MedeFile Makes Strides with the Senior Market BOCA RATON, FL, Jan. 28, 2010 -- MedeFile International, Inc. (OTCBB: MDFI), a leader in portable electronic medical records management, today announced that it has signed a marketing agreement with The Senior Site, Inc. The companies will collaborate on initiatives directed to U.S. seniors to promote member subscriptions for MedeFile’s comprehensive medical records management solution. The Senior Site, Inc. caters to an extremely important demographic for MedeFile by providing one-on-one consultations with individual families, caregivers to seniors and corporately by assisting employees in finding eldercare resources. By having a MedeFile each client of The Senior Site, Inc. will be in possession of a potentially live saving tool. Jo T. Letwaitis, President and CEO of The Senior Site, Inc. stated, “We strive to provide the caregivers of older Americans with various types of support and platforms that help them make decisions and follow through involving their loved one’s care. We believe every senior should have a MedeFile because of their vulnerabilities which unfortunately may include urgent admissions to nursing homes or assisted living facilities. With MedeFile’s services, caregivers can enjoy the convenience and peace of mind made possible from knowing that all of their loved ones’ actual medical records are within reach at all times. We are truly excited about this innovative service and believe that it will demonstrate the need for all caregivers to utilize.” The mission of The Senior Site, Inc. is to educate caregivers, professionals and the general public on ‘all things senior’ through various venues and platforms. The Senior Site, Inc. is an all-encompassing senior-centric, consulting company assisting elders, adult children, and other concerned parties in various aspects of a senior’s needs as they transition from independent, private residence living to the next phase in their life. “We are very excited to have Jo and her team of professionals at www.theseniorsite.com marketing MedeFile to seniors, a major target market for MedeFile. The benefits of seniors having a MedeFile are invaluable. Seniors tend to have more extensive and complex medical records and may not be best suited to keep track of all the information necessary for proper, thorough treatment. Getting a senior’s health and medical information organized and accessible could be an extremely complicated task that can be easily attained through the MedeFile services. With the emphasis on serving the needs of seniors by means of their caregivers, The Senior Site, Inc. team is ideally suited to help MedeFile penetrate this tremendous market. Additionally, this relationship will help MedeFile drive subscriber growth and in turn position our Company as the preferred solution provider to the healthcare industry,” added Milton Hauser, Chairman and CEO of MedeFile. About MedeFile International, Inc.

Headquartered in South Florida, MedeFile has a proprietary system for gathering and digitizing medical records so that individuals can have a comprehensive record of all of their medical visits. MedeFile's primary product is the MedeFile system, a highly secure system for gathering and maintaining medical records. The MedeFile system is designed to gather all of its members' actual medical records and create a single, comprehensive medical record that is accessible 24 hours a day, seven days a week.

Representing an advanced, yet easy-to-use, approach to portable, electronic medical records management, MedeFile combines state-of-the-art technology and the Internet to make medical data instantly accessible to each MedeFile subscriber and his or her authorized health care providers from anywhere in the world. In addition to accessing one's medical records through MedeFile's secure Internet portal found at www.medefile.com, members can carry their entire medical history and emergency information wherever they go on a unique device called a MedeDrive -- a proprietary USB drive designed to be carried on a keychain. The MedeDrive plugs into any USB port of a Windows-based PC; and because MedeDrive automatically loads its own viewer, users do not require any special programs or software to view data. MedeMobile provides on-the-go subscribers with the ability to enjoy even greater flexibility and access to their personal health information wherever and whenever they need it. MedeMinder is an electronic "reminder service" that utilizes automated phone service to assist its subscribers in remembering scheduled medication reminders, doctor appointments, prescriptions refills, and other time-sensitive treatment protocols. For more information about MedeFile and its annual subscription-based programs, please visit www.medefile.com

Safe Harbor Statement Under the Private Securities Litigation Act of 1995

With the exception of historical information, the matters discussed in this press release are forward-looking statements that involve a number of risks and uncertainties. The actual future results of MedeFile could differ significantly from those statements. Factors that could cause actual results to differ materially include risks and uncertainties such as the inability to finance the Company's operations or expansion, inability to hire and retain qualified personnel, changes in the general economic climate, including rising interest rates, and unanticipated events such as terrorist activities. In some cases, you can identify forward-looking statements by terminology such as "may," "will," "should," "expect," "plan," "anticipate," "believe," "estimate," "predict," "potential" or "continue," the negative of such terms, or other comparable terminology. These statements are only predictions. Although we believe that the expectations reflected in the forward-looking statements are reasonable, and such statements should not be regarded as a representation by the Company, or any other person, that such forward-looking statements will be achieved. We undertake no duty to update any of the forward-looking statements, whether as a result of new information, future events or otherwise. In light of the foregoing, readers are cautioned not to place undue reliance on such forward-looking statements. For further risk factors associated with our Company, review our SEC filings.