Criterial Signs of Phenotype)
- - - - -- - - - -- - - - -- - - - -
- - - - -- - - - -- - - - -- - - - -- - - - - - - - - -
- - - - -- - - - - - - - - -- - - - -- - - - - - - - - -
- - - - -- - - - -- - - - -- - - - -- - - - -
- - - - -- - - - -- - - - -
I. Etiological Processes(Distal Causes)
Genomic and Environmental Risk and Protective Factors
Neurodevelopmental SubstratesII. Speech Processes
(Proximal Causes)Representation
Auditory SomatosensoryTranscoding
Planning ProgrammingExecution
FeedforwardFeedback
aShriberg, L. D. (February, 2013). State of the Art in CAS Diagnostic Marker Research. Review paper presented at theChildhood Apraxia of Speech Association of North America Speech Research Symposium, Atlanta, GA.
Speech Disorders Classification System (SDCS)aPurpose Participants Findings ConclusionsSDCS
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III. Clinical Typology(Behavioral Phenotype)
Speech Delay(SD)
Speech Delay-Developmental Psychosocial Involvement
(SD-DPI)
Speech Delay-Otitis Media
With Effusion(SD-OME)
Motor Speech Disorder-Apraxia
Of Speech(MSD-AOS)
Speech Delay-
Genetic(SD-GEN)
Speech Errors(SE)
Motor Speech Disorder(MSD)
Speech Errors -/s/
(SE-/s/)
Motor Speech Disorder-
Not Otherwise Specified
(MSD-NOS)
Speech Errors -/r/
(SE-/r/)
Motor Speech Disorder-Dysarthria
(MSD-DYS)
IV. Diagnostic Markers(Criterial Signs of Phenotype)
- - - - -- - - - -- - - - -- - - - -
- - - - -- - - - -- - - - -- - - - -- - - - - - - - - -
- - - - -- - - - - - - - - -- - - - -- - - - - - - - - -
- - - - -- - - - -- - - - -- - - - -- - - - -
- - - - -- - - - -- - - - -
I. Etiological Processes(Distal Causes)
Genomic and Environmental Risk and Protective Factors
Neurodevelopmental SubstratesII. Speech Processes
(Proximal Causes)Representation
Auditory SomatosensoryTranscoding
Planning ProgrammingExecution
FeedforwardFeedback
Linear Representation of Speech and Motor Speech Classifications
aShriberg, L. D. (February, 2013). State of the Art in CAS Diagnostic Marker Research. Review paper presented at theChildhood Apraxia of Speech Association of North America Speech Research Symposium, Atlanta, GA.
Purpose Participants Findings ConclusionsSDCS
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Purpose Participants Findings ConclusionsSDCS
Cross-Classification (Matrix) Representation of Speech and Motor Speech Classifications
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Purpose Participants Findings ConclusionsSDCS
Cross-Classification (Matrix) Representation of Speech and Motor Speech Classifications
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Purpose Participants Findings ConclusionsSDCS
Cross-Classification (Matrix) Representation of Speech and Motor Speech Classifications
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Purpose Participants Findings ConclusionsSDCS
Cross-Classification of Speech and Motor Speech Disorders: Individual
Participant PT03
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Purpose Participants Findings ConclusionsSDCS
Cross-Classification of Speech and Motor Speech Disorders: Groupa
a Wilson, E. M., Abbeduto, L., Camarata, S. M., & Shriberg, L. D. (2016). Prevalence of speech and motor speech disorders and intelligibility correlates in persons with Down syndrome. Manuscript in preparation.
Down syndrome (n=50)
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Conversational speech task
Syllable Repetition Task (Shriberg & Lohmeier, 2008)
Data reduction
Narrow phonetic transcription
Prosody-voice coding
Acoustic analyses
Data analyses
PEPPER (Shriberg, Allen, McSweeny, & Wilson, 2001)
Purpose Participants Findings ConclusionsSDCS
Assessment
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Purpose Participants Findings ConclusionsSDCS
Standardized Measures of Motor Speech Disorders
Motor Speech Classification
Measure Descriptiona
MSD-NOS Precision-Stability Index (PSI) 32 speech, prosody, voice signs
MSD-CAS Pause Marker (PM) Four types of between-word inappropriate pauses
MSD-DYS Dysarthria Index (DI) 34 speech, prosody, and voice signs
Dysarthria Subtype Indices (DSI) 12-19 sign indices of five subtypes of dysarthria: Ataxic, Spastic, Hyperkinetic, Hypokinetic, Flaccid
a Duffy (2013); Mabie & Shriberg (2016); Shriberg & Mabie (2016); Shriberg, Strand, Fourakis, Jakielski, Hall, Karlsson, Mabie, McSweeny, Tilkens, & Wilson (2016); Tilkens, Karlsson, Fourakis, Hall, Mabie, McSweeny, Wilson, & Shriberg (2016).
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CND Groups 391 participants: 16p11.2, 22q11.2,
ASD, CAS, DS, FXS, GALT, IID, TBI
Typical-speaking Reference Groups 150 participants, 3-18 years of age 50 participants, 20-80 years of age
Comparison Groups 180 participants, 3-5 years of age, Idiopathic SSD 22 participants, 45-84 years of age, AAS (stroke
and PPAOS subgroups)
Purpose Participants Findings ConclusionsSDCS
Participantsa
a 16p11.2: 16p11.2 microdeletion syndrome; 22q11.2: 22q11.2 deletion syndrome; AAS: Adult-onset Apraxia of Speech; ASD: Autism Spectrum Disorder; CAS: Childhood Apraxia of Speech; DS: Down syndrome; FXS: Fragile X syndrome; GALT: Galactosemia; IID: Idiopathic Intellectual Disability; PPAOS: Primary Progressive Apraxia of Speech; SSD: Speech Sound Disorders; TBI: Traumatic Brain Injury
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8% in children with Idiopathic SD
27% in 4 CND with high prevalence of MSD 19% in 3 CND with low prevalence of MSD
The persistent MSD phenotype in some speakers with prior CAS
Purpose Participants Findings ConclusionsSDCS
MSD-NOS Prevalence Estimates
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Purpose Participants Findings ConclusionsSDCS
Perc
enta
ge o
f Par
ticip
ants
0
10
20
30
40
50
60
70
80
90
100
SD1(n=26)
3.60.0
8.3
19.212.1
SD2(n=58)
SD3(n=84)
SD4(n=12)
ALL(n=180)
MSD-NOS Prevalence Estimates:In Idiopathic SD
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8% in children with SD
27% in 4 CND with high prevalence of MSD 19% in 3 CND with low prevalence of MSD
The persistent MSD phenotype in some speakers with prior CAS
Purpose Participants Findings ConclusionsSDCS
MSD-NOS Prevalence Estimates
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Perc
enta
ge
0
10
20
30
40
50
60
70
80
90
100
Perc
enta
ge o
f Par
ticip
ants
NOS in 4 CND with High Prevalence of MSD: 22.6% – 33.3%
22q11.2 Deletion(n=18)
NOS DYS CAS DYS &CAS
Downsyndrome
(n=50)
NOS DYS CAS DYS &CAS
Fragile XSyndrome
(n=30)
NOS DYS CAS DYS &CAS
Galactosemia(n=31)
NOS DYS CAS DYS &CAS
Purpose Participants Findings ConclusionsSDCS
33.328.0 26.7
22.627.8
11.111.1 10.0
20.0
3.30.0
MSD-NOS Prevalence Estimates:In CND
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Perc
enta
ge
0
10
20
30
40
50
60
70
80
90
100
Perc
enta
ge o
f Par
ticip
ants
NOS in 4 CND with High Prevalence of MSD: 22.6% – 33.3%
22q11.2 Deletion(n=18)
NOS DYS CAS DYS &CAS
Downsyndrome
(n=50)
NOS DYS CAS DYS &CAS
Fragile XSyndrome
(n=30)
NOS DYS CAS DYS &CAS
Galactosemia(n=31)
NOS DYS CAS DYS &CAS
Purpose Participants Findings ConclusionsSDCS
33.328.0 26.7
22.627.8
11.111.1
40.0
10.0
20.0
36.7
3.30.0
16.1
6.5
12.9
MSD-NOS Prevalence Estimates:In CND
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Perc
enta
ge
0
10
20
30
40
50
60
70
80
90
100
Perc
enta
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f Par
ticip
ants
NOS in 3 CND with Low Prevalence of MSD: 9.1% – 25.2%
Traumatic Brain Injury(n=55)
NOS DYS CAS DYS &CAS
Purpose Participants Findings ConclusionsSDCS
25.2
1.8 1.8 0.0
Autism Spectrum Disorder
(n=42)
NOS DYS CAS DYS &CAS
16p11.2Deletion(n=111)
NOS DYS CAS DYS &CAS
14.3
0.0 0.0 0.0
9.1 9.1
1.8 1.8
MSD-NOS Prevalence Estimates:In CND
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Perc
enta
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0
10
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30
40
50
60
70
80
90
100
Perc
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f Par
ticip
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NOS in 3 CND with Low Prevalence of MSD: 9.1% – 25.2%
Traumatic Brain Injury(n=55)
NOS DYS CAS DYS &CAS
Purpose Participants Findings ConclusionsSDCS
25.2
1.8 1.8 0.0
Autism Spectrum Disorder
(n=42)
NOS DYS CAS DYS &CAS
16p11.2Deletion(n=111)
NOS DYS CAS DYS &CAS
14.3
0.0 0.0 0.0
9.1 9.1
1.8 1.8
MSD-NOS Prevalence Estimates:In CND
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8% in children with SD
27% in 4 CND with high prevalence of MSD 19% in 3 CND with low prevalence of MSD
The persistent MSD phenotype in some speakers with prior CAS
Purpose Participants Findings ConclusionsSDCS
MSD-NOS Prevalence Estimates
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Purpose Participants Findings ConclusionsSDCS
Patient 2a
a Rice, G. M., Raca, G., Jakielski, K. J., Laffin, J. J., Iyama-Kurtycz, C., Hartley, S. L. . . Shriberg, L. D. (2012). Phenotype of FOXP2 haploinsufficiency in a mother and son. American Journal of Medical Genetics: Part A, 158A, 174-181.
MSD-NOS Prevalence Estimates:In Some Speakers with Prior CAS
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0% - 30% CAS or DYS & CAS in 8 CND
DYS & CAS more prevalent than CAS in idiopathic CAS in stroke and PPAOS forms of AAS in several FOXP2 case studies
Purpose Participants Findings ConclusionsSDCS
MSD-CAS & MSD-DYS & CAS Prevalence Estimates
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Perc
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40
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MSD-CASMSD-DYS & CAS
Purpose Participants Findings ConclusionsSDCS
DS(n=50)
GALT(n=31)
22q(n=18)
IID(n=26)
TBI(n=55)
FXS(n=30)
16p(n=111)
ASD(n=42)
10.0
20.0
6.5
12.911.1 11.1
3.8 3.81.8 1.8 3.3
0.0 1.8 0.0 0.0 0.0
30.0
CAS in Eight ComplexNeurodevelopmental Disorders
22.2 19.4 7.6 3.6 3.3 1.8 0.0
MSD-CAS & MSD-DYS & CAS Prevalence Estimates
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0% - 30% CAS or DYS & CAS in 8 CND
DYS & CAS more prevalent than CAS in idiopathic CAS in stroke and PPAOS forms of AAS in several FOXP2 case studies
Purpose Participants Findings ConclusionsSDCS
MSD-CAS & MSD-DYS & CAS Prevalence Estimates
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Perc
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0
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MSD-CASMSD-DYS & CAS
Purpose Participants Findings ConclusionsSDCS
Neurogenetic(n=12)
50.0
100.0CAS AAS
Idiopathic(n=16)
Stroke(n=10)
PPAOS(n=12)
50.0
31.3
68.8
0.0
16.7
83.3
MSD-CAS & MSD-DYS & CAS Prevalence Estimates
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0% to 39% CAS or DYS & CAS in 9 CND
DYS & CAS more prevalent than CAS in idiopathic CAS in stroke and PPAOS forms of AAS in several FOXP2 case studies
Purpose Participants Findings ConclusionsSDCS
MSD-CAS & MSD-DYS & CAS Prevalence Estimates
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Purpose Participants Findings ConclusionsSDCS
Participant B(Shriberg et al., 2006; Tomblin et al., 2009)
MSD-CAS & MSD-DYS & CAS Prevalence Estimates
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Purpose Participants Findings ConclusionsSDCS
Participant T(Shriberg et al., 2006; Tomblin et al., 2009)
MSD-CAS & MSD-DYS & CAS Prevalence Estimates
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0% - 60% DYS or DYS & CAS in 8 CND
DYS more prevalent than DYS & CAS in 7 CND
Ataxic DYS most prevalent of the five dysarthria subtypes in CAS, AAS, DS, and FXS
Purpose Participants Findings ConclusionsSDCS
MSD-DYS & MSD-DYS & CAS Prevalence Estimates
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Perc
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ticip
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0
10
20
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40
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100
MSD-DYS MSD-DYS & CAS
Purpose Participants Findings ConclusionsSDCS
DS(n=50)
GALT(n=31)
22q(n=18)
IID(n=26)
TBI(n=55)
FXS(n=30)
16p(n=111)
ASD(n=42)
20.0
12.911.1
3.81.80.0 0.0 0.0
40.0
16.1
27.8
11.59.1
36.7
1.8 0.0
DYS in Eight ComplexNeurodevelopmental Disorders
60.0 38.9 36.7 29.0 15.3 10.9 1.8 0.0
MSD-DYS & MSD-DYS & CAS Prevalence Estimates
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0% to 60% DYS or DYS & CAS in 8 CND
DYS more prevalent than DYS & CAS in 7 CND
Ataxic DYS most prevalent of the five dysarthria subtypes in CAS, AAS, DS, and FXS
Purpose Participants Findings ConclusionsSDCS
MSD-DYS & MSD-DYS & CAS Prevalence Estimates
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Purpose Participants Findings ConclusionsSDCS
MSD-DYS & MSD-DYS & CAS Prevalence Estimates for Subtypes of Dysarthria
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One or more of three motor speech disorders (NOS, DYS, CAS) had substantial prevalence in the present samples of participants with complex neurodevelopmental disorders, and in participants with idiopathic Speech Delay.
NOS provides a useful classification entity for research and clinical applications.
CAS & DYS was more prevalent than CAS only, with implications for dimensional versus categorical nosologies in pediatric motor speech disorders.
Cross-classification of speech and motor speech disorders should provide informative phenotypes for explanatory, treatment, and preventive research.
Summary and ConclusionsPurpose Participants Findings ConclusionsSDCS
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ReferencesDuffy, J. R. (2013). Motor speech disorders: Substrates, differential diagnosis, and management (3rd ed.).
St. Louis, MO: Mosby.Mabie, H. L., & Shriberg, L. D. (2016). Reference data for competence, precision, and stability indices of
motor speech disorders. Technical Report in preparation. (Tech. Rep. No. 23). Phonology Project, Waisman Center, University of Wisconsin-Madison.
Rice, G. M., Raca, G., Jakielski, K. J., Laffin, J. J., Iyama-Kurtycz, C., Hartley, S. L. . . Shriberg, L. D. (2012). Phenotype of FOXP2 haploinsufficiency in a mother and son. American Journal of Medical Genetics: Part A, 158A, 174-181.
Shriberg, L.D. (February, 2013). State of the Art in CAS Diagnostic Marker Research. Review paper presented at the Childhood Apraxia of Speech Association of North America Speech Research Symposium, Atlanta, GA.
Shriberg, L. D., Allen, C. T., McSweeny, J. L., & Wilson, D. L. (2001). PEPPER: Programs to examine phonetic and phonologic evaluation records [Computer software]. Madison, WI: Waisman Center Research Computing Facility, University of Wisconsin-Madison.
Shriberg, L. D., Ballard, K. J., Tomblin, J. B., Duffy, J. R., Odell, K. H., & Williams, C. A. (2006). Speech, prosody, and voice characteristics of a mother and daughter with a 7;13 translocation affecting FOXP2. Journal of Speech, Language, and Hearing Research, 49, 500-525.
Shriberg, L. D., & Lohmeier, H. L. (2008). The Syllable Repetition Task (Tech. Rep. No. 14). Phonology Project, Waisman Center, University of Wisconsin-Madison.
Shriberg, L. D., & Mabie, H. L. (2016). Speech and motor speech classification findings for participantswith complex neurodevelopmental disorders. Technical Report in preparation. (Tech. Rep. No. 24).Phonology Project, Waisman Center, University of Wisconsin-Madison.
Shriberg, L. D., Strand, E. A., Fourakis, M., Jakielski, K. J., Hall, S. D., Karlsson, H. B., Mabie, H. L.,McSweeny, J. L., Tilkens, C. M., & Wilson, D. L. (2016). A diagnostic marker of Childhood Apraxia ofSpeech (CAS): I. Development and description of the Pause Marker (PM). Manuscript submitted forpublication.
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ReferencesTilkens, C. M., Karlsson, H. B., Fourakis, M., Hall, S. D., Mabie, H. L, McSweeny, J. L., . . . Shriberg, L.D.
(2016). A diagnostic marker of Childhood Apraxia of Speech. Technical Report in preparation. (Tech.Rep. No. 22). Phonology Project, Waisman Center, University of Wisconsin-Madison.
Tomblin, J.B., O'Brien, M., Shriberg, L.D., Williams, C., Murray, J., Patil, S., et al. (2009). Language featuresin a mother and daughter of a chromosome 7;13 translocation involving FOXP2. Journal of Speech,Language, and Hearing Research, 52, 1157-1174.
Wilson, E. M., Abbeduto, L., Camarata, S. M., & Shriberg, L. D. (2016). Prevalence of speech and motorspeech disorders and intelligibility correlates in persons with Down syndrome. Manuscript in preparation.